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Relationships between blood chromium exposure and liver injury:Exploring the mediating role of systemic inflammation in a chromate-exposed population

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Journal of Environmental Sciences 2024年第9期143卷 224-234页

作者： Zekang Su Yali Zhang Shiyi Hong Qiaojian Zhang jiayu Xu Guiping Hu Xiaojun Zhu Fang Yuan Shanfa Yu Tianchen Wang Guang Jia Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China School of Engineering Medicine and Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang UniversityBeijing 100191China National Center for Occupational Safety and Health Beijing 102308China Department of Occupational Health and Radiological Health Chongqing Centers for Disease Control and PreventionChongqing 400042China Henan Institute for Occupational Medicine Zhengzhou 450052China Department of Clinical Laboratory Third Hospital of Peking UniversityBeijing 100191China

Hexavalent chromium and its compounds are prevalent pollutants,especially in the work environment,pose a significant risk for multisystem toxicity and *** it is known that chromium accumulation in the liver can cause damage,the dose-response relationship between blood chromium(Cr)and liver injury,as well as the possible potential toxic mechanisms involved,remains poorly *** address this,we conducted a follow-up study of 590 visits from 305 participants to investigate the associations of blood Cr with biomarkers for liver injury,including serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),and direct bilirubin(DBIL),and to evaluate the mediating effects of systemic ***(PLT)and the platelet-to-lymphocyte ratio(PLR)were utilized as biomarkers of systemic *** the linear mixed-effects analyses,each 1-unit increase in blood Cr level was associated with estimated effect percentage increases of 0.82%(0.11%,1.53%)in TBIL,1.67%(0.06%,3.28%)in DBIL,0.73%(0.04%,1.43%)in ALT and 2.08%(0.29%,3.87%)in AST,***,PLT mediated 10.04%,11.35%,and 10.77%increases in TBIL,DBIL,and ALT levels induced by chromate,*** addition,PLR mediated 8.26%and 15.58%of the association between blood Cr and TBIL or *** findings shed light on the mechanisms underlying blood Cr-induced liver injury,which is partly due to worsening systemic inflammation.

关键词： Blood chromate Liver injury Systemic inflammation Mediation analysis

Trunk‑Inspired SWCNT‑Based Wrinkled Films for Highly‑Stretchable Electromagnetic Interference Shielding and Wearable Thermotherapy

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Nano-Micro Letters 2024年第11期16卷 429-444页

作者： Xiaofeng Gong Tianjiao Hu You Zhang Yanan Zeng Ye Zhang Zhenhua Jiang Yinlong Tan Yanhong Zou Jing Wang jiayu Dai Zengyong Chu College of Science National University of Defense TechnologyChangsha 410073People’s Republic of China Beijing Interdisciplinary Research Center National University of Defense TechnologyChangsha 410073People’s Republic of China School of Physics and Electronics Hunan UniversityChangsha 410082People’s Republic of China

Nowadays,the increasing electromagnetic waves generated by wearable devices are becoming an emerging issue for human health,so stretchable electromagnetic interference(EMI)shielding materials are highly *** trunks are capable of grabbing fragile vegetation and tearing trees thanks not only to their muscles but also to their folded *** by the wrinkled skin of the elephant trunks,herein,we propose a winkled conductive film based on single-walled carbon nanotubes(SWCNTs)for multifunctional EMI *** conductive film has a sandwich structure,which was prepared by coating SWCNTs on both sides of the stretched elastic latex cylindrical *** shrinking-induced winkled conductive network could withstand up to 200%tensile ***,when the stretching direction is parallel to the polarization direction of the electric field,the total EMI shielding effectiveness could surprisingly increase from 38.4 to 52.7 dB at 200%tensile *** is mainly contributed by the increased connection of the *** addition,the film also has good Joule heating performance at several voltages,capable of releasing pains in injured *** unique property makes it possible for strain-adjustable multifunctional EMI shielding and wearable thermotherapy applications.

关键词： Electromagnetic interference shielding Single-walled carbon nanotubes Wrinkles Stretchable Thermotherapy

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多媒体网络技术在高校教学中体现

科教导刊 2021年第7期 15-17页

作者：周佳玉 University of York 英国约克

新时期下,在信息技术的支持下,我国的教育事业也得到了飞速的发展。通过应用多媒体网络技术,可以将抽象的知识更加生动形象的展示给学生,在很大程度上也促进了我国高校教育的发展。基于此,文章分析了多媒体网络技术在高校教育中的应用... 详细信息

新时期下,在信息技术的支持下,我国的教育事业也得到了飞速的发展。通过应用多媒体网络技术,可以将抽象的知识更加生动形象的展示给学生,在很大程度上也促进了我国高校教育的发展。基于此,文章分析了多媒体网络技术在高校教育中的应用价值、应用问题以及体现,希望对实际的高校教育有所启示和帮助。

关键词：多媒体网络技术高校教学体现

Clinical efficacy and safety of kyphoplasty for the treatment of osteoporotic vertebral compression fractures at different surgical timings based on the theory of“dynamic-static integration”

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 86-92页

作者： Zunwang Li Jiang Chen Dekui Li jiayu Yang Jiaqi Qin Yuqing Guan Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China

Objective:To investigate the clinical efficacy and safety of percutaneous kyphoplasty at different surgical timings in the treatment of osteoporotic vertebral compression fracture(OVCF)based on the theory of“dynamic-static integration”.Methods:Patients with OVCF who underwent percutaneous kyphoplasty in our hospital were selected and divided into Groups A,B,and C for those undergoing surgery within 7,7—21,and>21 days of fracture *** variations in the amount of bone cement injected,pre-and post-operative pain levels,functional activity,deformity correction of the injured vertebrae,bone cement leakage,and vertebral body height loss were compared among the three ***:Regarding pain relief and functional activity,the postoperative Visual Analog Scale and Oswestry Disability Index scores of the three groups significantly ***,the deformities of the injured vertebrae in the three groups were significantly corrected,with Groups A and B exhibiting superior correction compared to Group ***,the bone cement leakage rates in groups A and C were higher than that in Group *** the 3-month follow-up,the loss of vertebral height in Group C was significantly higher than those in groups A and ***:Kyphoplasty is effective for OVCF *** surgery can effectively restore the vertebral height of the injured vertebra,reduce kyphosis,and reduce height loss of the injured vertebra after surgery;nevertheless,treatment within 1—3 weeks of the fracture can reduce the occurrence of bone cement leakage,making the surgery ***,surgical treatment within 1—3 weeks of fracture is safer and can achieve satisfactory therapeutic *** the perspective of traditional Chinese medicine,PKP surgery can transform the fracture end from a micromotion state to a fixed state,which fully embodies the theory of“dynamic-static integration”.

关键词： Kyphoplasty Operation timing Bone cement leakage Lost height of injured vertebra

Automation in road distress detection,diagnosis and treatment

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Journal of Road Engineering 2024年第1期4卷 1-26页

作者： Xu Yang Jianqi Zhang Wenbo Liu jiayu Jing Hao Zheng Wei Xu School of Future Transportation Chang'an UniversityXi'an 710064China School of Highway Chang'an UniversityXi'an 710064China School of Information Engineering Chang'an UniversityXi'an 710064China

Road transportation plays a crucial role in society and daily life,as the functioning and durability of roads can significantly impact a nation's economic *** the whole life cycle of the road,the emergence of disease is unavoidable,so it is necessary to adopt relevant technical means to deal with the *** study comprehensively reviews the advancements in computer vision,artificial intelligence,and mobile robotics in the road domain and examines their progress and applications in road detection,diagnosis,and treatment,especially asphalt ***,it analyzes the research progress in detecting and diagnosing surface and internal road distress and related techniques and algorithms are *** addition,also introduces various road gover-nance technologies,including automated repairs,intelligent construction,and path planning for crack *** their proven effectiveness in detecting road distress,analyzing diagnoses,and planning maintenance,these technologies still confront challenges in data collection,parameter optimization,model portability,system accuracy,robustness,and real-time ***,the integration of multidisciplinary technologies is imperative to enable the development of an integrated approach that includes road detection,diagnosis,and *** paper addresses the challenges of precise defect detection,condition assessment,and unmanned *** the same time,the efficiency of labor liberation and road maintenance is achieved,and the automation level of the road engineering industry is improved.

关键词： Road detection Road diagnosis Road treatment Deep learning Intelligent maintenance

GPCR-Gs mediates the protective effects of ginsenoside Rb1 against oxygen-glucose deprivation/re-oxygenation-induced astrocyte injury

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 33-43页

作者： Xi Wang Ying Liu Juan Li jiayu Xie Yi Dai Minke Tang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China Taihe Hospital Hubei University of MedicineShiyan 442000China School of Medicine Hyogo Medical UniversityNishinomiya 663-8501Japan

Objectives:To investigate whether the protective actions of ginsenoside Rb1(Rb1)on astrocytes are mediated through the G_(s)-type G-protein-coupled receptor(GPCR-G_(s)).Methods:Primary astrocyte cultures derived from neonatal mouse brain were *** injury was induced via oxygen-glucose deprivation/re-oxygenation(OGD/R).Cell morphology,viability,lactate dehydrogenase(LDH)leakage,apoptosis,glutamate uptake,and brain-derived neurotrophic factor(BDNF)secretion were assessed to gauge cell survival and *** blot was used to investigate the cyclic adenosine monophosphate(cAMP)and protein kinase B(Akt)signaling ***-G_(s)-specific inhibitors and molecular docking were used to identify target ***:Rb1 at concentrations ranging from 0.8 to 5μM did not significantly affect the viability,glutamate uptake,or BDNF secretion in normal ***/R reduced astrocyte viability,increasing their LDH leakage and apoptosis *** also decreased glutamate uptake and BDNF secretion by these ***1 had protective effects of astrocytes challenged by OGD/R,by improving viability,reducing apoptosis,and enhancing glutamate uptake and BDNF ***,Rb1 activated the cAMP and Akt pathways in these *** the GPCR-G_(s) inhibitor NF449 was introduced,the protective effects of Rb1 completely disappeared,and its activation of cAMP and Akt signaling pathways was significantly ***:Rb1 protects against astrocytes from OGD/R-induced injury through GPCR-G_(s) mediation.

关键词： Ginseng Ginsenoside Rb1 Receptor GPCR Astrocytes Neuroprotective effects

不平衡负载工况下三相变流器有源功率解耦控制

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电网技术 2019年第3期43卷 1056-1065页

作者：许泽富唐芬周家宇辛振 Poh Chiang Loh 国家能源主动配电网技术研发中心(北京交通大学) 北京市海淀区100044 北京电动车辆协同创新中心(北京交通大学) 北京市海淀区100044 香港中文大学电子工程系香港999077

三相电压源型变流器(VSC)对于微电网的稳定运行有着重要的作用。然而,孤岛工况下带三相不平衡负载运行时,交流侧产生的二次脉动功率耦合至直流侧,导致系统的工作性能降低并影响系统的寿命。针对该问题,在二次功率脉动分析的基础上,提出... 详细信息

三相电压源型变流器(VSC)对于微电网的稳定运行有着重要的作用。然而,孤岛工况下带三相不平衡负载运行时,交流侧产生的二次脉动功率耦合至直流侧,导致系统的工作性能降低并影响系统的寿命。针对该问题,在二次功率脉动分析的基础上,提出了一种基于虚拟三相瞬时功率的解耦控制策略,通过控制虚拟三相瞬时功率脉动分量为0,在不增加开关器件的情况下,利用LCL滤波器中电容提供负载所需二次脉动功率,实现交直流侧二次脉动功率解耦。在此基础上进一步分析了该拓扑结构直流侧所需的最低电压以及电流应力影响因素。最后仿真和实验结果均表明所提控制策略可以较好地实现功率解耦控制,直流侧源电流二次脉动分量大大减小,有利于提高系统控制性能和实现直流侧电容轻量化。

关键词：三相变流器不平衡负载二次脉动功率解耦

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近二十年佤族原始宗教研究综述

保山师专学报 2008年第3期27卷 3-7页

作者：周家瑜临沧师范高等专科学校云南临沧677000

二十年来,越来越多的学者致力于佤族原始宗教的研究,取得了丰硕的成果,这些研究主要体现在佤族原始宗教内容、原始宗教与佤族文化关系的研究等方面。缺乏理论深度的论著,缺少民族杂居区佤族原始宗教信仰情况的个案研究,以及外来宗教和... 详细信息

二十年来,越来越多的学者致力于佤族原始宗教的研究,取得了丰硕的成果,这些研究主要体现在佤族原始宗教内容、原始宗教与佤族文化关系的研究等方面。缺乏理论深度的论著,缺少民族杂居区佤族原始宗教信仰情况的个案研究,以及外来宗教和原始宗教并存状态下的佤族宗教信仰现状的研究,今后应进一步加强。

关键词：二十年佤族原始宗教原始宗教与佤族文化综述

Investigating explainable transfer learning for battery lifetime prediction under state transitions

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eScience 2024年第5期4卷 132-142页

作者： Tianze Lin Sihui Chen Stephen JHarris Tianshou Zhao Yang Liu jiayu Wan Global Institute of Future Technology Shanghai Jiao Tong UniversityNo.800 Dongchuan RoadShanghai 200240China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China SUSTech Energy Institute for Carbon Neutrality Southern University of Science and TechnologyShenzhen 518055China Energy Storage and Distributed Resources Division Lawrence Berkeley National LabBerkeleyCA 94720USA Data Science Research CenterDuke Kunshan UniversityNo.8 Duke AvenueKunshan 215316China Center for Advanced Energy System and Reliability Shanghai Jiao Tong UniversityNo.800 Dongchuan RoadShanghai 200240China

Battery lifetime prediction at early cycles is crucial for researchers and manufacturers to examine product quality and promote technology *** learning has been widely utilized to construct data-driven solutions for high-accuracy ***,the internal mechanisms of batteries are sensitive to many factors,such as charging/discharging protocols,manufacturing/storage conditions,and usage *** factors will induce state transitions,thereby decreasing the prediction accuracy of data-driven *** learning is a promising technique that overcomes this difficulty and achieves accurate predictions by jointly utilizing information from various ***,we develop two transfer learning methods,Bayesian Model Fusion and Weighted Orthogonal Matching Pursuit,to strategically combine prior knowledge with limited information from the target dataset to achieve superior prediction *** our results,our transfer learning methods reduce root-mean-squared error by 41%through adapting to the target ***,the transfer learning strategies identify the variations of impactful features across different sets of batteries and therefore disentangle the battery degradation mechanisms and the root cause of state transitions from the perspective of data *** findings suggest that the transfer learning strategies proposed in our work are capable of acquiring knowledge across multiple data sources for solving specialized issues.

关键词： Battery life prediction Transfer learning State transitions Explainability Degradation mechanism