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澳门特区“一基地”的政策体系

港澳研究 2024年第2期 73-81,96页

作者：鄞益奋刘家裕陈嘉业澳门理工大学社会经济与公共政策研究所中国澳门澳门理工大学人文及社会科学学院中国澳门

自从《粤港澳大湾区发展规划纲要》正式确立澳门特区“以中华文化为主流、多元文化共存的交流合作基地”的发展定位以来,澳门特区政府切实推进“一基地”建设,形成“弘扬主流文化,促进文化交流、加强文化保护,发展文化产业”的政策体系... 详细信息

自从《粤港澳大湾区发展规划纲要》正式确立澳门特区“以中华文化为主流、多元文化共存的交流合作基地”的发展定位以来,澳门特区政府切实推进“一基地”建设,形成“弘扬主流文化,促进文化交流、加强文化保护,发展文化产业”的政策体系。然而,澳门地区“文化交流合作基地”的政策体系较为分散,难以形成统一推进的合力。在澳门文化交流合作基地的政策体系中,文化优势没有得到充分挖掘、文化交流的广度深度有待加强、文化设施建设难以匹配文化中心定位、文化产业发展相对缓慢。优化澳门特区“一基地”的政策体系,要夯实文化交流合作基地建设的产业基础,实现“一中心、一平台、一基地”建设的紧密结合,致力将“一基地”建设成大湾区文化交流合作中心乃至全球文化交流合作中心,并强化粤澳合作和琴澳合作,共同推进“一基地”建设。

关键词：中华文化多元文化文化交流 “一基地”建设

敬畏与助人的关系:自我-他人重叠的中介作用

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心理发展与教育 2024年第4期40卷 499-509页

作者：王国芳田淑萍胥子健陈嘉晔杨敏齐中国政法大学社会学院北京100088 国家移民管理局北京100018 承德医学院心理学系承德067000 郑州大学教育学院郑州450001 郑州大学马克思主义学院郑州450001

为探索特质性敬畏与状态性敬畏与助人之间的关系及其心理机制,研究一采用问卷法探讨了特质性敬畏与助人行为的关系及自我-他人重叠的中介作用;研究二采用实验法探讨了状态性敬畏对助人行为的影响及自我-他人重叠的中介作用。结果表明:(1... 详细信息

为探索特质性敬畏与状态性敬畏与助人之间的关系及其心理机制,研究一采用问卷法探讨了特质性敬畏与助人行为的关系及自我-他人重叠的中介作用;研究二采用实验法探讨了状态性敬畏对助人行为的影响及自我-他人重叠的中介作用。结果表明:(1)个体的特质性敬畏水平越高,其助人行为水平也越高;(2)自我-他人重叠在特质性敬畏情绪与助人行为间起不完全中介作用;(3)与中性情绪相比,状态性敬畏能显著增加个体的金钱助人行为,但对时间助人行为没有显著影响;(4)自我-他人重叠在状态性敬畏与时间助人行为间起中介作用。研究从自我-他人之间联系的角度揭示了敬畏影响助人的作用机制,拓展了敬畏与社会行为的关系研究。

关键词：特质性敬畏状态性敬畏自我-他人重叠助人行为

Single-cell and spatially resolved omics:Advances and limitations

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药物分析学报:英文版 2023年第8期13卷 833-835页

作者： jiaye chen Yongcheng Wang Jina Ko Liangzhu Laboratory Zhejiang UniversityHangzhou310058China Department of Bioengineering University of PennsylvaniaPhiladelphiaUSA

Recent advances in experimental and computational single-cell and spatially resolved omics have opened new avenues for research in biology and *** technologies allow for the study of individual cells in unprecedented detail,providing insights into the heterogeneity within tissues and organs,and how different cells interact with each *** and other eukaryotes are composed of billions of cells,each with vastly heterogeneous cell types and functional cell states determined by intrinsic and extrinsic factors.

关键词： organs spatially resolved

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化工“三废”处理技术及其发展趋势研究

山东化工 2024年第5期53卷 261-262,266页

作者：金亮章留留陈佳业扬州联博药业有限公司江苏扬州225000

化工废水、废气和固废,合称为化工“三废”,是由工业化进程中产生的有害废物,会对环境和人类健康构成严重威胁。本文介绍了化工“三废”的来源,在此基础上,分别探讨了废水、废气以及固废等处理技术,并进一步展望了化工“三废”处理技术... 详细信息

化工废水、废气和固废,合称为化工“三废”,是由工业化进程中产生的有害废物,会对环境和人类健康构成严重威胁。本文介绍了化工“三废”的来源,在此基础上,分别探讨了废水、废气以及固废等处理技术,并进一步展望了化工“三废”处理技术的未来发展趋势,即精细化、绿色化以及微化工等,进而为化工“三废”的有效处理提供一定的参考。

关键词：化工三废处理

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Electronic structural engineering of bimetallic Bi-Cu alloying nanosheet for highly-efficient CO_(2) electroreduction and Zn-CO_(2) batteries

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Nano Research 2024年第5期17卷 3684-3692页

作者： Wenbo Wu jiaye Zhu Yun Tong Shuangfei Xiang Pengzuo chen School of Chemistry and Chemical Engineering Key Laboratory of Surface and Interface Science of Polymer Materials of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou 310018China

Regulating the electronic structure of Bi-based materials by alloying engineering is promising to promote the electrocatalytic activity,but it remains some challenges to be *** this study,a facile electrochemical co-deposition strategy is developed to synthesize the bimetallic Bi_(9)Cu_(1) alloy nanosheet on carbon cloth(Bi_(9)Cu_(1)/CC),which represents a novel self-supporting electrode for the electrocatalytic carbon dioxide(CO_(2))reduction reaction(CO_(2)RR).The Bi_(9)Cu_(1)/CC catalyst has achieved a remarkable catalytic performance with high Faradaic efficiencies(FE)of over 90%for formate at wide potentials from-0.7 to-1.2 V *** hydrogen electrode(RHE).Moreover,the reversible Zn-CO_(2) battery can be driven by Bi_(9)Cu_(1)/CC cathode with a largest power density of 1.4 mW·cm^(-2),and superior operating *** systematic characterizations and electrochemical results confirm that the improved catalytic active sites,the enhanced mass/charge transport and the optimal reaction kinetics of Bi nanosheet are realized for CO_(2)RR by Cu *** situ attenuated total reflection infrared(ATR-IR)result confirms the bimetallic Bi-Cu active sites prefer to follow the^(*)OCHO conversion *** density functional theory(DFT)calculations suggest that the Cu alloying contributes to the increased density of states near the Fermi surface of Bi and the optimized adsorption of^(*)OCHO intermediates on the Bi sites,resulting in the excellent catalytic performance.

关键词： electronic regulation bismuth nanosheet copper alloying CO_(2)electroreduction Zn-CO_(2)batteries

Potential mechanisms of non-suicidal self-injury(NSSI)in major depressive disorder:a systematic review

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General Psychiatry 2023年第4期36卷 220-230页

作者： Baichuan Wu Huifeng Zhang Jinghong chen jiaye chen Zhifen Liu Yuqi cheng Tifei Yuan Daihui Peng Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina General Psychiatry Editorial Office Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry The First Hospital of Shanxi Medical UniversityTaiyuanShanxiChina Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnanChina

Background Non-suicidal self-injury(NSSI)is a frequent and prominent phenomenon in major depressive disorder(MDD).Even though its prevalence and risk factors are relatively well understood,the potential mechanisms of NSSI in MDD remain *** To review present evidence related to the potential mechanisms of NSSI in *** According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines,articles for this systematic review were searched on Medline(through PubMed),Embase(through Elsevier),PsycINFO(through OVID)and Web of Science databases for English articles,as well as China National Knowledge Infrastructure(CNKI),SinoMed,Wanfang Data,and the Chongqing VIP Chinese Science and Technology Periodical(VIP)Databases for Chinese articles published from the date of inception to 2 August *** researchers(BW,HZ)independently screened studies based on inclusion and exclusion criteria and assessed their *** A total of 25157 studies were *** 25 of them were ultimately included,containing 3336 subjects(1535 patients with MDD and NSSI,1403 patients with MDD without NSSI and 398 HCs).Included studies were divided into 6 categories:psychosocial factors(11 studies),neuroimaging(8 studies),stress and hypothalamic-pituitary-adrenal(HPA)axis(2 studies),pain perception(1 study),electroencephalogram(EEG)(2 studies)and epigenetics(1 study).Conclusions This systematic review indicates that patients with MDD and NSSI might have specific psychosocial factors,aberrant brain functions and neurochemical metabolisms,HPA axis dysfunctions,abnormal pain perceptions and epigenetic alterations.

关键词： metabolism alterations mechanisms

伴有自杀意念的抑郁症患者犬尿氨酸代谢及与临床症状的动态关联分析

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中华精神科杂志 2024年第5期57卷 290-297页

作者：吴百川陈嘉烨赵冬梅金锋李华蔡亦蕴张慧凤彭代辉沈婷上海交通大学医学院附属精神卫生中心上海200030

目的探讨伴有自杀意念的抑郁症患者犬尿氨酸代谢通路是否存在异常,及与临床症状的动态关系。方法根据DSM-5诊断标准前瞻性纳入2019年7月至2022年7月于上海市精神卫生中心心境障碍就诊的68例抑郁症患者,其中男28例,女40例,年龄[M(Q_(1),Q... 详细信息

目的探讨伴有自杀意念的抑郁症患者犬尿氨酸代谢通路是否存在异常,及与临床症状的动态关系。方法根据DSM-5诊断标准前瞻性纳入2019年7月至2022年7月于上海市精神卫生中心心境障碍就诊的68例抑郁症患者,其中男28例,女40例,年龄[M(Q_(1),Q_(3))]为22.0(17.3,47.8)岁。根据贝克自杀意念量表(Beck Scale for Suicide Ideation,BSI)第4、5题认为是否有“弱”或“中等到强烈”的自杀意念将抑郁症患者分为伴自杀意念的抑郁症组(n=41)和不伴自杀意念的抑郁症组(n=27)。同时网络招募性别匹配的健康对照者72名,其中男29名,女43名,年龄为25.5(24.0,36.8)岁。使用24项汉密尔顿抑郁量表(Hamilton Depression Rating Scale-24,HAMD_(24))、汉密尔顿焦虑量表(Hamilton Anxiety Rating Scale,HAMA)、BSI分别评估抑郁症患者的抑郁症状、焦虑症状及自杀意念;并采集空腹静脉血检测所有受试者的血浆犬尿氨酸代谢物水平。对伴自杀意念的抑郁症患者进行随访,在第2、4周末重复抑郁症状、焦虑症状及自杀意念的评估和外周犬尿氨酸代谢物的检测。使用超高效液相色谱-三重四极杆质谱联用仪测定血浆中犬尿氨酸代谢物的水平。对血液学指标对数转化后进行Z-score标准化,不同代谢物的多重比较使用误报率校正。分析基线犬尿氨酸代谢物与量表分之间的关系;采用线性混合效应模型分析随访过程中犬尿氨酸代谢物与量表分的关系。结果抑郁症患者的外周吡啶甲酸(0.39±0.87比-0.23±1.09,t=3.89)、3-羟基犬尿氨酸与犬尿氨酸比值(3-hydroxykynurenine/kynurenine,3-HK/KYN)(0.38±0.85比-0.09±1.01,t=2.98)和3-HK(0.31±0.81比0.14±1.04,t=2.78)低于健康对照(均P0.05)。在伴有自杀意念的抑郁症患者中,基线HAMD_(24)、HAMA评分均与血浆3-HK(HAMD_(24):r=0.38;HAMA:r=0.39)和3-HK/KYN(HAMD_(24):r=0.34;HAMA:r=0.37)水平呈正相关(均P<0.05)。纳入年龄、性别因素后,对该组患者的随访量表评分与犬尿氨酸代谢物水平建立线性混合效应模型,结果显示HAMA评分在随访过程中对3-HK/KYN的正向影响具有统计学意义(B=0.04,t=2.46,P<0.05)。结论抑郁症患者存在犬尿氨酸代谢通路异常,3-HK及3-HK/KYN与伴有自杀意念的抑郁症患者的抑郁、焦虑水平存在相关关系,其中3-HK/KYN代表的犬尿氨酸-3-单加氧酶的活性与焦虑水平存在动态关联。

关键词：抑郁症成人犬尿氨酸自杀焦虑

Synergistic effect of carbon nanotube and encapsulated carbon layer enabling high-performance SnS_2-based anode for lithium storage

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Journal of Energy Chemistry 2024年第10期97卷 700-709,I0015页

作者： Chunwei Dong Yongjin Xia Zhijiang Su Zhihua Han Yang Dong Jingyun chen Fei Hao Qiyao Yu Qing Jiang jiaye Ye National Instituteof Clean-and-Low-Carbon Energy Beijing 102209China Key Laboratory of Automobile Materials Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022JilinChina State Key Laboratory of Explosion Science and Technology School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Tin disulfide(SnS_(2)),due to large interlayer spacing and high theoretical capacity,is regarded as a prospective anode material for lithium-ion ***,the poor electron conductivity of SnS_(2) and huge volumetric change during the lithiation/delithiation process lead to a rapid capacity decay of the battery,hindering its *** address these issues,herein,SnS_(2) is in-situ grown on the surface of carbon nanotubes(CNT)and then encapsulated with a layer of porous amorphous carbon(CNT/SnS_(2)@C)by simple solvothermal and further carbonization *** synergistic effect of CNT and porous carbon layer not only enhances the electrical co nductivity of SnS_(2) but also limits the huge volumetric change to avoid the pulverization and detachment of SnS_(2).Density functional theo ry calculations show that CNT/SnS_(2)@C has high Li^(+)adsorption and lithium storage capacity achieving high reaction ***,cells with the CNT/SnS_(2)@C anode exhibit a high lithium storage capacity of 837mAh/g after 100 cycles at 0.1 A/g and retaining a capacity of 529.8 mAh/g under 1.0 A/g after 1000 *** study provides a fundamental understanding of the electrochemical processes and beneficial guidance to design high-performance SnS_(2)-based anodes for LIBs.

关键词： Lithium-ion batteries Porous amorphous carbon Carbon nanotubes SnS_(2)-based anode Density functional theory calculations

Machine Learning Modeling of Protein-intrinsic Features Predicts Tractability of Targeted Protein Degradation

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Genomics, Proteomics & Bioinformatics 2022年第5期20卷 882-898页

作者： Wubing Zhang Shourya S.Roy Burman jiaye chen Katherine A.Donovan Yang Cao Chelsea Shu Boning Zhang Zexian Zeng Shengqing Gu Yi Zhang Dian Li Eric S.Fischer Collin Tokheim X.Shirley Liu Department of Data Science Dana-Farber Cancer InstituteBostonMA 02215USA Department of Biostatistics Harvard T.H.Chan School of Public HealthBostonMA 02115USA Department of Cancer Biology Dana-Farber Cancer InstituteBostonMA 02215USA Department of Biological Chemistry and Molecular Pharmacology Harvard Medical SchoolBostonMA 02115USA Department of Biomedical Informatics Harvard Medical SchoolBostonMA 02115USA Center of Growth Metabolismand AgingKey Laboratory of Bio-resource and Eco-environmentMinistry of EducationCollege of Life SciencesSichuan UniversityChengdu 610064China Research Scholar Initiative Graduate School of Arts and SciencesHarvard UniversityCambridgeMA 02138USA

Targeted protein degradation(TPD)has rapidly emerged as a therapeutic modality to eliminate previously undruggable proteins by repurposing the cell’s endogenous protein degradation ***,the susceptibility of proteins for targeting by TPD approaches,termed“degradability”,is largely ***,we developed a machine learning model,model-free analysis of protein degradability(MAPD),to predict degradability from features intrinsic to protein *** shows accurate performance in predicting kinases that are degradable by TPD compounds[with an area under the precision–recall curve(AUPRC)of 0.759 and an area under the receiver operating characteristic curve(AUROC)of 0.775]and is likely generalizable to independent non-kinase *** found five features with statistical significance to achieve optimal prediction,with ubiquitination potential being the most *** structural modeling,we found that E2-accessible ubiquitination sites,but not lysine residues in general,are particularly associated with kinase ***,we extended MAPD predictions to the entire proteome to find964 disease-causing proteins(including proteins encoded by 278 cancer genes)that may be tractable to TPD drug development.

关键词： Targeted protein degradation Degradability Protein-intrinsic feature Ubiquitination Machine learning