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Comparison of clinical features and outcomes of proliferative,fibrotic,and mixed subtypes of IgG4-related disease:A retrospective cohort study

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Chinese Medical Journal 2024年第3期137卷 303-311页

作者： Linyi Peng Xinlu zhang jiaxin Zhou Jieqiong Li Zheng Liu Hui Lu Yu Peng Yunyun Fei Yan Zhao Xiaofeng Zeng Wen zhang Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalNational Clinical Research Center for Dermatologic and Immunologic DiseasesState Key Laboratory of Complex Severe and Rare DiseasesThe Ministry of Education Key LaboratoryBeijing 100730China Institute of Clinical Medicine Peking Union Medical College Hospital(PUMCH)Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Background:Immunoglobulin G4-related disease(IgG4-RD)is a recently recognized immune-mediated disorder that can affect almost any organ in the human ***4-RD can be categorized into proliferative and fibrotic subtypes based on patients’clinicopathological *** study aimed to compare the clinical manifestations,laboratory findings,and treatment outcomes of IgG4-RD among different ***:We prospectively enrolled 622 patients with newly diagnosed IgG4-RD at Peking Union Medical College Hospital from March 2011 to August *** patients were divided into three groups according to their clinicopathological characteristics:proliferative,fibrotic,and mixed *** compared demographic features,clinical manifestations,organ involvement,laboratory tests,and treatment agents across three *** then assessed the differences in treatment outcomes among 448 patients receiving glucocorticoids alone or in combination with ***,risk factors of relapse were revealed by applying the univariate and multivariate Cox regression ***:We classified the 622 patients into three groups consisting of 470 proliferative patients,55 fibrotic patients,and 97 mixed patients,*** found that gender distribution,age,disease duration,and frequency of allergy history were significantly different among *** terms of organ involvement,submandibular and lacrimal glands were frequently involved in the proliferative subtype,while retroperitoneum was the most commonly involved site in both fibrotic subtype and mixed *** comparison of laboratory tests revealed that eosinophils(P=0.010),total IgE(P=0.006),high-sensitivity C-reactive protein(P<0.001),erythrocyte sedimentation rate(P<0.001),complement C4(P<0.001),IgG(P=0.001),IgG1(P<0.001),IgG4(P<0.001),and IgA(P<0.001),at baseline were significantly different among three *** with proliferative and mixed subtypes,the fibrotic subtype showed the

关键词： IgG4-related disease Proliferative subtype Fibrotic subtype Clinical features Treatment outcome

Branched-chain fatty acids from goat milk alleviate ulcerative colitis via the TLR4/NF-κB/NLRP3 pathway

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Food Science and Human Wellness 2023年

作者： jiaxin zhang Jinjing Zhong Zhengying Cui Yu Shen Yaping Zheng Yu zhang Chaoxin Man Yanmei Hou Qianyu Zhao Yujun Jiang Hyproca Nutrition Co. Ltd. Key Laboratory of Dairy Science Ministry of Education Department of Food Science Northeast Agricultural University

Branched-chain fatty acids (BCFAs) are new bioactive fatty acids with anti-inflammatory properties. However， the role of BCFAs in alleviating ulcerative colitis has not been clarified. Herein， we evaluated the protective effect of BCFAs from goat milk in mice with colitis induced using dextran sodium sulfate and explore the corresponding mechanism. These results show that BCFAs extracted from goat milk can significantly alleviate weight loss in mice， and reduce the disease activity index and the activity of myeloperoxidase while increasing the content of antioxidant enzymes in colon tissue and reducing the oxidation stress response. These data also show that BCFAs can down-regulate the gene and protein expression of the Toll-like receptor 4 (TLR4)/ nuclear factor kappa-B p65 (NF-κB p65)/NOD-like receptor thermal protein domain associated protein 3 (NLRP3) signaling pathway， and at the same time significantly reduce the expression of pro-inflammatory factors Tumor Necrosis Factor Alpha (TNF-α)， Interleukin 1β (IL-1β)， and Interleukin 18 (IL-18) in colon tissue， and significantly increase the expression of the anti-inflammatory factor Interleukin 10 (IL-10). In conclusion， these results demonstrated that BCFAs in goat milk exerted effects on colitis-related inflammatory cytokines and inhibited inflammation by inducing the TLR4/NF-κB/NLRP3 pathway to alleviate dextran sodium sulfate (DSS)-induced ulcerative colitis. This study provides evidence for the potential of BCFAs as bioactive fatty acids in food products and to ameliorate ulcerative colitis development in mice.

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DEFORMATION MEASUREMENT OF CON-DUCTING POLYTHIOPHENE THIN FILMS BY AN ELECTRONIC SPECKLE PATTERN INTERFEROMETRIC METHOD

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Acta Mechanica Solida Sinica 2002年第1期15卷 30-35页

作者： Wang Xishu zhang jiaxin Zhu Suiqun Shi Gaoquan Department of Engineering Mechanics Tsinghua UniversityBeijing 100084China Department of Chemistry Tsinghua UniversityBeijing 100084China

The deformation measurement of electrosynthesized polythiophene(Pth) thin films is difficult because of the small thickness and highflexibility of the specimen. An electronic speckle patterninterferom- etry (ESPI) method is used to measure the deformation ofPth films of thicknesses in the range of 4-65 μm . Theirstress-strain curves are obtained. It is found that the mechanicalproperties of Pth films are sensitive to the specimen thickness. Thetensile strength increases with decreasing thickness of thin filmfrom 10 μm. The influence of the electrochemical synthesisconditions on the mechanical properties of Pth films is also dis-Cussed.

关键词： polythiophene thin film eletrosynthesis mechanica properties electronicspeckle pattern interferometry

Protection of ±500 kV HVDC Double-circuit Converter Station from Lightning Induced Overvoltage

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高电压技术 2013年第8期39卷 2053-2060页

作者： DONG Manling YUAN Zhiyong LI Tianwei ZHAO Xiangen zhang jiaxin HE Junjia Electric Power Research Institute Henan Electric Power Corporation Zhengzhou 450052 China Electric Power Research Institute China Southern Power Grid Co. Ltd. Guangzhou 510623 China College of Electrical and Electronic Engineering Huazhong University of Science and Technology Wuhan 430074 China

In order to obtain reasonable schemes of arrester in converter stations, the arrester scheme of "Xiluodu-Guangdong HVDC ± 500 kV double circuit transmission" project against lighting induced overvoltage, which was designed according to the main principle of lightning protection in converter station, is discussed. A calculation of the lighting induced overvoltage in Zhaotong converter station un- der various operation modes is performed with ATP-EMTP software, then the surge arrester configuration of the converter station is decided, and the arrester protection schemes of smoothing reactor and neutral line are studied. It is concluded that additional protection is necessary because of the relatively large gap between protected disconnecting switch and arrester of metallic return transfer bus. Plus, the smoothing reactor (SR) arrester near the valve hall could be removed to improve the scheme’s economic performance.

关键词：高压直流输电过电压保护换流站双回路雷电感应 ATP-EMTP 平波电抗器避雷器

Nonclinical Study of the Active Components of Doxorubicin Hydrochloride Liposome Injection in Vivo

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Pharmacology & Pharmacy 2023年第9期14卷 363-375页

作者： Bing Wang Wangning zhang Ping Wang Qilin Zhou Kaiyu zhang jiaxin zhang Jiangwei Tian NMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation Shenzhen Institute for Drug Control Shenzhen China State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of TCM Evaluation and Translational Research School of Traditional Chinese Pharmacy China Pharmaceutical University Nanjing China

Objectives: A non-clinical study was performed to establish a LC-MS/MS method to determine the in vivo active components of doxorubicin hydrochloride liposome injection in the plasma of Sprague-Dawley rats. Methods: Ten male SD rats were administered tail vein with a single dose of 10 mg/kg, and the concentrations of doxorubicin hydrochloride in plasma, heart, liver, spleen, lung, and kidney were determined by liquid chromatography-tandem mass spectrometry, and the pharmacokinetic parameters were calculated. Results: The final concentration of doxorubicin hydrochloride ranged from 500 ng/mL to 250,000 ng/mL, and the lower limit of quantification was 500 ng/mL;the main pharmacokinetic parameters: T1/2 was (19.282 ± 10.305) h, Cmax was (118514.828 ± 26155.134) ng/mL, AUC0-24 and AUC0-∞ were (1216659.205 ± 192706.268) ng/mL⋅h and (2082244.523 ± 860139.487) ng/mL⋅h, MRT0-24 and MRT0-∞ were (9.237 ± 0.423) h and (26.52 ± 14.015) h, respectively, and clearance (CL) was (0.005 ± 0.002) mL/h⋅ng. Conclusions: The method is simple, rapid, and sensitive, which can be used for the determination of doxorubicin hydrochloride concentration in the plasma of SD rats and pharmacokinetic non-clinical studies.

关键词： Doxorubicin Hydrochloride Liposomes Pharmacokinetics LC-MS/MS

TiO_(2) nanofiber-supported copper nanoparticle catalysts for highly efficient methane conversion to C1 oxygenates under mild conditions

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Nano Research 2024年第5期17卷 3844-3852页

作者： Wencui Li Yu Ren Zean Xie Yipeng Wang Hang zhang Dianxiang Peng Hengfang Shen Hongfei Shi jiaxin Cai Peng Wang Tongxin zhang Zhen Zhao State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)Beijing 102249China Institute of Catalysis for Energy and Environment College of Chemistry&Chemical EngineeringShenyang Normal UniversityShenyang 110034China Institute of Petrochemical Technology Jilin Institute of Chemical TechnologyJilin 132022China

The selective oxidation of methane under mild conditions remains the“Holy Grail of Catalysis”.The key to activating methane and inhibiting over-oxidation of target oxygenates lies in designing active *** nanoparticles were loaded onto TiO_(2) nanofibers using the photo-deposition *** resulting catalysts were found to effectively convert methane into C1 oxygenated products under mild *** with previously reported catalysts,it delivers a superior performance of up to 2510.7 mmol·g_(Cu)^(-1)·h^(-1) productivity with a selectivity of around 100%at 80℃for 5 *** characterizations and density functional theory(DFT)calculations indicate that TiO_(2) in the mixed phase of anatase and rutile significantly increases the Cu^(+)/CuO ratio of the supported Cu species,and this ratio is linearly related to the formation rate of oxygen-containing *** CuI site promotes the generation of active O species from H_(2)O_(2) dissociation on Cu_(2)O(111).These active O species reduce the energy barrier for breaking the C-H bond of CH_(4),thus boosting the catalytic *** methane conversion mechanism was proposed as a methyl radical pathway to form CH_(3)OH and CH_(3)OOH,and then the generated CH_(3)OH is further oxidized to HOCH_(2)OOH.

关键词： TiO_(2)nanofiber copper nanoparticles photo-deposition method methane oxidation C1 oxygenates

湘西苗医刘氏小儿推拿流派“推五经”对缓解期哮喘患儿肠道菌群的影响

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山西中医药大学学报 2024年第1期25卷 38-46页

作者：谭欣欣李萍王梦玲石磊王鹏彭南彩张嘉昕李中正吉首大学医学院湖南吉首416000 吉首大学第一附属医院湖南吉首416000 吉首大学附属中医院湖南吉首416000 湘西苗医小儿推拿医工交叉与转化国家民委重点实验室湖南吉首416000

目的:观察湘西苗医刘氏小儿推拿流派“推五经”治疗缓解期哮喘患儿的疗效及对肠道菌群的影响,并探讨其作用机制。方法:30例健康儿童作为健康组,不予任何干预。将60例缓解期哮喘患儿随机分为健康教育组和推拿组,每组30例。健康教育组采... 详细信息

目的:观察湘西苗医刘氏小儿推拿流派“推五经”治疗缓解期哮喘患儿的疗效及对肠道菌群的影响,并探讨其作用机制。方法:30例健康儿童作为健康组,不予任何干预。将60例缓解期哮喘患儿随机分为健康教育组和推拿组,每组30例。健康教育组采用常规干预和健康教育,推拿组在健康教育组的基础上加用小儿推拿“推五经”,每日1次,每周4次。两组均治疗3个月。比较健康教育组及推拿组治疗前后的中医主要证候积分,采用16SrRNA测序技术检测两组患儿治疗后及健康组的肠道菌群。结果:与本组治疗前比较,推拿组患儿喘憋、胸闷、咳嗽气急、哮鸣音等中医主要证候评分均减少,差异有统计学意义(P2,P<0.05)。结论:湘西苗医刘氏小儿推拿流派“推五经”可有效改善缓解期哮喘患儿的中医主要证候,其机制可能与上调肠道有益菌的丰度,调整肠道微生态有关。上调哮喘患儿红蝽杆菌纲、红蝽菌目、粪球菌属的丰度,也为小儿推拿“推五经”可能改善哮喘患儿脑功能失调状态提供了参考依据。

关键词：湘西苗医刘氏小儿推拿哮喘缓解期肠道菌群 16SrRNA测序

急性温度胁迫对乌苏里拟鲿稚鱼抗氧化和非特异免疫功能的影响

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水产科学 2024年第4期43卷 580-589页

作者：陈军平武慧慧沈方方张佳鑫于若梦付永杰赵道全谢国强何一晴李秀杰河南省农业科学院长垣分院河南新乡453400 河南省水产科学研究院河南郑州450044 河南省黄河流域伊洛河水生生物野外科学观测研究站河南三门峡477000 长垣市农业农村局河南新乡453400

为探究水温骤变对乌苏里拟鲿稚鱼抗氧化和非特异免疫指标的影响,在26℃的水体中挑选300尾体质量为(2.3±0.3)g的稚鱼快速置于18、26℃(对照组)和33℃水体中胁迫24 h,随后置于26℃水体中恢复48 h,分别于胁迫期(0、3、6、12、24 h)和恢复... 详细信息

为探究水温骤变对乌苏里拟鲿稚鱼抗氧化和非特异免疫指标的影响,在26℃的水体中挑选300尾体质量为(2.3±0.3)g的稚鱼快速置于18、26℃(对照组)和33℃水体中胁迫24 h,随后置于26℃水体中恢复48 h,分别于胁迫期(0、3、6、12、24 h)和恢复期(3、6、12、24、48 h)进行取样检测各项指标。试验结果显示:胁迫期内,各试验组超氧化物歧化酶和过氧化氢酶活性均呈不断上升趋势并显著高于对照组(P0.05),其中33℃组过氧化氢酶活性显著高于对照组(P<0.05)。胁迫期内,各试验组谷丙转氨酶和谷草转氨酶活性均呈先升后降的趋势,18℃和33℃组谷丙转氨酶活性均显著高于对照组(P<0.05);温度骤变迫使18℃组溶菌酶活性显著下降(P<0.05),33℃组溶菌酶活性显著升高(P<0.05),至恢复期结束,各试验组谷草转氨酶和溶菌酶活性均恢复至对照组水平,仅33℃组谷丙转氨酶活性显著高于对照组(P<0.05)。试验结果表明,急性温度胁迫对乌苏里拟鲿稚鱼抗氧化和非特异性免疫功能产生了显著的影响,高温胁迫对乌苏里拟鲿幼鱼免疫机能造成了不可逆的损伤,建议日常养殖应密切关注水温变化,避免温度骤变对乌苏里拟鲿稚鱼造成损伤。

关键词：乌苏里拟鲿温度胁迫抗氧化酶免疫功能

Thyroid-stimulating hormone-thyroid hormone signaling contributes to circadian regulation through repressing clock2/npas2 in zebrafish

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Journal of Genetics and Genomics 2024年第1期51卷 61-74页

作者： Cheng Ji Yue Ou Wangjianfei Yu jiaxin Lv Fanmiao zhang Huashan Li Zeyun Gu Jiayuan Li Zhaomin Zhong Han Wang Center for Circadian Clocks Soochow UniversitySuzhouJiangsu 215123China School of Biology and Basic Medical Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu 215123China

Thyroid-stimulating hormone(TSH)is important for the thyroid gland,development,growth,and *** in TSH production or the thyrotrope cells within the pituitary gland cause congenital hypothyroidism(CH),resulting in growth retardation and neurocognitive *** human TSH is known to display rhythmicity,the molecular mechanisms underlying the circadian regulation of TSH and the effects of TSH-thyroid hormone(TH)signaling on the circadian clock remain *** we show that TSH,thyroxine(T4),triiodothyronine(T3),and tshba display rhythmicity in both larval and adult zebrafish and tshba is regulated directly by the circadian clock via both E′-box and *** tshba^(−/−)mutants manifest congenital hypothyroidism,with the characteristics of low levels of T_(4)and T_(3)and growth *** or overexpression of tshba alters the rhythmicity of locomotor activities and expression of core circadian clock genes and hypothalamic-pituitary-thyroid(HPT)axis-related ***,TSH-TH signaling regulates clock2/npas2 via the thyroid response element(TRE)in its promoter,and transcriptome analysis reveals extensive functions of Tshba in ***,our results demonstrate that zebrafish tshba is a direct target of the circadian clock and in turn plays critical roles in circadian regulation along with other functions.

关键词： Thyroid-stimulating hormone subunitβa (tshba) Thyroid hormone Circadian rhythm TALEN Zebrafish