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Science China(Information Sciences) 2024年第10期67卷 359-372页

作者： jiaxin xu Xiao MA Jingyang LIU Chunhui ZHANG Hongwei LI Xingyu ZHOU Qin WANG Institute of Quantum Information and Technology Nanjing University of Posts and Telecommunications Telecommunication and Networks National Engineering Research CenterNanjing University of Posts and Telecommunications Henan Key Laboratory of Quantum Information and Cryptography Strategic Support Force Information Engineering University

The realistic security of quantum key distribution(QKD) systems is currently a hot research topic in the field of quantum communications. There are always defects in practical devices, and eavesdroppers can make use of the security risk points of various devices to obtain key information. To date, current types of security analysis tend to analyze each security risk point individually, thereby posing great challenges for the overall security evaluation of QKD systems. In this paper, for the first time, we employ machine learning algorithms to identify the defects of different devices and certain attacks in real time, with an accuracy of 98%. It provides a novel solution for the practical security evaluation of QKD systems, thereby addressing the bottleneck problem of multiple risk points being difficult to address simultaneously in QKD systems,thus paving the way for the future large-scale application of quantum communication networks.

关键词： quantum key distribution device imperfections eavasdropping attacks real-time detection machine learning algorithms

Effect of resistant starch supplementation on the diversity and composition of human gut microbiota: A systematic review and meta-analysis

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Food Science and Human Wellness 2024年

作者： jiaxin xu Haocun Kong Caiming Li Xiaofeng Ban Zhaofeng Li Collaborative Innovation Center of Food Safety and Quality Control， Jiangnan University School of Food Science and Technology， Jiangnan University State Key Laboratory of Food Science and Technology， Jiangnan University

Resistant starch (RS) has attracted much researchers’ attention because of its health-beneficial effects. Gut microbiota obviously shapes human health， but the effects of RS supplementation on the changes of human gut microbiota remain unclear. This observational meta-analysis aimed to reveal the effects of RS intake on alpha diversity and composition of gut microbiota through meta-analysis. Two independent authors systematically searched articles from inception until February 2023 on four electronic databases. Twenty-four highly relevant trials were included conforming to Preferred Reporting Items for Systematic reviews and Meta-Analysis protocol， and a total of 816 individuals were included. Significant heterogeneity analyses revealed that RS intake notably decreased Shannon index (WMD: –0.11; 95% CI: –0.21， –0.01)， and stimulated the composition of health promoting bacteria genera， including Bifidobacterium (WMD: 1.75; 95% CI: 0.39， 3.11; WMD: 0.36; 95% CI: 0.04， 0.69)， Faecalibacterium (WMD: 0.70; 95% CI: 0.20， 1.20; ES: 0.91; 95% CI: 0.60， 1.23)， and Prevotella (WMD: 0.35; 95% CI: 0.01， 0.69). Taken together， the present study revealed that changes in the gut microbiota diversity and genera were correlated with RS supplementation， which may contribute to benefits in human health.

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Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis

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Neural Regeneration Research 2024年第10期19卷 2281-2289页

作者： Wang Liao Jiana Wei Chongxu Liu Haoyu Luo Yuting Ruan Yingren Mai Qun Yu Zhiyu Cao jiaxin xu Dong Zheng Zonghai Sheng Xianju Zhou Jun Liu Department of Neurology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Special Medical Service Center Neuroscience CenterIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangdongGuangdong ProvinceChina Department of Rehabilitation The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Disturbances in the microbiota-gut-brain axis may contribute to the development of Alzheimer's disease. Magnesium-L-threonate has recently been found to have protective effects on learning and memory in aged and Alzheimer's disease model mice. However, the effects of magnesium-L-threonate on the gut microbiota in Alzheimer's disease remain unknown. Previously, we reported that magnesium-L-threonate treatment improved cognition and reduced oxidative stress and inflammation in a double-transgenic line of Alzheimer's disease model mice expressing the amyloid-β precursor protein and mutant human presenilin 1(APP/PS1). Here, we performed 16S r RNA amplicon sequencing and liquid chromatography-mass spectrometry to analyze changes in the microbiome and serum metabolome following magnesium-Lthreonate exposure in a similar mouse model. Magnesium-L-threonate modulated the abundance of three genera in the gut microbiota, decreasing Allobaculum and increasing Bifidobacterium and Turicibacter. We also found that differential metabolites in the magnesiumL-threonate-regulated serum were enriched in various pathways associated with neurodegenerative diseases. The western blotting detection on intestinal tight junction proteins(zona occludens 1, occludin, and claudin-5) showed that magnesium-L-threonate repaired the intestinal barrier dysfunction of APP/PS1 mice. These findings suggest that magnesium-L-threonate may reduce the clinical manifestations of Alzheimer's disease through the microbiota-gut-brain axis in model mice, providing an experimental basis for the clinical treatment of Alzheimer's disease.

关键词： Alzheimer's disease APP/PS1 double-transgenic Alzheimer's disease mouse model inflammation intestinal barrier dysfunction magnesium-L-threonate microbiome microbiota-gut-brain axis oxidative stress serum metabolites

Optimization of Polysaccharides Extraction from Physalis alkekengi *** and Its Effect on the Expression of Inflammation-Related Proteins in SW620 Cells

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Proceedings of Anticancer Research 2024年第4期8卷 148-156页

作者： Dan Shao Chengxin Hao Yubi Mei jiaxin xu Tianjiao Wang Wei Yang Jiamei Wu Baicheng Medical College BaichengJilin 137000China

Objective:To establish an optimized aqueous extraction process for polysaccharides from Physalis alkekengi *** and to preliminarily explore its in vitro anti-inflammatory activity against colorectal cancer SW620 ***:A single-factor test combined with orthogonal test analysis was used to evaluate the effects of the material-to-liquid ratio,extraction temperature,and extraction time on the yield of polysaccharides from Physalis alkekengi *** antioxidant activity of the polysaccharides was assessed by analyzing their free radical scavenging ability in vitro,and the anti-inflammatory effect was evaluated using SW620 ***:The optimal extraction conditions were a material-to-liquid ratio of m(g):V(mL)=1:30,an extraction temperature of 100℃,and an extraction time of 40 minutes,with a predicted polysaccharide yield of 25.7%.The polysaccharides from Physalis peruviana peel effectively scavenged DPPH,superoxide anion,and hydroxyl *** treatment with Physalis peruviana polysaccharides,the levels of IL-1β,IL-18,and TNF-αin the cell culture medium were significantly reduced,and the phosphorylation level of P65 protein in SW620 cells was ***:This extraction method is stable and reliable,and the prepared Physalis alkekengi *** exhibit significant in vitro antioxidant and anti-inflammatory *** study provides a theoretical basis for developing drugs for the prevention and treatment of colorectal cancer.

关键词： Physalis alkekengi L.polysaccharide Antioxidant IL-1β Extraction process Colorectal cancer

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老年网络学习空间建设实然挑战与应然路径

继续教育研究 2024年第10期 43-48页

作者：徐嘉欣江苏开放大学资源建设中心江苏南京210036

为老年人群提供在线学习服务,建设老年学习空间是科学应对人口老龄化,将“老年人口负担”转化为“老年人口红利”的重要手段。以人工智能为代表的现代信息技术作为支撑、引领、推动现代化建设的重要力量,在老年学习方面体现跨时空通学... 详细信息

为老年人群提供在线学习服务,建设老年学习空间是科学应对人口老龄化,将“老年人口负担”转化为“老年人口红利”的重要手段。以人工智能为代表的现代信息技术作为支撑、引领、推动现代化建设的重要力量,在老年学习方面体现跨时空通学、融媒体易学、通虚实协学、精服务适学、聚智慧创学“五学”优势,可以完全支撑老年网络学习空间建设。老年网络学习建设需要将服务性作为建设方向、将终身性作为建设准则、将智能化作为建设目标、将数字化作为建设基础、将交互性作为建设样态,当前面临老年网络学习空间理论研究缺失、推广困难、建设队伍缺乏的挑战,需要将网络学习空间与互联网社交类平台融合,探索适老化老年学习形态和形成地域社群、兴趣社群和智慧社群等路径,推动老年网络学习空间建设。

关键词：教育信息化老年学习老年网络学习空间终身学习

中医药疗效评价指标体系构建方法中存在的问题及思考

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中医杂志 2024年第18期65卷 1875-1881页

作者：张彭张艺尹许家昕谢洋河南中医药大学第一附属医院河南省郑州市450000 河南中医药大学第一临床医学院河南省郑州市450000 河南省呼吸疾病循证评价国际联合实验室河南中医药大学呼吸疾病中医药防治省部共建协同创新中心/河南省中医药防治呼吸病重点实验室

指标的收集、筛选、赋权、综合评价是中医疗效评价指标体系建立的关键环节,通过系统梳理不同环节中的研究方法,分析其中存在的问题并提出思考与建议。指标收集方面,多采用文献研究和专家访谈法,患者的参与度不足;指标筛选方面,德尔菲法... 详细信息

指标的收集、筛选、赋权、综合评价是中医疗效评价指标体系建立的关键环节,通过系统梳理不同环节中的研究方法,分析其中存在的问题并提出思考与建议。指标收集方面,多采用文献研究和专家访谈法,患者的参与度不足;指标筛选方面,德尔菲法应用广泛,但尚缺乏指标筛选的标准和证据支持,少数研究应用了临床调查法;指标赋权方面,包括主观赋权法和客观赋权法,但多为单一种类赋权方法,指标权重缺乏可靠性;在综合评价方面,层次分析法、逼近理想点法、模糊综合评价法、秩和比法、模糊层次理想点法、灰色关联分析法、数据包络分析法等逐渐被应用于中医疗效评价研究,但多反映中医药的短期效应,无法凸显其远期疗效优势。基于此,提出在指标收集中应加强患者访谈,考虑患者观点;指标筛选过程中应为专家提供重要性判断的证据支持;指标赋权中,应融合主客观数据信息,积极开展优化组合赋权方法研究;最后搭建疾病信息化管理平台,构建动态综合评价模型,为中医药疗效评价提供思路与方法。

关键词：中医药疗效评价疗效评价指标指标权重综合评价模型

麦金太尔的美德伦理学:相对性或相对主义?--一种基于伽达默尔“第二等级的历史主义”的解读

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西部学刊 2024年第9期 125-129页

作者：许加鑫中国青年政治学院马克思主义学院北京100089

麦金太尔的美德伦理学从确立之初就不时遭受“道德相对主义”的指摘,这让他不得不反复撰文阐释和修正自己最初的观点。伽达默尔诠释学同样被施特劳斯用历史主义和相对主义所责难,可以说,他们二人的历史主义思想和对相对主义责难的回应... 详细信息

麦金太尔的美德伦理学从确立之初就不时遭受“道德相对主义”的指摘,这让他不得不反复撰文阐释和修正自己最初的观点。伽达默尔诠释学同样被施特劳斯用历史主义和相对主义所责难,可以说,他们二人的历史主义思想和对相对主义责难的回应有着诸多一致之处。他们共同站在“第二等级的历史主义”立场上,用相对性来对抗相对主义,并强调具体历史背景对于理解的先验性。在此种意义上,麦金太尔并非一位道德相对主义者,他从“第二等级的历史主义”出发区分了“参与者”和“旁观者”,继而在确保个人拥有“善良意志”的同时以更高层次的“相对性”打开了获得普遍道德真理的大门,这种真理观是一种诠释学意义上的开放真理观。

关键词：麦金太尔伽达默尔历史主义

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光交联制备可拉伸有机半导体材料

液晶与显示 2024年第7期39卷 867-874页

作者：徐宁陈显春徐佳馨王晓鸿邱龙臻合肥工业大学光电技术研究院特种显示技术国家工程实验室测量理论与精密仪器安徽省重点实验室安徽合肥230009 中建材玻璃新材料研究院集团有限公司硅基材料安徽省实验室安徽蚌埠233000

有机半导体材料因具备良好的溶液加工性以及优异的电荷传输性能,在柔性器件中展现出广阔的应用前景。本文介绍了一种制备可拉伸半导体材料的方法。该方法利用二苯甲酮光引发将3,6-二噻吩-2-基-2,5-二氢吡咯并[3,4-c]吡咯-1,4-二酮基共... 详细信息

有机半导体材料因具备良好的溶液加工性以及优异的电荷传输性能,在柔性器件中展现出广阔的应用前景。本文介绍了一种制备可拉伸半导体材料的方法。该方法利用二苯甲酮光引发将3,6-二噻吩-2-基-2,5-二氢吡咯并[3,4-c]吡咯-1,4-二酮基共轭聚合物(4Si)与聚二甲基硅氧烷进行光交联,研究了聚合物薄膜交联前后的电学性能和机械性能变化。结果显示,与未交联的4Si以及共混薄膜相比,交联薄膜的电学性能略微下降,但是机械性能得到了提升,起始裂纹应变由30%增加到50%。在100%的应变下,交联薄膜在平行应变方向上的迁移率为0.36 cm^(2)·V^(-1)·s^(-1),是初始迁移率的1.44倍。

关键词：可拉伸半导体二苯甲酮光交联机械性能

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车路协同环境下网联车出匝道控制和速度优化

汽车实用技术 2024年第1期49卷 57-61页

作者：徐嘉鑫刘逸茗长安大学汽车学院陕西西安710064

文章旨在探索一种新的智能网联车技术,可以有效地解决传统车辆汇入匝道冲突区域时减速甚至停车所带来的延误问题,并且可以在车路协同环境下,通过STM32等硬件实现两阶段的优化模型,以达到更好的效果。通过智能网联车的自动驾驶功能和速... 详细信息

文章旨在探索一种新的智能网联车技术,可以有效地解决传统车辆汇入匝道冲突区域时减速甚至停车所带来的延误问题,并且可以在车路协同环境下,通过STM32等硬件实现两阶段的优化模型,以达到更好的效果。通过智能网联车的自动驾驶功能和速度优化模型的配合,结合GPOPS软件寻找出车辆在匝道冲突区域行驶的最优轨迹,减少车辆在高速公路下匝道路段中不必要的加速、减速等情况、减少能耗、保证安全且提高车辆通行效率。

关键词：匝道冲突区域智能网联车车路协同生态控制

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K452合金表面CVD渗铝涂层制备温度对其750℃硫酸盐热腐蚀行为的影响

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中国腐蚀与防护学报 2024年第3期44卷 612-622页

作者：徐佳新耿树江王金龙王福会孙清云吴勇夏思瑶东北大学、沈阳材料科学国家研究中心东北大学联合研究分部沈阳110819 中国机械总院集团武汉材料保护研究所有限公司武汉430030

采用化学气相沉积(CVD)技术在K452合金表面沉积渗铝涂层,沉积温度分别为850、950和1050℃。研究了沉积温度对CVD渗铝涂层在750℃空气中表面沉积Na_(2)SO_(4)及Na_(2)SO_(4)+NaCl环境下热腐蚀行为的影响。采用扫描电子显微镜(SEM)、X射... 详细信息

采用化学气相沉积(CVD)技术在K452合金表面沉积渗铝涂层,沉积温度分别为850、950和1050℃。研究了沉积温度对CVD渗铝涂层在750℃空气中表面沉积Na_(2)SO_(4)及Na_(2)SO_(4)+NaCl环境下热腐蚀行为的影响。采用扫描电子显微镜(SEM)、X射线能谱仪(EDS)和X射线衍射仪(XRD)对腐蚀前和后的试样进行截面形貌观察和物相结构分析。结果表明,在750℃下表面沉积Na_(2)SO_(4)及Na_(2)SO_(4)+NaCl热腐蚀50 h后,3种涂层试样均表现出了较K452合金更好的抗热腐蚀性能,且涂层的抗热腐蚀性能随着涂层沉积温度的增加而增强。

关键词： CVD渗铝涂层沉积温度 Na_(2)SO_(4)腐蚀 Na_(2)SO_(4)+NaCl腐蚀