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Microplastics in sediment of the Three Gorges Reservoir:abundance and characteristics under different environmental conditions

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Journal of Oceanology and limnology 2024年第1期42卷 101-112页

作者： Wang li Bo ZU Yiwei liU Juncheng GUO jiawen li College of River and Ocean Engineering Chongqing Jiaotong UniversityChongqing 400074China Chongqing Research Academy of Ecology and Environmental Sciences Chongqing 401147China

Freshwater microplastic pollution is an urgent issue of global concern,and research on the distribution in reservoirs is lacking.We investigated the microplastic pollution levels in wet sediments collected from the Three Gorges Reservoir,the largest reservoir of China.Results show that microplastics were ubiquitous in the sediments of the Three Gorges Reservoir,and their abundance ranged from 59 to 276 pp/kg(plastic particles per kg,dry weight).Economic development and total population were important factors affecting the spatial heterogeneity of microplastic abundance,and the contribution of large cities along the reservoir to microplastic pollution should be paid with more attention.Fibrous microplastics were the most abundant type of microplastic particles in reservoir sediments,whereas polystyrene,polypropylene,and polyamide were the main types of polymers.The apparent spatial heterogeneity in morphology and color of microplastics is attributed to different anthropogenic or landbased pollution sources.Moreover,the accumulation of microplastics near the inlet of tributaries reflects the role of potential contributors of tributaries.More importantly,multiple bisphenols(BPs)and heavy metals detected at the microplastic surfaces indicate that microplastics can act as carriers of these pollutants in the environment in the same way as sediments did,which may alter the environmental fate and toxicity of these pollutants.Therefore,we conclude that the Three Gorges Reservoir had been contaminated with microplastics,which posed a stress risk for organisms who ingest them along with their associated pollutants(BPs,heavy metals).

关键词： microplastics Three Gorges Reservoir sediment bisphenol heavy metal

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Mitophagy in intracerebral hemorrhage:a new target for therapeutic intervention

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Neural Regeneration Research 2024年第2期19卷 316-323页

作者： Yiyang Chen Wenxuan Tang Xinqi Huang Yumei An jiawen li Shengye Yuan Haiyan Shan Mingyang Zhang Institute of Forensic Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu ProvinceChina Shanghai Key Lab of Forensic Medicine Key Lab of Forensic ScienceMinistry of Justice(Academy of Forensic Science)ShanghaiChina Department of Obstetrics and Gynecology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu ProvinceChina

Intracerebral hemorrhage is a life-threatening condition with a high fatality rate and severe sequelae.However,there is currently no treatment available for intracerebral hemorrhage,unlike for other stroke subtypes.Recent studies have indicated that mitochondrial dysfunction and mitophagy likely relate to the pathophysiology of intracerebral hemorrhage.Mitophagy,or selective autophagy of mitochondria,is an essential pathway to preserve mitochondrial homeostasis by clearing up damaged mitochondria.Mitophagy markedly contributes to the reduction of secondary brain injury caused by mitochondrial dysfunction after intracerebral hemorrhage.This review provides an overview of the mitochondrial dysfunction that occurs after intracerebral hemorrhage and the underlying mechanisms regarding how mitophagy regulates it,and discusses the new direction of therapeutic strategies targeting mitophagy for intracerebral hemorrhage,aiming to determine the close connection between mitophagy and intracerebral hemorrhage and identify new therapies to modulate mitophagy after intracerebral hemorrhage.In conclusion,although only a small number of drugs modulating mitophagy in intracerebral hemorrhage have been found thus far,most of which are in the preclinical stage and require further investigation,mitophagy is still a very valid and promising therapeutic target for intracerebral hemorrhage in the long run.

关键词： intracerebral hemorrhage mitochondrial dysfunction mitophagy neuroinflammation neuroprotection reactive oxygen species secondary brain injury therapeutic target

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The role of snapin in regulation of brain homeostasis

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Neural Regeneration Research 2024年第8期19卷 1696-1701页

作者： jiawen li Xinqi Huang Yumei An Xueshi Chen Yiyang Chen Mingyuan Xu Haiyan Shan Mingyang Zhang Shanghai Key Lab of Forensic Medicine Key Lab of Forensic ScienceMinistry of JusticeChina(Academy of Forensic Science)ShanghaiChina Institute of Forensic Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu ProvinceChina Department of Obstetrics and Gynecology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu ProvinceChina

Brain homeostasis refe rs to the normal working state of the brain in a certain period,which is impo rtant for overall health and normal life activities.Currently,there is a lack of effective treatment methods for the adverse consequences caused by brain homeostasis imbalance.Snapin is a protein that assists in the formation of neuronal synapses and plays a crucial role in the normal growth and development of synapses.Recently,many researchers have reported the association between snapin and neurologic and psychiatric disorders,demonstrating that snapin can improve brain homeostasis.Clinical manifestations of brain disease often involve imbalances in brain homeostasis and may lead to neurological and behavioral sequelae.This article aims to explo re the role of snapin in restoring brain homeostasis after injury or diseases,highlighting its significance in maintaining brain homeostasis and treating brain diseases.Additionally,it comprehensively discusses the implications of snapin in other extracerebral diseases such as diabetes and viral infections,with the objective of determining the clinical potential of snapin in maintaining brain homeostasis.

关键词： brain homeostasis diabetes neurological diseases snapin traumatic brain injury vesicle fusion

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High-performance liquid metal electromagnetic actuator fabricated by femtosecond laser

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International Journal of Extreme Manufacturing 2024年第2期6卷 511-521页

作者： Yiyu Chen Hao Wu Rui li Shaojun Jiang Shuneng Zhou Zehang Cui Yuan Tao Xinyuan Zheng Qianqian Zhang jiawen li Guoqiang li Dong Wu Jiaru Chu Yanlei Hu CAS Key Laboratory of Mechanical Behavior and Design of Materials Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education InstitutesDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230027People’s Republic of China Key Laboratory of Testing Technology for Manufacturing Process of Ministry of Education Southwest University of Science and TechnologyMianyang 621010People’s Republic of China Department of Mechanical Engineering The University of Hong KongHong Kong Special Administrative Region of ChinaPeople’s Republic of China

Small-scale electromagnetic soft actuators are characterized by a fast response and simplecontrol,holding prospects in the field of soft and miniaturized robotics.The use of liquid metal(LM)to replace a rigid conductor inside soft actuators can reduce the rigidity and enhance the actuation performance and robustness.Despite research efforts,challenges persist in the flexible fabrication of LM soft actuators and in the improvement of actuation performance.To address these challenges,we developed a fast and robust electromagnetic soft microplate actuator based on a laser-induced selective adhesion transfer method.Equipped with unprecedentedly thin LM circuit and customized low Young’s modulus silicone rubber(1.03 kPa),our actuator exhibits an excellent deformation angle(265.25?)and actuation bending angular velocity(284.66 rad·s^(-1)).Furthermore,multiple actuators have been combined to build an artificial gripper with a wide range of functionalities.Our actuator presents new possibilities for designing small-scaleartificial machines and supports advancements in ultrafast soft and miniaturized robotics.

关键词： soft actuators femtosecond laser liquid metal

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Accelerated intermediate conversion through nickel doping into mesoporous Co-N/C nanopolyhedron for efficient ORR

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Journal of Energy Chemistry 2022年第10期31卷 240-247,I0005页

作者： Jianxin Mao Peng liu jiawen li Jianyue Yan Shen Ye Wenbo Song College of Chemistry Jilin UniversityChangchun 130012JilinChina Department of Chemistry Graduate School of ScienceTohoku UniversitySendai 980-8577Japan

Engineering non-precious metals into nitrogen-doped carbon is employed to improve electrocatalyst activity towards oxygen reduction reaction(ORR). A nickel-doped Co-N/C mesoporous nanopolyhedron is successfully evoluted from a Ni-doped ZIF-67 precursor. The Ni & Co synergistic N/C catalyst exhibits a half-wave potential of 0.895 V(vs. reversible hydrogen electrode(RHE)) with a diffusion-limiting current density of 6.1 m A cm^(-2)for alkaline ORR at 1600 r min^(-1), which is competitive to commercial Pt/C in terms of cost, methanol tolerance, and long-term stability. In situ surface-enhanced Raman scattering(SERS) study reveals the formation and fast conversion of superoxide ion(O_(2)^(-)) intermediate on the catalyst surface. Density functional theory(DFT) calculations demonstrate the decrease of energy barrier for potential-determining step(O* protonation) by Co-Ni synergy as well as the reduction of adsorption energy on catalyst surface upon nickel doping. The joint results of in situ SERS study and DFT calculations suggest a favourable ORR process on nickel-doped Co-N/C.

关键词： Oxygen reduction reaction Nickel-doped Co-N/C mesoporous nanopolyhedron Ni&Co synergy Intermediate conversion In situ SERS study

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Insights Into the Interfacial Degradation of High-Voltage All-Solid-State lithium Batteries

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Nano-Micro Letters 2022年第12期14卷 1-13页

作者： jiawen li Yuchen Ji Haoran Song Shiming Chen Shouxiang Ding Bingkai Zhang Luyi Yang Yongli Song Feng Pan School of Advanced Material Peking University Shenzhen Graduate SchoolShenzhen 518055People’s Republic of China Guangzhou Key Laboratory of Clean Transportation Energy Chemistry School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhou 51006People’s Republic of China

Poly(ethylene oxide)(PEO)-based solid polymer electrolyte(SPE)is considered as a promising solid-state electrolyte for all-solid-state lithium batteries(ASSLBs).Nevertheless,the poor interfacial stability with high-voltage cathode materials(e.g.,liCoO_(2))restricts its application in high energy density solid-state batteries.Herein,high-voltage stable li_(3)AlF_(6) protective layer is coated on the surface of liCoO_(2) particle to improve the performance and investigate the failure mechanism of PEO-based ASSLBs.The phase transition unveils that chemical redox reaction occurs between the highly reactive liCoO_(2) surface and PEO-based SPE,resulting in structure collapse of liCoO_(2),hence the poor cycle performance of PEO-based ASSLBs with liCoO_(2) at charging voltage of 4.2 V vs li/li+.By sharp contrast,no obvious structure change can be found at the surface of li_(3)AlF_(6)-coated liCoO_(2),and the original layered phase was well retained.When the charging voltage reaches up to 4.5 V vs li/li+,the intensive electrochemical decomposition of PEO-based SPE occurs,leading to the constant increase of cell impedance and directly causing the poor performance.This work not only provides important supplement to the failure mechanism of PEO-based batter-ies with liCoO_(2),but also presents a universal strategy to retain structure stability of cathode-electrolyte interface in high-voltage ASSLBs.

关键词： Solid-state battery Poly(ethylene oxide) Surface modification Interface stability High-voltage cathode

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Femtosecond laser direct writing of functional stimulus-responsive structures and applications

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International Journal of Extreme Manufacturing 2023年第4期5卷 375-414页

作者： Yuxuan Zhang Dong Wu Yachao Zhang Yucheng Bian Chaowei Wang jiawen li Jiaru Chu Yanlei Hu CAS Key Laboratory of Mechanical Behavior and Design of Materials Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education InstitutesDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230027People’s Republic of China

Diverse natural organisms possess stimulus-responsive structures to adapt to the surrounding environment.Inspired by nature,researchers have developed various smart stimulus-responsive structures with adjustable properties and functions to address the demands of ever-changing application environments that are becoming more intricate.Among many fabrication methods for stimulus-responsive structures,femtosecond laser direct writing(FsLDW)has received increasing attention because of its high precision,simplicity,true three-dimensional machining ability,and wide applicability to almost all materials.This paper systematically outlines state-of-the-art research on stimulus-responsive structures prepared by FsLDW.Based on the introduction of femtosecond laser-matter interaction and mainstream FsLDW-based manufacturing strategies,different stimulating factors that can trigger structural responses of prepared intelligent structures,such as magnetic field,light,temperature,pH,and humidity,are emphatically summarized.Various applications of functional structures with stimuli-responsive dynamic behaviors fabricated by FsLDW,as well as the present obstacles and forthcoming development opportunities,are discussed.

关键词： stimulus-responsive structures femtosecond laser direct writing laser–matter interaction multifunctionality

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Non-cell-autonomous manner of AAV administration to attenuate cardiomyocyte hypertrophy by targeting paracrine signaling on ECM to reduce viral dosage

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Signal Transduction and Targeted Therapy 2022年第2期7卷 352-355页

作者： Lei liu Peng Yue Yue Zhang Yimin Hua Wenwei Bi Hualin Yan Hongyu liao jiawen li Kaiyu Zhou Yifei li Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE Department of PediatricsWest China Second University HospitalSichuan UniversityChengduSichuanChina Institute of Neuroscience and Medicine 4 INM-4Forschungszentrum JülichJülichGermany Department of Medical Ultrasound West China HospitalSichuan UniversityChengduSichuanChina

Dear Editor,Adeno-associated virus(AAV)is one of the most powerful vectors for exogenous gene delivery.1 However,the risks associated with the high dosages of AAV administration that are required to achieve meaningful effects limit the applicability of this method.Generally,AAV only presents cell autonomous manner in infected cells.Besides,mosaic genetic editing or gene therapy would trigger global biological function restore by above 30–40%infective ratio in heart diseases.

关键词： dosage AAV autonomous

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Polymeric Wetting Matrix for a Stable Interface between Solid-state Electrolytes and li Metal Anode

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Chinese Journal of Structural Chemistry 2022年第5期41卷 48-54页

作者： Haoran Song Shida Xue Shiming Chen Zijian Wang Yongli Song jiawen li Zhibo Song Luyi Yang Feng Pan School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhen 518055China

Succinonitrile(SN)based solid-state electrolytes(SSEs)have potential applications in lithium(li)batteries due to their ease of preparation and high ionic conductivity at room temperature.Here,a novel SSE consisting of poly(vinylidene fluoride-hexafluoropropy-lene)(PVDF-HFP),poly(methyl methacrylate)(PMMA)and li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3) with SN is fabricated,where PMMA is added to serve as a polymer matrix for better wettability of SN.Due to the addition of PMMA,improved room-temperature ionic conductivity of the SSE is resulted.More importantly,better interfacial contact as well as more stable solid-state electrolyte(SEI)layer between SSE and li anode can be also obtained.As a result,homogeneous and dendrite-free li plating can be achieved for over 1000 h in li symmetric cells.When coupled with liNi_(0.5)Mn_(0.3)Co_(0.2)O_(2) cathode and li anode,the proposed SSE delivers excellent cycling stability and rate capability in full-cells.By implementing SSEs with a polymeric wetting agent,this work provides fresh perspectives on stabilizing the interface between SSEs and li metal anodes.

关键词： li metal li dendrite poly(methyl methacrylate) succinonitrile composite solid-state electrolyte

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面向道路养护车辆的铝蜂窝式防撞缓冲垫防撞性能研究

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机械强度 2024年第3期46卷 595-601页

作者：刘波李佳文郑硕北京首发公路养护工程有限公司北京100000

为了降低错误行驶车辆对养护施工作业区造成的人员伤亡,提出了一种安装在道路养护车辆尾部的铝蜂窝式防撞缓冲垫。目前针对该类型防撞缓冲垫的研究较少,为此搭建了高精度防撞缓冲垫碰撞有限元模型,并利用数值仿真的方法,从吸能性能、可... 详细信息

为了降低错误行驶车辆对养护施工作业区造成的人员伤亡,提出了一种安装在道路养护车辆尾部的铝蜂窝式防撞缓冲垫。目前针对该类型防撞缓冲垫的研究较少,为此搭建了高精度防撞缓冲垫碰撞有限元模型,并利用数值仿真的方法,从吸能性能、可导向性能和阻挡性能三方面对铝蜂窝式防撞缓冲垫的防撞性能展开研究。研究结果表明,铝蜂窝式防撞缓冲垫可有效降低碰撞过程中司乘人员受到的冲击力和加速度。另外,合理的铝蜂窝强度对提高防撞性能至关重要。

关键词：道路养护车防撞缓冲垫数值模拟防撞性能

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