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Visualizing carboxyl-terminal domain of RNA polymerase Ⅱ recruitment by FET fusion protein condensates with DNA curtains

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Biophysics Reports 2022年第2期8卷 80-89页

作者： Linyu Zuo jiawei ding Zhi Qi Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdiscip-linary Studies Peking University

Many recent references show that living cells can form some membrane-less organelles by liquid–liquid phase separation(LLPS) of biomolecules, like proteins and nucleic acids. LLPS has been confirmed to link with many important biological functions in living cells, and one of the most important functions of biomolecular condensates is in the field of RNA transcription. Many studies confirm that mammalian RNA polymerase Ⅱ(Pol Ⅱ) molecules containing the CTD with different phosphorylation level are purposed to shuttle between initiation condensates and elongation condensates of RNA transcription. Traditional ensemble assays often experience difficulties in quantitively and directly recording the transient recruitment of Pol Ⅱ CTD. Novel single-molecule approach — DNA curtains can be used to directly visualize biomolecular condensates formation and also recruitment of RNA polymerase Ⅱ(Pol Ⅱ) carboxyl-terminal domain(CTD) at the target sites in solution and in real time. This method can offer the potential for new insights into the mechanism of gene transcription. Here, we highlight the detailed protocol of DNA curtains method for studying LLPS.

关键词： Liquid–liquid phase separation (LLPS) Biomolecular condensates Single-molecule biophysics DNA curtains In vitro transcription assay

人工智能技术在电力工程配电运维中的应用与研究

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自动化应用 2024年第S1期65卷 188-190页

作者：李硕丁佳伟曹浚源南通三新供电服务有限公司江苏南通226000 南通三新供电服务有限公司市郊工程服务分公司江苏南通226003

旨在探讨人工智能在电力工程配电运维领域的应用价值,以及其在配电网络规划、故障检测与诊断、数据分析和预测方面的潜力和优势。研究表明,人工智能技术对提升电力系统配电运维效能大有裨益,其能降低成本,提高安全与稳定性。

关键词：人工智能技术电力工程配电运维配电网络故障检测

人工智能技术在电力工程施工现场管控系统的应用

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电工技术 2024年第S1期 58-60页

作者：曹浚源李硕丁佳伟南通三新供电服务有限公司江苏南通226000 南通三新供电服务有限公司市郊工程服务分公司江苏南通226003

电力工程施工现场的有序管理,对确保工程顺利推进及安全达标至关重要。然而,鉴于施工环境的多样性和不确定性,传统管控方式面临挑战与局限。人工智能技术迅速崛起,电力工程领域对此应用潜力的关注度持续提升。基于此,探讨了人工智能如... 详细信息

电力工程施工现场的有序管理,对确保工程顺利推进及安全达标至关重要。然而,鉴于施工环境的多样性和不确定性,传统管控方式面临挑战与局限。人工智能技术迅速崛起,电力工程领域对此应用潜力的关注度持续提升。基于此,探讨了人工智能如何在电力工程施工现场管控系统中发挥作用,针对此问题,给出相应解决办法。

关键词：电力工程施工现场管控人工智能技术智能感知

基于耦合协调模型的复合干旱研究——以汉江中下游流域为例

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湖泊科学 2024年第5期36卷 1588-1598页

作者：王晴喻婷陈燕飞朱文龙丁佳伟孙咏曦董玉茹长江大学资源与环境学院武汉430010 湖北省水利水电科学研究院武汉430010

近年来,流域干旱逐年加剧,城市规模扩大和人口增加,使得水资源供需矛盾突出。因此,研究气象干旱与水文干旱之间的关系对水资源的影响以及评估不同城市对干旱的脆弱性至关重要。本文提出了复合干旱概念及判别标准;基于汉江中下游1973一2... 详细信息

近年来,流域干旱逐年加剧,城市规模扩大和人口增加,使得水资源供需矛盾突出。因此,研究气象干旱与水文干旱之间的关系对水资源的影响以及评估不同城市对干旱的脆弱性至关重要。本文提出了复合干旱概念及判别标准;基于汉江中下游1973一2020年逐月降水、径流数据,利用标准化降水指数和借助粒子群优化算法改进的标准化径流指数分析了汉江中下游气象干旱与水文干旱的时空变化;结合耦合协调度模型探究了复合干旱之间的关系及时空分布特征。结果表明:(1)时间上,汉江中下游春季干旱由水文干旱主导;夏季整体无旱;秋季干旱由气象干旱主导;冬季由气象干旱和复合干旱主导。(2)时间上,1973一2020年汉江中下游气象干旱与水文干旱整体耦合程度以较强(0.75荆门市>襄阳市>武汉市>天潜都市圈;2013年后各地区耦合度大小为:武汉市>天潜都市圈>襄阳市>荆门市>仙孝都市圈。(3)汉江中下游气象干旱与水文干旱耦合协调关系以高耦合中协调为主,且在研究期内耦合协调关系呈减弱状态,整体下降了7.8%。2013年以后汉江中下游流域天潜都市圈、武汉市干旱防治最为紧迫。本文提出的基于耦合协调模型研究复合干旱的思路和方法可为流域的干旱防治与发展提供理论依据,从而实现城市可持续发展。

关键词：复合性干旱耦合协调粒子群优化算法汉江中下游流域

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Janus纤维材料非对称导液指数模型的构建、测试系统及其评价

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纺织工程学报 2024年第4期2卷 12-24页

作者：翟倩张恒甄琪甘益杨自强丁佳伟中原工学院纺织学院郑州451191 中原工学院服装学院郑州451191 河南逸祥卫生科技有限公司河南新密452300 通标标准技术服务(上海)有限公司上海200030

为有效评价大面密度纤维材料的液体非对称传输性能,依据多孔材料液体吸附机理和Langmuir方程,本文在液体非对称传输行为理论分析的基础上,自主搭建了非对称导液测试系统,建立了非对称导液指数模型,并对两大类17种样品进行测试,获得了最... 详细信息

为有效评价大面密度纤维材料的液体非对称传输性能,依据多孔材料液体吸附机理和Langmuir方程,本文在液体非对称传输行为理论分析的基础上,自主搭建了非对称导液测试系统,建立了非对称导液指数模型,并对两大类17种样品进行测试,获得了最大吸液速率、平均吸液速率、终止吸液速率、相对含水量和非对称导液指数等液体传输行为特征参数,并与液态水分管理测试仪测试结果进行了对比分析。结果表明:对于累计单向传输指数分布在28.4~680.2区间的Janus纤维材料样品,非对称导液指数对应为21.0~437.4,且二者变化规律随样品润湿梯度和差动毛细效应结构特征的改变而趋于一致,具有高的相似性。另外,随着均一结构纤维材料样品面密度从162.6增大到375.8g/m^(2),累计单向传输指数从191.1增大到2177.6,而非对称导液指数在-68.0~45.0之间波动。所搭建的非对称导液测试系统和非对称导液指数模型可以很好的评价不同面密度纤维材料的液体非对称传输行为,丰富了功能性纤维材料的评价方法,为新型Janus纤维材料的结构设计和新品开发提供测试手段。

关键词：纤维材料非对称导液指数润湿性能液体传输测试系统

A multiphysics model for studying transient crevice corrosion of stainless steel

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Journal of Materials Science & Technology 2021年第1期60卷 186-196页

作者： jiawei ding Haitao Wang En-Hou Han CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei230026China

The transient crevice corrosion behavior of 304 stainless steel in NaCl solution has been investigated by a multiphysics coupling *** model considers local electrochemical reactions,transport of diffe rent species,and homogeneous *** moving mesh method is used to obtain the geometrical change of the crevice wall with time due to *** level set method is employed to quantitatively describe the influence of the precipitation process on electrochemical *** transient crevice corrosion morphology,potential and current distributions,and pH and chloride ion concentration distributions are obtained by *** effect of crevice geometry factors on the corrosion process is also *** simulation results are in good agreement with the experiments,showing that the model has high reliability.

关键词： Stainless steel Crevice corrosion Simulation Multiphysics Transient behavior

Promoted monolithic perovskite/organic tandem solar cells through elaborate manipulation of light transmission and carrier tunneling in interconnect junction

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Science China Chemistry 2024年第9期67卷 3131-3139页

作者： Rongbo Wang jiawei Zhang Juntao Zhao Ya Wang Yi ding Ying Zhao Xiaodan Zhang Guofu Hou Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage CenterSolar Energy Conversion CenterNankai UniversityTianjin 300350China Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Tianjin 300350China Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Tianjin 300350China State Key Laboratory of Photovoltaic Materials and Solar Cells Tianjin 300350China

Monolithic perovskite/organic tandem solar cells(TSCs)have emerged as promising thin film solar *** is recognized that interconnect junction plays a pivotal role in tandem ***,wide bandgap Cs_(0.25)FA_(0.75)Pb(I_(0.6)Br_(0.4))_(3)perovskite top-cell and narrow bandgap PM6:Y6:PC_(61)BM ternary organic bottom-cell were integrated in this study with several kinds of thin metal interconnect layers,which provides feasibility to elaborately manipulate light transmission and carrier tunneling process in interconnect *** is confirmed that,in comparison with Au,employing an Ag interconnect layer elevates integrated transmittance of light in longer wavelength regions,mainly because of the alleviated screening effect with a lower free electron concentration,which offers sufficient light harvest for the ***,established energy barriers with moderate height afford convenient extraction and recombination for both holes and ***,the performance of TSCs is promoted ***,an innovative Ag/Au double interconnect layer is proposed accordingly,which can preserve exceptional conductivity and light transmission and further reduce barrier height,especially for hole tunneling,by optimizing the band alignment between the interconnect layer and ***,the monolithic perovskite/organic TSC with a striking efficiency of 23.26% is *** a word,this study can pave a general approach toward high-performance TSCs integration.

关键词： tandem solar cells band alignment perovskite organic solar cells interconnect junction

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中医医联体推动中医药优质资源辐射的探索与实践

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中医药管理杂志 2024年第2期32卷 230-232页

作者：丁佳伟黄抒伟吕晓皑蔡利军鲍航行傅恩琴浙江中医药大学附属第一医院(浙江省中医院) 浙江杭州310000

中医医联体旨在有效提升基层中医医联体中医药服务能力,推进区域卫生健康事业高质量发展。近年来,浙江省中医院大力推进中医医联体建设,在实际工作中,紧密围绕合作协议,发挥省中医院管理、技术、人才、品牌等一体化优势,建立健全中医医... 详细信息

中医医联体旨在有效提升基层中医医联体中医药服务能力,推进区域卫生健康事业高质量发展。近年来,浙江省中医院大力推进中医医联体建设,在实际工作中,紧密围绕合作协议,发挥省中医院管理、技术、人才、品牌等一体化优势,建立健全中医医联体内同质化运行管理体制机制,取得一定成效,主要体现在基层中医医联体现代化医院管理水平、中医药服务水平、人才梯队建设和区域影响力提升。同时,努力克服群众就医观念“滞后”、基层中医医联体条件相对较差和信息化水平较低等问题,实现浙江省中医院和中医医联体单位影响力、辐射力的双提升。

关键词：中医医联体中医药优质资源资源下沉

Methanol steam reforming for hydrogen production driven by an atomically precise Cu catalyst

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Green Energy & Environment 2024年第7期9卷 1079-1084页

作者： Weigang Hu Haoqi Liu Yuankun Zhang jiawei Ji Guangjun Li Xiao Cai Xu Liu Wen Wu Xu Weiping ding Yan Zhu School of Chemistry and Chemical Engineering Nanjing University School of Physical Science and Technology Ningbo University

Plasmon-induced hot-electron transfer from metal nanostructures is being intensely pursed in current photocatalytic research,however it remains elusive whether molecular-like metal clusters with excitonic behavior can be used as light-harvesting materials in solar energy utilization such as photocatalytic methanol steam *** this work,we report an atomically precise Cu13cluster protected by dual ligands of thiolate and phosphine that can be viewed as the assembly of one top Cu atom and three *** Cu13H10（SR）3（PR’3）7(SR=2,4-dichlorobenzenethiol,PR’3=P（4-FC6H4）3) cluster can give rise to highly efficient light-driven activity for methanol steam reforming toward H2production.

关键词： Nanocluster Photocatalysis Methanol steam reforming Atomically precise Copper catalyst