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Genes & Diseases 2024年第5期11卷 105-108页

作者： liang Zhou Youyou li jiaren li Hanyu Yao Jin Huang Cheng li Long Wang Department of Urology The Third Xiangya Hospital of Central South UniversityChangshaHunan 410013China

In aging males,benign prostatic hyperplasia(BPH)is a chronic pathological process that primarily causes lower urinary tract *** to histopathology,BPH is caused by an imbalance between cell death and proliferation.1 However,the exact pathophysiology remains *** is a newly discovered form of programmed cell *** cell morphology is characterized primarily by the reduction or disappearance of mitochondrial cristae and mitochondrial shrinkage.2,3 Competing endogenous RNAs(ceRNAs)are important regulators of many biological processes and have been involved in various diseases.

关键词： prostatic endogenous BPH

LARRAZA-PUTTERMAN EQUATION INCLUDING VISCOSITY AND EXTERNAL DRIVE

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Chinese Journal of Acoustics 1989年第2期8卷 163-169页

作者： YAN jiaren, HUANG Guoxiang and li Hong(Xiangtan University) Xiangtan Univ

The weak nonlinear modulation of the surface wave of a three-dimensional imcompressible fluid without rotation, which is contained in a rectangular trough is studied by using the method of multiple scales perturbation theory. The effects of viscid and external drive on the motion, which modifies the Larraza- Putterman equation, are considered. The results are consistent with that of Miles.

关键词： LARRAZA-PUTTERMAN EQUATION INCLUDING VISCOSITY AND EXTERNAL DRIVE

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利钠肽、cGMP与急性缺血性脑卒中的相关研究进展

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中风与神经疾病杂志 2024年第5期41卷 470-475页

作者：李家任刘嘉禹张佳乐(综述) 石瑞丽郝肖琼(审校) 包头医学院生理学教研室内蒙古包头014040

利钠肽家族成员(NPs)与缺血性脑卒中(AIS)密切相关。既往研究证实NPs具有促进血管舒张、抗炎和抗凋亡等有益作用。其中心房钠肽(ANP)和脑钠肽(BNP)在心血管引起的有益作用与A型利钠肽受体(NPR-A)/环磷酸腺苷(cGMP)信号传导途径有关。随... 详细信息

利钠肽家族成员(NPs)与缺血性脑卒中(AIS)密切相关。既往研究证实NPs具有促进血管舒张、抗炎和抗凋亡等有益作用。其中心房钠肽(ANP)和脑钠肽(BNP)在心血管引起的有益作用与A型利钠肽受体(NPR-A)/环磷酸腺苷(cGMP)信号传导途径有关。随着C型利钠肽(CNP)及其依赖性受体(NPR-B)在脑组织中的发现,NPs为缺血性脑卒中的诊断和治疗提供新的思路。近期的研究已经证实ANP、BNP和CNP及其同源性受体对缺血性脑卒中引起的神经元损伤产生有益的影响。然而,NPs在其中介导的通路机制仍不清楚。本综述旨在对NPs、cGMP和急性缺血性脑卒中(AIS)的相关研究进行总结,为后期NPs在AIS的相关研究提供借鉴。

关键词：利钠肽急性脑缺血 cGMP

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A Constrained Local Neighborhood Approach for Efficient Markov Blanket Discovery in Undirected Independent Graphs

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Computers, Materials & Continua 2024年第8期80卷 2535-2555页

作者： Kun liu Peiran li Yu Zhang jiaren Ming li Xianyu Wang Cong li School of Information and Communication Engineering Hainan UniversityHaikou570228China National Key Laboratory of Science and Technology on Space Microwave China Academy of Space Technology Xi’anXi’an710100China Strategic Emerging Industries Department CRSC Communication&Information Group Co.Ltd.Beijing100070China Military Representative Bureau of the Army Equipment Department in Xi’an Xi’an710032China

When learning the structure of a Bayesian network,the search space expands significantly as the network size and the number of nodes increase,leading to a noticeable decrease in algorithm *** constraint-based methods typically rely on the results of conditional independence ***,excessive reliance on these test results can lead to a series of problems,including increased computational complexity and inaccurate results,especially when dealing with large-scale networks where performance bottlenecks are particularly *** overcome these challenges,we propose a Markov blanket discovery algorithm based on constrained local neighborhoods for constructing undirected independence *** method uses the Markov blanket discovery algorithm to refine the constraints in the initial search space,sets an appropriate constraint radius,thereby reducing the initial computational cost of the algorithm and effectively narrowing the initial solution ***,the method first determines the local neighborhood space to limit the search range,thereby reducing the number of possible graph structures that need to be *** process not only improves the accuracy of the search space constraints but also significantly reduces the number of conditional independence *** performing conditional independence tests within the local neighborhood of each node,the method avoids comprehensive tests across the entire network,greatly reducing computational *** the same time,the setting of the constraint radius further improves computational efficiency while ensuring *** to other algorithms,this method can quickly and efficiently construct undirected independence graphs while maintaining high *** simulation results show that,this method has significant advantages in obtaining the structure of undirected independence graphs,not only maintaining an accuracy of over 96%but also reducing the number of conditi

关键词： Bayesian network structure learning Markov blanket conditional independence

SphK2在氧糖剥夺/复糖复氧模型中对BV-2细胞损伤的影响

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包头医学院学报 2024年第9期40卷 24-28页

作者：张佳乐李家任张雅轩李超然乔婧姚璐牛愉捷郝肖琼包头医学院基础医学与法医学院包头医学院

目的:观察BV-2小胶质细胞在氧糖剥夺/复糖复氧(OGD/R)中鞘氨醇激酶2(SphK2)的表达情况，并探讨SphK2是否参与了OGD/R致BV-2小胶质细胞的损伤过程。方法:采用小鼠BV-2小胶质细胞制备OGD/R模型，选取氧糖剥夺时间为2 h,复氧复糖时间为0 h,... 详细信息

目的:观察BV-2小胶质细胞在氧糖剥夺/复糖复氧(OGD/R)中鞘氨醇激酶2(SphK2)的表达情况，并探讨SphK2是否参与了OGD/R致BV-2小胶质细胞的损伤过程。方法:采用小鼠BV-2小胶质细胞制备OGD/R模型，选取氧糖剥夺时间为2 h,复氧复糖时间为0 h, 3 h, 6 h, 12 h, 24 h。(1)设对照组，OGD 2 h组，OGD 2 h/R 3 h组，OGD 2 h/R 6 h组，OGD 2 h/R 12 h组，OGD 2 h/R 24 h组，观察细胞形态变化。细胞经OGD/R处理后CCK-8法检测细胞存活率。(2)设对照组，OGD 2 h/R 12 h组，OGD 2 h/R 12 h+ABC294640(SphK2特异抑制剂)组，用q-PCR及Western blot测定SphK2的基因及蛋白表达变化。结果:与对照组相比，随着OGD/R时间的延长，BV-2活力逐渐下降(P<0.001),细胞形态发生了不同程度的改变，且有不同程度的损伤；通过观察细胞生存情况确定OGD2 h/R12 h为最适宜的OGD/R时间，与对照组相比，经OGD/R处理后BV-2细胞中SphK2 mRNA表达水平显著升高(P<0.05),加入ABC294640显著抑制其表达升高(P<0.001);与对照组相比，经OGD/R处理后BV-2细胞中SphK2蛋白表达水平显著升高(P<0.001),加入ABC294640后，SphK2蛋白表达明显降低(P<0.001)。结论:OGD/R损伤后的小胶质细胞可以被SphK2激活，在其损伤过程中发挥着调控作用。

关键词：鞘氨醇激酶2 氧糖剥夺/复糖复氧小胶质细胞缺血性脑卒中

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Achieving Seconds-to-Hours Duration-Tunable Organic Long Persistent Luminescence from Carbon Dots-Based Exciplex Systems by Energy Gaps Regulation

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Chinese Journal of Chemistry 2024年第12期42卷 1407-1417页

作者： Yixuan Xu Kai Jiang linger Feng Xinyuan Tong Zuxu Zhou Fengshi li Yi Zhang jiaren Du Hengwei lin International Joint Research Center for Photo-responsive Molecules and Materials School of Chemical and Material EngineeringJiangnan UniversityWuxiJiangsu214122China State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxiJiangsu 214122China

Comprehensive Summary Duration-tunable afterglow materials have garnered considerable attention in various ***,carbon dots(CDs)-based long persistent luminescence(LPL)composites with a tunable duration in an ultrawide range of seconds-to-hours levels were designed and prepared for the first *** contrast to the established CD-based afterglow materials,we reported that CD-based composites exhibit LPL in the form of exciplexes and long-lived charge-separated states,enabling the LPL to be prolonged from several seconds to over one hour,exceeding the typical regulation range(limited to 1 min).Further studies revealed that the relationship between the excited and charge-transfer states of CDs plays a pivotal role in activating the LPL and regulating its ***,these composites exhibited high photoluminescence(PL)quantum yields of up to 60.63%,and their LPL was robust under ambient conditions,even in aqueous *** robust and superior LPL performance endows these composites with a strong competitive advantage in dynamic display systems,such as tags for time-resolved data encryption and displays of the remaining time of *** study offers an approach to preparing CDs-based LPL composites with tunable durations and may provide new insights for the development of rare-earth-free LPL materials.

关键词： Carbon dots Composites Charge separation Exciplex Persistent luminescence

Aloe emodin promotes mucosal healing by modifying the differentiation fate of enteroendocrine cells via regulating cellular free fatty acid sensitivity

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ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 3964-3982页

作者： Bao, Weilian Lyu, jiaren Feng, Guize Guo, linfeng Zhao, Dian You, Keyuan liu, Yang li, Haidong Du, Peng Chen, Daofeng Shen, Xiaoyan Fudan Univ Sch Pharm Dept Pharmacol Minist Educ Shanghai 201210 Peoples R China Fudan Univ Sch Pharm Key Lab Smart Drug Delivery Minist Educ Shanghai 201210 Peoples R China Fudan Univ Sch Pharm Dept Nat Med Shanghai 201210 Peoples R China Shanghai Jiao Tong Univ Xinhua Hosp Dept Colorectal & Anal Surg Sch Med Shanghai 200092 Peoples R China Shanghai Colorectal Canc Res Ctr Shanghai 200092 Peoples R China

The proper differentiation and reorganization of the intestinal epithelial cell population is critical to mucosal regeneration post injury. Label retaining cells (LRCs) expressing SRY-box transcription factor 9 (SOX9) promote epithelial repair by replenishing LGR5+ intestinal stem cells (ISCs). While, LRCs are also considered precursor cells for enteroendocrine cells (EECs) which exacerbate mucosal damage in inflammatory bowel disease (IBD). The factors that determine LRC-EEC differentiation and the effect of intervening in LRC-EEC differentiation on IBD remain unclear. In this study, we investigated the effects of a natural anthraquinone called aloe emodin (derived from the Chinese herb rhubarb) on mucosal healing in IBD models. Our findings demonstrated that aloe emodin effectively interfered with the differentiation to EECs and preserved a higher number of SOX9+ LRCs, thereby promoting mucosal healing. Furthermore, we discovered that aloe emodin acted as an antagonist of free fatty acid receptors (FFAR1), suppressing the FFAR1-mediated Gbg/serine/threonine-protein kinase (AKT) pathway and promoting the translo cation of forkhead box protein O1 (FOXO1) into the nucleus,ultimately resulting in the intervention of differentiation fate. These findings reveal the effect of free fatty acid accessibility on EEC differentiation and introduce a strategy for promoting mucosal healing in IBD by regulating the FFAR1/AKT/FOXO1 signaling pathway.

关键词： LRCs ISCs EECs IBD SOX9 Aloe emodin FFAR1 FOXO1 CHRONIC ULCERATIVE-COliTIS EVIDENCE-BASED CONSENSUS INSUliN-SECRETION GRANULE RELEASE DNA-BINDING FOXO1 INDUCTION RECEPTOR DISEASE BETA

Application on Neural PID Control of MN-AGC in Continuous Hot Rolling

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Application on Neural PID Control of MN-AGC in Continuous Ho...

Intelligent Decoupling for Flatness and Gauge Control System in Hot Strip Rolling

2010 Chinese Control and Decision Conference

作者： Boqun li,jiaren Guo,Zhiyong Zhao School of Electronic and Information Engineering University of Science and Technology liaoning,Anshan 114044

＜正＞It is always primary object to improve gauge control accuracy in hot strip *** based on conventional PID emerged when the controlled object is complex,nonlinear and ***-AGC based on single neuron PID controller is introduced for improving automatic gauge control accuracy and quality in continuous hot *** controller is applied in hydraulic AGC of *** practical application results have shown the effectiveness of this algorithm and control performance gets much better.

关键词： Continuous hot rolling Screw down MN-AGC Single neural PID control

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Intelligent Decoupling for Flatness and Gauge Control System...

2010 Chinese Control and Decision Conference

作者： Boqun li,jiaren Guo,Chuanqing Zhu School of Electronic and Information Engineering,University of Science and Technology liaoning,Anshan 114044

＜正＞Hot strip rolling is a very complicated nonlinear process,and characterized by couple between automatic flatness control （AFC） and automatic gauge control（AGC）.By analyzing actual rolling process and considering real application,a kind of intelligent decoupling algorithm based on single neuron PID is *** simulation results have shown this kind of controller has good performances of adaptively tracking target and resisting disturbances and superior to the conventional decoupled PID control in improving hot strip flatness and gauge accuracy.

关键词： AGC AFC Single Neuron Intelligent Decoupling

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双氯芬酸擦剂的制备及质量控制

中国医院药学杂志 1999年第2期19卷 114-115页

作者：李平李家仁张建林兰州医学院第一附属医院兰州兰州市药品检验所

为了降低双氯芬酸的不良反应而研制一种擦剂。方法：以甘油、聚乙二醇４００为辅料，月桂氮菜卓酮为透皮吸收促进剂，研制双氯芬酸擦剂。结果：本制备工艺可行，内在质量稳定。用紫外分光光度法测定本品含量，测定波长２８２ｎｍ，线性... 详细信息

为了降低双氯芬酸的不良反应而研制一种擦剂。方法：以甘油、聚乙二醇４００为辅料，月桂氮菜卓酮为透皮吸收促进剂，研制双氯芬酸擦剂。结果：本制备工艺可行，内在质量稳定。用紫外分光光度法测定本品含量，测定波长２８２ｎｍ，线性范围７．６０～１６．７２μｇ·ｍｌ－１，平均回收率９９．５４％，ＲＳＤ＝０．１１％。结论：本制剂制备简便，质量控制准确可靠。

关键词：双氯芬酸擦剂制备质量控制

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