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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-Yu Bian Yu-fang Feng Wen-Ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

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Slow-Light Propagation in a Tapered Dielectric Periodic Waveguide over Broad Frequency Range

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Chinese Physics letters 2011年第5期28卷 132-135页

作者： fang Yi-jiao CHEN Zhuo WANG Zhen-Lin Department of Physics and National Laboratory of Solid State Microstructures Nanjing UniversityNanjing 210093

A tapered waveguide composed of a one-dimensional periodic arrangement of dielectric materialis proposed for light *** equifrequency contours(EFC)of silicon-air multilayer photonic crystals within the first bandgap region are first studied.A zero-group-velocity at the first Brillouin zone boundary along the grating vector is *** propagation constants and eigenfrequencies of the first-order guiding modes are numerically investigated for photonic crystal waveguide structures with a finite *** frequency components of the guiding modes are found to slov and stop at different thicknesses inside such a tapered waveguide *** addition,the time-evolution of a femto-second pulse propagating in the tapered waveguide is also demonstrated.

关键词： waveguide Waveguide arrangement

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A second-order numerical method for elliptic equations with singular sources using local flter

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Chinese Journal of Aeronautics 2013年第6期26卷 1398-1408页

作者： Jiang Yongsong fang le Jing Xiaodong Sun Xiaofeng Francis leboeuf Department of Compressor Design AVIC Shenyang Engine Design and Research Institute School of Energy and Power Engineering Beihang University Ecole Centrale de Pe'kin Laboratoire International Associe'Beihang University MOE Key Laboratory of High-speed Railway Engineering Southwest Jiaotong University Ecole Centrale de Lyon Laboratoire de Me'canique des Fluides et d’Acoustique Universite' de LyonEcully 69134France

The presence of Dirac delta function in differential equation can lead to a discontinuity,which may degrade the accuracy of related numerical *** improve the accuracy,a secondorder numerical method for elliptic equations with singular sources is introduced by employing a local kernel *** this method,the discontinuous equation is convoluted with the kernel function to obtain a more regular *** the original equation is replaced by this fltered equation around the singular points,to obtain discrete numerical *** unchanged equations at the other points are discretized by using a central difference scheme.1D and 2D examples are carried out to validate the correctness and accuracy of the present *** results show that a second-order of accuracy can be obtained in the fltering framework with an appropriate integration ***,the present method does not need any jump condition,and also has extremely simple form that can be easily extended to high dimensional cases and complex geometry.

关键词： Computational aerodynamics Immersed boundary method Immersed interface method Kernel flter Singular source

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Synthesis of γ-Al2O3 with High Surface Area and Large Pore Volume by Reverse Precipitation- azeotropic Distillation Method

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Chemical Research in Chinese Universities 2013年第2期29卷 206-209页

作者： WU Yu-sheng MA jiao LI Ming-chun HU fang School of Materials Science and Engineering Shenyang University of Technology Shenyang 110870 P. R. China

γ-Al2O3 with high surface area and large pore volume combined with high thermal stability was synthe- sized by a reverse precipitation-azeotropic distillation method. The effects of azeotropic distillation on the characte- ristics of γ-Al2O3 were studied by means of X-ray diffraction（XRD）, Fourier transform infrared（FTIR） spectroscopy, transmission electron microscopy（TEM） and N2 adsorption-desorption. The results show that γ-Al2O3 dried by azeo- tropic distillation has excellent structure characteristics with a high surface area of 426 m2/g and a large pore volume of 2.56 cm3/g. After calcination at 1100 ℃, the surface area of γ-Al2O3 was still 92 mE/g with a large pore volume of 1.00 cma/g, indicating the potential application in catalyst and petroleum industry.

关键词： Reverse precipitation Azeotropic distillation y-Alumina n-Butyl alcohol Thermal stability

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Aerobic exercise suppresses hepatocellular carcinoma by downregulating dynamin-related protein 1 through PI3K/AKT pathway

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Journal of Integrative Medicine 2021年第5期19卷 418-427页

作者： Tong Zhao Bing-jie Guo Chu-lan Xiao jiao-jiao Chen Can Lü Fan-fu fang Bai Li School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Nanjing University of Chinese Medicine.Nanjing 210023 Jiangsu ProvinceChina

Objective: Exercise, as a common non-drug intervention, is one of several lifestyle choices known to reduce the risk of cancer. Mitochondrial division has been reported to play a key role in the occurrence and transformation of hepatocellular carcinoma(HCC). This study investigated whether exercise could regulate the occurrence and development of HCC through ***: Bioinformatics technology was used to analyze the expression level of dynamin-related protein1(DRP1), a key protein of mitochondrial division. The effects of DRP1 and DRP1 inhibitor(mdivi-1) on the proliferation and migration of liver cancer cells BEL-7402 were observed using cell counting kit-8, plate colony formation, transwell cell migration, and scratch experiments. Enzyme-linked immunosorbent assay, Western blot and real-time polymerase chain reaction were used to detect the expression of DRP1 and its downstream phosphoinositide 3-kinase(PI3 K)/protein kinase B(AKT) pathway. A treadmill exercise intervention was tested in a nude mouse human liver cancer subcutaneous tumor model expressing different levels of DRP1. The size and weight of subcutaneous tumors in mice were detected before and after ***: The expression of DRP1 in liver cancer tissues was significantly upregulated compared with normal liver tissues(Ple to inhibit the expression of DRP1 and decrease the size and weight of subcutaneous tumors. Moreover,the expression of phosphorylated PI3 K(p-PI3 K) and phosphorylated AKT(p-AKT) decreased in the exercise group. However, exercise could not change p-PI3 K and p-AKT levels after knocking down DRP1 or using mdivi-1 on subcutaneous ***: Aerobic exercise can suppress the development of

关键词： Aerobic exercise Hepatocellular carcinoma Dynamin-related protein PI3K/AKT pathway

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Effect of Alum-Amended Litter and Stocking Density on Ammonia Release and Footpad and Hock Dermatitis of Broilers

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Agricultural Sciences in China 2011年第5期10卷 777-785页

作者： ZHANG Hong-fang jiao Hong-chao SONG Zhi-gang LIN Hai Department of Animal Science Shandong Agricultural University Tai＇an 271018 P.R.China

Two experiments were conducted to evaluate the effect of alum on ammonia emission,live performance,and health of *** experiment 1,the effect of alum （0,2,and 4%） supplementation on the emission of ammonia was *** effects of alum-treated litter and stocking density （12,16,and 20 birds m-2） on the live performance and incidence of footpad and hock dermatitis were investigated in experiment *** supplementation in chicken excreta significantly decreased pH from 8.06 to 5.27 and 3.62 by 2 and 4% alum treatments,*** emission rate was reduced 73.0 and 75.8% by 2 and 4% alum treatments,*** suppressed litter urease activity was detected in 4% alum ***-amended litter （1 kg m-2） decreased atmosphere ammonia concentrations by 30% in broiler ***-amended litter maintained a lower pH until 35 d of *** weight （BW） gain was decreased by alum treatment in the period of 4-7 wk of *** stocking density （20 birds m-2） increased BW gain in the first 3 wk of age but decreased BW gain during the period of 4-7 wk of *** alum nor stocking density treatments had a significant effect on feed intake and feed ***-treated litter had no detrimental effect on the development of footpad and hock *** contrast,high stocking density （20 bird m-2） increased the incidence of footpad and hock *** result suggests that the decreased litter pH and suppressed bacterial urease activity by alum treatment is responsible for the decreased ammonia *** high stocking density,the increased litter moisture content should be responsible,at least partially,for the development of footpad and hock lesions.

关键词： ammonia stocking density litter alum broilers

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Prepared GdBa2 Cu3Oy Single Domain Superconducting Bulks in Air

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Journal of Rare Earths 2004年第z2期22卷 126-129页

作者： Zheng Minghui Xiao Ling Ren Hongtao jiao Yulei Xu Bin fang Yuan Research Center of Superconductirg Materials General Research Institute for Non-Ferrous MetalsBeijing 100088China NO.2 Steelmaking Plant of Hefei Iron & Steel Co. LtdHefei 230011China

The preparation of the single domain GBCO bulk with 25 mm in diameter in air was reported. In order to avoid the Gd ions substituted the Ba sites, different BaCuO2 contents was added into the precursor powders. Tc of the samples achieved 94.3 K. The magnetization hysteresis loops of the samples were measured at 77 K. It is shown that the irreverswas obtained.

关键词： superconductor GdBaCuO melt-textured-growth single domain

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Syntheses and Vasodilatory Activities of New Pyrazolo[4,3-d]pyrimidin-7-ones

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Chemical Research in Chinese Universities 2006年第4期22卷 468-473页

作者： ZHAO Yan-fang ZHAI Xin CHEN jiao-yue GUO Shu-chun GONG Ping School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P.R. China

A series of novel pyrazolo [ 4,3-d ] pyrimidin-7-ones was designed and synthesized in order to find new potent phosphodiesterase 5 inhibitors（PDE5）. The structures of all the compounds were confirmed by IR, ^1H NMR and MS; their in vitro vasodilatory activities were tested on isolated rabbit aortic spiral strips. Among them, compound X3 displays a significant vasodilatory activity, which is more potent than verapamil.

关键词： Pyrazolo[4,3-d]pyrimidin-7-one Synthesis Vasodilatory activity

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On the Compactness of Homeomorphisms with Integrable Dilatations

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Acta Mathematica Sinica,English Series 1998年第2期14卷 161-168页

作者： fang Ainong (Department of Mathematics,Shanghai jiao Tong University,Shanghai 200030,China) Department of Mathematics Shanghai Jiao Tong University

In this paper,a distortion theorem and some equicontinuity and compactness theorems are obtained for the homeomorphism f with the sphere dilatation H（x,f）∈Lloc（D）.

关键词： Quasiconformal mappings Distortion theorem Compactness μ-homeomorphism

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Retrospective Study Immune function status of postoperative patients with colon cancer for predicting liver metastasis

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 463-470页

作者： le Xiong fang-Chen Liu Department of Clinical Laboratory Xiangyang No.1 People’s HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina Department of Blood Transfusion Xiangyang No.1 People’s HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina

BACKGROUND Colon cancer(CC)has a high incidence *** resection is the main treatment method for CC;however,liver metastasis(LM)often occurs *** liver contains both innate and adaptive immune cells that monitor and remove abnormal cells and *** LM,tumor cells secrete cytokines and exosomes to adjust the immune microenvironment of the liver,thus forming an inhibitory immune microenvironment for colonization by circulating tumor *** indicates that the immune state of patients with CC plays a crucial role in the occurrence and progression of *** To observe and analyze the relationship between immune status and expression of tumor factors in patients with LM of CC,and to provide a scientific interven-tion method for promoting the patient *** A retrospective analysis was *** baseline data of 100 patients with CC and 100 patients with CC who suffered from postoperative LM and were admitted to our hospital from May 2021 to May 2023 were included in the non-occurrence and occurrence groups,*** immune status of the pa-tients and the expression of tumor factor-related indicators in the two groups were compared,and the predictive value of the indicators for postoperative LM in patients with CC was *** Compared with the non-occurrence group,the expression of serum carcinoem-bryonic antigen(CEA),CA19-9,CA242,CA72-4 and CA50 in patients in the occurrence group were significantly higher,while the expression of CD3+,CD4+,CD8+,natural killer(NK)and CD4+/CD25 in patients in the occurrence group were significantly lower(P0.05).Multivariate logistic regression model analysis revealed that the expressions of CEA,CA19-9,CA242,CA72-4,CA50,CD3+,CD4+,CD8+,NK,and CD4+/CD25 were associated with the LM in patients with *** expressions of serum CEA,CA19-9,CA242,CA72-4 and CA50,and low expressions of CD3+,CD4+,CD8+,

关键词： Colon cancer Liver metastases Immune status Tumor factors Predicted value

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