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Efficacy and Safety of Jianpi Jieyu Decoction for Patients with Mild-to-Moderate Depression of Xin(Heart)-Pi(Spleen)Deficiency Syndrome:A Multi-centre Randomized Controlled Study

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Chinese Journal of Integrative Medicine 2023年第4期29卷 299-307页

作者： CHEN Xu CHEN Jiu-xi HAN Xue-yan ZHAO Yang CAO Jing jiao Xiu-zhen LIU Hong-mei GUO Chun-li MENG Shuo LIANG Shuai QI Jiang-xia CHEN Dong LI Ming-xia jiao yun-xia WANG Ting-ting HONG xia Xiyuan Clinical Medical College Beijing University of Chinese MedicineBeijing 100091China Department of Encephalopathy Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China First College of Clinical Medicine Shandong University of Traditional Chinese MedicineJinan 250355China Institute of Clinical Pharmacology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Encephalopathy Botou Traditional Chinese Medicine Hospital of Hebei ProvinceBotou 062150China Institute of Basic Medicine Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Nephrology Pinggu HospitalBeijing Hospital of Traditional Chinese MedicineBeijing 101299China

Objective:To evaluate the efficacy and safety of Jianpi Jieyu Decoction(JJD)for treating patients with mild-to-moderate depression of Xin(Heart)-Pi(Spleen)deficiency(XPD)***:In this multi-center,randomized,controlled study,140 patients with mild-to-moderate depression of XPD syndrome were included from Xiyuan Hospital of China Academy of Chinese Medical Sciences and Botou Hospital of Traditional Chinese Medicine from December 2017 to December *** were randomly divided into JJD group and paroxetine group by using a random number table,with 70 cases in each *** patients in the JJD group were given JJD one dose per day(twice daily at morning and evening,100 m L each time),and the patients in the paroxetine group were given paroxetine(10 mg/d in week 1;20 mg/d in weeks 2-6),both orally administration for a total of 6 *** primary outcome was the change of 17-item Hamilton Depression Rating Scale(HAMD-17)score at week 6 from *** secondary outcomes included the Hamilton Anxiety Scale(HAMA)score,Traditional Chinese Medicine Symptom Scale(TCMSS),and Clinlcal Global Impression(CGI)scores at the 2nd,4th,and 6th weekends of treatment,HAMD-17 response(defined as a reduction in score of>50%)and HAMD-17 remission(defined as a score of 7)at the end of the 6th week of *** events(AEs)were also ***:From baseline to week 6,the HAMD-17 scores decreased 10.2±4.0 and 9.1±4.9 points in the JJD and paroxetine groups,respectively(P=0.689).The HAMD-17 response occurred in 60%of patients in the JJD group and in 50%of those in the paroxetine group(P=0.292);HAMD-17 remission occurred in 45.7%and 30%of patients,respectively(P=0.128).The differences of CGI scores at the 6th week were not statistically significant(P>0.05).There were significant differences in HAMD-17 scores between the two groups at 2nd and 4th week(P=0.001 and P=0.014).The HAMA scores declined 8.1±3.0 and 6.9±4.3 points from baseline to week 6 in the JJD and paroxe

关键词： depression Xin(Heart)-Pi(Spleen)deficiency syndrome Chinese medicine Jianpi Jieyu Decoction depression efficacy safety

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Emergency management capacity assessment for urban rail transit-an example of Beijing Metro Line 13

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Transportation Safety and Environment 2024年第1期6卷 109-115页

作者： jiao Liu yun Qi Wei Wang School of Emergency Management and Safety Engineering China University of Mining&Technology(Beijing)Beijing 100083China China Safety Science Journal Editorial Department China Occupational Safety and Health AssociationBeijing 100011China College of mechanical engineering and automation Liaoning University of TechnologyJinzhou 121001LiaoningChina

In order to improve the emergency management capability of urban rail transit system and reduce accidents during metro operation,an emergency management capability evaluation method combining analytic hierarchy process(AHP)and technique for order preference by similarity to ideal solution(TOPSIS)is *** on the Prevention Preparation Response Recovery(PPRR)model,factors influencing the emergency management capability of the urban rail transit system are summarized from the perspective of‘human,machine,environment and management’.Then,an emergency management capability evaluation index system containing of 20 secondary indicators is constructed in four stages:emergency prevention,emergency preparation,emergency response and emergency *** weights of indicators are calculated using the AHP method,and the closeness of each indicator to the optimal solution is analysed with the TOPSIS ***,take the Beijing Metro Line 13 as an example to investigate the level of emergency management capability of urban rail *** results show that the emergency management capability of Beijing’s urban rail transit system is‘well’,among which hazard prevention measures(0.31)and emergency response team(0.34)have a greater weight on the emergency management capability of rail *** model can more accurately assess the emergency management capability of urban rail transit and provide a basis for emergency management.

关键词： urban rail transit emergency management capability analytic hierarchy process(AHP) technique for order preference by similarity to ideal solution(TOPSIS) prevention preparation response recovery(PPRR)model

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中国数字普惠金融:发展逻辑、时空格局与区域差异

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兰州大学学报（社会科学版） 2022年第3期50卷 52-66页

作者：焦云霞中国社会科学院数量经济与技术经济研究所北京100732

从数字普惠金融内涵、概念出发阐释数字普惠金融发展逻辑,综合运用多种方法深入剖析我国数字普惠金融发展的时空格局与区域差异。根据非参数KDE、Moran’s I指数与空间Markov链估计的结果发现,2011-2020年我国数字普惠金融发展整体上经... 详细信息

从数字普惠金融内涵、概念出发阐释数字普惠金融发展逻辑,综合运用多种方法深入剖析我国数字普惠金融发展的时空格局与区域差异。根据非参数KDE、Moran’s I指数与空间Markov链估计的结果发现,2011-2020年我国数字普惠金融发展整体上经历了由两极分化到整体收敛的演化过程,并存在全局空间下的集聚现象;基于Dagum基尼系数及其分解可知,我国数字普惠金融区域差异呈缩小态势,且区域间差异是其主要来源;最后采用σ收敛、绝对和条件β收敛空间杜宾模型检验可知,数字普惠金融发展水平较低的地区正以更快的速度追赶水平较高的地区,随着时间推移区域差异将缩小。建议政府部门立足本地区数字普惠金融发展的优劣势因地制宜制定发展政策,发挥数字普惠金融的空间溢出效应和政府的支持引导作用。

关键词：数字普惠金融发展逻辑时空格局区域差异空间计量

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Oleuropein alleviates sepsis-induced acute lung injury via the AMPK/Nrf-2/HO-1 signaling

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 187-198页

作者： Shan-Hu Wang Yang-Yang Wu xiao-jiao xia Department of Pediatrics The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325027China

Objective:To explore the effect of oleuropein on sepsis-induced acute lung injury(ALI)in vitro and in vivo and investigate the underlying ***:In an lipopolysaccharide(LPS)-mediated cell model of sepsis-induced ALI and a cecal ligation and puncture-induced mouse model of septic ALI,CCK-8 assay and flow cytometry analysis were used to detect cell activity and *** and relevant assay kits were used to measure the levels of inflammatory cytokines and oxidative stress,*** blot was applied to determine the expression of apoptosis-and AMP-activated protein kinase(AMPK)/nuclear factor erythroid 2-related factor-2(Nrf-2)/heme oxygenase-1(HO-1)signaling-associated ***-1 staining,adenosine triphosphate(ATP)assay kit,and MitoSOX Red assays were performed to detect mitochondrial membrane potential,ATP content,and mitochondrial ROS formation,***,lung injury was evaluated by measuring lung morphological alternations,lung wet-to-dry ratio,myeloperoxidase content,and total protein ***:Oleuropein reduced inflammatory reaction,oxidative damage,and apoptosis,and ameliorated mitochondrial dysfunction in LPS-exposed BEAS-2B cells and mice with septic ***,oleuropein activated the AMPK/Nrf-2/HO-1 signaling ***,these effects of oleuropein were abrogated by an AMPK inhibitor compound ***:Oleuropein can protect against sepsis-induced ALI in vitro and in vivo by activating the AMPK/Nrf-2/HO-1 signaling,which might be a potential therapeutic agent for the treatment of sepsis-induced ALI.

关键词： AMPK/Nrf-2/HO-1 signaling Inflammatory response Lung damage Mitochondrial dysfunction Oleuropein Oxidative stress Sepsis

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Flow Field Characteristics of Multi-Trophic Artificial Reef Based on Computation Fluid Dynamics

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Journal of Ocean University of China 2024年第2期23卷 317-327页

作者： HUANG Junlin LI jiao LI Yan GONG Pihai GUAN Changtao xia Xu School of Engineering Ocean University of ChinaQingdao 266100China Yellow Sea Fisheries Research Institute Chinese Academy of Fishery SciencesKey Laboratory of Sustainable Development of Marine FisheriesMinistry of Agriculture and Rural AffairsQingdao Key Laboratory for Marine Fish Breeding and BiotechnologyQingdao 266071China Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266071China

On the basis of computational fluid dynamics,the flow field characteristics of multi-trophic artificial reefs,including the flow field distribution features of a single reef under three different velocities and the effect of spacing between reefs on flow scale and the flow state,were *** indicate upwelling,slow flow,and eddy around a single *** velocity,height,and volume of upwelling in front of a single reef were positively correlated with inflow *** length and volume of slow flow increased with the increase in inflow *** were present both inside and backward,and vorticity was positively correlated with inflow *** between reefs had a minor influence on the maximum velocity and height of *** the increase in space from 0.5 L to 1.5 L(L is the reef lehgth),the length of slow flow in the front and back of the combined reefs increased *** the space was 2.0 L,the length of the slow flow *** four different spaces,eddies were present inside and at the back of each *** maximum vorticity was negatively correlated with space from 0.5 L to 1.5 L,but under 2.0 L space,the maximum vorticity was close to the vorticity of a single reef under the same inflow velocity.

关键词： artificial reef flow field characteristics computation fluid dynamics multi-trophic structure

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Differences in insomnia-related self-reported outcomes among elderly hospitalized patients

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World Journal of Psychiatry 2024年第5期14卷 686-694页

作者： xia Ding Ling-xia Qi Dong-yun Sun Department of Gangzha General Medical Center The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Anesthesiology and Surgery The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Ophthalmic Surgery Room The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina

Insomnia is among the most common sleep disorders *** in older adults is a social and public health *** affects the physical and mental health of elderly hospitalized patients and can aggravate or induce physical *** subjective feelings and providing reasonable and standardized care for elderly hospitalized patients with insomnia are urgent *** To explore the differences in self-reported outcomes associated with insomnia among elderly hospitalized *** One hundred patients admitted to the geriatric unit of our hospital between June 2021 and December 2021 were included in this ***-reported symptoms were assessed using the Athens Insomnia Scale(AIS),Generalized Anxiety Disorder Scale-7(GAD-7),Geriatric Depression Scale-15(GDS-15),Memorial University of Newfoundland Scale of Happiness(MUNSH),Barthel Index Evaluation(BI),Morse Fall Scale(MFS),Mini-Mental State Examination,and the Short Form 36 Health Survey Questionnaire(SF-36).Correlation coefficients were used to analyze the correlation between sleep quality and self-reported *** of insomnia was analyzed using Logistic regression *** Nineteen patients with AIS≥6 were included in the insomnia group,and the incidence of insomnia was 19%(19/100).The remaining 81 patients were assigned to the non-insomnia *** were significant differences between the two groups in the GDA-7,GDS-15,MUNSH,BI,MFS,and SF-36 items(P<0.05).Patients in the insomnia group were more likely to experience anxiety,depression,and other mental illnesses,as well as difficulties with everyday tasks and a greater risk of falling(P<0.05).Subjective well-being and quality of life were poorer in the insomnia group than in the control *** AIS scores positively correlated with the GAD-7,GDS-15,and MFS scores in elderly hospitalized patients with insomnia(P<0.05).Logistic regression analysis showed that GDS-15≥5 was an independent risk factor for ins

关键词： Elderly hospitalized patients Insomnia Self-reported outcomes Symptoms Subjective feelings Correlation

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Dominance of rock exposure and soil depth in leaf trait networks outweighs soil quality in karst limestone and dolomite habitats

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Forest Ecosystems 2024年第5期11卷 632-641页

作者： Min jiao Jiawei Yan Ying Zhao Tingting xia Kaiping Shen Yuejun He Forestry College Research Center of Forest EcologyGuizhou UniversityGuiyang550025China

Leaf trait networks(LTNs)visualize the intricate linkages reflecting plant trait-functional *** karst vegetation,developed from lithological dolomite and limestone,generally exhibits differential communities,possibly due to habitat rock exposure,soil depth,and soil physicochemical properties variations,leading to a shift from plant trait variation to functional ***,how soil and habitat quality affect the differentiation of leaf trait networks remains *** were constructed for typical dolomite and limestone habitats by analyzing twenty-one woody plant leaf traits across fifty-six forest subplots in karst *** differences between dolomite and limestone LTNs were compared using network *** network association of soil and habitat quality was analyzed using redundancy analysis(RDA),Mantle's test,and a random forest *** limestone LTN exhibited significantly higher edge density with lower diameter and average path length when compared to the dolomite *** indicates LTN differentiation,with the limestone network displaying a more compact architecture and higher connectivity than the dolomite *** specific leaf phosphorus and leaf nitrogen contents of dolomite LTN,as well as the leaf mass and leaf carbon contents of limestone LTN,significantly contributed to network degree and closeness,serving as crucial node traits regulating LTN ***,both habitat LTNs significantly correlated with soil nitrogen and phosphorus,stoichiometric ratios,pH,and organic carbon,as well as soil depth and rock exposure rates,with soil depth and rock exposure showing greater relative *** depth and rock exposure dominate trait network differentiation,with the limestone habitat exhibiting a more compact network architecture than the dolomite habitat.

关键词： Leaf trait networks Functional traits Woody plant community Karst Dolomite Limestone

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X-ray-activated Bi^(3+)/Pr^(3+)co-doped LiYGeO_4 phosphor with UV and NIR dual-emissive persistent luminescence

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Journal of Rare Earths 2024年第5期42卷 955-961,I0005页

作者： xianggui Yin Hongyun Zhong Lin Liu Junpeng Shi xia Sun yun Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen361021China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China

X-ray-activated luminescence materials have broad application prospects in photodynamic therapy of deep *** them,X-ray-activated persistent luminescence materials(PLMs)exhibiting multiple emission peaks have drawn extensive attention for the ir capacity to achieve a combination of bioimaging and therapeutic ***,we developed a novel PLM,LiYGeO_4:Bi^(3+),Pr^(3+),that simultaneously exhibits UV and NIR dual persistent luminescence(PersL)emissions after irradiation by *** material can be re peatedly excited by X-ray and emits similar lumine scence intensity every time,which shows good PersL *** addition,LiYGeO_4:Bi^(3+),Pr^(3+)exhibits photostimulated PersL properties by stimulation with a red light-emitting diode(LED)or NIR laser after long-term *** work provides a new choice of X-ray-excited PLMs with UV and NIR dual emission and the novel phosphor shows promise as a potential candidate for the integration of treatment and diagnosis of deep tumors.

关键词： Co-doping X-ray-activated Dual emissions Persistent luminescence Rare earths

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A Novel Fracturing Fluid with High-Temperature Resistance for Ultra-Deep Reservoirs

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Fluid Dynamics & Materials Processing 2024年第5期20卷 975-987页

作者： Lian Liu Liang Li Kebo jiao Junwei Fang yun Luo Northwest Oilfield Branch China Petroleum&Chemical CorporationUrumqi830011China Sinopec Key Laboratory for Enhanced Recovery in Fractured and Cavernous Reservoir Urumqi830011China

Ultra-deep reservoirs play an important role at present in fossil energy *** to the related high temperature,high pressure,and high formation fracture pressure,however,methods for oil well stimulation do not produce satisfactory results when conventional fracturing fluids with a low pumping rate are *** response to the above problem,a fracturing fluid with a density of 1.2~1.4 g/cm^(3)was developed by using Potassium formatted,hydroxypropyl guanidine gum and zirconium crosslinking *** fracturing fluid was tested and its ability to maintain a viscosity of 100 mPa.s over more than 60 min was verified under a shear rate of 1701/s and at a temperature of 175℃.This fluid has good sand-carrying performances,a low viscosity after breaking the rubber,and the residue content is less than 200 mg/*** with ordinary reconstruction fluid,it can increase the density by 30%~40%and reduce the wellhead pressure of 8000 m level reconstruction ***,the new fracturing fluid can significantly mitigate safety risks.

关键词： Ultra-deep reservoir high-temperature resistance weighted fracturing fluid guanidine gum potassium formatted

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Construction of flower-like MoS_(2)decorated on Cu doped CoZn-ZIF derived N-doped carbon as superior microwave absorber

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Nano Research 2024年第9期17卷 8250-8260页

作者： yun Han Di Lan Mengjun Han Zihao xia Jiaxiao Zou Zirui Jia College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002China

The rational design of composition nanostructures and morphologies of the carbon-based composites materials has a significant potential for tuning electromagnetic parameters and thereby improving their performance as electromagnetic wave(EMW)*** this work,the flower-like Cu/Co-NC/MoS_(2)(NC=N-doped carbon skeleton)composites were successfully prepared by employing CuCoZn-ZIF(ZIF=zeolitic imidazolate framework)as precursor with subsequent annealing and hydrothermal *** unique flower-like morphology and electromagnetic synergy strategy between components enable the as-obtained Cu/Co-NC/MoS_(2)composites to exhibit outstanding microwave absorption ***,the minimum reflection loss of Cu/Co-NC/MoS_(2)reaches-54.36 dB at 2.7 *** the thickness reduces to 2.2 mm,the maximum effective absorption bandwidth can be achieved as large as 6.72 *** research develops useful ideas for optimizing multicomponent microwave absorbing materials.

关键词： ternary metal-organic frameworks(MOFs) MoS_(2) flower-like morphology microwave absorption

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