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A new via chain design method considering confidence level and estimation precision

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第9期13卷 702-710页

作者： xiao-hua LUO Li-sheng CHEN jiao-jiao ZHU xiao-lang YAN Institute of VLSI Design Zhejiang UniversityHangzhou 310027China

For accurate prediction of via yield, via chains are usually fabricated on test chips to investigate issues about vias. To minimize the randomness of experiments and make the testing results more convincing, the confidence level and estimation precision of the via failure rate are investigated in this paper. Based on the Poisson yield model, the method of determining an adequate number of total vias is obtained using the law of large numbers and the de Moivre-Laplace theorem. Moreover, for a specific confidence level and estimation precision, the method of determining a suitable via chain length is proposed. For area minimization, an optimal combination of total vias and via chain length is further determined. Monte Carlo simulation results show that the method is in good accordance with theoretical analyses. Results of via failure rates measured on test chips also reveal that via chains designed using the proposed method has a better performance. In addition, the proposed methodology can be extended to investigate statistical significance for other failure modes.

关键词： Poisson yield model Via chain Via failure rate Confidence level Estimation precision

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金针菇工厂化生产的液体菌种开发与应用

安徽农业科学 2017年第20期45卷 53-55页

作者：李国庆柯家厚焦小雨王燕李阿敏聂凡安徽省农业科学院园艺研究所安徽合肥230031 合肥市福泉现代农业科技有限公司安徽合肥230031

[目的]开发金针菇工厂化生产所需的液体菌种。[方法]从工厂化生产的菌株与二级液体菌种培养基的筛选,液体菌种培养条件的优化及金针菇液体菌种在工厂化生产的应用试验等方面进行研究。[结果]在4个金针菇工厂化生产菌株中,金针菇工厂化... 详细信息

[目的]开发金针菇工厂化生产所需的液体菌种。[方法]从工厂化生产的菌株与二级液体菌种培养基的筛选,液体菌种培养条件的优化及金针菇液体菌种在工厂化生产的应用试验等方面进行研究。[结果]在4个金针菇工厂化生产菌株中,金针菇工厂化生产的液体菌种开发宜以F白"18"为出发菌株;二级液体菌种的培养基宜为马铃薯15%、麸皮7%、蔗糖2%、磷酸二氢钾0.1%、硫酸镁0.05%;培养条件为接种量10%,转速150 r/min,温度23℃,pH自然,发酵罐培养时间结束点和适宜的菌龄均为144 h;在工厂化生产应用中,液体菌种较固体菌种发菌速度快,生产周期缩短9 d,生物转化率提高了6.38百分点。[结论]该研究可为金针菇工厂化生产所需液体菌种的开发提供技术方法。

关键词：金针菇工厂化生产液体菌种

Corrosion behavior of Cu/Al casting-rolled clad plates in different alkaline solution

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China Foundry 2021年第5期18卷 513-520页

作者： Yi-fan Zhang xiao-guang yuan xiao-jiao Zuo Hong-jun Huang yu-lin Cheng School of Materials Science and Engineering Shenyang University of technologyShenyang 110870China

The effect of pH value and different kinds of anions on the corrosion behavior of Cu/Al casting-rolled clad plates in the alkaline solution was evaluated by means of scanning electron microscopy(SEM),energy dispersive spectroscopy(EDS),X-ray diffraction(XRD),weight loss analysis,3D confocal laser scanning microscopy(CLSM)and electrochemical *** show the corrosion mainly occurs on the aluminum *** corrosion resistance of the Cu/Al decreases as the pH value *** pH≥12,the dissolution of the film layer is faster than the passivation *** addition of Cl^(-)ions reduces the corrosion resistance of the Cu/Al clad plates,which leads to pitting *** higher the concentration of Cl^(-)ions,the more prone the pitting to *** addition of SO_(4)^(2-)ions causes the denudation of the *** corrosion resistance of the Cu/Al is better in the alkaline solution containing NO_(3)^(-)ions than that in the solution containing Cl^(-)ions or SO_(4)^(2-)*** adding SO_(4)^(2-),NO^(3)^(-)and Cl^(-)to the pure alkaline solution,the corrosion resistance of the Cu/Al clad plates decreases.

关键词： Cu/Al clad plates alkaline solution pH anions electrochemistry casting-rolled

河龙区间典型流域径流年内分配对水土保持生态建设的响应

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水土保持研究 2025年第1期32卷 141-147+159页

作者：陈玮孙彭成肖培青李琼芳焦鹏河海大学水文水资源学院黄河水利委员会黄河水利科学研究院水利部黄土高原水土保持重点实验室

[目的]揭示河龙区间不同地貌区下典型流域的多年径流变化特征，明晰水土保持生态建设对其径流年内分配均匀程度的影响。[方法]选取河龙区间风沙区、土石山区和黄土丘陵沟壑区的秃尾河、三川河及延河流域，在收集各流域1960—2019年径流... 详细信息

[目的]揭示河龙区间不同地貌区下典型流域的多年径流变化特征，明晰水土保持生态建设对其径流年内分配均匀程度的影响。[方法]选取河龙区间风沙区、土石山区和黄土丘陵沟壑区的秃尾河、三川河及延河流域，在收集各流域1960—2019年径流观测和水土保持措施数据的基础上，构建基尼系数指标，量化径流年内分配均匀度，分析了流域径流年内分配的演变趋势与空间差异，探究了河龙区间流域径流年内分配对不同类型水土保持措施的响应特征。[结果]（1） 1960—2019年，3个典型流域径流量极显著减少，秃尾河、三川河和延河的年径流量减少幅度分别为-0.05亿m3/a,-0.03亿m3/a,-0.02亿m3/a;（2） 3个典型流域径流年内分配特征显著差异，风沙区的秃尾河流域径流年内分配最为均匀，土石山区次之，黄土丘陵沟壑区的延河流域年内分配最不均匀，各流域的径流基尼系数分别为0.2,0.35,0.6;（3）不同地貌区径流基尼系数均呈下降趋势，径流年内分配趋向均匀；（4）水土保持林草植被、梯田和淤地坝建设与径流基尼系数具有显著负相关关系。[结论]水土保持生态建设具有调节径流年内分配，促进河川径流年内分配更加均匀的作用。

关键词：水土保持与荒漠化治理径流年内分配基尼系数河龙区间

Design study of APS-U-type hybrid-MBA lattice for mid-energy DLSR

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Nuclear Science and Techniques 2021年第7期32卷 46-54页

作者： yu Zhao Yi jiao Sheng Wang Institute of High Energy Physics(IHEP) Chinese Academy of Sciences(CAS)Beijing 100049China University of Chinese Academy of Sciences(UCAS) Beijing 100049China Spallation Neutron Source Science Center(SNSSC) Dongguan 523803China

In recent years,a new generation of storage ring-based light sources,known as diffraction-limited storage rings(DLSRs),whose emittance approaches the diffraction limit for the range of X-ray wavelengths of interest to the scientific community,has garnered significant attention *** have begun to design and build *** various DLSR proposals,the hybrid multibend achromat(H-MBA)lattice enables sextupole strengths to be maintained at a reasonable level when minimizing the emittance;hence,it has been adopted in many DLSR *** on the H-7BA lattice,the design of the Advanced Photon Source Upgrade Project(APS-U)can effectively reduce emittance by replacing six quadrupoles with ***,we discuss the feasibility of designing an APS-U-type H-MBA lattice for the Southern Advanced Photon Source,a mid-energy DLSR light source with ultralow emittance that has been proposed to be built adjacent to the China Spallation Neutron *** linear and nonlinear dynamics are optimized to obtain a detailed design of this type of *** emittance is minimized,while a sufficiently large dynamic aperture(DA)and momentum acceptance(MA)are maintained.A design comprising 36 APS-U type H-7BAs,with an energy of 3 GeV and a circumference of 972 m,is *** horizontal natural emittance is 20 pm·rad,with a horizontal DA of 5.8 mm,a vertical DA of 4.5 mm,and an MA of 4%,as well as a long longitudinal damping time of 120 ***,a few modifications are performed based on the APS-U-type lattice to reduce the maximum value of damping time from 120 to 44 ms while maintaining other performance parameters at the same level.

关键词： Southern advanced photon source(SAPS) Diffraction-limited storage ring(DLSR) Hybrid multibend achromat(H-MBA) Advanced photon source upgrade project(APS-U) Lattice design

In vitro Antioxidant Effects of Porphyra haitanensis Peptides on H_2O_2-Induced Damage in HepG2 Cells

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Journal of Ocean University of China 2021年第2期20卷 421-428页

作者： CHEN Shengjun yu jiao HU xiao YANG Xianqing LI Laihao QI Bo DENG Jianchao Key Laboratory of Aquatic Product Processing Ministry of Agriculture and Rural AffairsNational Research and Development Center for Aquatic Product ProcessingSouth China Sea Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhou 510300China Co-Innovation Center of Jiangsu Marine Bio-Industry Technology Jiangsu Ocean UniversityLianyungang 222005China College of Food Science&Technology Shanghai Ocean UniversityShanghai 201306China

In this study,protein from Porphyra haitanensis was used as raw material to prepare an antioxidant peptide,and its antioxidant activity was evaluated in vitro.A model of H_2O_2-induced oxidative damage in Hep G2 cells was established,and the effects of Porphyra haitanensis hydrolysates (PHHs) on superoxide dismutase (SOD) activity and malondialdehyde (MDA) content were ***,the structure of PHHs was identified by ESI-MS/*** results showed that the 1,1-diphenyl-2-pyridylhydrazine(DPPH)-free radical-scavenging ability of PHHs was the strongest (59.28%at 1.0 mg m L~(-1)) when hydrolyzed with an acidic protease for 4 *** with different concentrations had protective effects on H_2O_2-induced damage to Hep G2 cells,and the protective effect was enhanced with increasing *** the level was 400μg m L~(-1),the cell survival rate was as high as 88.62%.Moreover,PHHs can significantly reduce oxidative damage to Hep G2 cells by H_2O_2,improve SOD activity,and reduce MDA *** tetrapeptide Asp-Lys-Ser-Thr,with a molecular weight of 448 Da,was identified as an important fraction of PHHs by high-resolution mass spectrometry.

关键词： Porphyra haitanensis hydrolysates(PHHs) antioxidant peptides radical-scavenging activity cell antioxidant capacity electrospray ionization-mass spectrometry

Coexistence and local Mittag–Leffler stability of fractional-order recurrent neural networks with discontinuous activation functions

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Chinese Physics B 2019年第4期28卷 131-140页

作者： yu-jiao Huang Shi-Jun Chen Xu-Hua Yang Jie xiao College of Computer Science and Technology Zhejiang University of Technology

In this paper, coexistence and local Mittag–Leffler stability of fractional-order recurrent neural networks with discontinuous activation functions are addressed. Because of the discontinuity of the activation function, Filippov solution of the neural network is defined. Based on Brouwer's fixed point theorem and definition of Mittag–Leffler stability, sufficient criteria are established to ensure the existence of (2k + 3)~n (k ≥ 1) equilibrium points, among which (k + 2)~n equilibrium points are locally Mittag–Leffler stable. Compared with the existing results, the derived results cover local Mittag–Leffler stability of both fractional-order and integral-order recurrent neural networks. Meanwhile discontinuous networks might have higher storage capacity than the continuous ones. Two numerical examples are elaborated to substantiate the effective of the theoretical results.

关键词： fractional-order recurrent neural network local Mittag–Leffler stability discontinuous activation function

Ginkgo Biloba Extract Ameliorates Scopolamine-induced Memory Deficits via Rescuing Synaptic Damage

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Current Medical Science 2022年第3期42卷 474-482页

作者： Gui-jiao ZHANG Dong ZHENG Huan yu xiao-ping LUO Wei WU Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective Alzheimer’s disease(AD)is the most common age-related neurodegenerative *** evidence suggests that synaptic dysfunction is associated with the onset and progression of ***,Ginkgo biloba extract(EGb)is one of the most frequently investigated herbal medicines for enhancing cognition and alleviating neurodegenerative *** study aimed to investigate the effect and the mechanism of EGb on AD-like synaptic *** Scopolamine(SCO)-induced rats were used to mimic AD-like memory *** water maze test and fear conditioning test were conducted to evaluate the memory status of rats in response to different ***,the synapse alterations were assessed by Golgi staining,and Western blotting was conducted to assess the protein expression of PSD95,GluN2B,synapsin-1,and *** transcription quantitative polymerase chain reaction was applied to detect the mRNA expression of PSD95 and the levels of miR-1-3p/*** EGb supplement alleviated the learning and memory deficits induced by SCO in behavioral ***,EGb treatment attenuated synaptic damage elicited by SCO,manifested as increased dendritic spine density and the proportion of mushroom-type spines in hippocampal *** investigation indicated that EGb rescued the expression of synaptic-related proteins,especially PSD95,and decreased the levels of miR-1-3p/miR-206-3p in the rat *** The application of EGb effectively treats SCO-induced memory impairments probably by suppressing miR-1-3p/miR-206-3p and elevating the expression of PSD95.

关键词： Ginkgo biloba extract Alzheimer’s disease synapse PSD95 MiR-1 MiR-206

Super-Grignard reagents(R_(2)Mg·LiCl)mediated covalent-anionic-radical polymerization capable of low?and reactive hydrogen compatibility

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Chinese Chemical Letters 2023年第9期34卷 335-339页

作者： Min Su Meng-Qin Pu Hang xiao yu-jiao Chen Wen-Ming Wan Key Laboratory of Coal to Ethylene Glycol and Its Related Technology State Key Laboratory of Structural ChemistryCenter for Excellence in Molecular SynthesisFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China

The precise synthesis of polymer with narrow molecular weight distribution(?)and well-defined architectures is very essential to exploring the functions and properties of polymer ***,a universal polymerization method capable of low?and reactive hydrogen compatibility is reported by introducing super-Grignard reagents(R_(2)Mg?Li Cl)into polymer *** mild conditions,various monomers,including nonpolar polystyrene and 4-methoxystyrene that cannot be initiated by Grignard reagents,and polar methacrylate,are successfully polymerized with full monomer conversion and low?.This approach is amenable to wide varieties of initiators,polymerization temperature,and feed ratio,which makes it attractive for applications in polymer *** adding methanol and water during the polymerization process,the reactive hydrogen compatibility of this method is confirmed,which makes this method avoid the rigorous restriction on polymerization conditions of anionic ***,chain extension polymerization and block copolymerization are achieved and demonstrate the livingness of chain propagation,enabling the facile synthesis of well-defined macromolecular *** work therefore expands the methodology libraries of living polymerization,which may cause inspirations to polymer science.

关键词： R_(2)Mg·LiCl Grignard reagent Living polymerization Covalent-anionic-radical polymerization Block copolymerization