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Exposure to ephedrine attenuates Th1/Th2 imbalance underlying OVA-induced asthma through airway epithelial cell-derived exo-somal lnc-TRPM2-AS

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Chinese Journal of Natural Medicines 2024年第6期22卷 530-540页

作者： HU Yan WANG Mengqing XIE Jing jiao luojia DING Yi LUO Yinhe Department of Pediatrics The First Hospital of Hunan University of Chinese MedicineChangsha 410007China Hunan University of Chinese Medicine Changsha 410208China Department of Rehabilitation Medical CollegeChangsha Civil Affairs Vocational and Technical CollegeChangsha 410004Hunan ProvinceChina Teaching and Research Office of Chinese and Western Combination Hunan University of Chinese MedicineChangsha 410208China

Although various anti-inflammatory medications,such as ephedrine,are employed to manage cough-variant asthma,their underlying mechanisms are yet to be fully *** studies suggest that exosomes derived from airway epithelial cells(AECs)contain components like messenger RNAs(mRNAs),micro-RNAs(miRNAs),and long noncoding RNA(lncRNA),which play roles in the occurrence and progression of airway *** study investigates the influence of AEC-derived exosomes on the efficacy of ephedrine in treating cough-variant *** established a mouse model of asthma and measured airway resist-ance and serum inflammatory cell ***-time polymerase chain reaction(RT-qPCR),Western blotting,and enzyme-linked im-munosorbent assay(ELISA)analyses were used to assess gene and protein expression *** were isolated and *** immunoprecipitation(RIP)and RNA pull-down assays were conducted to examine the interaction between hnRNPA2B1 and *** the ovalbumin(OVA)-challenged mouse model,ephedrine treatment reduced inflammatory responses,air-way resistance,and Th1/Th2 cell *** from OVA-treated AECs showed elevated levels of lnc-TRPM2-AS1,which were diminished following ephedrine *** exosomal lnc-TRPM2-AS1 mediated the Th1/Th2 imbalance in CD4^(+)T cells,with its packaging into exosomes being facilitated by *** study unveils a novel mechanism by which ephedrine ameli-orates OVA-induced CD4^(+)T cell imbalance by suppressing AEC-derived exosomal *** findings could provide a theoretical framework for using ephedrine in asthma treatment.

关键词： Asthma Ephedrine Exosomal lnc-TRPM2-AS1 Th1/Th2 imbalance HnRNPA2B1 Airway epithelial cells

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儿童中医健康服务人才培养模式构建与实践

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中国中医药图书情报杂志 2024年第5期48卷 241-243页

作者：冯祥李江山李武刘伟张治国阳玉涓宁炯杰焦珞珈湖南中医药大学湖南长沙410208 长沙市优儿帮儿童健康公益服务中心湖南长沙410208 长沙诺贝尔摇篮教育科技有限责任公司湖南长沙410005 怀化市第二人民医院湖南怀化418200

中医药在儿童健康服务中起着不可替代的重要作用,培养高素质的中医药服务型人才,是发挥中医药独特优势的重要途径之一。本研究以湖南省中医药改革示范区建设为契机,利用湖南中医药大学平台优势,以儿童健康服务为核心,通过“物”“术”... 详细信息

中医药在儿童健康服务中起着不可替代的重要作用,培养高素质的中医药服务型人才,是发挥中医药独特优势的重要途径之一。本研究以湖南省中医药改革示范区建设为契机,利用湖南中医药大学平台优势,以儿童健康服务为核心,通过“物”“术”“法”“道”4个层次构建儿童中医健康服务人才培养模式,为儿童中医健康服务的人才培养提供可借鉴的模板与经验。

关键词：儿童中医健康服务人才培养模式构建

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中医文化融入新时代统战工作的若干思考

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湖南中医药大学学报 2021年第6期41卷 948-951页

作者：焦珞珈湖南中医药大学湖南长沙410208

中医文化历史悠久,源远流长,是中国优秀传统文化的重要组成部分,其蕴含的价值理念和原创思维,不仅体现在医学领域,也体现在新时代统一战线工作中。新时代统一战线工作与中医文化核心价值理念息息相通,新时代统一战线蕴含中医文化核心价... 详细信息

中医文化历史悠久,源远流长,是中国优秀传统文化的重要组成部分,其蕴含的价值理念和原创思维,不仅体现在医学领域,也体现在新时代统一战线工作中。新时代统一战线工作与中医文化核心价值理念息息相通,新时代统一战线蕴含中医文化核心价值理念“人本观”“自然观”“中和观”。应积极探索中医文化融入新时代统战工作的实践路径,将中医整体观融入构建中华民族伟大复兴的伟大实践中,将中医辨证论治方法融入“新型五大关系”中,将中医治未病理念融入做深做细做实新三类人员统战工作中。

关键词：中医文化新时代统一战线人本观自然观中和观

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Extreme single-excitation subradiance from two-band Bloch oscillations in atomic arrays

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Photonics Research 2024年第3期12卷 571-580页

作者： luojia WANG DA-WEI WANG LUQI YUAN YAPING YANG XIANFENG CHEN State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Interdisciplinary Center for Quantum Information and State Key Laboratory of Modern Optical Instrumentation Zhejiang Province Key Laboratory of Quantum Technology and Deviceand School of PhysicsZhejiang UniversityHangzhou 310027China MOE Key Laboratory of Advanced Micro-Structured Materials School of Physics Science and EngineeringTongji UniversityShanghai 200092China Shanghai Research Center for Quantum Sciences Shanghai 201315China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China

Atomic arrays provide an important quantum optical platform with photon-mediated dipole–dipole interactions that can be engineered to realize key applications in quantum information processing.A major obstacle for such applications is the fast decay of the excited *** controlling two-band Bloch oscillations of single excitation in an atomic array under an external magnetic field,here we show that exotic subradiance can be realized and maintained with orders of magnitude longer than the spontaneous decay time in atomic arrays with the finite *** key finding is to show a way for preventing the wavepacket of excited states scattering into the dissipative zone inside the free space light cone,which therefore leads to the excitation staying at a subradiant state for an extremely long decay *** show that such operation can be achieved by introducing a spatially linear potential from the external magnetic field in the atomic arrays and then manipulating interconnected two-band Bloch oscillations along opposite *** results also point out the possibility of controllable switching between superradiant and subradiant states,which leads to potential applications in quantum storage.

关键词： excitation Bloch decay

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新形势下中医药文化宣传教育的实施路径

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湖南中医药大学学报 2023年第8期43卷 1498-1502页

作者：焦珞珈王静湖南中医药大学湖南长沙410208

中医药在疾病预防与治疗、健康养生等方面参与面广、参与度深、认可度高,展现出独特作用,彰显了民族传统文化的时代价值。为发挥中医药文化在中医药事业发展中的先锋作用,依托新形势下中医药文化宣传教育的时代机遇,剖析现阶段中医药宣... 详细信息

中医药在疾病预防与治疗、健康养生等方面参与面广、参与度深、认可度高,展现出独特作用,彰显了民族传统文化的时代价值。为发挥中医药文化在中医药事业发展中的先锋作用,依托新形势下中医药文化宣传教育的时代机遇,剖析现阶段中医药宣传教育过程中存在的宣传内容科学性不够、宣传队伍专业性不强、宣传对象针对性不高、宣传平台多样性不足等问题,探索增强中医药文化教育宣传的创新策略。立足健康中国战略,打破中医药文化宣传教育困境,推动中医药文化宣传国际化发展,创新宣传理念、方式与内容,拓宽宣传平台,促进中医药传承创新发展。

关键词：新形势中医药文化宣传教育传承创新国际传播健康中国

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习近平新时代网络意识形态思想探析——兼论高校网络意识形态工作的指导作用

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现代信息科技 2019年第6期3卷 180-182页

作者：肖小芹刘莉银洁童千千焦珞珈湖南中医药大学

近几年,习近平总书记以马克思主义意识形态思想为指导,结合当前我国意识形态工作和互联网发展的客观现状,通过讲话、报告等方式就网络意识形态工作发表了许多重要的意见,形成了独特的网络意识形态思想,为高校更好地开展网络意识形态工... 详细信息

近几年,习近平总书记以马克思主义意识形态思想为指导,结合当前我国意识形态工作和互联网发展的客观现状,通过讲话、报告等方式就网络意识形态工作发表了许多重要的意见,形成了独特的网络意识形态思想,为高校更好地开展网络意识形态工作提供了理论指导和行动指南。

关键词：习近平新时代网络意识形态

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南极和格陵兰岛GPS连续台站背景噪声时空特性

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地球物理学报 2024年第1期67卷 63-76页

作者：潘元进张小红吴奇文焦佳爽丁浩沈嗣钧武汉大学测绘学院武汉430079 湖北珞珈实验室武汉430079 武汉大学中国南极测绘研究中心武汉430079 大地测量与地球动力学国家重点实验室武汉430077

基于GPS观测数据获取的陆地垂向运动对研究现今两极区域的冰川质量变化具有重要的科学意义.受地表环境负荷对GPS时间序列中背景噪声空间异质性的影响,在利用GPS时间序列获取垂向速度场时,估计结果存在较大不确定度.本文针对南极和格陵... 详细信息

基于GPS观测数据获取的陆地垂向运动对研究现今两极区域的冰川质量变化具有重要的科学意义.受地表环境负荷对GPS时间序列中背景噪声空间异质性的影响,在利用GPS时间序列获取垂向速度场时,估计结果存在较大不确定度.本文针对南极和格陵兰岛区域的GPS连续观测时间序列中背景噪声的空间特性对速度场及其不确定度的影响问题,利用地表环境负荷模型(包括大气、非潮汐海洋和水文负荷)和重力卫星GRACE/GRACE-FO观测数据反演的地表弹性形变对GPS时间序列进行了改正.通过对改正前后的数据进行背景噪声特性分析,揭示出修正环境负荷形变能够有效降低极区GPS时间序列背景噪声幅度,但是大气和非潮汐海洋负荷改正造成了大多数台站背景噪声谱指数的减小,南极和格陵兰岛分别约为其GPS台站总数的46.1%和84.6%,直接导致了对GPS速度不确定度估计的改善效果不明显.对背景噪声空间异质性的研究结果表明,极区台站的背景噪声参数主要表现为随纬度变化的空间特性.

关键词： GPS GRACE/GRACE-FO 环境负荷 GPS背景噪声

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Assessment of the high-resolution estimations of global and diffuse solar radiation using WRF-Solar

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Advances in Climate Change Research 2023年第5期14卷 720-731页

作者： Yun-Bo LU Lun-Che WANG jiao-jiao ZHOU Zi-Geng NIU Ming ZHANG Wen-Min QIN Hubei Key Laboratory of Regional Ecology and Environmental Change School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Hunan Key Laboratory of Remote Sensing of Ecological Environment in Dongting Lake Area School of Geography and Information EngineeringChina University of GeosciencesWuhanChina Hubei luojia Laboratory Wuhan 430079China

Compared with physical models,WRF-Solar,as an excellent numerical forecasting model,includes abundant novel cloud physical and dynamical processes,which enablesenable the high-frequency output of radiation components which are urgently needed by the solar energy ***,the popularisation of WRF-Solar in a wide range of applications,such as the estimation of diffuse radiation,suffers from unpredictable influences of cloud and aerosol optical property *** study assessed the accuracy of the improved numerical weather prediction(WRF-Solar)model in simulating global and diffuse *** optical properties at 550 nm,which were provided by a moderate resolution imaging spectroradiometer,were used as input to analyse the differences in accuracies obtained by the model with/without aerosol *** sensitivity of WRF-Solar to aerosol and cloud optical properties and solar zenith angle(SZA)was *** results show the superiority of WRF-Solar to WRF-Dudhia in terms of their root mean square error(RMSE)and mean absolute error(MAE).The coefficients of determination between WRF-Solar and WRF-Dudhia revealed no statistically significant difference,with values greater than 0.9 for the parent and nested *** addition,the relative RMSE(RRMSE%)reached 46.60%.The experiment on WRF-Solar and WRF-Dudhia revealed a negative bias for global radiation,but WRF-Solar attained a slightly lower RMSE and higher correlation coefficient than *** WRF-Solar-simulated results on diffuse radiation under clear sky conditions were slightly poorer,with RMSE,RRMSE,mean percentage error and MAE of 181.93 W m^(−2),170.52%,93.04%and 138 W m^(−2),*** on Himawari-8 cloud data,statistical results on cloud optical thickness(COT)for cloudy days revealed that WRF-Solar overestimated diffuse radiation at COTs greater than ***,when the aerosol optical depth was greater than or equal to 0.8,WRF-Solar also overestimated the diffuse radiation

关键词： WRF-Solar Solar radiation simulation Cloud optical thickness Aerosol optical depth Dependency analysis

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Observation of flat-band and band transition in the synthetic space

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Advanced Photonics 2022年第3期4卷 114-121页

作者： Guangzhen Li luojia Wang Rui Ye Shijie Liu Yuanlin Zheng Luqi Yuan Xianfeng Chen Shanghai jiao Tong University School of Physics and AstronomyState Key Laboratory of Advanced Optical Communication Systems and NetworksShanghaiChina Shanghai Research Center for Quantum Sciences ShanghaiChina Shandong Normal University Collaborative Innovation Center of Light Manipulation and ApplicationsJinanChina

.Constructions of synthetic lattices in modulated ring resonators attract growing attention to interesting physics beyond the geometric dimensionality,where complicated connectivities between resonant frequency modes are explored in many theoretical *** implement experimental demonstration of generating a stub lattice along the frequency axis of light,in two coupled ring resonators of different lengths,with the longer one dynamically *** a synthetic photonic structure intrinsically exhibits the physics of flat *** show that the time-resolved band structure read-out from the drop-port output of the excited ring is the intensity projection of the band structure onto a specific resonant mode in the synthetic momentum space,where gapped flat band,mode localization effect,and flat-to-nonflat band transition are observed in experiments and verified by *** work provides evidence for constructing a synthetic stub lattice using two different rings,which,hence,makes a solid step toward experimentally constructing complicated lattices in multiple rings associated with synthetic frequency dimensions.

关键词： synthetic dimensions ring resonators dynamic modulation flat band.

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Direct extraction of topological Zak phase with the synthetic dimension

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Light(Science & Applications) 2023年第4期12卷 671-679页

作者： Guangzhen Li luojia Wang Rui Ye Yuanlin Zheng Da-Wei Wang Xiong-Jun Liu Avik Dutt Luqi Yuan Xianfeng Chen State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Research Center for Quantum Sciences Shanghai 201315China Interdisciplinary Center for Quantum Information and Zhejiang Province Key Laboratory of Quantum Technology and Device Department of PhysicsZhejiang UniversityHangzhou 310027China InternationalCenter for Quantum Materials and School of Physics Peking UniversityBeijing 100871China International Quantum Academy Shenzhen 518048China Department of Mechanical Engineering Institute for Physical Science and TechnologyUniversity of MarylandCollege ParkMD 20742USA Collaborative Innovation Center of Light Manipulation and Applications Shandong Normal UniversityJinan 250358China

Measuring topological invariants is an essential task in characterizing topological phases of *** are usually obtained from the number of edge states due to the bulk-edge correspondence or from interference since they are integrals of the geometric phases in the energy *** is commonly believed that the bulk band structures could not be directly used to obtain the topological ***,we implement the experimental extraction of Zak phase from the bulk band structures of a Su-Schrieffer-Heeger(SSH)model in the synthetic frequency *** synthetic SSH lattices are constructed in the frequency axis of light,by controlling the coupling strengths between the symmetric and antisymmetric supermodes of two bichromatically driven *** measure the transmission spectra and obtain the projection of the time-resolved band structure on lattice sites,where a strong contrast between the non-trivial and trivial topological phases is *** topological Zak phase is naturally encoded in the bulk band structures of the synthetic SSH lattices,which can hence be experimentally extracted from the transmission spectra in a fiber-based modulated ring platform using a laser with telecom *** method of extracting topological phases from the bulk band structure can be further extended to characterize topological invariants in higher dimensions,while the exhibited trivial and non-trivial transmission spectra from the topological transition may find future applications in optical communications.

关键词： topological trivial synthetic

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