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Transactions of Tianjin University 2024年第4期30卷 305-313页

作者： jiao Tang xiao Tang Jiaxiang Tang Wei Qi Qianwei Pan Jinhong Zeng Housheng xia Jianping Zhou Zhongyi Sheng Junfeng Niu Zhejiang Tiantai xianghe Industrial Co. Ltd.Taizhou 317200China Zhejiang xianghe Track Fastener Research Institute Taizhou 317200China Shaoxing Institute for Food and Drug Control Shaoxing 312000China Key Laboratory of Chemical and Biological Processing Technology for Farm Products of Zhejiang Province School of Biological and Chemical EngineeringZhejiang University of Science and TechnologyHangzhou 310023China

Herein,a novel method for fl uorometric detection of soybean trypsin inhibitor(SBTI)activity based on a water-soluble poly(diphenylacetylene)derivative was *** quenching of the polymer via p-nitroaniline,produced from the trypsin-catalyzed decomposition of N-benzoyl-DL-arginine-4-nitroanilide hydrochloride(L-BAPA),was well described using the Stern-Volmer *** activity was quantitatively assessed based on changes in the fl uorescence intensity of the *** strategy has several advantages,such as high sensitivity and ease of ***,its applicability to other biochemical analyses is promising.

关键词： Fluorometric detection Soybean trypsin inhibitor Inhibition activity Fluorescence quenching

Cognitive dysfunction in schizophrenia patients caused by downregulation of γ-aminobutyric acid receptor subunits

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World Journal of Psychiatry 2024年第6期14卷 784-793页

作者： Xi Chen Ya-Nan Zhou xiao-Zi Lu Ren-jiao Li Yi-Fan Xiong xia Sheng Wei-Wei Zhu Department of Child and Adolescent Psychiatric Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Psychiatry Qingdao Mental Health CenterQingdao 266034Shandong ProvinceChina Department of Psychiatry Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Sleep Disorders and Neurosis Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina

BACKGROUND The expression pattern of gamma aminobutyric acid(GABA)receptor subunits are commonly altered in patients with schizophrenia,which may lead to nerve excitation/inhibition problems,affecting cognition,emotion,and *** To explore GABA receptor expression and its relationship with schizophrenia and to provide insights into more effective *** This case-control study enrolled 126 patients with schizophrenia treated at our hospital and 126 healthy volunteers who underwent physical examinations at our hospital during the same *** expression levels of the GABA receptor subunits were detected using 1H-magnetic resonance *** recognized cognitive battery tool,the MATRICS Consensus Cognitive Battery,was used to evaluate the scores for various dimensions of cognitive *** correlation between GABA receptor subunit downregulation and schizophrenia was also *** Significant differences in GABA receptor subunit levels were found between the case and control groups(P0.05).CONCLUSION Downregulation of the GABA receptor subunits is positively correlated with *** other words,when GABA receptor subunits are downregulated in patients,cognitive impairment becomes more severe.

关键词： Cognitive function Schizophrenia Downregulation Gamma-aminobutyric acid receptor subunits Correlation

A review on DFACS(II):Modeling and analysis of disturbances and noises

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Chinese Journal of Aeronautics 2024年第5期37卷 120-147页

作者： Chenglei YUE Bohan jiao Zhaohui DANG xiaokui YUE Yonghe ZHANG Yuanqing xia Li DUAN Qinglei HU Qifan LIU Pengcheng WANG Ming GUO Zhansheng DUAN Bing CUI Chu ZHANG xiaodong SHAO School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 710699China School of Automation Beijing Institute of TechnologyBeijing 100081China Institute of Mechanics Chinese Academy of SciencesBeijing 710043China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Automation Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

This paper presents Part II of a review on DFACS,which specifically focuses on the modeling and analysis of disturbances and noises in *** Part I,the system composition and dynamics model of the DFACS were *** this paper,we discuss the effects of disturbance forces and noises on the system,and summarize various analysis and modeling methods for these interferences,including the integral method,frequency domain analysis method,and magnitude evaluation *** analyzing the impact of disturbances and noises on the system,the paper also summarizes the system’s performance under slight ***,we highlight current research difficulties in the field of DFACS noise ***,this paper provides valuable insights into the modeling and analysis of disturbances and noises in DFACSs,and identifies key areas for future research.

关键词： Drag-free DFACS Disturbance Analysis Noise Analysis Frequency Domain Analysis Performance Evaluation

A review on DFACS(I):System design and dynamics modeling

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Chinese Journal of Aeronautics 2024年第5期37卷 92-119页

作者： Bohan jiao Qifan LIU Zhaohui DANG xiaokui YUE Yonghe ZHANG Yuanqing xia Li DUAN Qinglei HU Chenglei YUE Pengcheng WANG Ming GUO Zhansheng DUAN Bing CUI Chu ZHANG xiaodong SHAO School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 710699China School of Automation Beijing Institute of TechnologyBeijing 100081China Institute of Mechanics Chinese Academy of SciencesBeijing 710043China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Automation Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

The Drag-Free and Attitude Control System(DFACS)is a critical platform for various space missions,including high precision satellite navigation,geoscience and gravity field measurement,and space scientific *** paper presents a comprehensive review of over sixty years of research on the design and dynamics model of ***,we examine the open literature on DFACS and its applications in Drag-Free missions,providing readers with necessary background information on the ***,we analyze the system configurations and main characteristics of different DFACSs,paying particular attention to the coupling mechanism between the system configuration and dynamics ***,we summarize the dynamics modeling methods and main dynamics models of DFACS from multiple perspectives,including common fundamentals and specific ***,we identify current challenges and technological difficulties in the system design and dynamics modeling of DFACS,while suggesting potential avenues for future *** paper aims to provide readers with a comprehensive understanding of the state-of-the-art in DFACS research,as well as the future prospects and challenges in this field.

关键词： Drag-Free DFACS System Design Dynamics Modeling Control design

Selective sintering of magnesia-calcia materials by utilizing hot spots during induction sintering process

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Journal of Iron and Steel Research International 2024年第8期31卷 1914-1922页

作者： yun-jie Dong Zhou-fu Wang Hao Liu Yan Ma Xi-tang Wang Nian Yi Zhong-feng xia Yu-xuan Zhu Cheng-ji Deng Ling Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 110325LiaoningChina

Magnesia-calcia refractories are widely used in the production process of clean steel due to their excellent high-tem-perature stability,slag resistance and ability to purify molten ***,there are still problems such as difficult sintering and easy ***-calcia materials with various calcium oxide contents were prepared by using induction sintering,and the sintering property combined with the hydration resistance of the materials was *** experimental results showed that the magnesia-calcia materials prepared under induction field had higher density,microhardness and hydration *** particular,the relative density of induction sintered magnesia-calcia materials with 50 mo1%CaO was greater than 98%,and the average grain size of CaO was 4.56μm,which was much larger than that of traditional sintered *** order to clarify the densification and microstructure evolution mechanism of the magnesia-calcia materials,the changes in temperature and magnetic field throughout the sintering process were analyzed by using finite element *** results showed that the larger heating rate and higher sintering temperature under the induction sintering mode were beneficial to the rapid *** addition,the hot spots generated within the material due to the difference in high-temperature electric conductivity between MgO and CaO were the critical factor to realize selective sintering in MgO-CaO system,which provides a novel pathway to solve the problem of difficult sintering and control the microstructure of high-temperature composite material used in the field of high-purity steel smelting.

关键词： Magnesia-calcia material Induction sintering Hot spot Selective sintering Density Microstructure control Hydration resistance

GM-CSF Promotes the Development of Dysfunctional Vascular Networks in Moyamoya Disease

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Neuroscience Bulletin 2024年第4期40卷 451-465页

作者： Huiqin Li xiang Cao Xinya Gu Mengqi Dong Lili Huang Chenglu Mao Shengnan xia Haiyan Yang Xinyu Bao Yongbo Yang yun Xu Department of Neurology and Neurosurgery Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210008China Department of Neurology and Neurosurgery Nanjing Drum Tower HospitalState Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical DiseasesNanjing UniversityNanjing210008China Department of Neurology and Neurosurgery Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical UniversityNanjing210008China Department of Neurology and Neurosurgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjing210008China Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjing210008China Jiangsu Provincial Key Discipline of Neurology Nanjing210008China Nanjing Neurology Medical Center Nanjing210008China

Moyamoya disease(MMD)is a chronic occlusive cerebrovascular disease with the development of a network of abnormal *** inflammation is associated with the occurrence and development of ***,the mechanisms underlying the formation of the abnormal vascular network remain ***-eight patients with MMD,26 ischemic stroke patients,and 26 unrelated healthy volunteers were enrolled in this study The data showed that the levels of granulocyte-macrophage colony-stimulating factor(GM-CSF)were higher in MMD patients than in healthy controls(P<0.01),and GM-CSF was mainly from Th1 and Th17 cells in *** found that increased GM-CSF drove monocytes to secrete a series of cytokines associated with angiogenesis,inflammation,and *** summary,our findings demonstrate for the first time the important involvement of GM-CSF in MMD and that GM-CSF is an important factor in the formation of abnormal vascular networks in MMD.

关键词： Moyamoya disease Vascular endothelial cells GM-CSF VEGF

Multi-time Collaborative Restoration for Integrated Electrical-gas Distribution Systems Based on Rolling Optimization

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 660-671页

作者： Jingyang yun Zheng Yan yun Zhou Peichao Zhang Weidong Hu Key Laboratory of Control of Power Transmission and Conversion of Ministry of Education Department of Electrical EngineeringShanghai Jiao Tong University

This paper proposes a multi-time collaborative restoration model for integrated electricity-gas distribution sys-tems(IEGDSs)considering multiple resources after extreme weather *** on the linearized power flow constraints of the unbalanced electrical distribution system(EDS)and gas distribution system(GDS),this problem can be formulated as a mixed-integer linear programming(MILP)*** improve the efficiency and veracity of the solution,a rolling optimiza-tion based two-stage method is developed with the first stage solved by a linear approximation model,and the second stage solved by real-time updated rolling *** solving the MILP problem using rolling optimization,the proposed model and solution method achieve efficient and reliable collaborative restoration of IEGDS considering multiple resources and unbal-anced operation characteristics of *** effectiveness of the proposed model and method is validated by using an IEGDS made of a 37-bus unbalanced EDS and 11-node *** Terms-Electricity-gas system,mix-integer linear programming,power system restoration.

关键词： Electricity-gas system mix-integer linear programming power system restoration

Ziwan-Taoren herb pair can exert an therapeutical effect in primary Sjogren’s syndrome through inhibiting the TLR/NF-κB pathway

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Traditional Medicine Research 2024年第8期9卷 11-22页

作者： Kuok-Tong Lei yun-xia Wu yun Lu Zi-Shan Wang Thi-Huong Nguyen Qiu-Ying Cai Wen Zhu Yue Wang First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210000China Faculty of Traditional Medicine Phenikaa UniversityHa Noi 100803Vietnam Department of Rheumatology and Immunology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000China

Background:Ziwan and Taoren(ZT)is a classic medicine pair in the formula of Mai Dong Di Shao Decoction,has been used to treat primary Sjogren’s syndrome(pSS)for more than 20 *** its action mechanism is still *** study is aimed to reveal the potential mechanism of ZT treated pSS and discover its active compounds of ZT and therapeutic target for ***:Firstly,the potential pathways of ZT for pSS treatment were predicted through network pharmacology and GO and KEGG enrichment ***,the inter-structural relationships between active compounds of ZT and target proteins were visualized using molecular docking ***,efficacy and mechanism were conducted through in vivo experiments,such as water intake,spleen index,hematoxylin-eosin staining pathological changes,ELISA,Western Blot analysis,and immunofluorescence ***:Nine active compounds were extracted from network pharmacology,including quercitrin,luteolin,kaempferol,β-sitosterol,isorhamnetin,galangin,hederagenin,diosmetin and gibberellin *** disease targets were identified:RELA,TP53,AKT1,interleukin(IL)6,MAPK1,ESR1,IL10;with RELA being the most core *** and GO enrichment analysis indicated that ZT may act through the TLR/NF-κB/RELA inflammatory mechanism *** results of molecular docking showed that ZT’s active compounds bind well to the RELA(p65)*** vivo results demonstrated that a high dose of ZT significantly improved water intake and reduced lymphocytes infiltration in submandibular gland pathology in NOD *** expression content of AQP5 and vasoactive intestinal peptide in the submaxillary gland was significantly increased,while levels of inflammatory factors such as tumor necrosis factor-α,IL-6,and IL-1βalong with protein expressions including toll-like receptor4,p-p65 and p-IKKα/βin NF-κB pathway were ***:The ZT treatment exhibits a promising efficacy in mitigating dryness symptoms of pSS,potentially attr

关键词： traditional Chinese medicine primary Sjogren’s syndrome NF-κB RELA

Regulated reaction pathway of CO_(2)photoreduction into CH_(4)by metal atom pair sites

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Rare Metals 2024年第9期43卷 4620-4627页

作者： Dong-Po He Guang-Bing Huang Jun Hu Yang Wu xiao-Dong Li Qing-xia Chen Shan Zhu Wen-Sheng Yan Jun-Fa Zhu Yang Pan Xing-Chen jiao Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China Hefei National Research Center for Physical Sciences at Microscale National Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei 230026China Max Planck Institute of Microstructure Physics Weinberg 206120 HalleGermany State Grid Anhui Electric Power Research Institute Hefei 230601China

The carbon dioxide(CO_(2))reduction process involves complex protonation,making the resulting product often *** achieve the desired product,it is crucial to manipulate the reaction ***,we build the metal atom pair sites for selective CO_(2)photoreduction into *** a prototype,Ni atom pair sites loaded on the Mo S_(2)nanosheets were synthesized and verified by highresolution transmission electron microscopy(HRTEM),X-ray photoelectron spectroscopy(XPS)and X-rayabsorption near edge structure spectra(XANES).In-situ Fourier transform infrared spectroscopy(FTIR)monitors the*CHO group,a crucial intermediate in CH_(4)production,during CO_(2)photoreduction on the Ni-Mo S_(2)nanosheets,whereas this monitoring is not observed for the Mo S_(2)***,theoretical calculations disclose that over the Ni-Mo S_(2)nanosheet slab,the formation energy of*CHO intermediates is determined to be lower(0.585 e V)than the desorption energy of*CO intermediates for CO production(0.64 e V),implying the higher selectivity of CH_(4)production.

关键词： steps dioxide desired

A novel semi-dominant allele of the transmembrane NAC transcription factor ZmNTL2 reduces the size of multiple maize organs

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The Crop Journal 2024年第3期12卷 676-687页

作者： Chuan Li yun Bai Yuwei Hou Siyu Wang Yue Xin Tao Yu Jing Wang xiaowei Liu Hongyang Yi Chao xia Hai Lan Moju Cao State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Maize Research InstituteSichuan Agricultural UniversityChengdu 611130SichuanChina Jilin Engineering Research Center for Crop Biotechnology Breeding College of Plant ScienceJilin UniversityChangchun 130012JilinChina

Maize plant architecture influences planting density and,in turn,grain *** of the plant architecture-related traits can be described as organ *** describe a miniature maize mutant,Tiny plant 4(Tip4),which exhibits reduced size of multiple organs and exhibits a semi-dominant monofactorial inheritance *** cloning confirmed that a 4-bp deletion in the NAC TF with transmembrane motif 1-Like(NTL)gene ZmNTL2,denoted as ZmNTL2^(Δ),confers the Tip4 ***-PCR showed that ZmNTL2 was expressed in all tested ***2 functions as a transcriptional activator and is located in both the nucleus and *** mutation does not affect the mRNA abundance of ZmNTL2 locus,but it does result in the loss of transmembrane domain and confines the ZmNTL2^(Δ)protein to the *** out ZmNTL2 has no effect on maize organ size development,indicating that the 4-bp deletion might be a gain-of-function mutation in organ size *** transcriptome sequencing with cytokinin and auxin content determination suggests that the decreased organ size may be possibly mediated by changes in hormone homeostasis.

关键词： Organ size c-ray mutagenesis Membrane-bound NAC TF Hormone homeostasis Maize