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悬吊运动训练对痉挛型脑瘫患儿运动和躯干功能的影响作用观察

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首都食品与医药 2022年第22期29卷 45-47页

作者：罗柯军张俊杨晓晓毛娇林勇遵义医科大学第三附属医院(遵义市第一人民医院) 贵州遵义563000

目的分析悬吊运动训练对痉挛型脑瘫患儿运动和躯干功能的影响作用.方法选取2021年3月-2021年8月遵义市第一人民医院收治的80例痉挛型脑瘫患儿进行研究,均给予常规康复训练,观察组在此基础上进行悬吊运动训练,采用粗大运动功能测试量表... 详细信息

目的分析悬吊运动训练对痉挛型脑瘫患儿运动和躯干功能的影响作用.方法选取2021年3月-2021年8月遵义市第一人民医院收治的80例痉挛型脑瘫患儿进行研究,均给予常规康复训练,观察组在此基础上进行悬吊运动训练,采用粗大运动功能测试量表-88(GMFM-88)、躯干功能量表(TIS)和Berg平衡量表对康复训练效果进行评价.结果训练后两组患儿GMFM-88评分较训练前提高,且观察组D区评分和E区评分高于对照组,差异有统计学意义(P<0.05).训练后两组患儿Berg评分和TIS评分均较训练前提高,且观察组Berg评分和TIS评分高于对照组,差异有统计学意义(P<0.05).结论悬吊运动训练对痉挛型脑瘫患儿运动和躯干功能均有较好改善作用,可纳入常规康复项目.

关键词：痉挛型脑瘫悬吊运动训练躯干功能运动功能平衡功能

Effects of Variant Rates and Noise on Epidemic Spreading

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Chinese Physics Letters 2011年第5期28卷 282-284页

作者： LI Wei GAO Zong-mao GU jiao Complexity Science Center and Institute of Particle Physics Huazhong Normal UniversityWuhan 430079 Max-Planck-Institute for Mathematics in the Sciences

We introduce variant rates,for both infection and recovery and noise into the susceptible-infected-removed(SIR)modelfor epidemic *** changing rates are taken mainly due to the changing profiles of an epidemic during its ***,the noise parameter which is taken from a given distribution,*** can describe the fluctuations of the infection and recovery *** numerical simulations show that the SIR model with variant rates and noise and can improve the fitting with real SARS data in the near-stationary stage.

关键词： evolution infection epidemic

Epidemic Spreading in a Multi-compartment System

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Chinese Physics Letters 2012年第2期29卷 233-236页

作者： GAO Zong-mao GU jiao LI Wei College of Physical Science and Technology Huazhong Normal UniversityWuhan 430079 Max-Planck-Institute for Mathematics in the Sciences Leipzig 04103Germany Complexity Science Center&Institute of Particle Physics Huazhong Normal UniversityWuhan 430079

We introduce the variant rate and white noise into the susceptible-infected-removed (SIR) model for epidemics,discuss the epidemic dynamics of a multiple-compartment system,and describe this system by using master *** both the local epidemic spreading system and the whole multiple-compartment system,we find that a threshold could be useful in forecasting when the epidemic ***,numerical simulations show that a model with the variant infection rate and white noise can improve fitting with real SARS data.

关键词： equations system removed

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犊鼻穴治疗膝关节骨性关节炎的文献研究

江西中医药大学学报 2016年第3期28卷 118-121页

作者：冒姣娜黄超陈树涛潘毅付勇江西中医药大学研究生院南昌330006 江西中医药大学附属医院南昌330006

目的:探讨犊鼻穴对治疗膝关节骨性关节炎的临床价值,为指导针灸临床提供资料参考和方法启示。方法:通过查阅古今文献,对针灸犊鼻穴治疗膝关节骨性关节炎的内容进行整理与分析。结果:犊鼻穴为治疗膝关节骨性关节炎常用穴和有效穴。结论:... 详细信息

目的:探讨犊鼻穴对治疗膝关节骨性关节炎的临床价值,为指导针灸临床提供资料参考和方法启示。方法:通过查阅古今文献,对针灸犊鼻穴治疗膝关节骨性关节炎的内容进行整理与分析。结果:犊鼻穴为治疗膝关节骨性关节炎常用穴和有效穴。结论:针灸犊鼻穴治疗膝关节骨性关节炎方法多样且疗效显著,值得临床借鉴与应用。

关键词：犊鼻穴膝关节骨性关节炎文献研究

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

Theoretical screening of cooperative N-bridged dual-atom sites for efficient electrocatalytic nitrogen reduction with remolding insight

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Nano Research 2024年第4期17卷 3413-3422页

作者： Huimei Chen Yan Yang Chi jiao Zhiwen Zhuo Junjie mao Yan Liu Key Laboratory of Functional Molecular Solids Ministry of EducationCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China

The electrocatalytic nitrogen reduction reaction(e-NRR)is a promising alternative method for the Haber–Bosch ***,it still faces many challenges in searching for high activity,stability,and selectivity catalysts and ascertaining the catalytic mechanism with complete ***,a series of graphene-based N-bridged dual-atom catalysts(M1-N-M2/NC)are systematically investigated via first-principle calculation and a high-throughput screening *** result unveils that N_(2) adsorption on M1-N-M2/NC in bridge-on adsorption mode can effectively break the scaling relationship on single-atom catalysts(SACs).Moreover,V-N-Ru/NC and V-N-Os/NC are systematically screened out as promising e-NRR catalysts,with extremely low limiting potentials of-0.20 and-0.18 V,***,the adsorption site competition between*N_(2) and*H,as well as the competitive twin reactions of hydrogen evolution reaction(HER)on intermediates(N_(n)H_(m))during the e-NRR process,is systematically evaluated to form a remodeling insight for the reactions in mechanism,and the e-NRR of new proposed dual-atom catalysts(DACs)is strategically optimized for its high-efficiency performance potential via our remolding insight in e-NRR *** work provides new ideas and insights for the design and mechanism of e-NRR catalysts and an effective strategy for rapidly screening highly efficient e-NRR catalysts.

关键词： nitrogen reduction dual-atom catalysts high-throughput screening hydrogen evolution reaction density functional theory calculations

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遗传积分型本构方程的两种推演方法及比较

地下空间与工程学报 2008年第1期4卷 42-44页

作者：焦春茂赵春风张征石振明同济大学岩土及地下工程教育部重点实验室浙江省交通厅工程质量监督局杭州310004

积分算子解法是求解粘弹性问题的一种重要的解析方法,推演材料的积分型本构方程是此种求解方法的重要步骤。文章分别采用由微分型本构方程直接求解的方法与依据蠕变核与松弛核的关系求解的方法推演了H-K体的以ε(t)表示σ(t)的遗传积分... 详细信息

积分算子解法是求解粘弹性问题的一种重要的解析方法,推演材料的积分型本构方程是此种求解方法的重要步骤。文章分别采用由微分型本构方程直接求解的方法与依据蠕变核与松弛核的关系求解的方法推演了H-K体的以ε(t)表示σ(t)的遗传积分方程,结果表明第一种方法适用于具有给定微分型本构关系的模型,第二种方法适用于由蠕变试验得到蠕变方程的情形,并且具有普遍适用性。

关键词：遗传积分方程粘弹性积分算子解法

Direct electrocatalytic reduction of p-nitrophenol at room temperature ionic liquid modified electrode

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Chinese Chemical Letters 2008年第10期19卷 1156-1158页

作者： Wei Sun mao Xia Yang Qiang Jiang Kui jiao College of Chemistry and Molecular Engineering Key Laboratory of Eco-Chemical Engineering of Ministry of Education Qingdao University of Science and Technology Qingdao 266042 PR China

Direct electrochemical reduction ofp-nitrophenol （PNP） was investigated on a room temperature ionic liquid N-butylpyridinium hexafluorophosphate （BPPF6） modified carbon paste electrode （CILE）. The cathodic peak potential was positively shifted and the peak currents were increased compared to that obtained on traditional carbon paste electrode （CPE）. The results indicated that the presence of ionic liquid BPPF6 on the electrode surface showed excellent catalytic ability to the electrochemical reduction of PNP. The electrochemical behaviors of PNP on the CILE were investigated by cyclic voltammetry and the conditions such as the scan rate, the buffer pH, the substrate concentration were optimized. The electrochemical parameters were further calculated with the results of the electron transfer number （n）, the charge-transfer coefficient （α） and the surface concentration （Гr） as 1.76, 0.37 and 2.47 × 10^-9 mol/cm^2, respectively, for the selected reductive peak. The results indicated that PNP showed an irreversible adsorption-controlled electrode process on the CILE.

关键词： N-Butylpyridinium hexafluorophosphate Ionic liquid p-Nitrophenol Cyclic voltammetry Electrocatalysis

热敏灸对膝骨性关节炎兔模型IL-1β、TNF-α、MMP-13的影响

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中华中医药杂志 2018年第9期33卷 3913-3917页

作者：章海凤陈树涛冒姣娜潘毅黄超熊俊颜纯钏夏雷翔付勇江西中医药大学附属医院南昌330006 江西中医药大学研究生院南昌330000

目的:观察热敏灸对膝骨性关节炎(KOA)兔模型白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-13(MMP-13)的影响,探讨热敏灸治疗KOA的作用机制。方法:42只雄性日本大耳兔按随机数字表随机分为空白组、模型组、假手术组... 详细信息

目的:观察热敏灸对膝骨性关节炎(KOA)兔模型白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-13(MMP-13)的影响,探讨热敏灸治疗KOA的作用机制。方法:42只雄性日本大耳兔按随机数字表随机分为空白组、模型组、假手术组(每组6只)以及艾灸组(24只)。空白组正常饲养,模型组与艾灸组采用木瓜蛋白酶注射膝关节建立KOA模型,假手术组采用腔内注射0.9%氯化钠溶液造模,每日强迫活动30min,造模15d。造模结束后,艾灸组艾灸犊鼻穴,40min/次,1次/d,共14d,根据兔艾灸过程中温度变化分为热敏灸组和非热敏灸组,两组各随机抽取6只;空白组、模型组、假手术组正常饲养,不予任何干预刺激。治疗结束后,采用放射免疫法检测关节液IL-1β、TNF-α含量,Real-time PCR检测法检测软骨MMP-13含量。结果:与空白组相比,模型组、热敏灸组、非热敏灸组、假手术组IL-1β、TNF-α、MMP-13表达均升高(P<0.05,P<0.01);与模型组相比,热敏灸组、非热敏灸组、假手术组其表达显著降低(P<0.05,P<0.01);与非热敏灸组相比,热敏灸组表达明显偏低(P<0.05,P<0.01)。结论:热敏灸能抑制IL-1β、TNF-α、MMP-13表达,减少炎症反应,缓解关节损害,这可能是热敏灸治疗KOA的效应机制之一。

关键词：热敏灸膝骨性关节炎白细胞介素-1β 肿瘤坏死因子-α 基质金属蛋白酶-13