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Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs

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Food Science and Human Wellness 2022年第1期11卷 143-154页

作者： Yuanyuan Zhao Jinfeng Bi jianyong yi Jian Peng Qiancheng Ma Institute of Food Science and Technology Chinese Academy of Agricultural Sciences(CAAS)Key Laboratory of Agro-Products ProcessingMinistry of Agriculture and Rural AffairsBeijing 100193China Sericultural and Agri-FoodResearch Institute Guangdong Academy of Agricultural SciencesGuangdong Key Laboratory of Agricultural Products ProcessingGuangzhou 510610China School of Food Science and Technology Dalian Polytechnic UniversityDalian 116034China

Recently,pectin has been used as an alternative for commercial prebiotic products to modulate gut *** this study,the standard diet(Chow group)and high fat diet containing 0%(HF group),1%,3%,5%,8% or 12%(m/m)apple pectin(HF-P group)were offered ad libitum for 8 weeks to 4-week C57BL/6J mice(n=10/group).Results showed that body weight gain(R^(2)=–0.990),subcutaneous adipose accumulation(R^(2)=–0.930),serum triglyceride elevation(R_(2)=–0.879),acetate(R^(2)=0.955)and propionate concentration reduction(R2=0.985)were suppressed by pectin from 1% to 12%,indicating dose response to pectin ***,abundance of obesity-related bacteria Coriobacteriaceae,and pectin-degradating bacteria,Faecalibaculum,Ruminococcus were significantly increased with pectin dosage increased,and the R^(2) were 0.936,0.963 and 0.937,***,attenuations for colonic injury and liver steatosis were observed after adding 5% and 8% pectin,*** study confirmed the dose-sensitive manner of pectin to alleviate HF-induced obesity by modulating gut microbiota and enhancing short-chain fatty acids production.

关键词： Pectin Dosage Obesity Gut microbiota Short-chain fatty acid

Stability of phenolic compounds and drying characteristics of apple peel as affected by three drying treatments

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Food Science and Human Wellness 2021年第2期10卷 174-182页

作者： Qiancheng Ma Jinfeng Bi jianyong yi Xinye Wu Xuan Li Yuanyuan Zhao Key Laboratory of Agro-products Processing Ministry of Agriculture and Rural AffairsInstitute of Food Science and TechnologyChinese Academy of Agricultural SciencesBeijing 100193China School of Food Science and Technology Dalian Polytechnic UniversityDalian 116034China

To realize high-value utilization of discarded apple peel,this study investigated the effects of three selected commercial drying methods on drying kinetics,microstructure,color,phenolic stability and antioxidant capacity of apple *** peel was dehydrated by hot air drying(AD)at 75,65 and 55℃,heat pump drying(HP)at 65,55 and 45℃,and vacuum freeze-drying(FD),*** results showed that HP was superior to AD and FD in terms of drying *** addition,HP at 65℃provided high-quality dried apple peel due to less browning and brighter appearance,the highest retention of total phenolics(29.35 mg/g)and the strongest antioxidant activities,with the highest ABTS and FRAP value of 127.15 and 219.57μmol TE/g,*** content of the six major individual phenolics,*** acid,(-)-epicatechin,hyperoside,rutin,phlorizin and quercitrin,were found to be the highest in HP dried ***,the content of rutin was even increased after HP compared to the fresh *** drying efficiency,organoleptic quality and phenolic stability of the products,HP at 65°C is suggested for drying of apple peel.

关键词： Apple peel Heat pump drying Phenolic compounds Antioxidant capacity Color

Advanced nanofabrication for elastic inorganic aerogels

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Nano Research 2024年第10期17卷 8842-8862页

作者： Xiaota Cheng Xinyi Chang Fan Wu Yalong Liao Kai Pan Hao Fong jianyong Yu yi-Tao Liu Bin Ding Innovation Center for Textile Science and Technology College of TextilesDonghua UniversityShanghai 201620China Aerospace Institute of Advanced Material and Processing Technology Beijing 100074China College of Materials Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China

Inorganic aerogels with low density,high porosity,large specific surface area,and superior mechanical properties are excellent candidate materials in fields such as thermal management,energy,catalysis,and biomedical applications.A comprehensive overview of existing elastic inorganic aerogels is provided,covering their structural units,preparation methods,mechanical performances,and ***,based on the constituent building blocks and microstructures,a detailed analysis of the mechanical properties and guidelines for elastic design of aerogels is *** with a succinct summary of prospective developmental direction,this review deliberates on the challenges and potential opportunities of elastic inorganic aerogels,with the intent of providing a versatile platform for designing new types of elastic inorganic aerogels for various applications.

关键词： inorganic aerogels compressive stretchable fabrication mechanical performances applications

A Novel Multi-classifier Integrated Model for Chinese Noun Sense Disambiguation

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通讯和计算机（中英文版） 2006年第5期3卷 8-13页

作者： jianyong Duan yi Hu Weilin Wu Hui Liu Ruzhan Lu Department of Computer Science and Engineering Shanghai Jiaotong University Shanghai 200030 China

We propose a Multi-classifier Compatible Computational Model (MCCM) for Chinese noun sense disambiguation in this paper. In natural language processing, many problems can be viewed as classification in nature. However, different classifiers cannot be efficiently integrated by a general standard. Quantification rule is introduced for flexible integration of statistical and rule-based classifiers. Rules are traced into the corpus for acquiring their quantification information. The other contribution is Projected Performance Evaluation Matrix (P-PEM). Classification performance is improved because it contains more accurate classification information for every classifier. Many faint classifiers boost a powerful MCCM model. Finally the experiment shows its advantages.

关键词：语言程序中国自然语言处理计算机语言

Bortezomib depended on PRDM1 and TP53 to exert therapeutic effect in activated B-cell-like diffuse large B-cell lymphoma

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Genes & Diseases 2024年第2期11卷 550-553页

作者： Jing Tang Yue Li Jiazhu Wu Haorui Shen Hua yin Jinhua Liang Li Wang jianyong Li yi Xia Wei Xu Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China

PR/SET domain 1(PRDM1)gene is located on chromosome 6q21,encoding the B lymphocyte-induced maturation protein 1(BLIMP1).1 It is reported that loss of PRDM1 function is exacerbated in activated B-cell-like(ABC)-diffuse large B cell lymphoma(DLBCL)and associated with inferior ***,it remains unclear what leads to PRDM1 inactivation and the drug resistance mechanism caused by abnormal inactivation of *** investigated the contribution of PRDM1 gene as a prognosis and potential therapeutic target for ABC-DLBCL patients and further clarified the possible mechanism of PRDM1 abnormal *** first proposed that TP53 could regulate PRDM1 by histone ubiquitination modification at the post-transcriptional level.

关键词： PRDM1 TP53 therapeutic

Genotyping on circulating tumor DNA improves mutation detection rate in high-risk diffuse large B-cell lymphoma

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Genes & Diseases 2024年第4期11卷 116-119页

作者： yi Xia Li Wang Jinhua Liang Haorui Shen Jiazhu Wu Hua yin Yue Li Huayuan Zhu jianyong Li Wei Xu Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China

Diffuse large B-cell lymphoma(DLBCL)is the most common lymphoma with heterogeneous clinical *** who are primarily refractory to the frontline therapy or relapse less than 12 months after diagnosis have an extremely di... 详细信息

关键词： lymphoma diagnosis clinical

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果蔬食品中类胡萝卜素生物利用度研究进展

中国食品学报 2019年第9期19卷 286-297页

作者：易建勇侯春辉毕金峰刘璇中国农业科学院农产品加工研究所农业农村部农产品加工重点实验室北京100193 天津科技大学食品工程与生物技术学院天津300457

类胡萝卜素是一类重要的微量营养物质,其有益生理功效与果蔬食品中类胡萝卜素的绝对含量相关,更取决于其生物利用度。然而,由于类胡萝卜素的特殊存在形式和疏水特性,其从食物中释放并被吸收利用的比例通常非常低。本文综述了影响果蔬食... 详细信息

类胡萝卜素是一类重要的微量营养物质,其有益生理功效与果蔬食品中类胡萝卜素的绝对含量相关,更取决于其生物利用度。然而,由于类胡萝卜素的特殊存在形式和疏水特性,其从食物中释放并被吸收利用的比例通常非常低。本文综述了影响果蔬食品中类胡萝卜素生物利用度的关键因素,包括类胡萝卜素的种类和存在形式、食品(微观)结构和添加油脂对生物利用度的影响,展望果蔬食品中类胡萝卜素生物利用度的研究进展,可为生产具有较高类胡萝卜素生物利用度的果蔬食品及设计相应加工工艺提供理论依据。

关键词：类胡萝卜素生物利用度生物有效性微观结构脂类

Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer(NECTAR):a multi-center phase 2 study

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1721-1729页

作者： Zhengyang Yang Jiale Gao jianyong Zheng Jiagang Han Ang Li Gang Liu yi Sun Jie Zhang Guangyong Chen Rui Xu Xiao Zhang yishan Liu Zhigang Bai Wei Deng Wei He Hongwei Yao Zhongtao Zhang Department of General Surgery Beijing Friendship HospitalCapital Medical UniversityState Key Lab of Digestive HealthNational Clinical Research Center for Digestive DiseasesBeijingChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Air Force Medical UniversityXi'anChina Department of General Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of General Surgery Beijing Xuanwu HospitalCapital Medical UniversityBeijingChina Department of General Surgery Tianjin Medical University General HospitalTianjinChina Department of Anorectal Tianjin People's HospitalTianjinChina Department of Radiology Beijing Friendship Hospital Capital Medical UniversityBeijingChina Department of Pathology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Thoracic Surgery/Institute of Thoracic Oncology West China HospitalSichuan UniversityChengduChina

Adding PD-1 blockade in the neoadjuvant regimens for locally advanced rectal cancer(LARC)patients with microsatellite stable(MsS)/mismatch repair-proficient(pMMR)tumors is an attractive,but debatable *** phase 2,multicenter,prospective,single-arm study enrolled patients from 6 centers from June 2021 to November *** advanced rectal cancer(LARC,cT_(3-4a)N_(0)M_(0) and cT_(1-4a)N_(1-2)M_(0))patients aged≥18 years with the distance from distal border of tumor to anal verge≤10 cm(identified by Magnetic Resonance Imaging)were qualifed for *** patients received long-course radiotherapy(50 Gy/25 fractions,2 Gy/fraction,5 days/week)and three 21-day cycles capecitabine(850-1000 mg/m2,bid,po,day1-14)and three 21-day cycles tislelizumab(200 mg,***,day8)as *** mesorectal excision(TME)was 6-12 weeks after the end of radiotherapy to achieve radical resection.A total of 50 patients were enrolled in this *** pathological complete response rate was 40.0%[20/50,95%confidence interval(CI):27.61-53.82%],while 15(30.0%,95%CI:19.1-43.75%),9(18.0%,95%CI:9.77-30.8%),2(4.0%,95%CI:1.10-13.46%)patients respectively achieved grade 1,2,and 3 tumor ***-related adverse events(TRAEs)occurred in 28(56.0%)LARC patients,including 26(52.0%)with grade I-II and 2(4.0%)with grade II(1 with grade 3 immune-related colitis and 1 with grade 3 rash).PD-1 blockade plus long-course chemoradiotherapy(CRT)showed promising therapeutic effects according to pathological complete response rate and is well-tolerated in LARC patients.A larger randomized controlled study is desired to further validate the above findings.

关键词： rectal cancer phase

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苹果多酚的组成和功能特性研究现状与展望

中国食品学报 2020年第11期20卷 328-340页

作者：李旋毕金峰刘璇吴昕烨易建勇中国农业科学院农产品加工研究所农业部农产品加工综合性重点实验室北京100193

苹果多酚是广泛存在于苹果中的次级代谢产物,主要包括5类组分,即:酚酸、黄烷三醇、黄酮醇类、二氢查尔酮类及花青素类。苹果多酚组成和含量与苹果品类种属密切相关,取决于与其相关的基因表达及催化相关组分合成、转化的一系列酶的表达... 详细信息

苹果多酚是广泛存在于苹果中的次级代谢产物,主要包括5类组分,即:酚酸、黄烷三醇、黄酮醇类、二氢查尔酮类及花青素类。苹果多酚组成和含量与苹果品类种属密切相关,取决于与其相关的基因表达及催化相关组分合成、转化的一系列酶的表达水平和活性。苹果多酚的积累受到栽培方式、环境条件、果实成熟度和贮藏条件影响存在较大变异。苹果多酚组成的不同影响并决定其活性水平。苹果多酚的酚羟基、还原酮结构、原花青素的缩合结构赋予其强的抗氧化力,是苹果多酚功能性及应用的物质和结构基础。苹果多酚对食品加工中色泽、风味、质地的形成以及在食品保藏方面的应用已有较为深入的研究。苹果多酚的生理活性涉及的降血糖、降血脂,修复组织器官损伤,预防和抑制癌细胞增殖、迁移及凋亡,提高机体免疫和体能,促进毛发生长和皮肤活性方面的研究也已深入至机理层面。本文综述近年来苹果多酚的组成、生物合成、资源分布,食品加工功能性及生理生化功能性,为苹果多酚资源的挖掘和功能应用提供思路和借鉴。

关键词：苹果多酚生物合成加工特性生理活性功能