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Frontiers in Energy 2024年第1期18卷 80-88页

作者： Ting DENG Shuaiqiang JIA Shitao HAN jianxin zhai Jiapeng JIAO Xiao CHEN Cheng XUE Xueqing XING Wei XIA Haihong WU Mingyuan HE Buxing HAN School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200062China Institute of Eco-Chongming Shanghai 202162China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China

Electrocatalytic CO_(2)reduction(ECR)offers an attractive approach to realizing carbon neutrality and producing valuable chemicals and fuels using CO_(2)as the ***,the lack of cost-effective electrocatalysts with better performances has seriously hindered its ***,a one-step co-electrodeposition method was used to introduce Zn,a metal with weak^(*)CO binding energy,into Cu to form Cu/Zn intermetallic catalysts(Cu/Zn IMCs).It was shown that,using an H-cell,the high Faradaic efficiency of C_(2+)hydrocarbons/alcohols()could be achieved in ECR by adjusting the surface metal components and the applied *** suitable conditions,FEC_(2+)and current density could be as high as 75%and 40 mA/cm^(2),*** with the Cu catalyst,the Cu/Zn IMCs have a lower interfacial charge transfer resistance and a larger electrochemically active surface area(ECSA),which accelerate the ***,the^(*)CO formed on Zn sites can move to Cu sites due to its weak binding with*CO,and thus enhance the C–C coupling on the Cu surface to form C_(2+)products.

关键词： carbon dioxide electroreduction electrochemistry co-electrodeposition intermetallic catalysts value-added chemicals

Conversion of polyethylene to gasoline:Influence of porosity and acidity of zeolites

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Frontiers in Energy 2023年第6期17卷 763-774页

作者： Chunyu LI Haihong WU Ziyu CEN Wanying HAN Xinrui ZHENG jianxin zhai Jiao XU Longfei LIN Mingyuan HE Buxing HAN Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Beijing National Laboratory for Molecular Sciences CAS Laboratory of Colloid and Interface and ThermodynamicsCAS Research/Education Center for Excellence in Molecular SciencesCenter for Carbon Neutral ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China Institute of Eco-Chongming Shanghai 202162China

Plastic waste is causing serious environmental problems. Developing efficient, cheap and stable catalytic routes to convert plastic waste into valuable products is of great importance for sustainable development, but remains to be a challenging task. Zeolites are cheap and stable, but they are usually not efficient for plastic conversion at a low temperature. Herein a series of microporous and mesoporous zeolites were used to study the influence of porosity and acidity of zeolite on catalytic activity for plastics conversion. It was observed that H-Beta zeolite was an efficient catalyst for cracking high-density polyethylene to gasoline at 240℃, and the products were almost C_(4)–C_(12) alkanes. The effect of porosity and acidity on catalytic performance of zeolites was evaluated, which clearly visualized the good performance of H-Beta due to high surface area, large channel system, large amount accessible acidic sites. This study provides very useful information for designing zeolites for efficient conversion of plastics.

关键词： plastics conversion polyethylene zeolites acidity porosity

Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis

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Food Science and Human Wellness 2024年第4期13卷 1845-1855页

作者： Jiang Cao Leilei Yu jianxin Zhao Hao Zhang Wei Chen Yuzheng Xue Qixiao zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch Wuxi 214122China Department of Gastroenterology Affiliated Hospital of Jiangnan UniversityWuxi 214122China

The high intraspecies heterogeneity of Baciillus coagulans leads to significant phenotypic differences among different ***,6 *** strains were tested in the present study using an irritable bowel syndrome(IBS)animal model to determine whether the IBS-alleviating effects of *** strains are *** results of this study showed that the ingestion of *** GBI-30,6086,and *** CCFM1041 significantly alleviated IBS symptoms in *** contrast,other *** strains showed no or limited alleviating effects on IBS *** to our experimental results,the two main common features of these strains were as follows:1)The resistance of vegetative cells to bile salts,and 2)ability to synthesize specific lipids and secondary *** strains based on these two indicators may greatly reduce costs and provide a basis for mining new functional *** *** results also suggest that administration of *** could significantly regulate microbiota dysbiosis in animal ***,the close relationships between the gut microbiota,gut microbiota metabolites,and IBS were further confirmed in this study.

关键词： Baciillus coagulans Irritable bowel syndrome Resistance to bile salts Comparative genomic analysis Gut microbiota

A direct real-time polymerase chain reaction assay for rapid high-throughput detection of highly pathogenic North American porcine reproductive and respiratory syndrome virus in China without RNA purification

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Journal of Animal Science and Biotechnology 2015年第1期6卷 22-28页

作者： Kang Kang Keli Yang Jiasheng Zhong Yongxiang Tian Limin Zhang jianxin zhai Li Zhang Changxu Song Christine Yuan Gou Jun Luo Deming Gou College of Animal Science and Technology Northwest A&F University College of Life Sciences Shenzhen Key Laboratory of Microbial Genetic EngineeringShenzhen University Hubei Key Laboratory of Animal Embryo and Molecular Breeding Institute of Animal Husbandry and VeterinaryHubei Academy of Agricultural Sciences Shenzhen Ao Dong Inspection and Testing Technology Co .Ltd Veterinary Medicine Institute Guangdong Academy of Agricultural Sciences Northwestern University

Background： Porcine reproductive and respiratory syndrome virus （PRRSV）, and particularly its highly pathogenic genotype （HP-PRRSV）, have caused massive economic losses to the global swine industry. Results： To rapidly identify HP-PRRSV, we developed a direct reaL-time reverse transcription polymerase chain reaction method （dRT-PCR） that could detect the virus from serum specimen without the need of RNA purification Our dRT-PCR assay can be completed in 1.5 h from when a sample is received to obtaining a result. Additionally, the sensitivity of dRT-PCR matched that of conventional reverse transcription PCR （cRT-PCR） that used purified RNA The lowest detection limit of HP-PRRSV was 6.3 TCIDs0 using dRT-PCR. We applied dRT-PCR assay to 144 field samples and the results showed strong consistency with those obtained by cRT-PCR. Moreover, the dRT-PCR method was able to tolerate 5-20% （v/v） serum. Conclusions： Our dRT-PCR assay allows for easier, faster, more cost-effective and higher throughput detection of HP-PRRSV compared with cRT-PCR methods. To the best of our knowledge, this is the first report to describe a real-time RT-PCR assay capable of detecting PRRSV in crude serum samples without the requirement for purifying RNA. We believe our approach has a great potential for application to other RNA viruses.

关键词： Highly pathogenic Porcine reproductive and respiratory syndrome virus Real-time RT-PCR

Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice

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Food Science and Human Wellness 2024年第1期13卷 90-100页

作者： Xiaoxiang Gao Chenbo Yue Ruocen Tian Leilei Yu Fengwei Tian jianxin Zhao Wei Chen Qixiao zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Akkermansia muciniphila play an important in ameliorating obesity but is not allowed for direct consumption in most *** date,microbiota-directed foods selectively promote the targeted human gut microbes,providing a strategy for *** *** studies have indicated the potential regulation of the polyphenol on ***,a polyphenol screening based on *** upregulation was performed in *** acid(CGA)exhibited a greater response to *** ***,we found that CGA did not directly promote *** growth or mucin *** and metabolomics revealed that the increased abundance of *** resulted from the inhibition of CGA on Desulfovibrio and Alistipes and the influence of docosahexaenoic acid,β-hydroxybutyrate,and ***,to confirm the regulation of CGA on *** under disease conditions,high-fat diet-fed mice were *** results showed CGA promoted *** growth,and we expectedly found that CGA suppressed the augment in body weight of mice,significantly attenuated adipose tissue abnormality,provided liver protection and improved gut barrier *** results suggest that CGA inhibits the development of ***,our results indicate that microbiota-directed food is a promising approach for the treatment of obesity.

关键词： Akkermansia muciniphila polyphenol chlorogenic acid obesity

2’-Fucosyllactose alleviate immune checkpoint blockade-associated colitis by reshaping gut microbiota and activating AHR pathway

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Food Science and Human Wellness 2024年第5期13卷 2543-2561页

作者： Shikai Yan Leilei Yu Fengwei Tian jianxin Zhao Wei Chen Qixiao zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Immune checkpoint blockade(ICB)therapeutics are highly effective in cancer immunotherapy,but gastrointestinal toxicity limited the *** microbiota plays a crucial role in ICB-associated colitis.2’-Fucosyllactose(2’FL)is most abundance prebiotic in human milk that can reshape gut microbiota and exert immune regulatory *** study aimed to determine the effects of 2’FL on ICB-associated colitis and to uncover the mediating ***-associated colitis was induced by the ipilimumab and dextran sulfate *** administration of 2’FL(0.6 g/(kg∙day))ameliorated ICB-induced colitis by enhancing regulatory T cells(Treg)and the M2/M1 ratio of macrophages in colon.2’FL treatment also increased the expression of tight junction proteins(zonula occludens-1(ZO-1)and mucin 2(MUC2))and antioxidant stress indicators(superoxide dismutase(SOD)and catalase(CAT)).In addition,administration of 2’FL increased the abundance of Bifidobacterium and Lactobacillus,and elevated the levels of microbial metabolites,such as indole-3-lactic acid(ILA),which activated the aryl hydrocarbon receptor ligands(AHR)*** protective effect of 2’FL was abolished upon depletion of gut microbiota,and ILA treatment partially simulated the protective effect of 2’***,2’FL did not exhibit inhibition of antitumor *** findings suggest that 2’FL could serve as a potential protective strategy for ICB-associated colitis by modulating the intestinal microbiota and bacterial metabolites.

关键词： 2’-Fucosyllactose Immune checkpoint blockade-associated colitis Gut microbiota Metabolomics Regulatory T cells(Treg)

Rational protein engineering of thermostable heparinase I from Bacteroides thetaiotaomicron for highly efficient heparin degradation

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Food Science and Human Wellness 2024年

作者： Chuan Zhang Ruohan Zhao Leilei Yu Qixiao zhai jianxin Zhao Hao Zhang Xuegang Luo Fengwei Tian Wei Chen State Key Laboratory of Food Science and Technology， Jiangnan University School of Food Science and Technology， Jiangnan University Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education & Tianjin Key Lab of Industrial Microbiology， College of Biotechnology， Tianjin University of Science and Technology National Engineering Research Center for Functional Food， Jiangnan University

Heparin， a glycosaminoglycan， is a stable source of carbon that supports the growth of microorganisms in the human intestine. It is also a commonly used anticoagulant drug in clinical practice， with significant therapeutic effects. Low molecular weight heparin （LMWH） is a highly active low molecular weight fragment obtained via enzymatic reaction or the chemical degradation of heparin. LMWH has been applied globally in the prevention and treatment of venous thromboembolism in thrombosis patients. Simultaneously， as a potential prebiotic， because of its low molecular weight， LMWH can be well degraded by the gut microbiota to maintain intestinal balance. Enzymatic heparin degradation has recently emerged as a viable disposal method for LMWH preparation; however， only very few benchmark enzymes have been thoroughly described and subjected to protein engineering to improve their properties over the past few years. The commercialization of enzymes will require the development of robustly engineered enzymes that meet the demands of industrial processes. Herein， we report a rational protein engineering strategy that includes molecular dynamic simulations of flexible amino acid mutations and disulfide bond screening. Several Bt-HepI mutants were obtained and screened for high thermal stability. We obtained the Bt-HepID204C/K208C/H189W/Q198Rvariant， which features a stabilized protein surface structure， with a 1.3-fold increase in kcat/Km， a 2.44-fold increase in thermal stability at 50℃， and a 1.8-fold decrease in the average molecular weight of LMWH produced at 40℃ compared with that seen with Bt-HepIWT. Our study establishes a strategy to engineer thermostable HepI to underpin its industrial applications.

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Efficient electrocatalytic reduction of carbon dioxide to ethylene on copper–antimony bimetallic alloy catalyst

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Chinese Journal of Catalysis 2020年第7期41卷 1091-1098页

作者： Shuaiqiang Jia Qinggong Zhu Haihong Wu Meng’en Chu Shitao Han Ruting Feng Jinghui Tu jianxin zhai Buxing Han Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Colloid and Interface and ThermodynamicsCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China

The exploration of efficient electrocatalysts for the reduction of CO2 to C2H4 is of significant importance but is also a challenging ***-based bimetallic catalysts are extremely promising for efficient CO2 *** this work,we synthesize a series of porous bimetallic Cu–Sb alloys with different compositions for the catalytic reduction of CO2 to *** is demonstrated that the alloy catalysts are much more efficient than the pure Cu *** performance of the alloy catalysts depended strongly on the ***,the alloy with a Cu:Sb ratio of 10:1 yielded the best results;it exhibited a high C2H4 Faradaic efficiency of 49.7%and a high current density of 28.5 mA cm?2 at?1.19 V vs.a reversible hydrogen electrode(RHE)in 0.1 M KCl *** the best of our knowledge,the electrocatalytic reduction of CO2 to C2H4 using Cu–Sb alloys as catalysts has not been *** excellent performance of the porous alloy catalyst is attributed to its favorable electronic configuration,large surface area,high CO2 adsorption rate,and fast charge transfer rate.

关键词： Carbon dioxide reduction Ethyene Electrocatalyst Copper-antimony bimetallic alloy Synergistic effect

基于生物信号纳米放大技术的戊肝病毒检测基因芯片

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武汉大学学报（理学版） 2007年第4期53卷 475-480页

作者：杨永翟建新王业富武汉大学生命科学学院湖北武汉430072

建立了一种利用"双探针夹心银染"技术快速检测戊型肝炎病毒(HEV)的基因芯片方法.提取的病毒核酸经过RT-PCR扩增,PCR体系中用掺入生物素修饰的dUTP扩增得到带有生物素的核酸片段,5′末端-NH2修饰的同源寡核苷酸作为捕获探针固定到处理后... 详细信息

建立了一种利用"双探针夹心银染"技术快速检测戊型肝炎病毒(HEV)的基因芯片方法.提取的病毒核酸经过RT-PCR扩增,PCR体系中用掺入生物素修饰的dUTP扩增得到带有生物素的核酸片段,5′末端-NH2修饰的同源寡核苷酸作为捕获探针固定到处理后的玻片上,该探针识别病毒的带有生物素的核酸片段,而链霉亲和素标记的胶体金与生物素紧密结合,通过银沉积在金颗粒表面放大信号可以目视结果.采用该方法对已经确证的86个血清样本进行检测,检出52个阳性和34个阴性样本,结果与荧光定量PCR检出一致.

关键词：纳米颗粒生物素链霉亲和素戊肝病毒基因检测

Li_(2)O对中性硼硅玻璃黏度性能的影响

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河南科技 2021年第26期40卷 127-129页

作者：翟建新济源市耀辉玻璃制品有限公司河南济源459000

将锂辉石加入中性硼硅玻璃配方中,用锂辉石中的Li_(2)O等量替代原配方化学组成中的B_(2)O_(3)、Na_(2)O,研究Li_(2)O等量替代B_(2)O_(3)、Na_(2)O后Li_(2)O加入量对中性硼硅玻璃黏度性能的影响。试验结果表明,随着Li_(2)O替代B_(2)O_(3)... 详细信息

将锂辉石加入中性硼硅玻璃配方中,用锂辉石中的Li_(2)O等量替代原配方化学组成中的B_(2)O_(3)、Na_(2)O,研究Li_(2)O等量替代B_(2)O_(3)、Na_(2)O后Li_(2)O加入量对中性硼硅玻璃黏度性能的影响。试验结果表明,随着Li_(2)O替代B_(2)O_(3)、Na_(2)O质量分数的增加,中性硼硅玻璃低温黏度点均有不同程度的下降。对于相同含量的Li_(2)O、B_(2)O_(3)、Na_(2)O,Li_(2)O降低中性硼硅玻璃低温黏度点的能力比B_(2)O_(3)、Na_(2)O强。因此,加入Li_(2)O可以降低中性硼硅玻璃低温热处理温度。对于相同含量的Li_(2)O、B_(2)O_(3)、Na_(2)O,Li_(2)O降低中性硼硅玻璃高温黏度点的能力远比B_(2)O_(3)、Na_(2)O强。因此,引进Li_(2)O可以显著降低玻璃加工对应的温度。Li_(2)O可以显著降低中性硼硅玻璃低温、高温黏度点,因此,可以降低低温热处理及高温玻璃加工对应的温度,达到降低生产成本和节能减排的目的。

关键词：中性硼硅玻璃黏度节能降耗