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Chinese Journal of Natural Medicines 2024年第5期22卷 441-454页

作者： SHAO Siyuan SUN Mohan MA Xianjie jiang jianwei TIAN Jinying ZHANG Jianjun YE Fei LI Shuai State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Five novel(9,10-dihydro)phenanthrene and bibenzyl trimers,as well as two previously identified biphenanthrenes and bibenzyls,were isolated from the tubers of Bletilla *** structures were elucidated through comprehensive analyses of NMR and HRESIMS spectroscopic *** absolute configurations of these compounds were determined by calculating rotational energy barriers and comparison of experimental and calculated ECD *** 5b and 6 exhibited inhibitory effects on LPS-induced NO production in BV-2 cells,with IC_(50) values of 12.59±0.40 and 15.59±0.83μmol·L^(-1),respectively.A mechanistic study suggested that these compounds may attenuate neuroinflammation by reducing the activation of the AKT/IκB/NF-κB signaling ***,compounds 3a,6,and 7 demonstrated significant PTP1B inhibitory activities,with IC_(50) values of 1.52±0.34,1.39±0.11,and 1.78±0.01μmol·L^(-1),*** investigation revealed that compound 3a might inhibit LPS-induced PTP1B overexpression and NF-κB activation,thereby mitigating the neuroinflammatory response in BV-2 cells.

关键词： Bletilla striata Phenanthrene/bibenzyl trimer NO inhibition AKT/IκB/NF-κB signaling pathway PTP1B inhibitory effect

红色资源:老区乡村振兴的新引擎——以芜湖市繁昌区中分村为例

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安徽商贸职业技术学院学报 2024年第2期23卷 20-24页

作者：钱烨蒋建伟安徽机电职业技术学院工商管理学院安徽芜湖241000 安徽师范大学学生处安徽芜湖241000

红色资源是传播红色文化、传承红色基因的重要媒介,也是老区乡村振兴的重要引擎。通过对中分村红色资源保护和开发的问卷调查、访谈后发现,红色资源为老区乡村振兴高质量发展注入了红色基因、奠定了产业基础和提供了发展方向,但也存在... 详细信息

红色资源是传播红色文化、传承红色基因的重要媒介,也是老区乡村振兴的重要引擎。通过对中分村红色资源保护和开发的问卷调查、访谈后发现,红色资源为老区乡村振兴高质量发展注入了红色基因、奠定了产业基础和提供了发展方向,但也存在红色产业发展理念落后、专业人才紧缺、空间发展受限等问题。研究提出,老区乡村振兴应在强化党建引领、拓展红色产业链、引入数字媒体技术、打造红色产业品牌、培养红色专业人才等方面下功夫,进而推进红色资源赋能计划,实现乡村振兴高质量发展。

关键词：红色资源高质量发展党建引领红色产业链

Structural design of the fluted shaped charge liner using multi-section optimization method

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Defence Technology(防务技术) 2023年第7期25卷 249-262页

作者： Shengjie Sun jianwei jiang Shuyou Wang Jianbing Men Mei Li State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081PR China Tangshan Research Institute Beijing Institute of TechnologyTangshan 063000HebeiPR China

Spin effect of the small diameter shaped charge results in the centrifugal stress during the jet stretching process. Consequently, the jet scatters, which deceases the jet penetration capability. In the present study, a multi-section method was proposed to design the spin-compensation liner. The spincompensation rate(SCR) of the liner was defined as the specific angular velocity that a fluted liner can offset. Based on the plain stress theory, SPH numerical method was applied to study the converging process of the 2D fluted structure. The spin-compensation mechanism of the fluted structure was illustrated. Then, nine cross sections were chosen along the liner axis equidistantly. On each of the section, a 2D fluted structure was designed to offset a given initial angular velocity. After, the optimized fluted structures were integrated into a 3D fluted liner. Jet appearances of the normal liner and the fluted liners under different initial angular velocities were compared, which verifies the practicality of the multi-sectional method. The multi-section optimization method provides a new efficient method of designing the shaped charge liner for a specific usage.

关键词： Fluted liner Spin-compensation SPH Structural optimization

Targeting ferroptosis opens new avenues for the development of novel therapeutics

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4716-4745页

作者： Shumin Sun Jie Shen jianwei jiang Fudi Wang Junxia Min The First Affiliated Hospital Institute of Translational MedicineThe Second Affiliated HospitalSchoolof Public HealthCancer CenterState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhouChina

Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,including altered iron homeostasis,reduced defense against oxidative stress,and abnormal lipid *** studies have provided compelling evidence supporting the notion that ferroptosis plays a key pathogenic role in many diseases such as various cancer types,neurodegenerative disease,diseases involving tissue and/or organ injury,and inflammatory and infectious diseases.

关键词： peroxidation diseases homeostasis

肠道菌群和瘤内菌群失调在肝细胞癌免疫逃逸中的研究进展

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暨南大学学报（自然科学与医学版） 2024年第2期45卷 111-123页

作者：相乐阳古建仪周俊臻沈威鹏张清曹明溶蒋建伟暨南大学附属第一医院肝胆外科广东广州510630 暨南大学基础医学与公共卫生学院生物化学与分子生物学系广东广州510632 暨南大学附属第一医院乳腺外科广东广州510630

近年来,免疫治疗在不可切除肝细胞癌(HCC)的系统治疗中发挥了重要的作用并逐渐跻身一线治疗方案。即使目前各个指南均推荐一线使用的阿替利珠单抗联合贝伐珠单抗方案,其对HCC患者的客观缓解率等指标仍有较大的提升空间,部分原因在于大量... 详细信息

近年来,免疫治疗在不可切除肝细胞癌(HCC)的系统治疗中发挥了重要的作用并逐渐跻身一线治疗方案。即使目前各个指南均推荐一线使用的阿替利珠单抗联合贝伐珠单抗方案,其对HCC患者的客观缓解率等指标仍有较大的提升空间,部分原因在于大量HCC患者对免疫治疗有原发性耐药,导致肿瘤免疫逃逸。肿瘤免疫逃逸与肿瘤微环境因素和肿瘤内因素密切相关。研究发现HCC患者广泛存在菌群失调,包括肠道菌群失调及瘤内菌群丰度的改变,前者可能通过脂多糖、菌群代谢产物(如次级胆汁酸和短链脂肪酸)或自身的结构蛋白等与肿瘤微环境中的免疫细胞相互作用,后者可能在HCC细胞或免疫细胞内直接参与基因表观遗传学水平表达和物质代谢的调控,进而改变HCC细胞的生物学特性和肿瘤微环境,诱导抑制性肿瘤微环境,引起HCC细胞免疫逃逸。本文对HCC患者中菌群失调的类型进行了归纳总结,并从肠道菌群和瘤内菌群两方面对HCC免疫逃逸的可能机制进行综述,以期为探究HCC患者菌群与免疫治疗耐药之间的关系提供参考。

关键词：肝细胞癌免疫逃逸肿瘤微环境菌群失调

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优质籼型三系不育系星泰A的选育与应用

杂交水稻 2024年第3期39卷 76-78页

作者：刘玉龙李中希郭爱军周小波曾燕蒋建为杨正仁湖南洞庭高科种业股份有限公司湖南岳阳414000 岳阳市农业科学研究院水稻研究所湖南岳阳414000

星泰A是湖南洞庭高科种业股份有限公司、岳阳市农业科学研究院用岳4B/广占63S的F3作母本,以鑫B为父本进行杂交,F9代与鑫A测交后多代回交转育育成的优质籼型三系不育系,具有不育性稳定、配合力强、米质优、易繁殖、所配组合生育期短等特... 详细信息

星泰A是湖南洞庭高科种业股份有限公司、岳阳市农业科学研究院用岳4B/广占63S的F3作母本,以鑫B为父本进行杂交,F9代与鑫A测交后多代回交转育育成的优质籼型三系不育系,具有不育性稳定、配合力强、米质优、易繁殖、所配组合生育期短等特点。利用星泰A与R018配制的杂交组合星泰优018于2022年通过国家农作物品种审定委员会审定。

关键词：杂交水稻不育系星泰A 优质选育

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Theory,technology and application of grouted bolting in soft rock roadways of deep coal mines

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1463-1479页

作者： Hongpu Kang jianwei Yang Pengfei jiang Fuqiang Gao Wenzhou Li Jiafeng Li Huiyuan Chen Coal Mining Research Institute China Coal Technology and Engineering Group Co.Ltd.Beijing 100013China Coal Mining Branch China Coal Research InstituteBeijing 100013China State Key Laboratory of Intelligent Mining and Strata Control Beijing 100013China

The grouted bolt,combining rock bolting with grouting techniques,provides an effective solution for controlling the surrounding rock in deep soft rock and fractured *** has been extensively applied in numerous deep mining areas characterized by soft rock roadways,where it has demonstrated remarkable control *** article systematically explores the evolution of grouted bolting,covering its theoretical foundations,design methods,materials,construction processes,monitoring measures,and methods for assessing its *** overview encompassed several key elements,delving into anchoring theory and grouting reinforcement *** new principle of high pretensioned high-pressure splitting grouted bolting collaborative active control is introduced.A fresh method for dynamic information design is also *** discussion touches on both conventional grouting rock bolts and cable bolts,as well as innovative grouted rock bolts and cables characterized by their high pretension,strength,and sealing hole *** examination of the merits and demerits of standard inorganic and organic grouting materials versus the new inorganic–organic composite materials,including their specific application conditions,was ***,the article presents various methods and instruments to assess the support effect of grouting rock bolts,cable bolts,and grouting ***,it provides a foundation for understanding the factors influencing decisions on grouted bolting timing,the sequence of grouting,the pressure applied,the volume of grout used,and the strategic arrangement of grouted rock bolts and cable *** application of the high pretensioned high-pressure splitting grouted bolting collaborative control technology in a typical kilometer-deep soft rock mine in China—the soft coal seam and soft rock roadway in the Kouzidong coal mine,Huainan coal mining area,was ***,the existing problems in grouted bolting control

关键词： deep coal mine soft rock roadway grouted bolting rock bolt and cable grouting material high-pressure splitting grouting collaborative control technology

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基于恶劣环境的通信产品可靠性研究

移动信息 2024年第6期46卷 13-16页

作者：蒋剑伟周勇陈奕钊吴林印王国法俸玉祥中国电子科技集团公司第三十四研究所广西桂林541004 北京跟踪与通信技术研究所北京100000

文中介绍了一种信息通信产品如何在复杂多变的应用环境下,实现机动便携、快速开通、稳定使用的方案,并详细阐述了方案设计,开展了模拟仿真试验。

关键词：信息通信恶劣环境级联组合机动便携仿真分析

Investigation on the spatial distribution characteristics of behind-armor debris formed by the perforation of EFP through steel target

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Defence Technology（防务技术） 2020年第1期16卷 119-135页

作者： Xin Wang jianwei jiang Shengjie Sun Jianbing Men Shuyou Wang State Key Laboratory of Explosion Science and Technology Beijing Institution of TechnologyChina

The behind-armor debris(BAD) formed by the perforation of an EFP is the main damage factor for the secondary destruction to the behind-armor *** at investigating the BAD caused by EFP,flash X-ray radiography combined with an experimental witness plate test method was used,and the FEM-SPH adaptive conversion algorithm in LS-DYNA software was erployed to model the perforation *** simulation results of the debris cloud shape and number of debris were in good agreement with the flash X-ray radiographs and perforated holes on the witness plate,*** numerical simulations of EFP's penetration under various impact conditions were *** results show that,an ellipsoidal debris cloud,with the major-to-minor axis radio(a/b)smaller than that caused by shaped charge jets,was formed behind the *** the increase of target thickness(h) and decrease of impact velocity(v_0) and obliquity(θ),the value of a/b *** number of debris ejected from target is significantly higher than that from *** on the statistical analysis of the spatial distribution of the BAD,An engineering calculation model was established considering the influence of h,v_0 and θ.The model can with reasonable accuracy predict the quantity and velocity distribution characteristics of BAD formed by EFP.

关键词： Behind-armor debris EFP FEM-SPH adaptive conversion algorithm Spatial distribution

改进自适应双边滤波Canny算子在自动化设备中的应用

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河南工程学院学报（自然科学版） 2024年第1期36卷 76-80页

作者：张宝童文超姜建伟陈岩岩叶姗姗赵室伟淮南师范学院机械与电气工程学院安徽淮南232008 菲律宾科技大学工业教育学院马尼拉0900 深圳市豪恩汽车电子装备股份有限公司广东深圳518109 晋西工业集团有限责任公司山西太原030027

为提升镜头图像边缘检测效果与自动化设备组装合格率,提出了基于自适应双边滤波Canny算子的检测方法。首先采用双边滤波处理图像强度并保存边缘信息,进行加权平均去除噪声,然后采用改进Canny算子检测图像中的边缘细节信息,抑制非边缘部... 详细信息

为提升镜头图像边缘检测效果与自动化设备组装合格率,提出了基于自适应双边滤波Canny算子的检测方法。首先采用双边滤波处理图像强度并保存边缘信息,进行加权平均去除噪声,然后采用改进Canny算子检测图像中的边缘细节信息,抑制非边缘部分的噪声干扰,自适应调整滤波程度,得到更准确的边缘检测结果,最后利用霍夫曼变换检测镜片图像的圆心和切口位置信息,提高了组装效率和准确性。结果表明,该算法为镜头自动化组装提供了一种有效的解决方案,具有较高的实用价值。

关键词：自适应双边滤波 Canny算子霍夫曼变换