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Chinese Journal of Mechanical Engineering 2024年第3期37卷 151-169页

作者： jianwei wang Haoxi Zhang Shaocun Han Hang Li Peng wang Kai Feng State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China

Low damping characteristics have always been a key sticking points in the development of gas *** application of squeeze film dampers can significantly improve the damping performance of gas lubricated *** paper proposed a novel hermetic diaphragm squeeze film damper(HDSFD)for oil-free turbomachinery supported by gas lubricated *** types of HDSFDs with symmetrical structure were proposed for good damping *** considering the compressibility of the damper fluid,based on hydraulic fluid mechanics theory,a dynamic model of HDSFDs under medium is proposed,which successfully reflects the frequency dependence of force *** on the dynamic model,the effects of damper fluid viscosity,bulk modulus of damper fluid,thickness of damper fluid film and plunger thickness on the dynamic stiffness and damping of HDSFDs were *** experimental test rig was assembled and series of experimental studies on HDSFDs were *** damper fluid transverse flow is added to the existing HDSFD concept,which aims to make the dynamic force coefficients independent of *** the force coefficient is still frequency dependent,the damping coefficient at high frequency excitation with damper fluid supply twice as that without damper fluid *** results serve as a benchmark for the calibration of analytical tools under development.

关键词： Hermetic diaphragm squeeze film damper Compressibility Dynamic model Experimental studies

Programmable silicon-photonic quantum simulator based on a linear combination of unitaries

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Photonics Research 2024年第8期12卷 1760-1767页

作者： YUE YU YULIN CHI CHONGHAO ZHAI JIESHAN HUANG QIHUANG GONG jianwei wang State Key Laboratory for Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Frontiers Science Center for Nano-optoelectronics&Collaborative Innovation Center of Quantum Matter Peking UniversityBeijing 100871China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Yangtze Delta Institute of Optoelectronics Peking UniversityNantong 226010China Hefei National Laboratory Hefei 230088China Department of Electrical and Computer Engineering University of WashingtonSeattleWashington 98195USA China Mobile Research Institute Beijing 100053China

Simulating the dynamic evolution of physical and molecular systems in a quantum computer is of fundamental interest in many *** implementation of dynamics simulation requires efficient quantum *** Lie-Trotter-Suzuki approximation algorithm,also known as the Trotterization,is basic in Hamiltonian dynamics simulation.A multi-product algorithm that is a linear combination of multiple Trotterizations has been proposed to improve the approximation ***,implementing such multiproduct Trotterization in quantum computers remains challenging due to the requirements of highly controllable and precise quantum entangling operations with high success ***,we report a programmable integrated-photonic quantum simulator based on a linear combination of unitaries,which can be tailored for implementing the linearly combined multiple Trotterizations,and on the simulator we benchmark quantum simulation of Hamiltonian *** modify the multi-product algorithm by integrating it with oblivious amplitude amplification to simultaneously reach high simulation precision and high success *** quantum simulator is devised and fabricated on a large-scale silicon-photonic quantum chip,which allows the initialization,manipulation,and measurement of arbitrary four-qubit states and linearly combined unitary *** an example,the quantum simulator is reprogrammed to emulate the dynamics of an electron spin and nuclear spin coupled *** work promises the practical dynamics simulations of real-world physical and molecular systems in future large-scale quantum computers.

关键词： quantum Hamiltonian linearly

ROS-responsive nanoparticles targeting inflamed colon for synergistic therapy of inflammatory bowel disease via barrier repair and anti-inflammation

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Nano Research 2024年第6期17卷 5409-5423页

作者： Ding wang Qi Jiang Ruoyu Shen Lijun Peng Wentao Zhou Tingting Meng Fuqiang Hu jianwei wang Hong Yuan College of Pharmaceutical Science Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009China

The destruction of the intestinal barrier is likely to cause an increase in intestinal permeability and cause pathological *** studies have demonstrated that intestinal barrier function plays an important role in the occurrence and development of inflammatory bowel disease(IBD).Oral administration is the most common route for intestinal *** this study,a synergistic strategy is proposed for IBD management through active barrier repair combined with anti-inflammatory treatment,which can interrupt the pathological process of IBD,resulting in the significantly improved efficacy of existing *** on the specific pH values and high reactive oxygen species(ROS)levels in inflammatory sites of IBD,an orally administrated ROS-responsive drug delivery system targeting inflamed colon has been designed,and confirmed in vitro and in *** anti-inflammatory drug dexamethasone acetate(Dex)and the barrier function regulator LY294002 are delivered by the synthesized nanocarrier to treat IBD synergistically by inhibiting inflammation and actively repairing the intestinal barrier through tight junctions(TJs).The accumulation of nanocarriers in the inflamed colon and synergistic efficacy has been validated in mice with *** brief,a drug delivery system and a therapeutic strategy for IBD are successfully developed.

关键词： nanotechnology reactive oxygen species(ROS)-responsive targeted delivery inflammatory bowel disease(IBD) intestinal barrier combination treatment

Dual modulation of homogeneous nanomaterialization and electrochemical activation enhancing zinc ion storage

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Science China Chemistry 2024年

作者： jianwei wang Huan wang Kangning wang Wenhui wang Wenlin Zhang Yanzhong Zhen School of Chemistry & Chemical Engineering Yan'an University

Vanadium-based electrode materials are widely investigated,but the low specific capacity and slow electrochemical kinetics in aqueous zinc-ion batteries still limit their commercial ***,the VS2/CaV4O9material with the morphology of nanoflower was synthesized by a one-step hydrothermal *** to the blocky structure of pure VS2material,the VS2/CaV4O9material is composed of thinner homogeneous *** open structures could provide abundant electrochemical active sites and ion transport channels,and then promote the electrochemical reaction *** addition,they can also buffer the bulk strain during the reaction *** improve the utilization of vanadium elements,an in-situ electrochemical activation strategy is used to explore the storage performance of the VS2/CaV4O9material,the different activation voltage range of 0.4–1.6 and 0.4–1.4 V are selected,*** with the longer activation plateau of activated-VS2,the VS2/CaV4O9cathode could quickly reach the activation state in the range of 1.4–1.6 V and cause the release of additional Zn storage sites *** VS2/CaV4O9cathode delivers a higher power density of 37,000 W kg-1and a significant energy density of 423 Wh *** the high current density of 15 A g-1,the VS2/CaV4O9cathode still has a discharge capacity of 183.9mAh g-1after 5,000 cycles,and the capacity decay rate per cycle is only 0.0042%.Continuous cyclic voltammetry （CV） curves,electrochemical impedance spectroscopy （EIS） measurements,density functional theory （DFT） calculation and galvanostatic intermittent titration technique （GITT） measurements demonstrate that the VS2/CaV4O9cathode has a faster ion diffusion/charge transfer ***,the assembled flexible device has an excellent mechanical stability.

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PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis ina Temporal Manner

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Research 2024年第1期2023卷 33-48页

作者： Fangqian wang Yuxiao Ye Zengjie Zhang wangsiyuan Teng Hangxiang Sun Xupeng Chai Xingzhi Zhou Jiayu Chen Haochen Mou Yinwang Eloy Xiaoqiang Jin Liang Chen Zhenxuan Shao Yan Wu Yue Shen An Liu Peng Lin jianwei wang Xiaohua Yu Zhaoming Ye Department of Orthopedic Surgery the Second Affiliated HospitalZhejang University School of MedicineHangzhou CityZhejiang ProvincePR China Orthopedics Research Institute of Zhejang University Hangzhou CityZhejiang ProvincePR China Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou CityZhejiang ProvincePR China School of Material Science and Engineering University of New South WalesSydney 2052Australia

Platelet-derived growth factor-BB(PDGF-BB)/platelet-derived growth factor receptor-β(PDGFR-β)pathway is conventionally considered as an important pathway to promote osteogenesis;however,recent study suggested its role during osteogenesis to be *** the differential functions of this pathway during 3 stages of bone healing,we hypothesized that temporal inhibition of PDGF-BB/PDGFR-βpathway could shift the proliferation/differentiation balance of skeletal stem and progenitor cells,toward osteogenic lineage,which leads to improved bone *** first validated that inhibition of PDGFR-βat late stage of osteogenic induction effectively enhanced differentiation toward *** effect was also replicated invivo by showing accelerated bone formation when block PDGFR-βpathway at late stage of critical bone defect healing mediated using ***,we found that such PDGFR-βinhibitor-initiated bone healing was also effective in the absence of scaffold implantation when administrated ***,timely inhibition of PDGFR-βblocked extracellular regulated protein kinase 1/2 pathway,which shift proliferation/differentiation balance of skeletal stem and progenitor cell to osteogenic lineage by upregulating osteogenesis-related products of Smad to induce *** study offered updated understanding of the use of PDGFR-βpathway and provides new insight routes of action and novel therapeutic methods in the field of bone repair.

关键词： healing sized implantation

Impact of corticosteroids on initiation and half-year durability of humoral response in COVID-19 survivors

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 48-55页

作者： Yeming wang Li Guo Guohui Fan Yang Han Qiao Zhang Lili Ren Hui Zhang Geng wang Xueyang Zhang Tingxuan Huang Weiyang wang Lan Chen Lixue Huang Xiaoying Gu Xinming wang Jingchuan Zhong Ying wang Hui Li Jiapei Yu Zhibo Liu Chaolin Huang Bin Cao jianwei wang National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesChina-Japan Friendship HospitalBeijing 100029China National Health Commission Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 102629China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical SciencesBeijing 100029China School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeState Key Laboratory of Respiratory Health and MultimorbidityKey Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College)Ministry of EducationBeijing 100730China National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Clinical research and Data managementCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Jin Yin-tan Hospital WuhanHubei 430023China Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Rheumatology and Clinical Immunology Chinese Academy of Medical Sciences&Peking Union Medical CollegeNational Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID)Ministry of Science&TechnologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College Hospital(PUMCH)Key Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationBeijing 100730China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospsitalInstitute of Respiratory MedicineChinese

Background:The impact of corticosteroids on humoral responses in coronavirus disease 2019(COVID-19)sur-vivors during the acute phase and subsequent 6-month period remains *** study aimed to determine how the use of corticosteroids influences the initiation and duration of humoral responses in COVID-19 survivors 6 months after infection ***:We used kinetic antibody data from the lopinavir-ritonavir trial conducted at Jin Yin-Tan Hospital in January 2020,which involved adults hospitalized with severe COVID-19(LOTUS,ChiCTR2000029308).Anti-body samples were collected from 192 patients during hospitalization,and kinetic antibodies were monitored at all available time points after ***,plasma samples were collected from 101 COVID-19 survivors for comprehensive humoral immune measurement at the half-year follow-up *** main focus was comparing the humoral responses between patients treated with systemic corticosteroid therapy and the non-corticosteroid ***:From illness onset to day 30,the median antibody titre areas under the receiver operating characteristic curve(AUCs)of nucleoprotein(N),spike protein(S),and receptor-binding domain(RBD)immunoglobulin G(IgG)were significantly lower in the corticosteroids *** AUCs of N-,S-,and RBD-IgM as well as neutralizing antibodies(NAbs)were numerically lower in the corticosteroids group compared with the non-corticosteroid ***,peak titres of N,S,RBD-IgM and-IgG and NAbs were not influenced by *** 6-month follow-up,we observed a delayed decline for most binding antibodies,except N-IgM(𝛽−0.05,95%CI[−0.10,0.00])in the corticosteroids group,though not reaching statistical *** significant difference was observed for ***,for the half-year seropositive rate,corticosteroids significantly accelerated the decay of IgA and IgM but made no difference to N-,S-,and RBD-IgG or ***,corticosteroids group showed a trend towards d

关键词： COVID-19 Corticosteroid Immunity Antibody Humoral response

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原发中纵隔病变的影像学特点和鉴别诊断

中华肿瘤杂志 2024年第5期46卷 449-456页

作者：陈佳琪王建卫国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院影像诊断科北京100021

目的探讨原发中纵隔病变的患病情况及增强CT影像学特征,以提高对中纵隔肿瘤的认识及术前诊断的准确度。方法回顾性分析2012年1月至2022年12月中国医学科学院肿瘤医院诊治的84例中纵隔原发病变患者的临床、影像和病理学资料,总结不同组... 详细信息

目的探讨原发中纵隔病变的患病情况及增强CT影像学特征,以提高对中纵隔肿瘤的认识及术前诊断的准确度。方法回顾性分析2012年1月至2022年12月中国医学科学院肿瘤医院诊治的84例中纵隔原发病变患者的临床、影像和病理学资料,总结不同组织学类型病变的CT影像特征。结果84例患者中,间叶源性肿瘤24例(28.6%,包括周围神经鞘瘤13例,血管源性肿瘤5例,脂肪源性肿瘤3例,恶性孤立性纤维性肿瘤2例,滑膜肉瘤1例),前肠囊肿23例(27.4%),巨大淋巴结增生12例(14.3%),胸骨后甲状腺肿3例(3.6%),神经内分泌癌10例(11.9%),淋巴造血系统肿瘤8例(9.5%,包括淋巴瘤7例,组织细胞肉瘤1例),心包间皮瘤4例(4.8%)。不同组织学类型的中纵隔原发病变影像表现多样,具有特定的影像学特征:成熟脂肪成分见于3例脂肪肉瘤,钙化见于2例甲状腺肿及7例巨大淋巴结增生,增强扫描强化明显见于2例孤立性纤维性肿瘤、3例甲状腺肿、11例巨大淋巴结增生,纵隔肿大淋巴结见于6例淋巴瘤及3例间皮瘤,高侵袭性见于4例间皮瘤及9例神经内分泌癌。结论原发中纵隔病变发病率低且组织学类型丰富,其影像表现多样,可根据不同组织学类型病变的特异影像学特征进行术前鉴别诊断。

关键词：中纵隔纵隔肿瘤体层摄影术,X线计算机影像诊断

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肺磨玻璃结节干预策略

中华肿瘤防治杂志 2024年第4期31卷 233-240页

作者：崔舒蕾王建卫国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院影像诊断科北京100021

目的总结肺磨玻璃结节(GGN)干预管理策略的研究进展,旨在为临床对GGN的诊治决策提供参考,减少过度诊治。方法以“磨玻璃结节、病理、基因突变、手术、深度学习”为中文关键词,“ground-glass nodule、pathology、gene mutation、surg... 详细信息

目的总结肺磨玻璃结节(GGN)干预管理策略的研究进展,旨在为临床对GGN的诊治决策提供参考,减少过度诊治。方法以“磨玻璃结节、病理、基因突变、手术、深度学习”为中文关键词,“ground-glass nodule、pathology、gene mutation、surgery、deep learning”为英文关键词,检索中国知网及PubMed数据库2007-01-01-2023-02-30相关文献。纳入标准:肺GGN的研究现状及干预管理相关文献。排除标准:可信度较低的文献。最终纳入文献67篇。结果随着低剂量CT的广泛应用,肺GGN的检出率逐年提高。短暂性GGN多与良性病变有关,持续存在的GGN恶性概率高且呈惰性生长。GGN影像学表现能在一定程度上反映其浸润程度并预测其生长模式。预测GGN的生长模式除了传统临床及影像学方法,基因层面的研究也占有一席之地。部分GGN生长后再实施手术不影响其预后,可适当延长该部分GGN的手术窗口期。GGN患者选择亚肺叶切除可以获得良好的预后,同时获得比传统肺叶切除更好的术后生存质量。人工智能尤其深度学习技术对GGN的检出、浸润程度的判断和生长预测都有一定帮助。结论对于GGN的干预目前已经开始由积极干预向适时干预转变,手术最佳干预时机以及部分GGN是否需要干预有待更多的研究支持。

关键词：肺结节磨玻璃结节病理基因突变手术深度学习综述文献

预处理过滤性能对生物滞留设施污染负荷的影响研究

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给水排水 2024年第6期50卷 16-21页

作者：邱琴岳鹏王坚伟上海建科检验有限公司上海201108 上海同晟环保科技有限公司上海200082

搭建3种不同土壤介质层的生物滞留设施,研究预处理设施的过滤效果对生物滞留设施污染负荷的影响,并针对预处理设施常用的过滤介质开展单次及累积污染物去除效果的研究。研究表明,预处理设施能够显著提升下游生物滞留设施的极限污染负荷... 详细信息

搭建3种不同土壤介质层的生物滞留设施,研究预处理设施的过滤效果对生物滞留设施污染负荷的影响,并针对预处理设施常用的过滤介质开展单次及累积污染物去除效果的研究。研究表明,预处理设施能够显著提升下游生物滞留设施的极限污染负荷和排空速率。预处理设施SS去除率从0%提高到40%时,生物滞留设施的极限污染负荷提升80%左右;预处理设施SS去除率从40%提高到60%时,生物滞留设施的极限污染负荷提升幅度开始减弱。从综合效益角度考量,建议预处理设施SS去除率为40%左右。

关键词：预处理生物滞留设施过滤污染负荷 SS去除率

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纵隔肿瘤的影像诊断及研究进展

中华肿瘤防治杂志 2024年第1期31卷 47-52页

作者：陈佳琪王建卫国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院影像诊断科北京100021

目的总结纵隔肿瘤的影像学诊断思路及其在影像学方面的最新研究进展。方法应用PubMed和CNKI期刊全文数据库检索系统,以“纵隔、计算机断层扫描、磁共振成像”等为关键词,检索从建库至2023-05-31发表的相关中英文文献,整理和总结纵隔不... 详细信息

目的总结纵隔肿瘤的影像学诊断思路及其在影像学方面的最新研究进展。方法应用PubMed和CNKI期刊全文数据库检索系统,以“纵隔、计算机断层扫描、磁共振成像”等为关键词,检索从建库至2023-05-31发表的相关中英文文献,整理和总结纵隔不同分区好发肿瘤的影像学表现,同时对纵隔肿瘤影像诊断的最新研究进展进行文献回顾,以探究未来的研究方向。结果纵隔肿瘤种类繁多、发病率较低,其影像表现复杂多样,鉴别诊断困难,通常需要临床、影像、病理、实验室检查共同综合诊断。CT功能成像、MRI定量和成像技术及分子功能成像在纵隔诊断领域应用逐渐广泛,近年来影像组学和深度学习在纵隔肿瘤诊断及预后方面的研究日益增多。结论未来可继续将影像学检查新技术应用于纵隔肿瘤的诊断及预后方向,同时进一步探究深度学习及人工智能在纵隔的应用。

关键词：纵隔肿瘤影像诊断体层摄影术 X射线计算机磁共振成像