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An integrated virtual geographic environmental simulation framework:a case study of flood disaster simulation

Geo-Spatial Information Science 2014年第4期17卷 190-200页

作者： Yulin DING Qing zhu Hui LIN State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanChina Institute of Space and Earth Information Science The Chinese University of Hong KongHong KongChina Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengduChina

Dynamic flood disaster simulation is an emerging and promising technology significantly useful in urban planning,risk assessment,and integrated decision support *** is still an important issue to integrate the large assets such as dynamic observational data,numerical flood simulation models,geographic information technologies,and computing resources into a unified *** the intended end user,it is also a holistic solution to create computer interpretable representations and gain insightful understanding of the dynamic disaster processes,the complex impacts,and interactions of disaster *** particular,it is still difficult to access and join harmonized data,processing algorithms,and models that are provided by different environmental information *** this paper,we demonstrate a virtual geographic environments-based integrated environmental simulation framework for flood disaster management based on the notion of interlinked resources,which is capable of automated accumulating and manipulating of sensor data,creating dynamic geo-analysis and three-dimensional visualizations of ongoing geo-process,and updating the contents of simulation models representing the real *** prototype system is evaluated by applying it as a proof of concept to integrate in situ weather observations,numerical weather and flood disaster simulation models,visualization,and analysis of the real time flood *** applications indicate that the developed framework can be adopted for use by decision-makers for short-term planning and control since the resulting simulation and visualization are completely based on the latest status of environment.

关键词： flood virtual geographic environments(VGE) dynamic data driven active simulation geo-model and geo-data integration

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Average Fidelity of Teleportation in Quantum Noise Channel

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Communications in Theoretical Physics 2006年第5期45卷 802-806页

作者： HAO Xiang ZHANG Rong zhu Shi-Qun School of Physical Science and Technology Suzhou University Suzhou 215006 China

The effects of amplitude damping in quantum noise channels on average fidelity of quantum teleportation are analyzed in Bloeh sphere representation for every stage of teleportation. When the quantum channels are varied from maximally entangled states to non-maximally entangled states, it is found that the effects of noise channels on the fidelity are nearly equivalent to each other for strong quantum noise. The degree of damage on the fidelity of non-maximally entangled channels is smaller than that of maximally entangled channels. The average fidelity of values larger than 2/3 may be one representation indirectly showing how much the unavoidable quantum noise is.

关键词： average fidelity teleportation quantum noise channel Bloch sphere

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Photothermal/matrix metalloproteinase-2 dual-responsive gelatin nanoparticles for breast cancer treatment

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Acta Pharmaceutica Sinica B 2021年第1期11卷 271-282页

作者： Xiaojie Chen Jiafeng Zou Ke Zhang Jingjing zhu Yue Zhang Zhihong zhu Hongyue Zheng Fanzhu Li Ji-Gang Piao College of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Libraries of Zhejiang Chinese Medical University Zhejiang Chinese Medical UniversityHangzhou 310053China

The chemotherapy combined with photothermal therapy has been a favorable approach for the treatment of breast *** present study,nanoparticles with the characteristics of photothermal/matrix metalloproteinase-2(MMP-2)dual-responsive,tumor targeting,and size-variability were designed for enhancing the antitumor efficacy and achieving"on-demand"drug release *** on the thermal sensitivity of gelatin,we designed a size-variable gelatin nanoparticle(GNP)to encapsulate indocyanine green(ICG)and doxorubicin(DOX).Under an 808 nm laser irradiation,GNP-DOX/ICG responded photothermally and swelled in size from 71.58?4.28 to 160.80?9.51 nm,which was beneficial for particle retention in the tumor sites and release of the loaded ***,GNP-DOX/ICG showed a size reduction of the particles to 33.24?4.11 nm and further improved drug release with the degradation of overexpressed MMP-2 in *** the subsequently performed in vitro experiments,it was confirmed that GNP-DOX/ICG could provide a therapeutic effect that was enhanced and ***,GNP-DOX/ICG could efficiently suppress the growth of 4 T1 tumor in *** conclusion,this study may provide a promising strategy in the rational design of drug delivery nanosystems based on gelatin for chemo-photothermal therapy to achieve synergistically enhanced therapeutic efficacy against breast cancer.

关键词： Breast cancer Gelatin Indocyanine green Doxorubicin Nanoparticle Size-variable Chemoephotothermal therapy MMP-2

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Editorial for a special issue“Nano energy materials and devices for miniaturized electronics and smart systems”

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Nano Materials Science 2021年第2期3卷 105-106页

作者： Feng zhu Oliver G.Schmidt Changchun Institute of Applied Chemistry China Leibniz IFW DresdenGermany Chemnitz Chemnitz University of Technology Germany

The Smart Era urgently demands small-size, low-energy consuming and multi-functional devices which can satisfy versatile application scenarios, including autonomous systems, wireless sensor networks,biomedical equipment, wearable gadgets, and the Internet of *** overwhelming trend has drawn much attention and stimulates intensive collaborative efforts spanning diverse fundamental and applied research related to energy generation-harvesting-storage-managementapplications at the small scale. For instance, on one hand.

关键词： energy smart versatile

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AoATG5 plays pleiotropic roles in vegetative growth,cell nucleus development,conidiation,and virulence in the nematode-trapping fungus Arthrobotrys oligospora

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Science China(Life Sciences) 2022年第2期65卷 412-425页

作者： Duanxu Zhou Yingmei zhu Na Bai Le Yang Meihua Xie Jiangliu Yang Meichen zhu Ke-Qin Zhang Jinkui Yang State Key Laboratory for Conservation and Utilization of Bio-Resources and Key Laboratory for Microbial Resources of the Ministry of Education Yunnan UniversityKunming 650091China School of Life Sciences Yunnan UniversityKunming 650091China

Autophagy is an evolutionarily conserved process in eukaryotes,which is regulated by autophagy-related genes(ATGs).Arthrobotrys oligospora is a representative species of nematode-trapping(NT)fungi that can produce special traps for nematode *** elucidate the biological roles of autophagy in NT fungi,we characterized an orthologous Atg protein,AoAtg5,in *** found that AoATG5 deletion causes a significant reduction in vegetative growth and conidiation,and that the transcript levels of several sporulation-related genes were significantly downregulated during sporulation *** addition,the cell nuclei were significantly reduced in theΔAoATG5 mutant,and the transcripts of several genes involved in DNA bio-synthesis,repair,and ligation were significantly ***ΔAoATG5 mutants,the autophagic process was significantly impaired,and trap formation and nematocidal activity were significantly *** transcriptome analysis results showed that AoAtg5 is involved in the regulation of multiple cellular processes,such as autophagy,nitrogen metabolism,DNA biosynthesis and repair,and vesicular *** summary,our results suggest that AoAtg5 is essential for autophagy and significantly contributes to vegetative growth,cell nucleus development,sporulation,trap formation,and pathogenicity in ***,thus providing a basis for future studies focusing on related mechanisms of autophagy in NT fungi.

关键词： Arthrobotrys oligospora autophagy-related gene AoATG5 phenotypic traits transcriptome analysis sporulation cell nucleus development

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Brief Communications:QTLNetworkR:an interactive R package for QTL visualization

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第7期11卷 512-515页

作者： Wen-jun ZHENG Jian YANG Jun zhu Institute of Bioinformatics Zhejiang University Hangzhou 310029 China Queensland Institute of Medical Research Brisbane Queensland 4006 Australia

QTLNetworkR is an R package that aims to provide a user-friendly and platform-independent tool to visualize quantitative trait loci (QTL) mapping results. The graphical functions of the QTLNetworkR are based upon lattice and grid packages, and the graphical user interface (GUI) of the QTLNetworkR is built upon RGtk2 and gWidgetsRGtk2 packages. Six functions are designed to help visualize marker interval, putative QTL, QTL-by- environment interactions, marker interval interactions, epistasis, and the predicted genetic architecture of complex traits. It is especially helpful in profiling results for multiple traits at multiple environments. The current version of QTLNetworkR is able to accept QTL mapping results from QTLNetwork, and it is ready for possible extensions to import results from some other QTL mapping software packages. In addition, we presented a QTL mapping result in rice (Oryza sativa) as an example to describe the features of QTLNetworkR.

关键词： Visualization Quantitative trait loci (QTL) QTL mapping R package QTLNetworkR

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金属有机骨架基固相萃取-高效液相色谱法检测水产品中5种氟喹诺酮类药物残留

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食品科学 2025年第3期46卷 222-229页

作者：牛灿杰叶素丹朱千聪胡玉霞浙江经贸职业技术学院

采用溶剂热法合成新型金属有机骨架材料UiO-66-NH2，建立基于UiO-66-NH2的固相萃取-高效液相色谱同时检测水产品中5种氟喹诺酮类药物残留的方法。样品经体积分数1.0%甲酸-乙腈溶液提取，正己烷脱脂，提取液旋蒸浓缩后，采用pH 8.0的氨... 详细信息

采用溶剂热法合成新型金属有机骨架材料UiO-66-NH2，建立基于UiO-66-NH2的固相萃取-高效液相色谱同时检测水产品中5种氟喹诺酮类药物残留的方法。样品经体积分数1.0%甲酸-乙腈溶液提取，正己烷脱脂，提取液旋蒸浓缩后，采用pH 8.0的氨水溶液复溶，经装有30 mg UiO-66-NH2的固相萃取柱富集净化，6 mL 20%乙酸-甲醇溶液洗脱，氮吹近干复溶后，利用高效液相色谱-荧光检测器检测。在建立的实验条件下，5种FQs在0.005～0.50 mg/L范围内线性关系良好，决定系数（R2）为0.999 9～1.0，回收率为81.4%～104.8%，相对标准偏差为1.29%～4.93%，检出限为0.21～2.05μg/kg。制备的固相萃取柱可重复使用达5次，绿色环保、经济成本低，所建立的方法具有良好的准确度、精密度、重现性及选择性，适用于水产品中多种痕量氟喹诺酮类药残的同时检测。

关键词：金属有机骨架固相萃取高效液相色谱水产品氟喹诺酮类药物

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Creating burdock polysaccharide-oleanolic acid-ursolic acid nanoparticles to deliver enhanced anti-inflammatory effects:fabrication,structural characterization and property evaluation

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Food Science and Human Wellness 2023年第2期12卷 454-466页

作者： Shanshan zhu Zhichang Qiu Xuguang Qiao Geoffrey I.N.Waterhouse Wenqing zhu Wenting Zhao Qiuxia He Zhenjia Zheng Key Laboratory of Food Processing Technology and Quality Control of Shandong Higher Education Institutes College of Food Science and EngineeringShandong Agricultural UniversityTai’an 271018China The School of Chemical Sciences The University of AucklandAuckland 1025New Zealand Institute of Agri-food Processing and Nutrition Vegetable Research CenterBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China Biology Institute Qilu University of Technology(Shandong Academy of Sciences)Jinan 250103China

This study explored the potential of polysaccharides from Actium lappa(ALPs)as natural wall materials for producing ALP-based nanoparticles to deliver poorly water-soluble oleanolic acid(OA)and ursolic acid(UA).Encapsulating OA+UA with ALPs(ALP:OA+UA,50:1;OA:UA,1:1)changed the crystalline nature to a more amorphous state through hydrogen bonding and involving O-H/C-O/O-C-O ***-OA/UA nanoparticles had a particle size and zeta potential(in water)of 199.1 nm/-7.15 mV,with a narrow unimodal size distribution,and excellent pH,salt solution,temperature and storage *** with ALPs,ALPOA/UA nanoparticles showed enhanced anti-inflammatory activity(especially at a dose of 100μg/mL)in a CuSO-induced zebrafish inflammation model via down-regulating the NF-κB signalling pathway and gene expression of associated transcription factors and cytokines(TNF-α,IL-1βand IL-8).Therefore,ALP-based nanoparticles are natural and anti-inflammatory carriers for hydrophobic bioactive molecules.

关键词： Encapsulation Structural features Particle size Zeta potential Thermodynamic properties In vivo verification

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A New Fifth-Order Finite Volume Central WENO Scheme for Hyperbolic Conservation Laws on Staggered Meshes

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Advances in Applied Mathematics and Mechanics 2022年第5期14卷 1059-1086页

作者： Shengzhu Cui Zhanjing Tao Jun zhu State Key Laboratory of Mechanics and Control of Mechanical Structures and Key Laboratory of Mathematical Modelling and High Performance Computing of Air Vehicles(NUAA) MIITNanjing University of Aeronautics and AstronauticsNanjingJiangsu 210016China School of Mathematics Jilin UniversityChangchunJilin 130012China

In this paper,a new fifth-order finite volume central weighted essentially non-oscillatory(CWENO)scheme is proposed for solving hyperbolic conservation laws on staggered *** high-order spatial reconstruction procedure using a convex combination of a fourth degree polynomial with two linear polynomials(in one dimension)or four linear polynomials(in two dimensions)in a traditional WENO fashion and a time discretization method using the natural continuous extension(NCE)of the Runge-Kutta method are applied to design this new fifth-order CWENO *** new finite volume CWENO scheme uses the information defined on the same largest spatial stencil as that of the same order classical CWENO schemes[37,46]with the application of smaller number of unequal-sized spatial *** the new nonlinear weights are adopted,the new finite volume CWENO scheme could obtain the same order of accuracy and get smaller truncation errors in L1 and L¥norms in smooth regions,and control the spurious oscillations near strong shocks or contact *** new CWENO scheme has advantages over the classical CWENO schemes[37,46]on staggered meshes in its simplicity and easy extension to *** one-dimensional and two-dimensional benchmark numerical examples are provided to illustrate the good performance of this new fifthorder finite volume CWENO scheme.

关键词： Finite volume scheme central WENO scheme NCE of Runge-Kutta method staggered mesh

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Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1αpathway

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Bioactive Materials 2024年第3期33卷 444-459页

作者： Fengtian Sun Yuntong Sun Xiaoling Wang Junyan zhu Shenyuan Chen Yifan Yu Mengyao zhu Wenrong Xu Hui Qian Jiangsu Key Laboratory of Medical Science and Laboratory Medicine Department of Laboratory MedicineSchool of MedicineJiangsu UniversityZhenjiang212013JiangsuChina Department of Clinical Laboratory Affiliated Jinhua HospitalZhejiang University School of MedicineJinhua321000ZhejiangChina Department of Laboratory Medicine Zhongshan Hospital(Xiamen)Fudan UniversityXiamen361006FujianChina NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology&Shanghai Key Laboratory of Embryo and Reproduction Engineering Shanghai200040China

Diabetic retinopathy(DR)is a leading cause of blindness worldwide with limited treatment *** stem cell-derived small extracellular vesicles(MSC-sEVs)hold promise as a cell-free therapy for retinal *** this study,we present evidence that the intravitreal injection of MSC-sEVs improved retinal function and alleviated retinal apoptosis,inflammation,and angiogenesis in both db/db mice and streptozotocin-induced diabetic ***,hyperglycemia-induced activation of hypoxia-inducible factor-1α(HIF-1α)inhibited the tripartite motif 21(TRIM21)-mediated ubiquitination and degradation of enhancer of zeste homologue 2(EZH2),ultimately resulting in the downregulation of peroxisome proliferator-activated receptor-γcoactivator-1α(PGC-1α)through EZH2-induced methylation *** presence of miR-5068 and miR-10228 in MSC-sEVs targeted the HIF-1α/EZH2/PGC-1α*** blockade of miR-5068 and miR-10228 abolished the retinal therapeutic effects of ***,we engineered MSC-sEVs with elevated levels of miR-5068 and miR-10228 to enhance retinal repair ***,our findings provide novel insights into the mechanism underlying DR progress and highlight the potential of MSC-sEVs,especially engineered MSC-sEVs,as a therapeutic option for DR.

关键词： Small extracellular vesicles Diabetic retinopathy Mesenchymal stem cell MiRNA Engineering

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