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Decentralized Adaptive Control of a Class of Discrete-time Nonlinear Hidden-Leader Follower Multi-agent Systems 36

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Decentralized Adaptive Control of a Class of Discrete-time N...

梯度稀释标准加入在FIA分光光度法中的应用

第36届中国控制会议

作者： Xinghong Zhang Hongbin ma jiannan Wang School of Automation Beijing Institute of Technology

ISBN: (纸本)9781538629185

In this paper,decentralized adaptive control is investigated for a class of discrete-time nonlinear hidden leaderfollower multi-agent *** from the conventional leader-follower multi-agent system,among all the agents,there exists a hidden leader that knows the desired reference trajectory,while the follower agents know neither the desired reference signal nor who is a *** dynamics of each agent is described by the nonlinear discrete-time auto-regressive model with unknown parameters,and each agent is intrinsically nonlinearly coupled with its neighbors through history *** order to deal with the uncertainties and nonlinearity,a projection algorithm is applied to identify *** on the certainty equivalence principle in adaptive control theory,the control law for the hidden leader agent is designed to track the desired reference signal,and the local control law for each follower agent is designed using neighborhood history *** the decentralized adaptive control,the hidden leader agent is shown to track the desired reference signal successfully,all the follower agents follow the hidden leader agent,and the closed-loop system eventually achieves strong synchronization under uncertain strong *** the end,the simulation results show the validity of the proposed scheme of decentralized adaptive control.

关键词： Decentralized Adaptive Control Discrete-time System Nonlinear Multi-agent System Hidden Leader System Identification

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分析仪器 1989年第2期 50-53页

作者：杨建男马成龙王忠厚于冬梅辽宁大学化学系

根据FIA梯度稀释技术建立了一种新的标准加入方法,只需要注入一种标准溶液,就能形成浓度梯度。本方法流路简单,使用手动进样阀。使用UV分光光度计,用本法测定标准试样中的铁和锰,取得了满意的结果。每小时可测试60个样品。

关键词：梯度稀释分光光度分析 FIA 铁锰

Geology,Mineralogy,and Isotopic Characteristics of the Zhonghe Ag-Pb-Zn Deposit,Western Henan Province,Central China

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Journal of Earth Science 2022年第1期33卷 177-192页

作者： jiannan Xu Changqian ma Shuo Yin Yunzhen Chang Huimin Jia Zhongjie Wang Liangliang Shi State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of GeosciencesWuhan 430074China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China No.1 Institute of Geological and Mineral Resources Survey Henan Bureau of Geo-Exploration&Mineral DevelopmentLuoyang 471000China

Located in Luoning County,western Henan Province,Central China,the Zhonghe Ag-Pb-Zn ore field,is a newly discovered deposit in the Xiaoshan *** bodies controlled by NNW Faults occur as veins within the Paleoproterozoic Xiong’er Group or the Early Cretaceous porphyritic *** that the Zhonghe deposit has been covered by thick Quaternary sediments,the paragenetic mineral assemblage was determined mainly by microscopic observations,including the quartzsiderite-pyrite alteration (StageⅠ),polymetallic sulfide precipitation (StageⅡ),silver mineralization(Stage Ⅲ),and quartz-carbonate stage (StageⅣ).The host minerals for silver are diverse,such as freibergite,pyrargyrite,polybasite,argyrodite,canfieldite,argentite,and native silver,whereas those for Pb and Zn are galena and sphalerite,*** order to constrain the ore-forming components of the Zhonghe deposit,a combined in-situ analysis was conducted on represented sulfides from StageⅡand Stage Ⅲ.In-situ δ^(34)S values of the analyzed sulfides,including the pyrite,chalcopyrite,sphalerite,and galena,display a relatively narrow range (0.90‰-5.0‰),which is close to magmatic sulfur *** ^(206)Pb/^(204)Pb and^(207)Pb/^(204)Pb ratios show a narrow range (17.140-17.360 and 15.385-15.490),whereas the ^(208)Pb/^(204)Pb ratios exhibit a broad variation (36.601-37.943),indicating a contamination of the Xiong’er *** of geochronological and geochemical data from the Xiaoshan District,we contend that the ore-forming materials of the Zhonghe Ag-Pb-Zn deposit are originated from the lower crust,which has presumably been influenced by the large-scale lithospheric delamination of the eastern North China Craton during the Early *** consideration of the geological setting,mineralogy,and geochemical compositions,we suggest that the Zhonghe Ag-Pb-Zn deposit is characterized as intermediate sulfidation type epithermal deposit,and may be a potential exploration target for porphyry Mo-Cu deposi

关键词： S-Pb isotopes Ag-Pb-Zn deposit metal source isotopes ore deposit geology

不同轮作模式对桔梗生长、根际土壤微生物及土壤酶活性的影响

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生物资源 2024年第2期46卷 126-133页

作者：刘鹏飞王晓琴张美茜张薇麻剑南于娟贾鑫内蒙古医科大学药学院内蒙古呼和浩特010110

为研究不同轮作模式对桔梗根际土壤微生物及土壤酶活性的影响,从土壤微生态角度探寻一种无公害防治桔梗连作障碍的方式,以二年生桔梗为试材,采用盆栽试验的方法,以桔梗-桔梗(JG-JG)为对照,研究了桔梗-北沙参(JG-SS)、桔梗-玉米(JG-YM)... 详细信息

为研究不同轮作模式对桔梗根际土壤微生物及土壤酶活性的影响,从土壤微生态角度探寻一种无公害防治桔梗连作障碍的方式,以二年生桔梗为试材,采用盆栽试验的方法,以桔梗-桔梗(JG-JG)为对照,研究了桔梗-北沙参(JG-SS)、桔梗-玉米(JG-YM)、桔梗-防风(JG-FF)和桔梗-牛膝(JG-NX)不同轮作模式下对桔梗生长及土壤微生物和土壤酶活性的影响,分析筛选出桔梗的最优轮作模式。研究发现,JG-YM和JG-NX轮作模式下桔梗各生物量指标均优于其他处理;通过不同轮作种植模式对桔梗根际土壤微生物数量的影响研究发现,JG-SS、JG-YM、JG-NX、JG-FF细菌数量高于桔梗连作处理;JG-YM和JG-FF整体放线菌数量变化高于桔梗连作处理;JG-YM和JG-NX真菌数量与桔梗连作处理相比增长最为缓慢。通过不同轮作种植模式对桔梗根际土壤酶活性的影响研究发现,JG-NX的脲酶、蔗糖酶和纤维素酶活性高于其他四种处理。通过测定不同轮作模式下的桔梗生物量、桔梗根际土壤微生物数量和土壤酶活性,表明桔梗与牛膝或玉米轮作种植能改善种植土壤环境,缓解桔梗的连作障碍,可为桔梗的规范化种植奠定基础。

关键词：桔梗轮作生物量土壤微生物数量土壤酶活性

医药院校课程思政改革背景下中药生物技术课程教学实践探讨

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中国中医药现代远程教育 2020年第8期18卷 174-174,I0001,F0004页

作者：贾鑫张传领岳鑫张英麻剑南于娟王晓琴内蒙古医科大学药学院内蒙古呼和浩特010110

开展"课程思政"对高校实现立德树人的人才培养目标具有重要意义。本文以"中药生物技术"课程为例,分析了目前内蒙古医科大学中药资源与开发专业本科生的"中药生物技术"课程的教学现状及开展课程思政的必要性,就实施"中药生物技术"课程"... 详细信息

开展"课程思政"对高校实现立德树人的人才培养目标具有重要意义。本文以"中药生物技术"课程为例,分析了目前内蒙古医科大学中药资源与开发专业本科生的"中药生物技术"课程的教学现状及开展课程思政的必要性,就实施"中药生物技术"课程"课程思政"教学改革进行了探讨,从教学目标的设置、教学理念的转变、思政元素的挖掘、教学手段的多元化、教学效果的评价等方面探讨专业课如何思政及思政的教学价值,实现立德树人的教学效果。

关键词：中药生物技术课程思政教学改革

新疆特殊环境下寻常型银屑病Th1/Th2及Th17/Treg细胞失衡的研究

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中国中西医结合皮肤性病学杂志 2021年第5期20卷 461-466页

作者：王惠琳谭红陈文俊王欢马健楠张伟伟李佳佳新疆军区总医院新疆维吾尔自治区乌鲁木齐830000

目的探讨辅助性T细胞(Th)1/Th2,Th17/调节性T细胞(Treg)2组细胞轴在新疆特殊环境下寻常型银屑病(PV)患者中失衡表达。方法流式细胞仪检测89例PV患者及25例健康对照者辅助性T细胞(Th)1、Th2、Th17和Treg的比例,密度梯度磁性分选Treg后使... 详细信息

目的探讨辅助性T细胞(Th)1/Th2,Th17/调节性T细胞(Treg)2组细胞轴在新疆特殊环境下寻常型银屑病(PV)患者中失衡表达。方法流式细胞仪检测89例PV患者及25例健康对照者辅助性T细胞(Th)1、Th2、Th17和Treg的比例,密度梯度磁性分选Treg后使用流式液相多重蛋白定量技术(CBA)测定所有样本外周血血浆中白细胞介素(IL)-2、IL-6、IL-17A、干扰素(IFN)-γ荧光强度(MFI);同时用酶联免疫吸附测定(ELISA)法检测患者IL-10及血清转化生长因子(TGF)-β1的水平。结果PV患者外周血Th1、Th17比例、Th1/Th2、IL-2、IFN-γ、IL-6、IL-17A的MFI均显著高于正常对照组(P0.05)。结论Th1/Th2及Th17/Treg轴的失衡可能在新疆高原高寒特殊环境下的PV的发病及进展中发挥着重要作用。

关键词：银屑病辅助性T细胞1 辅助性T细胞2 辅助性T细胞17 调节性T细胞特殊环境(高原高寒缺氧)

High-Affinity Decoy PD-1 Mutant Screened from an Epitope-Specific Cell Library

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Engineering 2021年第11期7卷 1557-1565页

作者： Hao Liu Chunxia Qiao Naijing Hu Zhihong Wang Jing Wang jiannan Feng Beifen Shen Yuanfang ma Longlong Luo State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijing 100850China Joint National Laboratory for Antibody Drug Engineering The First Affiliated HospitalSchool of MedicineHenan UniversityKaifeng 475004China School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjing 210009China

Immunotherapy with anti-programmed cell death protein-1(PD-1)/programmed cell death ligand-1(PDL1)monoclonal antibodies has become routine in the treatment of many kinds of human cancers,such as lung cancer,intestinal cancer,and *** PD-1/PD-L1 pathway inhibits T cell activation in the micro-environment,making it an attractive target against ***-type(WT)PD-1 ectodomain has been shown to have difficulty blocking PD-1/PD-L1 mixture formation due to its low *** present work uses three-dimensional(3D)crystal complex structures to analyze the interaction by which PD-1 binds to PD-L1 or *** also reports on a theoretical study of the binding mode between PD-1 and its clinical antibody *** on the theoretical binding analysis of PD-1 and its ligands(i.e.,PD-L1 and PD-L2)or antibody(Opdivo),a small-content,epitope-oriented mammalian cell library was established for *** three rounds of cell sorting,the decoy PD-1 mutant 463,which presented a higher affinity than WT PD-1 to the PD-L1(the affinity has increased by almost three orders of magnitude)was screened *** exhibited an inhibitory effect against PD-1 to prevent it from forming mixtures with PD-L1,which was similar to the effect of the commercial anti-PD-L1 antibody atezolizumab(ATE).The median effective concentration(EC50)value of the decoy mutant was 0.031 μg·mL^(-1) in comparison with 0.063 μg·mL^(-1) for ATE;both values were much lower than that of WT PD-1,at 2.571 μg·mL^(-1).The 463 decoy mutant reversed the inhibitory function of PD-1 in T cell activation;furthermore,10 mg·kg^(-1) of 463 inhibited about 75%of tumor growth in vivo in a MC38 transgenic xenograft mice model,which was similar to the activity of *** interestingly,an even lower dose of 463(2 mg·kg^(-1))showed a better effect than 10 mg·kg^(-1) of WT *** work offers the decoy 463 with an improved curative effect,which holds potential to become a good option against PD-1/PD-L1-related cancers.

关键词： Decoy PD-1 PD-L1 mammalian cell library Epitope-oriented

组蛋白去乙酰化酶3对恒定型自然杀伤性T细胞发育和功能的调控作用

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吉林大学学报（医学版） 2020年第2期46卷 205-213页

作者：郑全辉雷冰袁鸿儒马剑楠刘兆基张郡刘倚博张冰张爱红郑爱华张颖李会婷田枫河北省慢性疾病重点实验室河北省唐山市慢性病基础研究重点实验室华北理工大学基础医学院免疫学系河北唐山063210 河北医科大学第三医院骨外科河北石家庄050051 河北省唐山市工人医院ICU 河北唐山063000 北京大学医学部实验动物科学部北京100191

目的:探讨组蛋白去乙酰化酶3(HDAC3)缺失对恒定型自然杀伤性T细胞(iNKT)数量、发育表型和细胞因子产生功能的影响,确定HDAC3在iNKT细胞发育和功能发挥中的调控作用。方法:采用T细胞特异的hdac3基因敲除(HDAC3KO)及其野生型正常对照(WT)... 详细信息

目的:探讨组蛋白去乙酰化酶3(HDAC3)缺失对恒定型自然杀伤性T细胞(iNKT)数量、发育表型和细胞因子产生功能的影响,确定HDAC3在iNKT细胞发育和功能发挥中的调控作用。方法:采用T细胞特异的hdac3基因敲除(HDAC3KO)及其野生型正常对照(WT)小鼠,每种小鼠各取3~5只,分离小鼠胸腺、脾脏、淋巴结和肝脏淋巴细胞,采用细胞表面抗体染色和流式细胞术检测HDAC3对iNKT细胞数量和发育表型的变化,实验至少重复3次。采用HDAC3KO小鼠及其同系***小鼠,每种小鼠各取4~6只;提取以上2种小鼠骨髓细胞,混合后经尾静脉注入经γ射线照射的***小鼠,以制备骨髓混合嵌合体模型,8周后流式细胞术检测不同骨髓来源iNKT细胞在胸腺的产生和发育,实验重复3次。选取HDAC3KO和WT小鼠,每种各取小鼠3~5只;采用iNKT细胞特异激活剂半乳糖神经酰胺腹腔注射4 h后,收集各组小鼠脾脏淋巴细胞和血清,分别采用细胞内染色、流式细胞术和酶联免疫吸附实验(ELISA)法检测HDAC3作用下iNKT细胞因子水平,实验至少重复3次。结果:与WT小鼠比较,HDAC3KO小鼠胸腺和外周免疫器官中iNKT细胞比例和数量均明显降低(P<0.05),且HDAC3KO小鼠胸腺iNKT细胞中CD44-NK1.1-和CD44+NK1.1-细胞比例明显升高(P<0.05),而CD44+NK1.1+、CD122+、CD69+和DX5+细胞比例明显降低(P<0.05)。骨髓混合嵌合体实验,与正常***小鼠来源的骨髓细胞比较,来源于HDAC3KO小鼠的骨髓细胞产生的iNKT细胞数量明显减少(P<0.05),同时iNKT细胞中CD44+NK1.1+细胞比例也明显降低(P<0.05)。细胞因子胞内染色和ELISA法检测,与WT小鼠比较,HDAC3KO小鼠iNKT细胞和血清中IFN-γ和IL-4水平均明显降低(P<0.05)。结论:HDAC3缺失通过内源性机制导致iNKT细胞数量减少,细胞发育成熟受阻;同时HDAC3缺失导致iNKT细胞因子产生功能明显降低。提示HDAC3在iNKT细胞的发育和功能发挥中具有重要调控作用。

关键词：组蛋白去乙酰化酶3 恒定型自然杀伤性T细胞细胞发育细胞功能

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思政教育融入药用植物栽培学教学的探索

中国中医药现代远程教育 2020年第18期18卷 152-154页

作者：岳鑫刘德旺张英于娟贾鑫徐晶光麻剑南王晓琴包保全内蒙古医科大学药学院内蒙古呼和浩特010110

药用植物栽培学是中药资源与开发专业的主干课程,课程内容是学生从事中药材人工种植、引种驯化、田间管理、生产加工的必备知识。本文从思想和认知角度分析学生对药用植物栽培学课程不感兴趣的原因,并探讨思政教育融入药用植物栽培学课... 详细信息

药用植物栽培学是中药资源与开发专业的主干课程,课程内容是学生从事中药材人工种植、引种驯化、田间管理、生产加工的必备知识。本文从思想和认知角度分析学生对药用植物栽培学课程不感兴趣的原因,并探讨思政教育融入药用植物栽培学课程产生的积极作用,包括:增强学生对中医药的认可和信心;激发学生对专业精神的追求;培养学生艰苦朴素的优良作风。

关键词：思政教育中药资源与开发药用植物栽培学教学改革