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lncRNA AC005224.4/miR-140-3p/SNAI2 regulating axis facilitates the invasion and metastasis of ovarian cancer through epithelial-mesenchymal transition

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Chinese Medical Journal 2023年第9期136卷 1098-1110页

作者： Tingchuan Xiong Yinghong Wang yuan Zhang jianlin yuan Changjun Zhu Wei Jiang Department of Gynecologic Surgery The Third Affiliated Teaching Hospital of Xinjiang Medical University(Affiliated Cancer Hospital)XinjiangUrumqi 830011China Center of Heath Management the First Affiliated Hospital of Xinjiang Medical UniversityXinjiangUrumqi 830011China Department of Clinical Laboratory The Third Affiliated Teaching Hospital of Xinjiang Medical University(Affiliated Cancer Hospital)XinjiangUrumqi 830011China Laboratory of Molecular and Cellular Systems Biology College of Life ScienceTianjin Normal UniversityTianjin 300387China Tianjin Key Laboratory of Animal and Plant Resistance College of Life SciencesTianjin Normal UniversityTianjin 300387China The Third Affiliated Teaching Hospital of Xinjiang Medical University(Affiliated Cancer Hospital) XinjiangUrumqi 830011China State Key Laboratory of Molecular Oncology National Cancer center Cancer HospitalChinese Academy of Medical SciencesBeijing 100021China

Background:Ovarian cancer is one of the most widespread malignant diseases of the female reproductive system *** plurality of ovarian cancer is diagnosed with metastasis in the abdominal ***-mesenchymal transition(EMT)exerts a vital role in tumor cell ***,it remains unclear whether long non-coding RNA(lncRNA)are implicated in EMT and influence ovarian cancer cell invasion and *** study was designed to investigate the impacts of lncRNA AC005224.4 on ovarian ***:LncRNA AC005224.4,miR-140-3p,and snail family transcriptional repressor 2(SNAI2)expression levels in ovarian cancer and normal ovarian tissues were determined using real-time quantitative polymerase chain reaction(qRT-PCR).Cell Counting Kit-8(CCK-8)and Transwell(migration and invasion)assays were conducted to measure SKOV3 and CAOV-3 cell proliferation and metastasis.E-cadherin,N-cadherin,Snail,and Vimentin contents were detected using Western *** mouse xenograft assay was utilized to validate AC005224.4 effects in ***-luciferase reporter gene assay confirmed the targeted relationship between miR-140-3p and AC005224.4 or ***:AC005224.4 and SNAI2 upregulation and miR-140-3p downregulation were observed in ovarian cancer tissues and *** of AC005224.4 observably moderated SKOV3 and CAOV-3 cell proliferation,migration,invasion,and EMT process in vitro and impaired the tumorigenesis in ***-140-3p was a target of AC005224.4 and its reduced expression level was mediated by ***-140-3p mimics decreased the proliferation,migration,and invasion of ovarian cancer ***2 was identified as a novel target of miR-140-3p and its expression level was promoted by either AC005224.4 overexpression or miR-140-3p *** of SNAI2 also facilitated ovarian cancer cell viability and ***:AC005224.4 was confirmed as an oncogene via sponging miR-140-3p and promoted SNAI2 expression,contrib

关键词： Epithelial-mesenchymal transition LncRNA AC005224.4 Ovarian cancer miR-140-3p Tumor metastasis

Mutually exclusive epigenetic modification on SIX6 with hypermethylation for precancerous stage and metastasis emergence tracing

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2683-2686页

作者： Shihua Dong Zhicong Yang Peng Xu Wanxiang Zheng Baolong Zhang Fangqiu Fu Zhanrui Mao jianlin yuan Haiquan Chen Wenqiang Yu Shanghai Epiprobe Biotechnology Co. LtdShanghaiChina Shanghai Public Health Clinical Center&Department of General Surgery Huashan Hospital&Cancer Metastasis Institute&Institutes of Biomedical SciencesShanghai Medical CollegeFudan UniversityShanghaiChina Department of Urology Xijing HospitalAir Force Medical UniversityXi’anShaanxiChina Department of Thoracic Surgery Fudan University Shanghai Cancer Center&Institute of Thoracic Oncology&State Key Laboratory of Genetic EngineeringFudan UniversityShanghaiChina

Dear Editor,Aberrant DNA methylation gets involved in cancer initiation,progression,and recurrence,which in turn makes it an ideal cancer *** methylation markers or their panels have been developed in diverse cancer ***,the model-constructing based marker mining strategy and incompatibility of application have greatly impeded their ways to ***,single methylation marker applicable to all/most cancer types and multiple clinical scenarios is desperately *** hope came from the unexpected observation that HIST1H4F was universally hypermethylated in all 17 cancer types;thus,we raised the concept of“Universal Cancer Only Marker(UCOM)”and established a paradigm for discovery and clinical application of UCOM.1 Recently,a novel UCOM,hypermethylated PCDHGB7,was identified and found to advance cervical cancer(CC)screening to the precancerous stage.2 During the screening of UCOM,we discerned a bunch of cancer cell-differentially methylated regions.1 Among them,sine oculis(SIX)homeobox family of transcription factors,which were found to function as tumorigenesis regulator by promoting epithelial-to-mesenchymal transition and metastasis recently in addition to their traditional roles in tissue formation and organogenesis,3 sparked our special ***,we interrogate whether SIX6 methylation could serve as a novel UCOM and its potential applications.

关键词： metastasis precancerous raised

我国基础教育评价制度的结构、问题及完善路径

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中国考试 2022年第1期 53-62页

作者：袁建林熊颖湖南大学教育科学研究院长沙410082

基础教育评价制度是基础教育评价活动所需遵循的特定行为准则和规范。依据制度基础、功能与形式考察我国基础教育评价制度结构,可将其划分为督导评估制度、质量监测制度、升学考试制度和常态化教学评价制度4种类型。当前基础教育评价制... 详细信息

基础教育评价制度是基础教育评价活动所需遵循的特定行为准则和规范。依据制度基础、功能与形式考察我国基础教育评价制度结构,可将其划分为督导评估制度、质量监测制度、升学考试制度和常态化教学评价制度4种类型。当前基础教育评价制度存在一些问题,未能适应基础教育改革与发展的需要,主要表现为制度共识的异化、评价制度的内部动力不足、评价制度的多元性不足、制度功能迷失、外部评价制度不健全。为完善我国基础教育评价制度,要着力反思制度的建构逻辑,从促进形成基础教育评价的多重社会共识、激活评价制度的内在活力、优化评价制度的形式与内容、改善评价制度的外部环境等方面着手。

关键词：基础教育评价评价制度教育评价改革外部评价第三方评价

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核心素养测量:理论依据与实践指向

教育研究 2017年第7期38卷 21-28,36页

作者：袁建林刘红云北京师范大学教育学部(中国基础教育质量监测协同创新中心) 北京师范大学心理学院

从教育测量的视角考量,核心素养是一类高度抽象、结构复杂的高阶能力,超越了知识和一般能力的范畴,传统教育测量范式的应用面临着极大挑战。核心素养测量需要教育测量理论、方法、技术的系统性革新。在理论层面,需要以"证据中心的设计"(... 详细信息

从教育测量的视角考量,核心素养是一类高度抽象、结构复杂的高阶能力,超越了知识和一般能力的范畴,传统教育测量范式的应用面临着极大挑战。核心素养测量需要教育测量理论、方法、技术的系统性革新。在理论层面,需要以"证据中心的设计"(ECD)理论为依据,围绕"基于证据进行推理"的核心思想进行测验设计与开发。在实践层面,要充分利用信息技术工具,提供动态性、交互性的测验环境,建构复杂的任务情境,获取复杂、详尽、类型多样的测验数据。此外,复杂数据中的测量证据提取是关键,由此需要清晰定义证据规则,合理利用自动化证据抽取方法,从复杂数据中获取推论学生核心素养的证据。

关键词：核心素养教育测量方法证据中心的设计

合作问题解决能力测量:真实性与过程性评价视角

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电化教育研究 2022年第5期43卷 100-108页

作者：袁建林刘红云湖南大学教育科学研究院湖南长沙410082 北京师范大学心理学部北京100875

合作问题解决能力是一种复杂的高阶技能,其有效测量面临困境。文章遵循真实性与过程性评价理念,尝试建构全新教育测验形式,探索合作问题解决能力有效测量的方法与过程。首先,基于真实性评价理念建构真实任务情境,开发具有真实性、交互... 详细信息

合作问题解决能力是一种复杂的高阶技能,其有效测量面临困境。文章遵循真实性与过程性评价理念,尝试建构全新教育测验形式,探索合作问题解决能力有效测量的方法与过程。首先,基于真实性评价理念建构真实任务情境,开发具有真实性、交互性、动态性的测验任务。其次,获取学生在测验任务中的过程性表现,从过程数据中提取有意义的行为模式作为观测指标,以此形成合作问题解决能力的测量证据。再次,鉴于“两人交互”的合作形式和三种观测指标并存的项目结构,应用两维度Rasch模型进行测验分析和估计学生能力。模型拟合结果显示测验项目的MNSQ值处于0.87~1.34之间,项目的整体分离度为0.981,大部分项目的区分度大于0.3,学生能力分布符合一般实际,表明测量模型拟合较好,测验项目质量较高。研究结果说明基于真实任务与过程性测验表现测量合作问题解决能力是一种可行的途径,这种新测验形式对复杂技能的有效测量具有重要借鉴意义。

关键词：合作问题解决能力测量真实性评价过程性评价

合作问题解决能力的测评:PISA2015和ATC21S的测量原理透视

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外国教育研究 2016年第12期43卷 45-56页

作者：袁建林刘红云北京师范大学教育学部北京100875 北京师范大学心理学院北京100875

如何利用技术测量高阶能力,是当前国际教育测评领域研究的前沿课题。PISA2015和ATC21S分别利用"人机交互"的方法和"人人交互"的方法测量了学生的合作问题解决能力。"人机交互"基于会话代理技术,将项目嵌入学生与代理的对话过程,获取学... 详细信息

如何利用技术测量高阶能力,是当前国际教育测评领域研究的前沿课题。PISA2015和ATC21S分别利用"人机交互"的方法和"人人交互"的方法测量了学生的合作问题解决能力。"人机交互"基于会话代理技术,将项目嵌入学生与代理的对话过程,获取学生的项目反应,推断其潜在能力。"人人交互"实时记录两名学生合作完成任务过程中的对话与关键行为,形成过程流数据,利用评分算法从过程流数据中抽取证据推断学生的潜在能力。合作问题解决能力的测评为我国教育测评领域的发展提供了以下思考:加快发展基于计算机的测评技术,加强对高阶能力的测评研究,改进测评的功能。

关键词：合作问题解决测量方法 PISA2015 ATC21S

澳大利亚基础教育质量监测数字化测试改革的实践特征及经验启示

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中国考试 2023年第8期 75-84页

作者：袁建林李紫晴湖南大学长沙410082

数字化测试导致测验形式的根本性变化,深刻影响着教育质量监测的功能与形态。澳大利亚读写与算术能力评估项目(National Assessment Program-Literacy and Numeracy,NAPLAN)自2022年起全面实施数字化测试。与纸笔测试相比,NAPLAN数字化... 详细信息

数字化测试导致测验形式的根本性变化,深刻影响着教育质量监测的功能与形态。澳大利亚读写与算术能力评估项目(National Assessment Program-Literacy and Numeracy,NAPLAN)自2022年起全面实施数字化测试。与纸笔测试相比,NAPLAN数字化测试改革具有5个显著特征:1)采用自适应测试模式;2)开发技术增强型试题;3)应用自动评分技术;4)及时反馈垂直等值的结果报告;5)不断完善基础技术准备和组织流程。NAPLAN数字化测试的改革经验对我国基础教育质量监测的未来发展具有4点重要启示:1)全面开发数字化测试;2)采用计算机自适应测试;3)建立学科垂直发展量尺;4)强化基础教育监测的改进功能。

关键词：基础教育质量监测 NAPLAN 数字化测试教育评价改革澳大利亚

Prospective clinical studies at the efficacy of brucea javanica oil,mitomycin and BCG for preventing postoperative relapse of superficial bladder cancer through perfusion

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The Chinese-German Journal of Clinical Oncology 2011年第4期10卷 228-231页

作者： Fuli Wang Weijun Qin Geng Zhang Yuntao Zhang Heliang Liu Lijun Yang He Wang jianlin yuan Department of Urology Xijing Hospital The Fourth Military Medical University Xi＇an 710032 China

Objective:The aim of this study was to evaluate the effects and safety of brucea javanica oil,mitomycin and BCG for preventing postoperative relapse of superficial bladder cancer through ***:From July 2000 to May 2006,178 patients with primary superficial bladder cancer(Ta-1,G1-2) were divided into three groups after operation in random:57 patients in group A received perfusion of 60 mL 10% brucea javanica oil,and 66 patients in group B received perfusion of 20 mg mitomycin while 55 patients in group C received perfusion of 120 mg *** perfusions per patient were carried out regularly a week after *** were followed up for clinical,analytical and cystoscopic evaluations every 3 months for 2 *** tumor relapse rates and side effects after treatment were ***:The relapse rate was 14.04%(8/57),34.85%(23/66) and 18.18%(10/55) in group A,B and C *** relapse rate in group A was obviously lower than that in group B(χ2 = 6.17,P < 0.05).Disease free interval in group A was significantly different from that in group B(F = 7.03,P < 0.05).Side effect in group A(12.28%) was observably lower than that in group B(43.94%) and group C(83.64%)(χ2AB = 15.72,P < 0.01;χ2AC = 55.34,P < 0.01).Conclusion:Perfusion of 10% brucea javanica oil after operation is safer and more effective in preventing superficial bladder tumour relapse and worth for popularizing.

关键词： bladder cancer drug therapy perfusion regional cancer relapse local

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学校增值评价:模型择优与实践进路

教育发展研究 2024年第2期44卷 16-24页

作者：袁建林唐瑞希罗仲尤湖南大学教育科学研究院长沙410006

增值评价模型的选用是学校增值评价的关键,已有理论与实践未能就此形成定论。模型比较是确定最优模型的基本思路。本研究遵从异质性模型比较逻辑,提出以增值测度结果的一致性、模型预测精度和增值测度结果的跨时间稳定性作为模型比较指... 详细信息

增值评价模型的选用是学校增值评价的关键,已有理论与实践未能就此形成定论。模型比较是确定最优模型的基本思路。本研究遵从异质性模型比较逻辑,提出以增值测度结果的一致性、模型预测精度和增值测度结果的跨时间稳定性作为模型比较指标,对多元线性回归模型、多水平线性回归模型和多水平分位数回归模型进行比较。综合模型特点与比较结果,依据模型选择策略,发现多水平分位数回归模型是学校增值评价较为理想的模型。反思学校增值评价实践,要警惕测度方法的科学性隐患、评价内容的片面性以及新的“唯分数”问题。推进学校增值评价实践健康发展,要进一步优化增值测度的精确性与稳定性,把握好学校增值评价的实践策略,拓展学校增值评价内容,开展实质性学校增值评价,以此达成学校增值评价的原本意图。

关键词：学校增值评价增值评价模型选择增值评价实践