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帕博利珠单抗联合白蛋白结合型紫杉醇和铂类一线治疗复发转移性头颈部鳞癌:一项前瞻性Ⅱ期临床研究

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中华耳鼻咽喉头颈外科杂志 2024年第4期59卷 321-328页

作者：陈馨蕊谢祖成鲁海珍杨建良桂琳国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院内科、抗肿瘤分子靶向药物临床研究北京市重点实验室北京100021 国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院病理科北京100021

目的评价帕博利珠单抗联合白蛋白结合型紫杉醇和铂类一线治疗复发/转移性头颈部鳞状细胞癌(recurrent or metastatic head and neck squamous-cell carcinoma,R/M HNSCC)患者的疗效和安全性。方法本研究为前瞻性、单臂、开放、Ⅱ期临床... 详细信息

目的评价帕博利珠单抗联合白蛋白结合型紫杉醇和铂类一线治疗复发/转移性头颈部鳞状细胞癌(recurrent or metastatic head and neck squamous-cell carcinoma,R/M HNSCC)患者的疗效和安全性。方法本研究为前瞻性、单臂、开放、Ⅱ期临床研究,纳入中国医学科学院肿瘤医院即将接受晚期一线治疗的R/M HNSCC患者,进行帕博利珠单抗联合白蛋白结合型紫杉醇和顺铂或卡铂方案治疗;治疗6周期,疾病获得控制的患者继续帕博利珠单抗维持治疗至疾病进展或出现不可耐受的毒性或完成共35周期的治疗。主要研究终点为客观缓解率,次要研究终点包括总生存期、无进展生存期和安全性指标。按实体瘤疗效评价标准1.1版进行疗效评价,生存分析采用Kaplan-Meier法,不良事件采用美国国家癌症研究所不良事件通用术语标准5.0版进行评估。结果2021年4月23日至2023年3月22日共纳入30例R/M HNSCC患者,其中男性28例,女性2例,中位年龄为67岁。中位随访时间为14.5个月,客观缓解率为70.0%,疾病控制率为96.7%,中位无进展生存期和总生存期分别为11.6个月和18.8个月,中位缓解持续时间为17.3个月。≥3级的治疗相关不良事件包括白细胞减少(26.7%)、中性粒细胞减少(26.7%)、外周神经毒性(3.3%)、皮疹(3.3%)、肾上腺皮质功能减退(3.3%)和免疫相关性肺炎(3.3%);最常见的免疫相关不良事件是甲状腺功能减退(40.0%)。结论帕博利珠单抗联合白蛋白结合型紫杉醇和铂类方案一线治疗中国R/M HNSCC患者初步显示出较好的抗肿瘤活性和良好的耐受性。

关键词：头颈部肿瘤癌,鳞状细胞帕博利珠单抗白蛋白结合型紫杉醇铂类

PhaseⅠdose-finding study of sorafenib with FOLFOX4 as firstline treatment in patients with unresectable locally advanced or metastatic gastric cancer

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Chinese Journal of Cancer Research 2015年第3期27卷 239-246页

作者： Yihebali Chi jianliang yang Sheng yang Yongkun Sun Bo Jia Yuankai Shi Department of Medical Oncology Cancer HospitalChinese Academy of Medical Sciences & Peking Union Medical College National Center for Anticancer Drugs Clinical Study Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs

Objective： To determine the maximum tolerated dose（MTD）, dose-limiting toxicity（DLT） and efficacy of sorafenib in combination with FOLFOX4（oxaliplatin/leucovorin（LV）/5-fluorouracil） as first-line treatment for advanced gastric cancer, we performed a phase I dose-finding study in nine evaluable patients with unresectable locally advanced or metastatic gastric cancer or gastroesophageal junction adenocarcinoma. Methods： According to modified Fibonacci method, the design of this study was to guide elevation of the sorafenib dosage to the next level（from 200 mg twice daily to 400 mg twice daily and then, if tolerated, 600 mg twice daily）. If the patient achieved complete response（CR）, partial response（PR） or stable disease（SD） after eight cycles of treatment, combination chemotherapy was scheduled to be discontinued and sorafenib monotherapy continued at the original dose until either disease progression or unacceptable toxicity. Results： In sorafenib 200 mg twice daily group, DLT was observed in 1 of 6 patients, and in 400 mg twice daily group, it was observed in 2 of 3 patients. Seven of 9（77.8%） evaluable patients achieved PR, with a median overall survival（OS） of 11.8 [95% confidence interval（CI）： 8.9-14.7] months. Common adverse effects include hand-foot syndrome, leukopenia, neutropenia, anorexia, and ***： Twice-daily dosing of sorafenib 200 mg in combination with FOLFOX4 was proven effective and safe for the treatment of advanced gastric cancer, and could be an appropriate dosage for subsequent phase II clinical studies.

关键词： Sorafenib gastric cancer FOLFOX4

Piecewise Acoustic Source Imaging with Unknown Speed of Sound Using a Level-Set Method

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1070-1095页

作者： Guanghui Huang jianliang Qian yang yang Petroleum Geo-Services HoustonTX 77079USA Department of Mathematics Michigan State UniversityEast LansingMI 48824USA Department of Computational Mathematics Science and EngineeringMichigan State UniversityEastLansingMI48824USA

We investigate the following inverse problem:starting from the acoustic wave equation,reconstruct a piecewise constant passive acoustic source from a single boundary temporal measurement without knowing the speed of *** the amplitudes of the source are known a priori,we prove a unique determination result of the shape and propose a level set algorithm to reconstruct the *** the singularities of the source are known a priori,we show unique determination of the source amplitudes and propose a least-squares fitting algorithm to recover the source *** analysis bridges the low-frequency source inversion problem and the inverse problem of *** proposed algorithms are validated and quantitatively evaluated with numerical experiments in 2D and 3D.

关键词： Inverse gravimetry Acoustic source imaging Inversion of sound speed Level-set method Inverse problem

基于全生命周期理论的半钢子午线轮胎环境影响

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环境工程学报 2024年第6期18卷 1754-1764页

作者：辛春林姜博雯张月萌刘士雄李岩韩冬礼祁学智杨建亮北京化工大学经济管理学院北京100029 北化中国工业碳中和研究院北京100029 河南省水务规划设计研究有限公司郑州450001 北京化工大学材料科学与工程学院北京100029 中国橡胶工业协会废橡胶综合利用分会南京210018

轮胎产业作为传统制造行业,在创造巨大经济效益的同时,也带来了巨大的环境问题。为了分析轮胎产业的潜在环境影响,寻找轮胎的减排减能潜力,基于全生命周期理论,以半钢子午线轮胎为研究对象,考虑轮胎生产、运输、使用直至废轮胎利用的生... 详细信息

轮胎产业作为传统制造行业,在创造巨大经济效益的同时,也带来了巨大的环境问题。为了分析轮胎产业的潜在环境影响,寻找轮胎的减排减能潜力,基于全生命周期理论,以半钢子午线轮胎为研究对象,考虑轮胎生产、运输、使用直至废轮胎利用的生命周期闭环全过程,建立碳排放模型和能量消耗模型,并构建回收利用阶段的碳减排—削减清单和能量排放—削减清单,对比分析废轮胎连续低温热解、间歇低温热解和催化裂解的碳减排量、碳减排率、净碳盈余指标和能量削减量、能量削减率、净能量盈余指标。结果表明:1 t轮胎在整个生命周期中,共计消耗了3.52×10^(5) MJ一次能源,排放了1.01×10^(4) kg二氧化碳;在轮胎整个生命周期中,运输和使用阶段的碳排放量以及能量消耗最大。针对轮胎各阶段环境影响分析,可知轮胎生产阶段关键碳排放元素包括炭黑、电、合成橡胶以及钢丝帘线等;关键能源消耗元素包括合成橡胶、炭黑以及蒸汽等;3种资源利用方式中连续低温热解的碳回收效果最好,催化裂解的能量回收效果最好;再生回收物是废轮胎碳削减和能量削减的最主要的贡献来源。

关键词：半钢子午线轮胎生命周期热解碳减排能量削减

Theoretical Analysis of Critical period in Microbend Fiberoptic Sensor

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光通信技术 1997年第4期 271-275页

作者： yang jianliang Xiang Qing Huang Dexiu（Huazhong University of science and Technology Wuhan 430074）

The simple， intuitive ray-tracing is used to analyze microbend fiberoptic *** Is presented in this paper that the critical period of microbend fiberoptic sensor is the spatial repeat distance of rays with maximum entrance angle traveling in optical fibers，and this conclusion is coincident with the complicated coupled-mode theoretical analysis and experimental results．

关键词： Optical fiber sensor Microbend optical fiber Critical period

Autologous peripheral blood stem cell mobilization following dose-adjusted cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy alone or in combination with rituximab in treating high-risk non-Hodgkin's lymphoma

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Chinese Journal of Cancer 2015年第11期34卷 522-530页

作者： Yuankai Shi Ping Zhou Xiaohong Han Xiaohui He Shengyu Zhou Peng Liu jianliang yang Changgong Zhang Lin Gui Yan Qin Sheng yang Liya Zhao Jiarui Yao Shuxiang Zhang Department of Medical Oncology Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs

Background: The regimen of cyclophosphamide, doxorubicin, vincristine, and prednisolone(CHOP) is an eicient treatment of non-Hodgkin's lymphoma(NHL). This study aimed to assess the eicacy and toxicity of dose-adjusted CHOP alone or in combination with rituximab(R-CHOP) by examining the stem cell mobilization in NHL patients. Factors afecting the collection of CD34+ cells were also ***: Our retrospective study included 39 patients eligible for autologous stem cell transplantation: 14 patients who expressed CD20 and were inancially eligible received R-CHOP for autologous peripheral blood stem cell(APBSC) mobilization; the remaining 25 patients received ***: The median CD34+ cell yield was 7.01 × 106 cells/kg body weight(range 1.49–28.39 × 106 cells/kg body weight), with only two patients failing to meet the target CD34+ cell harvest of ber of apheresis procedures per patient was 1(range 1–3). The≥2.0 APBS× 106 cells/kg body weight. The median numC mobilization yield of the CHOP group appeared to be higher than that of the R-CHOP group(P response(CR) rate in = 0.005), whereas the success rate was similar between groups. R-CHOP elevated the completeB cell lymphoma patients as compared with CHOP(P = 0.01). No signiicant diferences in toxicity or engraftment were observed between the two ***: The present study demonstrated that dose-adjusted CHOP chemotherapy efectively mobilized APBSCs in NHL patients and that the addition of rituximab to dose-adjusted CHOP chemotherapy elevated the CR rate for patients with B-cell lymphoma.

关键词： Stem cell transplantation, Mobilization, CHOP regimen, Rituximab, Non-Hodgkin's lymphoma

Distributed Event-triggered Control for Frequency Restoration in Islanded Microgrids with Reduced Trigger Condition Checking

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CSEE Journal of Power and Energy Systems 2024年第5期10卷 2156-2165页

作者： Yulin Chen Donglian Qi Zhenming Li Zhenyu Wang Xinyi yang jianliang Zhang College of Electrical Engineering Zhejiang UniversityHangzhou 310027China

For islanded microgrids(MGs),distributed control is regarded as a preferred alternative to centralized control for the frequency restoration of ***,distributed control with successive communication restricts the efficiency and resilience of the control *** address this issue,this paper proposes a distributed event-triggered control strategy for the frequency secondary control in islanded *** proposed event-triggered control is Zeno behavior free and enables each DG to update and propagate its state to neighboring DGs only when a specific“event”occurs,which significantly reduces the communication *** with the existing event-triggered control,a trigger condition checking period of the proposed event-triggered control is provided to reduce the computation burden when checking the trigger ***,using the aperiodicity and intermittent properties of the communication,a simple detection principle is proposed to detect and isolate the compromised communication links in a timely and economic fashion,which improves the resilience of the system against FDI ***,the control effectiveness of the proposed control scheme is validated by the simulation results of the tests on an MG with 4 DGs.

关键词： Distributed control event-triggered control islanded microgrid secondary control

Pathobiology of ovarian carcinomas

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Chinese Journal of Cancer 2015年第1期34卷 50-55页

Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. We report herein the newly described molecular abnormalities in epithelial ovarian cancers(carcinomas). Immunohistochemistry and molecular testing help pathologists to decipher the significant heterogeneity of this disease. Our better understanding of the molecular basis of ovarian carcinomas represents the first step in the development of targeted therapies in the near future.

关键词：卵巢癌病理学卵巢肿瘤上皮细胞分子检测生殖细胞免疫组化靶向治疗

Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP

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Cancer Biology & Medicine 2022年第6期19卷 893-909页

作者： Yan Qin Haizhu Chen Peng Liu Changgong Zhang jianliang yang Lin Gui Xiaohui He Liqiang Zhou Shengyu Zhou Shiyu Jiang Hongxin Jiang Yuankai Shi Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Department of Medical Oncology Suzhou Municipal HospitalAffiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215001China

Objective:Limited data about the prognostic significance of BCL2 mutations and BCL2 copy number variations in diffuse large B-cell lymphoma(DLBCL)are *** study aimed to comprehensively describe BCL2 genetic alterations in DLBCL patients,and examine correlation of BCL2,TP53 and other genetic alterations with outcomes in patients treated with ***:Probe capture-based high-resolution sequencing was performed on 191 patients diagnosed with de novo ***,BCL2,and BCL6 protein expressions were detected by ***:The presence of BCL2 alterations significantly correlated with poor progression-free survival(PFS)(5-year PFS:13.7%vs.40.8%;P=0.003)and overall survival(OS)(5-year OS:34.0%vs.70.9%;P=0.036).Importantly,patients who harbored BCL2 gain/amplifications(BCL2GA/AMP)also had a remarkably inferior 5-year PFS(11.1%vs.38.3%;P<0.001)and OS(22.1%vs.69.6%;P=0.009).In contrast,neither BCL2 mutations nor BCL2 translocations were significantly prognostic for *** analyses showed that the presence of BCL2 alterations,especially BCL2GA/AMP,TP53 mutations,and International Prognostic Index(IPI)were significantly associated with inferior PFS and *** prognostic models for OS were constructed based on 3 risk factors,including BCL2 alterations(Model 1)or BCL2GA/AMP(Model 2),TP53 mutations,and IPI,to stratify patients into 4 risk groups with different survival ***:This study showed that DLBCL patients treated with R-CHOP,BCL2 alterations,especially BCL2GA/AMP and TP53 mutations were significantly associated with inferior outcomes,which were independent of the *** novel prognostic models we proposed predicted outcomes for DLBCL patients treated with R-CHOP,but further validation of the prognostic models is still warranted.

关键词： BCL2 TP53 genetic alterations diffuse large B-cell lymphoma prognosis