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编辑学报 2008年第5期20卷 452-453页

作者：闫建军周口师范学院学报编辑部河南周口466000

论述图形与图像的区别和联系,从编辑学角度,用点、线、面符号理论对其进行再构造。实践表明,以点、线、面符号正确区别图形与图像,分类进行扫描输入,也能满足北大方正排版系统的需要。

关键词：图形图像编辑学缔构

Pulmonary embolism after transcatheter arterial chemoembolization for hepatocellular carcinoma:a retrospective analysis on 10 years' experience

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Journal of Medical Colleges of PLA(China) 2011年第3期26卷 134-143页

作者： Li Jing yanYiqun Huang Liang yan jianjun Zhou Feiguo Zhang Xianghua Liu Caifeng Department of Hepatic Surgery I Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

To study the clinical characteristics and treatment of pulmonary embolism （PE） after transcatheter arterial chemoembolization （TACE） for hepatocellular carcinoma （HCC）. Methods： The clinical records of 13 512 patients diagnosed with HCC and received TACE from January 2000 to December 2009 were reviewed. Among these patients, 5 031 were allocated into group A who had one or more disorders like diabetes, hypertension, coronary heart disease, obesity or varicose vein of lower limb, while the other 8 481 patients who did not have such disorders were in group B. Results： A total of 39 185 TACE procedures were performed for the 13 512 patients. Five （0.01%） patients in group A developed PE after TACE, of whom two recovered 4 and 5 d later with early anticoagulant therapy while the hypertension, coronary heart disease, obesity or varicose vein of lower limb are possibly more likely to develop PE other 3 died of respiratory failure within 5 h. The mortality of PE was 60% （3/5）. Conelusion： HCC patients with diabetes, after TACE than those without such disorders. Patients who have such disorders should be more carefully observed after TACE and early treatment with heparin should be applied once PE develops.

关键词： Pulmonary embolism Transcatheter arterial chemoembolization Hepatocellular carcinoma Complication

Chronic acalculous cholecystitis:correlation of clinical assessment,laboratory data and final histopathology

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Journal of Medical Colleges of PLA(China) 2012年第2期27卷 101-112页

作者： yan jianjun Zhu Qian Shen Jun Zhou Feiguo Huang Liang Liu Caifeng Zhang Xianghua Cong Wenming yan Yiqun Department of Hepatic Surgery I Eastern Hepatobiliary Surgery Hospital Second Military Medical UniversityShanghai 200438 China

Objective:To summarize and analyze the clinical and histopathological features of chronic acalculous cholecystitis (CAC) and to investigate the diagnosis and surgical treatment of chronic acalculous ***:The study subjects were 39 patients with chronic biliary symptoms but no evidence of stones in the gallbladder by B ultrasonography and magnetic resonance cholopancreatography (MRCP) (CAC group).The CCC group consisted of 66 patients taken randomly from concurrent all patients of chronic calculous cholecystitis (CCC).All patients accepted fibergastroscopy,B ultrasonography,MRCP,laboratory examination *** retrospectively analyzed the clinical features,B ultrasonography and MRCP findings,histopathological results and clinical outcomes between the two ***:All the 39 patients were diagnosed by clinical symptoms,B ultrasonography,fatty meal gallbladder contractability studies under ultrasound,fibergastroscopy and magnetic resonance cholangiopancreatography (MRCP),what's more,they were pathologically verified *** all patients,there was a complete absence of gallbladder wall *** epithelial defect was found in 21 patients in CAC group (53.8%) and 16 patients in CCC group (24.2%) respectively (P***:Chronic acalculous cholecysti

关键词： Cholecystitis Histopathology Cholecystectomy Gallbladder contractability Magnetic resonance cholangiopancreatography

Long-term survival for spontaneous rupture of hepatocellular carcinoma treated with hepatectomy

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Journal of Medical Colleges of PLA(China) 2012年第3期27卷 161-182页

作者： Zhu Qian yan jianjun Zhang Xianghua Cao Jie Huang Liang Li Jing Shen Jun Zhou Feiguo yan Yiqun Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China

Objective- To determine the prognostic factors of ruptured hepatocellular carcinoma （HCC） and report the management of patients with spontaneous rupture of HCC in a single center during a 5-year period and to evaluate one-stage hepatectomy Methods- A series of 4,209 patients with HCC were collected at Eastern Hepatobiliary Surgery Hospital from April 2002 to November 2006, of whom 200 patients （4.8%） with ruptured HCC were studied retrospectively regarding their clinical characteristics and prognostic factors. The one-stage therapeutic approach to manage ruptured HCC consisted of initial management by conservative method, transarterial embolization （TAE） or surgical hepatectomy. Results of various treatments were evaluated and compared in the randomly selected 202 patients with no history of rupture during the same study period. Results： A total of 200 patients with spontaneous rupture of HCC were studied who underwent surgical treatment （n=105）, TAE 33 and conservative treatment （ConT 62）. A multivariate analysis using the Cox hazard regression model （including all the patients n=200） identified surgical hepatectomy as the only independent factor determining a relatively long survival period （P〈0.0001） On the other hand, in a further analysis of the patients in whom surgical hepatectomy was successfully performed （n=105）, which identified a maximum tumor size exceeding 6 cm as significant determinants of a poor 12-month （P=0.036）, and a multivariate analysis did not identify as any inverse independent factor determining relatively long-term survival, only a maximum tumor size exceeding 6 cm exhibited a tendency toward being a determinant factor （P=0.083）. Conelusionz Considering the high propensity to spontaneous rupture, as long as preoperatively clinical evaluation meet surgery requirements, elective one-stage hepatectomy for patients with ruptured HCC is the first treatment option. Prolonged survival could be achieved in selected patients with hepatic resection,

关键词： Hepatocellular carcinoma Rupture Prognosis Hepatectomy

基于子图同构与事例匹配的装配体局部结构相似性分析

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计算机辅助设计与图形学学报 2010年第2期22卷 299-305页

作者：周炜郑建荣颜建军华东理工大学机械与动力工程学院上海200237

基于事例推理是解决面向装配的设计和装配工艺规划问题的有效方法,装配体检索是应用此方法的关键步骤.为此提出一种基于子图同构与事例匹配的装配体局部结构相似性分析方法.该方法将装配体零件间的装配关系用属性邻接图来表示,通过对装... 详细信息

基于事例推理是解决面向装配的设计和装配工艺规划问题的有效方法,装配体检索是应用此方法的关键步骤.为此提出一种基于子图同构与事例匹配的装配体局部结构相似性分析方法.该方法将装配体零件间的装配关系用属性邻接图来表示,通过对装配体中联结关系的定性分类及装配体属性邻接图预处理规则的定义,利用Ullmann算法匹配出相似的装配体图(子图)结构,并给出了装配体局部结构相似度计算公式.最后通过实例验证了文中方法的有效性.

关键词：装配体模型事例匹配子图同构相似计算

Treatment of esophagogastric anastomotic leak via perianastomotic drain

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Treatment of esophagogastric anastomotic leak via perianasto...

中国第九届全国食管癌学术会议

作者： Qin jianjun,Li Yin,yan Ming,Wang Guolei,,Zhang Ruixiang

＜正＞Objective:Our objective was to evaluate the effectiveness of a novel method of perianastomotic drain via ***:The most efficient treatment of such leaks remains controversial and there is no standard management of gastroesophageal anastomotic *** the conservative approach,perianastomotic drain is very useful..Methods:We undertook a retrospective review of 5 patients who developed anastomotic leakage,out of 324 patients undergoing oesophagectomy with gastric *** 5 patients had placement of perianastomotic drain via *** other conservative method of treatment was chosen, consisted of absence of oral intake,naso-gastric suction drainage,enteral feeding（via a naso-jejunal tube） and continued antibiotic ***:The perianastomotic drains were placed successfully in all 5 *** of the patients underwent *** were all *** median period to clinical healing was 33 days（range,23-49 days;mean,36.6days）. The median hospital stay after the perianastomotic drainage procedure in the 5 patients was 37 days（range,28-55 days）.Conclusion:This procedure proved to be safe,and effective in the treatment of esophagogastric anastomotic leaks with perianastomotic drain via *** of the infected material is the most important aspect of treatment.

关键词： Esophagectomy Anastomotic leak Perianastomotic drain

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完善防震减灾法律机制的立法建议

理论导刊 2009年第3期 95-97页

作者：杨建军吉林大学法学院长春130012

四川汶川大地震后的抗震救灾实践启示我们,防震减灾立法应当注重法律机制的完善、法律条文的细化,提高法律的可操作性。完善防震减灾立法应当做到:完善预防机制,建立地震的官方观测、预报与民间观测、预报相结合的体制;促进信息的公开... 详细信息

四川汶川大地震后的抗震救灾实践启示我们,防震减灾立法应当注重法律机制的完善、法律条文的细化,提高法律的可操作性。完善防震减灾立法应当做到:完善预防机制,建立地震的官方观测、预报与民间观测、预报相结合的体制;促进信息的公开与透明、建立救灾款物信息披露制度,加强对于救灾物资的法律监管、审计监督、行政检查等。此外,还应当提高震后建筑物的重建标准,强化建筑标准的执行,加强对于救灾志愿者的招募与管理。同时,应当加快相关配套法律的完善,建立较系统的防震减灾法律机制。

关键词：防震减灾预防法律机制法律监督法律责任

Expanding the targeting scope of CRISPR/Cas9-mediated genome editing by Cas9 variants in Brassica

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aBIOTECH 2024年第2期5卷 202-208页

作者： Wenjing Li Xuan Li Chunyang Wang Guanzhong Huo Xinru Zhang Jintai Yu Xiaoxiao Yu Jing Li Chao Zhang jianjun Zhao yan Li Jun Li State Key Laboratory of North China Crop Improvement and Regulation College of Life SciencesHebei Agricultural UniversityBaoding 071001China Hebei Key Laboratory of Plant Physiology and Molecular Pathology Hebei Agricultural UniversityBaoding 071001China Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei Collaborative Innovation Center of Vegetable Industry in HebeiCollege of HorticultureHebei Agricultural UniversityBaoding 071001China College of Modern Science and Technology Hebei Agricultural UniversityBaoding 071001China

CRISPR/Cas9,presently the most widely used genome editing technology,has provided great potential for functional studies and plant ***,the strict requirement for a protospacer adjacent motif(PAM)has hindered the application of the CRISPR/Cas9 system because the number of targetable genomic sites is ***,the engineered variants Cas9-NG,SpG,and SpRY,which recognize non-canonical PAMs,have been successfully tested in plants(mainly in rice,a monocot).In this study,we evaluated the targeted mutagenesis capabilities of these Cas9 variants in two important Brassica vegetables,Chinese cabbage(Brassica rapa ***)and cabbage(Brassica oleracea ***).Both Cas9-NG and SpG induced efficient mutagenesis at NGN PAMs,while SpG outperformed Cas9-NG at NGC and NGT *** achieved efficient editing at almost all PAMs(NRN>NYN),albeit with some self-targeting activity at transfer(T)-DNA *** SpRY-induced mutants were detected in cabbage plants in a PAM-less ***,an adenine base editor was developed using SpRY and TadA8e deaminase that induced A-to-G conversions within target sites using non-canonical ***,the toolboxes developed here induced successful genome editing in Chinese cabbage and *** work further expands the targeting scope of genome editing and paves the way for future basic research and genetic improvement in Brassica.

关键词： Brassica Cas9 variants CRISPR Genome editing Non-canonical PAM

Design and synthesis of tri-substituted pyrimidine derivatives as bifunctional tumor immunotherapeutic agents targeting both A2A adenosine receptors and histone deacetylases

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Chinese Chemical Letters 2024年第1期35卷 295-299页

作者： Ruiquan Liu Wenwen Duan Wenzhong yan Jinfeng Zhang jianjun Cheng iHuman Institute ShanghaiTech UniversityShanghai 201210China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

The A_(2A)adenosine receptor(A_(2A)AR)has attracted attention as an emerging immunotherapeutic target with several antagonists being evaluated in clinical ***,A_(2A)AR antagonists show limited efficacy as ***,we communicate our design and synthesis of a novel series of A_(2A)AR/histone deacetylase(HDAC)bifunctional inhibitors,based on the core structure of the A_(2A)AR antagonist The new compounds were designed using a pharmacophore-merging strategy and features a tri-substituted pyrimidine *** binding affinity for A_(2A)AR and inhibitory activity against HDACs of all the new compounds were tested.A number of compounds exhibited nanomolar or subnanomolar activity against both targets and some showed equally potent antiproliferative activity against MC38,CT26 and HCT116 colon cancer lines compared to HDAC inhibitors SAHA and MGCD-0103 in *** binding poses of compound 5a in both A_(2A)AR and HDAC1 were predicted by molecular docking ***,these results suggest these tri-substituted pyrimidine derivatives are promising leads for developing A_(2A)AR/HDAC dual-acting compounds as novel antitumor agents.

关键词： Bifunctional A_(2A)AR antagonism HDAC inhibition Cancer Immunotherapy

资源、环境双重约束下的湖南省产业生态化发展路径

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经济地理 2017年第6期37卷 183-189页

作者：颜建军徐雷李扬湖南商学院湖南省"2011两型社会与生态文明"协同创新中心中国湖南长沙410205

运用向量协整关系分析、脉冲响应分析方法,借助湖南省1995—2014年的宏观经济统计数据,从资源约束条件和环境约束条件两个视角,探讨湖南产业生态化的发展路径。实证分析表明:(1)从资源约束的视角来看,湖南省的能源消费、产业结构升级与... 详细信息

运用向量协整关系分析、脉冲响应分析方法,借助湖南省1995—2014年的宏观经济统计数据,从资源约束条件和环境约束条件两个视角,探讨湖南产业生态化的发展路径。实证分析表明:(1)从资源约束的视角来看,湖南省的能源消费、产业结构升级与经济增长之间具有长期相对稳定的均衡关系,尽管湖南经济发展水平的提高是以较高的能源消耗为代价,但经济发展水平的提高带来的产业结构升级有助于降低能源消耗。综合比较来看,湖南能源消费的"高碳"刚性特征依旧明显;(2)从环境约束的视角来看,湖南在"三废"治理方面,废水治理取得的成效最为显著,工业固体废物治理取得的成效其次,而工业废气的治理成效却并不十分明显。从研究结论来看,产业生态化发展是湖南省突破资源环境约束实现可持续发展的必然选择。因此提出提高煤炭加工转化效率、构建生态工业园区、发挥生态产业价值链的协同效应等政策建议。

关键词：绿色发展产业生态化资源约束环境约束发展路径