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Prompt and precise identifcation of various sources of infection in response to the prevention of malaria re-establishment in China

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Infectious Diseases of Poverty 2022年第2期11卷 97-97页

作者： jianhai Yin He Yan Mei Li National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Center for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghai 200025China

Prompt and precise diagnosis of patients is an essential component of malaria control and elimination strategies,it is even more vital for the prevention of malaria re-establishment in the post elimination *** eliminating malaria in China,the strategy for prevention of malaria re-establishment was updated in a timely manner from the elimination strategy focusing on each case/focus to the prevention of re-establishment focusing on timely identifcation of the source of ***,there are numerous challenges,such as the persistent large number of imported malaria cases,the long-term threat of border malaria,unknown levels of asymptomatic infections and Plasmodium falciparum HRP2/3 gene deletions,and the continuous spreading of antimalarial drug ***,the detection capacity also need to be further improved to meet the timely detection of all sources of infection,otherwise it is bound to occur introduced malaria cases and malaria re-establishment in the presence of malaria vector ***,it is necessary to continuously strengthen the malaria detection competency at all levels,promote the research and development on the malaria parasitological testing technologies,thus improving the timely detection of various sources of infection,and preventing the re-establishment of malaria.

关键词： Malaria Re-establishment Diagnosis Laboratory competency Quality control

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尼龙化工废水深度处理及回用

工业水处理 2014年第10期34卷 81-82,87页

作者：屈建海河南神马尼龙化工有限公司河南平顶山467000

为改善废水资源回用率低的现状,某尼龙化工有限公司采用"固定化微生物曝气滤池(3T-BAF)+混凝沉淀+砂滤+消毒"的处理工艺对尼龙化工生产废水进行深度处理并回用。结果表明,该工艺运行稳定,产水各项指标均满足该公司对回用水的要求,具有... 详细信息

为改善废水资源回用率低的现状,某尼龙化工有限公司采用"固定化微生物曝气滤池(3T-BAF)+混凝沉淀+砂滤+消毒"的处理工艺对尼龙化工生产废水进行深度处理并回用。结果表明,该工艺运行稳定,产水各项指标均满足该公司对回用水的要求,具有显著的环境效益。

关键词：尼龙化工废水固定化微生物曝气滤池工艺混凝沉淀砂滤消毒回用

Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1

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hLife 2024年第10期2卷 527-541页

作者： Qi Pan Xiaomin Xing jianhai Yu Qiang Chen Haizhan Jiao Wanqin Zhang Yingfen Wen Ming Gao Wei Zhao Lei Yu Hongli Hu Kobilka Institute of Innovative Drug Discovery School of MedicineThe Chinese University of Hong KongShenzhenGuangdongChina Guangzhou Eighth People’s Hospital Guangzhou Medical UniversityGuangdongChina BSL-3 Laboratory(Guangdong) Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangdongChina

Antibodies targeting non-structural protein 1(NS1)confer protection against Zika virus(ZIKV).Although monoclonal an-tibodies(MAbs)3G2 and 4B8 are more potent than MAb 4F10 in suppressing ZIKV infection in neonatal mice models,the epitopes are ***,we determined the Cryo-electron microscopy(Cryo-EM)structures of ZIKV NS1 in com-plex withﬁve human antibodies at 2.6–2.9Å*** I antibodies(3G2 and 4B8)recognize the previously un-reported epitopes on the outer surface of the NS1 *** unique binding mode of Group I antibodies led to a stronger recognition of the cell surface form of NS1 and completely inhibited secreted form non-structural protein 1(sNS1)-induced endothelial permeability via their immunoglobulin G(IgG)and *** II antibodies(4F10,2E11,and 14G5)recognize common epitopes in the distal end of the b-ladder domain,with a blockade efﬁciency that may be related to their afﬁnity for the sNS1 protein and the presence of full-length ***ﬁndings elucidate the correlation between epitope recognition and protective efﬁcacy of anti-NS1 antibodies and highlight the diagnostic and therapeutic potential of 3G2 and 4B8.

关键词： Zika virus(ZIKV) non-structural protein 1(NS1) monoclonal antibodies(MAbs) epitopes

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含有闭孔的镍基合金涂层微观结构及性能

稀有金属材料与工程 2018年第1期47卷 219-222页

作者：丁坤英于建海中国民航大学天津300300 天津市民用航空器适航与维修重点实验室天津300300

利用等离子喷涂和重熔技术制备多孔型镍基自熔性合金涂层,采用扫描电镜、显微硬度计、材料试验机、热膨胀仪等设备对涂层的微观组织、热膨胀系数和压缩过程中的力学性能进行分析。结果表明,涂层中存在封闭孔洞,大部分呈近似球形,直径在3... 详细信息

利用等离子喷涂和重熔技术制备多孔型镍基自熔性合金涂层,采用扫描电镜、显微硬度计、材料试验机、热膨胀仪等设备对涂层的微观组织、热膨胀系数和压缩过程中的力学性能进行分析。结果表明,涂层中存在封闭孔洞,大部分呈近似球形,直径在30~100μm;孔隙率由0.53%上升至30.6%时,涂层材料的弹性模量下降69.5%,弹性变形范围上升68.7%;在40~220℃的范围内,多孔涂层的平均线膨胀系数随着孔隙率的增加而下降。近球形闭孔的存在提升了原有材料的弹性变形范围,降低了热膨胀系数,使其可以实现低膨胀、高回弹的功能。

关键词：镍基合金封闭孔洞弹性模量弹性变形范围热膨胀系数

Development and application of high-precision multifunction astronomical plate digitizers in China

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Astronomical Techniques and Instruments 2024年第1期1卷 71-75页

作者： Meiting yang Yong Yu Liangliang Wang Zhengjun Shang Changshun Liu Lixin Zheng Zhendong Chen Jing yang Dongmei Da Shan Dong Shiyin Shen Zhenghong Tang jianhai Zhao Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China

Before charge-coupled device detectors became widely employed in observational astronomy,for more than a hundred years,the main detection method was photography on astronomical glass ***,in order to preserve these historical data and maintain their usability,the International Astronomical Union has appealed to all countries for global digitization of astronomical plates by developing or adopting advanced digitization *** digitizers with high precision and high measuring speed represent key equipment for this *** Shanghai Astronomical Observatory and the Nishimura Co.,Ltd in Japan cooperated between 2013 and 2016 to develop the first Chinese high-precision astronomical plate digitizer,which was then used for complete digitization of all nighttime-observation astronomical plates in ***,in 2019–2021,the Shanghai Astronomical Observatory independently developed new models of plate digitizers that enabled countries such as Uzbekistan and Italy to digitize their astronomical ***,a new high-precision and multifunction digitizer was also used to digitize valuable microscope slides from the Shanghai Natural History Museum,providing a successful example of cross-domain application of high-precision digitization technology.

关键词： Astrometry-instrumentation Detectors-methods Data analysis-techniques Image processing

A Review of Seismicity in 1997

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Earthquake Research in China 1998年第2期12卷 94-103页

作者： Ding jianhai,Liu Jie,and Yu SurongCenter for Analysis and Prediction,SSB,Beijing 100036,China

Ⅰ. SURVEY OF GLOBAL SEISMICITY A total of 23 earthquakes with M_s ≥ 7.0 occurred over the world in 1997 according to the determination of the Chinese Seismic Station Network. The strongest one was the Kamchatka peninsula earthquake (M_s 7.9, December 5, 1997) (Fig. 1). Although the frequency and strength of global seismicity was lower compared with the higher activity state in 1995 and 1996, the frequency of seismicity was still obviously higher than the average level during this century.

关键词： A Review of Seismicity in 1997

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PKI多级混合信任模型及其信任路径构建

计算机工程 2005年第14期31卷 138-140页

作者：朱建海杨树堂倪佑生上海交通大学信息安全工程学院上海200030

主要研究了PKI信任模型及其信任路径的构建。对常用的信任模型进行了简要分析,在此基础上提出了一种适合中等规模PKI需要的多级混合模型,引入嵌套证书和信任矩阵的概念,通过预验证的方法,减少用户在验证证书时需要进行的公钥运算的次数... 详细信息

主要研究了PKI信任模型及其信任路径的构建。对常用的信任模型进行了简要分析,在此基础上提出了一种适合中等规模PKI需要的多级混合模型,引入嵌套证书和信任矩阵的概念,通过预验证的方法,减少用户在验证证书时需要进行的公钥运算的次数,提高了路径寻找和证书验证的效率和速度。

关键词：公钥基础设施信任模型信仟路径构建 NPKI

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跨越新世纪的海洋生物高技术前沿

高技术通讯 2000年第7期10卷 1-4页

作者：相建海中国科学院海洋研究所青岛266071

结合我国实际 ,就新世纪海洋生物高技术前沿和应用领域进行了阐述。

关键词：海洋生物学生物工程分子学

一种280 mW,78 dB SNR,88 dB SFDR流水线ADC设计

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固体电子学研究与进展 2019年第3期39卷 220-225,234页

作者：于健海尹亮梧州学院电子与信息工程学院广西梧州543002 哈尔滨工业大学MEMS中心哈尔滨150000

为满足接收机系统的应用需求,采用标准0.18μm CMOS工艺设计实现了一款16bit高精度高速pipelined ADC,电源电压1.8V,采样频率120MHz。为了降低SHA-less结构带来的非线性问题,引入高线性输入缓冲器。测试结果表明,在不明显增加芯片功耗... 详细信息

为满足接收机系统的应用需求,采用标准0.18μm CMOS工艺设计实现了一款16bit高精度高速pipelined ADC,电源电压1.8V,采样频率120MHz。为了降低SHA-less结构带来的非线性问题,引入高线性输入缓冲器。测试结果表明,在不明显增加芯片功耗的同时能够实现较高的性能,有效位数达到13bit。输入信号57MHz,幅度-1dBFS时,SNR、SNDR、SFDR分别达到78dBFS、78dBFS、88dB;输入信号313MHz、幅度-1dBFS时,SNR、SNDR、SFDR分别达到70dBFS、70dBFS、78dB。

关键词：高精度高速流水线模数转换器无采样保持放大器非线性