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航空锂离子蓄电池组维护保障研究

化工时刊 2024年第2期38卷 1-4页

作者：钱陈吴江雪李艳峰 94783部队长兴313111 空军南京航空四站装备修理厂南京210042

针对航空锂离子蓄电池组的维护与管理需求,通过研究锂离子蓄电池工作原理、组成、功能结构,基于使用维护流程和要求,引入了一款信息化航空锂离子蓄电池组维护检测设备,重点介绍了维护检测设备的功能、结构、原理。加强航空蓄电池组的维... 详细信息

针对航空锂离子蓄电池组的维护与管理需求,通过研究锂离子蓄电池工作原理、组成、功能结构,基于使用维护流程和要求,引入了一款信息化航空锂离子蓄电池组维护检测设备,重点介绍了维护检测设备的功能、结构、原理。加强航空蓄电池组的维护管理,可有效延长蓄电池组的使用寿命,确保飞行安全。

关键词：航空锂离子蓄电池维护

机制砂制备高强度高性能混凝土的性能试验研究

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广东建材 2024年第8期40卷 46-48页

作者：何荣周勇彭华程吴江雪毕节市七星关区晶鑫建筑有限公司

为探究高强度高性能混凝土制备过程中,机制砂取代天然河砂的可行性,对机制砂制备高强度高性能混凝土的性能展开研究。结果表明,机制砂混凝土板的单位面积开裂面积为43mm^(2)/m^(2),抗裂等级达到L-V级,显著低于河砂混凝土。机制砂混凝土... 详细信息

为探究高强度高性能混凝土制备过程中,机制砂取代天然河砂的可行性,对机制砂制备高强度高性能混凝土的性能展开研究。结果表明,机制砂混凝土板的单位面积开裂面积为43mm^(2)/m^(2),抗裂等级达到L-V级,显著低于河砂混凝土。机制砂混凝土制备试件的电通量达Q-Ⅳ级,DRCM达RCM-Ⅳ级,且数值均低于河砂混凝土。河砂混凝土和机制砂混凝土抗硫酸盐等级均能够达到KS150级以上,且耐蚀系数相差不大。

关键词：高性能混凝土机制砂性能测试耐久性能

粉煤灰不同掺加方式对再生骨料混凝土弹性模量的影响研究

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广东建材 2024年第7期40卷 9-12页

作者：何荣吴江雪周勇彭华程毕节市七星关区晶鑫建筑有限公司

为探究再生混凝土复掺矿粉和粉煤灰、单掺粉煤灰下弹性模量差异,文中就粉煤灰不同掺加方式对再生骨料混凝土弹性模量的影响展开研究。结果表明,掺入再生骨料的各组混凝土试件具有低于常规混凝土的弹性模量,单掺粉煤灰后混凝土弹性模量... 详细信息

为探究再生混凝土复掺矿粉和粉煤灰、单掺粉煤灰下弹性模量差异,文中就粉煤灰不同掺加方式对再生骨料混凝土弹性模量的影响展开研究。结果表明,掺入再生骨料的各组混凝土试件具有低于常规混凝土的弹性模量,单掺粉煤灰后混凝土弹性模量进一步降低。而复掺粉煤灰与矿渣后混凝土弹性模量与粉煤灰和矿渣掺入比例有关,其中粉煤灰掺量为10%、矿渣掺量为20%时试件具有较高弹性模量。对于复掺粉煤灰和矿渣的再生混凝土,其抗压强度与弹性模量之间具有良好相关性,并通过回归计算得到经验公式。

关键词：再生骨料混凝土粉煤灰弹性模量回归分析

Expression of glucocorticoid receptor isoforms in cutaneous hemangiomas and vascular malformations

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Chinese Medical Journal 2005年第12期118卷 977-981页

作者： jiangxue-wu WANGGuang-huan LIJian-hong CHENZhong-xian HEFei DepartmentofPediatricSurgery SecondAffiliatedHospitalofShantouUniversityMedicalCollegeShantou515041China

Background Hemangiomas are the most common tumors in children. Some hemangiomas may require intervention because of their location, size, behavior, or potential for important complications. Pharmacological therapy with glucocorticoids is the mainstay treatment, but there is no consensus on therapeutic regimens or candidate selection, therapeutic efficacy vaires, and the mechanism mediating the beneficial effects of glucocorticoids remains unclear. This study was performed to investigate the expression patterns of the glucocorticoid receptor (GR) and its α isoform (GRα) in cutaneous hemangiomas and vascular *** SP immunohistochemical technique was used to examine the expression of GR(e-20) (GR) and GR (p-20) (GRα) on vascular endothelial cells in 80 specimens that included 33 proliferating hemangiomas, 32 involuting hemangiomas, 7 vascular malformations as well as 8 normal skin tissues, all obtained from infants and children. GR and GRα expression in prepared tissue slides were examined using automated computer-assisted microscopic analysis. Mean gray scale values were compared among the various tumor *** The mean gray scale values of GR were 127.0±6.4 and 121.4±6.6 in hemangiomas and vascular malformations respectively, but this difference was not statistically significant ( P =0.104). However, these values were all markedly higher than that of normal skin, which was only 108.6±6.8 ( P =0.001 and P =0.000 for comparison with hemangiomas and vascular malformations respectively). The gray scale of GR in proliferation and involuting hemangiomas were 127.9±4.8 and 126.0±5.8 respectively, but this difference was not significant ( P =0.146). However, GRα expression in hemangiomas, vascular malformations and normal skin declined gradually in stepwise fashion (127.3±5.4, 120.4±6.1 and 109.9±5.3 respectively; P <0.001). GRα expression was higher in proliferating hemangiomas than in involuting hemangiomas (127.2±6.3 and 122.5±6.3; P =0.004).Conclus

关键词： hemangioma · vascular malformation · immunohistochemistry · glucocorticoid receptor

Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells

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Chinese Journal of Cancer 2017年第12期36卷 726-736页

作者： Rong Geng Xin Tan Zhixiang Zuo jiangxue wu Zhizhong Pan Wei Shi Ranyi Liu Chen Yao Gaoyuan Wang Jiaxin Lin Lin Qiu Wenlin Huang Shuai Chen State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer MedicineSun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510507GuangdongP.R.China Department of Experimental Research Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Colorectal Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Guangdong Esophageal Cancer Institute Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Guangdong Provincial Key Laboratory of Tumor.Targeted Drugs and Guangzhou Enterprise Key Laboratory of Gene Medicine Guangzhou Doublle Bioproducts Co.Ltd.Guangzhou 510507GuangdongP.R.China

Background: The mitogen-activated extracellular signal-regulated kinase 1/2(MEK1/2) inhibitor trametinib has shown promising therapeutic effects on melanoma, but its efficacy on colorectal cancer(CRC) is limited. Synthetic lethality arises with a combination of two or more separate gene mutations that causes cell death, whereas individual mutations keep cells alive. This study aimed to identify the genes responsible for resistance to trametinib in CRC cells,using a synthetic lethal short hairpin RNA(shRNA) screening ***: We infected HT29 cells with a pooled lentiviral shRNA library and applied next-generation sequencing to identify shRNAs with reduced abundance after 8-day treatment of 20 nmol/L trametinib. HCT116 and HT29 cells were used in validation studies. Stable ring finger protein 183(RNF183)-overexpressing cell lines were generated by pcDNA4-myc/his-RNF183 transfection. Stable RNF 183-knockdown cell lines were generated by infection of lentiviruses that express RNF183 shRNA, and small interference RNA(siRNA) was used to knock down RNF183 *** real-time PCR was used to determine the mRNA expression. Western blotting, immunohistochemical analysis, and enzyme-linked immunosorbent assay(ELISA) were used to evaluate the protein abundance. MTT assay,colony formation assay, and subcutaneous xenograft tumor growth model were used to evaluate cell ***: In the primary screening, we found that the abundance of RNF183 shRNA was markedly reduced after treatment with trametinib. Trametinib induced the expression of RNF183, which conferred resistance to drug-induced cell growth repression and apoptotic and non-apoptotic cell deaths. Moreover, interleukin-8(IL-8) was a downstream gene of RNF183 and was required for the function of RNF183 in facilitating cell growth. Additionally, elevated RNF183 expression partly reduced the inhibitory effect of trametinib on IL-8 expression. Finally, xenograft tumor model showed the synerg

关键词： Synthetic lethal Colorectal cancer Ring finger protein 183 Mitogen-activated extracellular signalregulated kinase 1/2 Trametinib

Translational oncology toward benefiting cancer patients:the Sun Yat-sen University Cancer Center experience

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Science China(Life Sciences) 2016年第10期59卷 1057-1062页

作者： Mathilde Guerin Chaonan Qian Qian Zhong Qian Cui Yunmiao Guo Jinxin Bei Jianyong Shao Xiaofeng Zhu Wenlin Huang jiangxue wu Ranyi Liu Qiang Liu Jing Wang Weihua Jia Xiaohui Zheng Yixin Zeng Sun Yat-sen University Cancer Center Guangzhou 510060China

Cancer is a leading cause of death in China with an estima- tion of nearly 2 million deaths every year （Chen and Fu, 2011b）. Matter of a public health importance in China and worldwide, the scientific community is still facing many obstacles to eradicate cancer： complexity of a mul- ti-factorial disease with organ-based specificities, high fail- ure rate of many anti-cancer drugs in clinical trials, lack of understanding of the cancer genesis factors.

关键词：癌症患者中山大学肿瘤转化器官特异性多因子疾病公共卫生抗癌药物

Hartree型非线性薛定谔方程解的无条件唯一性

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杭州师范大学学报（自然科学版） 2021年第5期20卷 517-524页

作者：武江雪韩征方聪慧付雪杭州师范大学数学学院浙江杭州311121

本文主要研究了Hartree型非线性薛定谔方程解在Sobolev空间中的无条件唯一性,在证明无条件唯一性的过程中,运用了负阶Sobolev空间,非齐次Strichartz估计以及解的改善正则性.

关键词：线性薛定谔方程 Hartree型无条件唯一性负阶Sobolev空间非齐次Strichartz估计

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基于风险因素构建早产儿视网膜病变筛查模型

临床眼科杂志 2023年第3期31卷 232-237页

作者：王静李忠民郭晓慧吴姜雪陈祖凤朱俊卿陈宏伟阜阳市妇女儿童医院眼科:阜阳师范大学附属第一医院眼科 236000 阜阳师范大学

目的分析早产儿视网膜病变(ROP)的风险因素,构建列线图筛查模型并进行效能验证,为临床提供一款量化、简便的评估工具。方法回顾性病例分析。总结2020年5月至2022年5月于我院新生儿重症监护病房(NICU)初步判断为高危ROP共788例为研究对象... 详细信息

目的分析早产儿视网膜病变(ROP)的风险因素,构建列线图筛查模型并进行效能验证,为临床提供一款量化、简便的评估工具。方法回顾性病例分析。总结2020年5月至2022年5月于我院新生儿重症监护病房(NICU)初步判断为高危ROP共788例为研究对象,以3:1随机分为训练组591例和验证组197例。根据广域眼底成像系统检查结果最终确诊85例ROP,其中训练组66例和验证组19例。纳入临床因素包括孕周、剖宫产、多胎妊娠、前置胎盘、羊水污染、妊娠期高血压和糖尿病、流产史、胎儿出生体重、性别、宫内窒息、胎儿生长受限(FGR)、胎膜早破(PROM)、1 min和5 min Apgar评分、临床治疗(肺表面活性物质、机械通气、输血)、体重增加量、合并疾病(呼吸窘迫综合征、缺血缺氧性脑病、凝血障碍、支气管肺发育不良)、胎儿血清N末端-B型脑利钠肽前体(NT-proBNP)。结果首先对训练组ROP与无ROP单因素比较发现,ROP孕周和出生体重较小,1 min和5 minApgar评分降低,体重增加量减少,NT-proBNP水平升高,宫内窒息、FGR和羊水污染增多,肺表面活性物质、机械通气和输血增多,呼吸窘迫综合征、缺血缺氧性脑病、凝血障碍和支气管肺发育不良增多,差异均有统计学意义(P0.05)。决策曲线显示,训练组和验证组均有较好的临床净获益。结论本研究开发一款可视化较强的列线图模型可用于指导临床筛选高危ROP,并提供早期恰当的临床治疗,具有较好的临床价值,值得推广应用。

关键词：早产儿视网膜病变筛查列线图早产儿

A Hybrid Biofuel and Triboelectric Nanogenerator for Bioenergy Harvesting

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Nano-Micro Letters 2020年第4期12卷 53-64页

作者： Hu Li Xiao Zhang Luming Zhao Dongjie Jiang Lingling Xu Zhuo Liu Yuxiang wu Kuan Hu Ming‑Rong Zhang jiangxue Wang Yubo Fan Zhou Li Beijing Advanced Innovation Centre for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Chinese Education MinistrySchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083People’s Republic of China CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro‑Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083People’s Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Physical Education Jianghan UniversityWuhan 430056People’s Republic of China Center on Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004People’s Republic of China Department of Radiopharmaceuticals Development National Institute of Radiological SciencesNational Institutes for Quantum and Radiological Science and TechnologyChiba 263‑8555Japan

Various types of energy exist everywhere around us,and these energies can be harvested from multiple sources to power micro-/nanoelectronic system and even personal electronic *** this work,we proposed a hybrid energy-harvesting system(HEHS)for potential in vivo *** HEHS consisted of a triboelectric nanogenerator and a glucose fuel cell for simultaneously harvesting biomechanical energy and biochemical energy in simulated body *** two energy-harvesting units can work individually as a single power source or work simultaneously as an integrated *** design strengthened the flexibility of harvesting multiple energies and enhanced corresponding electric *** with any individual device,the integrated HEHS outputs a superimposed current and has a faster charging *** the harvested energy,HEHS can power a calculator or a green light-emitting diode *** the widely existed biomechanical energy and glucose molecules in the body,the developed HEHS can be a promising candidate for building in vivo self-powered healthcare monitoring system.

关键词： Self-powered Triboelectric nanogenerator Glucose fuel cell Hybrid energy harvester Bioenergy