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维普期刊数据库博看期刊

Protective mechanism of Coprinus comatus polysaccharide on acute alcoholic liver injury in mice,the metabolomics and gut microbiota investigation

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Food Science and Human Wellness 2024年第1期13卷 401-413页

作者： jinyan Yu jianguang Sun Min Sun Weidong Li Dongmei Qi Yongqing Zhang Chunchao Han School of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China Hepatology Department of Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250355China Experimental center Shandong University of Traditional Chinese MedicineJinan 250355China

Coprinus comatus polysaccharide(CCP)has significant hepatoprotective *** explore hepatoprotective mechanism of CCP,the study analyzed preventive effect of CCP on acute alcoholic liver injury in mice by histopathological examination and biochemical ***,hepatoprotective mechanism was also analyzed in conjunction with metabolomics and proliferation of gut *** results showed that CCP significantly decreased alanine aminotransferase(ALT),aspartate aminotransferase(AST)and triglyceride(TG)levels in serum of alcoholic liver disease(ALD)*** examination showed that CCP can significantly improve liver *** results showed that there were significant differences in the level of metabolites in liver tissue of control group,ALD group and CCP group,including taurine,xanthosine,fumaric acid and arachidonic acid,among *** pathways analysis showed that hepatoprotective effect of CCP was related to energy metabolism,biosynthesis of unsaturated fatty acids,amino acids metabolism and lipid ***,CCP inhibited an increase in the number of Clostridium perfringens,Enterobacteriaceae and Enterococcus,and a decrease in the number of Lactobacillus and Bifidobacterium in the gut of ALD *** these findings suggested that CCP treatment reversed the phenotype of ethanol-induced liver injury and the associated metabolites pathways.

关键词： Coprinus comatus Polysaccharide Alcoholic liver disease Metabolomics Gut microbiota

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PLC低频数据传输可靠性设计

电声技术 2022年第3期46卷 71-74页

作者：纪建光洁创贸易(上海)有限公司上海201107

通过分析一个低频数据传输故障实例,提出可靠性改良方案,包括硬件冗余、数据刷新检验、故障决策及日志追溯等。改良系统加强了故障显性提示,提升了容错性能,并为精确追溯故障影响范围设计了日志记录。同时,运用统计方法确定参数容许范围... 详细信息

通过分析一个低频数据传输故障实例,提出可靠性改良方案,包括硬件冗余、数据刷新检验、故障决策及日志追溯等。改良系统加强了故障显性提示,提升了容错性能,并为精确追溯故障影响范围设计了日志记录。同时,运用统计方法确定参数容许范围,以达到效率和有效性的平衡。

关键词：硬件冗余刷新检验日志追溯

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Journal of Materials Science & Technology 2019年第8期35卷 1712-1718页

作者： Shude ji Shiyu Niu jianguang Liu School of Aerospace Engineering Shenyang Aerospace University Shenyang 110136 China Beijing Key Laboratory of Civil Aircraft Structures and Composite Materials Beijing Aeronautical Science & Technology Research Institute of COMAC Beijing 102211 China

The Zn-added ultrasonic assisted friction stir lap welding(UaFSLW) was carried out to improve the quality of dissimilar Al/Mg alloys joint. The effects of ultrasonic power on the joint quality were also *** results indicated that the larger effective lap width and mixing region between Mg and Al(Mg/Al MR) were attained by Zn foil addition and external ultrasonic assistance. Compared with the conventional joint, the finer and better-distributed Mg-Zn IMCs placing the continuous Al-Mg IMCs were formed in the Mg/Al MR of the Zn-added UaFSLW joint. The Zn foil addition and external ultrasonic assistance significantly improved the tensile shear load of the joint, and the load was increased with the increase of the ultrasonic power. The maximum tensile shear load of 7.95 kN was attained, which was 52.6% larger than that of the conventional joint.

关键词： Dissimilar Al/Mg alloys Friction stir lap welding Zn foil Ultrasonic power Microstructures Tensile shear load

Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)

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Military Medical Research 2020年第3期7卷 249-282页

作者： Ying-Hui jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang jianguang ji jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical Research Center for Respiratory Diseases China-Japan Friendship HospitalBeijing 100029China Department of Pulmonary and Critical Care Medicine China-Japan Friendship HospitalBeijing 10029China Leishenshan Hospital in Wuhan Wuhan 430200China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institutes of Evidence-based Medicine and Knowledge Translation Henan UniversityKaifeng 475000HenanChina Department of Medical Imaging Guizhou Provincial People’s HospitalGuiyang 550002China Departments of Orthopedics Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical Research Center for Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Peking Union Medical College Hospital(PUMCH)Peking Union Medical CollegeChinese Academy of Medical Sciences(CAMS)Beijing 100730China Center for Primary Health Care Research Lund University and Region Skåne25002 MalmöSweden Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 403371China Department of Allergology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 43071China Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong UniversityJinan 250002China Department of Respiratory and Critical Care Medicine Suizhou Central HospitalHubei University of MedicineSuizhou 441300HubeiChina Department of Clinic Pharmacy Second People’s Hospital of Huaihua Ci

The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the *** and treatment guidelines for clinicians caring for patients are *** the early stage,we have issued"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)";now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based *** formed a working group of clinical experts and *** steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge *** searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)*** were either strong or weak,or in the form of ungraded consensus-based ***,we issued 34 *** them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based *** covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung

关键词： COVID-19 SARS-CoV-2 Recommendation Chemoprophylaxis Diagnosis Treatment Discharge management Traditional Chinese medicine guideline

基于OBE理念构建应用型本科高校内部教学质量监测与保障体系

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科教导刊 2024年第12期 22-24页

作者：姬冬玲李建光梅琳新疆科技学院新疆库尔勒841000

构建有效运行、促进发展的内部质量监测与保障体系,有助于提升应用型本科高校人才培养质量,实现应用型本科高校教育教学工作高质量发展。遵循OBE理念,以提升教学质量为成果导向,构建以“建立质量意识—建设质量规范—形成质量文化—实... 详细信息

构建有效运行、促进发展的内部质量监测与保障体系,有助于提升应用型本科高校人才培养质量,实现应用型本科高校教育教学工作高质量发展。遵循OBE理念,以提升教学质量为成果导向,构建以“建立质量意识—建设质量规范—形成质量文化—实现质量立校”为主线的教学质量监测与保障体系,有效支撑应用型人才培养目标的达成,推动应用型本科高校探索构建中国式高等教育发展模式。

关键词： OBE理念应用型教学质量监测与保障体系

维普期刊数据库博看期刊

A review of the estimation of downward surface shortwave radiation based on satellite data:Methods, progress and problems

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Science China Earth Sciences 2020年第6期63卷 774-789页

作者： Husi LETU jiancheng SHI Ming LI Tianxing WANG Huazhe SHANG Yonghui LEI Dabin ji jianguang WEN Kun YANG Liangfu CHEN Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100010China Deparment of Earth System Science Tsinghua UniversityBeijing 100049China

The estimation of downward surface shortwave radiation(DSSR)is important for the Earth’s energy budget and climate change *** review was organised from the perspectives of satellite sensors,algorithms and future trends,retrospects and summaries of the satellite-based retrieval methods of DSSR that have been developed over the past 10 *** shortwave radiation reaching the Earth’s surface is affected by both atmospheric and land surface *** recent years,studies have given detailed considerations to the factors which affect *** is important to improve the retrieval accuracy of cloud microphysical parameters and aerosols and to reduce the uncertainties caused by complex topographies and high-albedo surfaces(such as snow-covered areas)on DSSR *** review classified DSSR retrieval methods into four categories:empirical,parameterisation,look-up table and machine-learning methods,and evaluated their advantages,disadvantages and *** efforts are needed to improve the calculation accuracy of atmospheric parameters such as cloud,haze,water vapor and other land surface parameters such as albedo of complex terrain and bright surface,organically combine machine learning and other methods,use the new-generation geostationary satellite and polar orbit satellite data to produce highresolution DSSR products,and promote the application of radiation products in hydrological and climate models.

关键词： Downward surface shortwave radiation Satellite remote sensing Cloud optical property Terrain correction

基于中国全科医生的糖尿病医患沟通技能培训设计与开发

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中国全科医学 2024年第7期27卷 816-821页

作者：姚弥林恺樊洁婷纪欣鑫王颖董爱梅韩晓宁齐建光迟春花 Shamil Haroon Dawn Jackson KK Cheng Richard Lehman 北京大学第一医院全科医学科北京市100034 北京大学医学部全科医学系北京市100191 汕头大学医学院第一附属医院全科医学中心广东省汕头市515041 火箭军特色医学中心内分泌科北京市100088 汕头大学医学院广东省汕头市515041 北京大学第一医院教育处北京市100034 北京大学第一医院内分泌科北京市100034 北京大学第一医院心血管科北京市100034 北京大学第一医院儿科北京市100034 北京大学第一医院健康管理中心北京市100034 英国伯明翰大学应用健康研究院伯明翰B152TT 英国伯明翰大学医学院伯明翰B152TT

全科医生作为居民健康“守门人”,在基层糖尿病等慢性疾病管理中发挥着重要作用。糖尿病管理可以延缓病情进展、减少糖尿病并发症和改善患者健康结局,这需要患者和医生之间的有效沟通并互相协作。全科医生具备良好的沟通能力有助于与糖... 详细信息

全科医生作为居民健康“守门人”,在基层糖尿病等慢性疾病管理中发挥着重要作用。糖尿病管理可以延缓病情进展、减少糖尿病并发症和改善患者健康结局,这需要患者和医生之间的有效沟通并互相协作。全科医生具备良好的沟通能力有助于与糖尿病患者建立长期的照护关系、帮助患者建立有效的自我管理技能。本文总结了本研究团队在多种理论框架指导下的全科医生糖尿病沟通技能培训的设计和开发:基于系统综述发现的循证依据,通过定性研究进一步探索糖尿病患者与全科医生的沟通体验和想法,以及混合方法研究设计理念获取全科医学对于医患沟通培训内容的优先排序,旨在为高质量的基层糖尿病管理提供新思路,并为基于证据和医学教育框架设计全科医生相关培训项目提供借鉴。

关键词：糖尿病沟通技能在职培训培训设计全科医生

维普期刊数据库博看期刊

Modulation of Sex Expression in Four Forms of Watermelon by Gibberellin, Ethephone and Silver Nitrate

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Horticultural Plant Journal 2017年第3期3卷 91-100页

作者： ZHANG jie SHI jianting ji Gaojie ZHANG Haiying GONG Guoyi GUO Shaogui REN Yi FAN jianguang TIAN Shouwei XU Yong National Engineering Research Center for Vegetables Beijing Academy of Agriculture and Forestry SciencesKey Laboratory of Biology and Genetic Improvement of Horticultural Crops(North China)Beijing Key Laboratory of Vegetable Germplasm Improvement

There has been no systematic research on the effect of plant growth regulators and silver nitrate treatments on the control of sex expression in watermelon. In this study, we tested sex expression responses of four watermelon forms(monoecism, gynoecism, andromonoecism,and hermaphrodite) to gibberellin, ethephon and silver nitrate treatments. Results have shown that, in monoecious plants, gibberellins(GA_3)and ethephon treatments reduced the percentage of female flowers and delayed the occurrence of the first female flower, while silver nitrate induced the formation of bisexual flowers. In gynoecious plants, both ethephon and silver nitrate treatments transformed some female flowers into bisexual flowers, and treatment with ethephon resulted in a mass of abnormal flowers, while no obvious effect of treatment with GA_3 was observed. In andromonoecious plants, ethephon and GA_3 treatments delayed the occurrence of the first bisexual flower, and GA_3 reduced the percentage of bisexual flowers, while no distinct effect for silver nitrate treatment was observed. In hermaphroditic plants, ethephon treatment induced the appearance of numerous abnormal flowers, while no obvious effects for GA_3 and silver nitrate treatments were *** analyzed the transcription levels of all the expressed aminocyclopropane-1-carboxylic acid synthase(ACS) homologues in two gynoecious mutants and their wild types. We also tested the gene expression of CitACS4 which had been recognized as the andromonoecious gene in all treatments. All these results suggested that the best masculinizing treatment for breeding of the gynoecious line is silver nitrate, which repressed the expression of CitACS4 and induced many bisexual flowers for use in self-fertilization subsequently.

关键词： watermelon sex expression gibberellins(GA3) ethephon silver nitrate

负压区的存在对刚性陶瓷过滤器脉冲反吹性能的影响

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工程热物理学报 2000年第1期21卷 58-61页

作者：姬忠礼郭建光清华大学化工系北京100084 石油大学机电系北京102200

利用压电式压力传感器测定了陶瓷过滤器在脉冲反吹过程中滤管内动态压力的变化规律，表明在脉冲反吹快要结束和正常过滤尚未开始的过渡过程中，滤管内存在严重的负压区。利用单个颗粒轨道模型分析了部分已被吹离滤管表面的小颗粒在负压... 详细信息

利用压电式压力传感器测定了陶瓷过滤器在脉冲反吹过程中滤管内动态压力的变化规律，表明在脉冲反吹快要结束和正常过滤尚未开始的过渡过程中，滤管内存在严重的负压区。利用单个颗粒轨道模型分析了部分已被吹离滤管表面的小颗粒在负压区的作用下会重新返回到滤管壁，从而证实了负压区是影响刚性陶瓷过滤器稳定运行的重要原因。

关键词：陶瓷过滤器脉冲反吹负压区性能过滤器