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江西省重症患者凝血功能障碍诊疗现状的问卷调查

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血栓与止血学 2022年第2期28卷 2013-2018页

作者：曾庆波宋景春邓星平江西省中西医结合学会血栓与止血专业委员会中国人民解放军联勤保障部队第九〇八医院重症医学科/南昌市血栓与止血学重点实验室南昌330002

目的对江西省重症患者凝血功能障碍诊疗现状进行问卷调查,旨在明确江西省重症监护病房(Inten⁃sive care unit,ICU)凝血功能障碍常见原因及监测手段,评价重症监护病房医师对凝血功能障碍的诊疗能力。方法2021年10月5日至12日对江西省二... 详细信息

目的对江西省重症患者凝血功能障碍诊疗现状进行问卷调查,旨在明确江西省重症监护病房(Inten⁃sive care unit,ICU)凝血功能障碍常见原因及监测手段,评价重症监护病房医师对凝血功能障碍的诊疗能力。方法2021年10月5日至12日对江西省二甲以上医院重症监护病房137名医师进行问卷调查,调查内容包括医师基本信息、凝血功能障碍常见原因、诊断与治疗能力三方面相关问题,并进行统计分析。结果被调查者三甲医院及综合ICU所占比例最高,本科以上学历者占98.5%。感染是ICU中发生血小板减少、凝血酶原时间、活化部分凝血酶原时间延长及弥散性血管内凝血(disseminate intravascular coagulation,DIC)的主要原因。接受调查的医院中血栓弹力图普及率为79.0%,51.8%的医师认为血栓弹力图是重症患者凝血功能诊断最有价值的项目,但仅有41.7%的医生熟练使用血栓弹力图。仍有33.3%的医师主要依靠临床经验诊断DIC。治疗脓毒症性DIC时,89.8%的医生认为需要进行抗凝治疗,54.6%的医师选择使用低分子肝素,但仅有14.6%的医师采用抗活化X因子(Xa)活性监测抗凝。结论感染是江西省ICU内凝血功能障碍的主要原因。江西省二甲以上医院ICU基本具备重症患者凝血功能障碍的诊疗条件,但在规范诊疗方面仍需加强培训。

关键词：凝血功能障碍问卷调查诊断治疗

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老年骨质疏松性肩关节周围骨折诊疗中国专家共识(2023版)

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中华创伤杂志 2023年第4期39卷 289-298页

作者：胡衍王栋梁陈晓施忠民周凤金张建政陈雁西曹烈虎王思成王剑飞王宏亮冯勇应志敏胡成栋韩庆林李明陈晓涛顾峥嵘黄标通熊蠡茗张云飞王志伟禹宝庆王勇张磊杨雷童培建刘曦明周强牛丰杨伟国张文财陈世杰贾金鹏杨强沈涛于斌张鹏张勇苗军孙廓林浩东俞银贤王金武陶坤万大千王蕾马昕易诚青刘宏建张堃刘国辉张殿英侯志勇翁习生张英泽苏佳灿中华医学会骨科学分会青年骨质疏松学组中国老年学和老年医学学会老年病学分会骨科专家委员会中国医师协会骨科医师分会青年委员会骨质疏松学组上海中西医结合学会骨质疏松专业委员会上海交通大学医学院附属新华医院上海200092 上海交通大学附属第六人民医院上海200233 西安交通大学附属红会医院西安710054 中国人民解放军总医院第七医学中心北京100007 复旦大学附属中山医院上海200032 上海市宝山区罗店医院上海201908 上海中冶医院上海200941 延安大学附属医院延安716000 阜阳市人民医院阜阳236000 华中科技大学同济医学院附属协和医院武汉430022 浙江大学医学院附属第二医院杭州310009 邯郸市中心医院邯郸056001 南通大学附属医院南通226001 宁波市第六医院宁波315040 青海省人民医院西宁810000 上海大学转化医学研究院上海200444 空军军医大学唐都医院西安710038 东方肝胆外科医院上海200433 上海市浦东新区人民医院上海200135 温州市中西医结合医院温州325001 上海中医药大学附属曙光医院上海201203 温州医科大学附属第二医院骨科温州325027 浙江省中医院杭州310003 解放军中部战区总医院武汉430000 重庆医科大学附属第三医院重庆401120 吉林大学白求恩第一医院长春130062 香港大学李嘉诚医学院中国香港999077 暨南大学附属第一医院广州510630 中南大学湘雅三医院长沙410013 中国人民解放军总医院第一医学中心北京100048 天津医院天津300211 中国医科大学附属盛京医院沈阳110004 北京协和医院北京100032 山东第一医科大学附属省立医院济南250021 南昌大学第二附属医院南昌330006 上海市第一人民医院上海200080 上海交通大学医学院附属第九人民医院上海200011 上海市第十人民医院上海200072 同济大学附属同济医院上海200065 上海交通大学医学院附属瑞金医院上海200025 复旦大学附属华山医院上海200040 复旦大学附属浦东医院上海200135 郑州大学第一附属医院郑州450001 北京大学人民医院北京100044 河北医科大学第三医院石家庄050051 不详

肩关节周围骨折是老年人最常见的骨折类型之一,术后常出现内固定失败、肱骨头缺血坏死、上肢功能障碍等不良事件,严重危害老年人群运动健康。相比骨量正常的肩关节周围骨折类型,骨质疏松性骨折类型复杂、愈合慢、康复效果差,临床处理更... 详细信息

肩关节周围骨折是老年人最常见的骨折类型之一,术后常出现内固定失败、肱骨头缺血坏死、上肢功能障碍等不良事件,严重危害老年人群运动健康。相比骨量正常的肩关节周围骨折类型,骨质疏松性骨折类型复杂、愈合慢、康复效果差,临床处理更为棘手,且目前国内尚无该类骨折诊疗的指南或共识。为此,中华医学会骨科学分会青年骨质疏松学组、中国老年学和老年医学学会老年病学分会骨科专家委员会、中国医师协会骨科医师分会青年委员会骨质疏松学组、上海中西医结合学会骨质疏松专业委员会组织相关专家制订《老年骨质疏松性肩关节周围骨折诊疗中国专家共识(2023版)》,从骨质疏松性肩关节周围骨折的诊断、治疗策略等方面提出9条推荐意见,旨在推广规范化、系统化、个性化诊疗理念,改善老龄化背景下骨质疏松性肩关节周围骨折患者功能预后与生活质量。

关键词：老年人骨质疏松肩骨折康复共识

Fos expressions in the rat brainstem following intake of sweet tastant

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Fos expressions in the rat brainstem following intake of swe...

中国肿瘤整合诊治指南:腹膜肿瘤(胃肠肿瘤部分)

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Ke CHEN~a,Jian-Qun YAN~(*,a,b),Jin-Rong LI~a,Qian WANG~a,Bo LU~a a Department of Physiology and Pathophysiology b Key Laboratory of Environment and Genes Related to Diseases,Ministry of Education,Xi’an Jiaotong University School of medicine,Xi’an 710061,China

Sweet taste represents the caloric properties of food,and is involved in the regulation of homeostasis of internal environment of the *** is a sweet tastant enrich of *** is essential for survival and development of *** saccharin hardly contains energy though it binds to the same sweet taste receptor and induces the related physiological *** nucleus of the solitary tract(NST) and parabrachial nuclei (PBN) in rat brainstem are important nuclei in the sweet taste transmission *** probe in the activities in brainstem taste related nuclei involving in the sweet taste perception,we performed typical immunohistochemistry method to detect the Fos expression in the rat brainstem after intake of 0.25 mol/L sucrose and 0.005 mol/L saccharin solution respectively to analyze the different Fos expression induced respectively by simple sweet taste information(saccharin) and the integrative effect of sweet taste information and ***,we found that the diaminobenzidine-labeled Fos-like immunoreactive(FLI) appeared as dark-brown staining within cell *** the NST,FLI-positive neurons were surveyed in 4 representative rostral-caudal *** of sucrose increased the number of neurons expressing FLI in the caudal NST(cNST) at the level of the area postrema(AP)(F

关键词： sucrose Fos expression NST PBN saccharin

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消化肿瘤杂志（电子版） 2023年第2期15卷 100-108页

作者：中国抗癌协会腹膜肿瘤专业委员会崔书中雷子颖不详广州医科大学附属肿瘤医院

腹膜肿瘤发病率高、预后差,源于胃癌、结直肠癌和阑尾黏液瘤等的继发性腹膜肿瘤临床常见,患者数量多、治疗难、疗效差。传统观点认为,腹膜肿瘤属于晚期肿瘤,患者生存期短,仅能维持3~6个月,通常提供姑息性对症治疗。近年来,以细胞减灭术(... 详细信息

腹膜肿瘤发病率高、预后差,源于胃癌、结直肠癌和阑尾黏液瘤等的继发性腹膜肿瘤临床常见,患者数量多、治疗难、疗效差。传统观点认为,腹膜肿瘤属于晚期肿瘤,患者生存期短,仅能维持3~6个月,通常提供姑息性对症治疗。近年来,以细胞减灭术(CRS)联合腹腔热灌注化疗(HIPEC)为主的整合治疗策略对防治腹膜肿瘤疗效独特,可显著提高患者的生存率和生活质量。《中国肿瘤整合诊治指南:腹膜肿瘤》在中国抗癌协会的指导下,由腹膜肿瘤专业委员会组织国内相关领域权威专家共同完成。指南聚焦我国腹膜肿瘤流行病学特征、遗传背景及国内研究成果,以整合医学理念为引领,强调多学科整合诊治(MDT to HIM),注重“防-筛-诊-治-康”全程管理。本指南主要针对胃肠来源的腹膜肿瘤,旨在规范临床诊疗流程、提高整合诊治水平,共同促进我国胃肠腹膜肿瘤的防治工作。

关键词：腹膜肿瘤胃肠肿瘤指南

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阻塞性睡眠呼吸暂停综合征患者血管内皮损伤的观察

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中国中西医结合耳鼻咽喉科杂志 2010年第6期18卷 308-311页

作者：张群苏梅王雅辉张希龙南京医科大学第一附属医院呼吸科

目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)患者血管内皮功能变化指标血浆一氧化氮(NO)及内皮素(ET)与内皮细胞(EC)凋亡的内在联系。方法随机选择43例中年健康者为对照组,59例OSAS患者为OSAS组,后者进一步被划分为2个亚组:轻度OSAS组(21例... 详细信息

目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)患者血管内皮功能变化指标血浆一氧化氮(NO)及内皮素(ET)与内皮细胞(EC)凋亡的内在联系。方法随机选择43例中年健康者为对照组,59例OSAS患者为OSAS组,后者进一步被划分为2个亚组:轻度OSAS组(21例)和中重度OSAS组(38例)。测定和比较组间的血浆NO、ET及其比值的动态变化,并探讨其与血浆凋亡EC水平的关系。结果与对照组相比,OSAS组的血浆NO水平明显降低(58.47±13.04 mol/L vs 31.68±7.74 mol/L,P<0.01),而ET水平明显增高(31.68±12.74 ng/L vs 50.21±14.02 ng/L,P<0.05),NO/ET明显下降(1.67±0.62 vs 0.59±0.34,P<0.01)。中重度OSAS患者较轻度OSAS患者血浆NO水平降低、ET水平升高、NO/ET降低(均为P<0.05)。与对照组相比,血浆NO的降低、ET的增高和NO/ET的下降在轻度OSAS患者中较显著(均为P<0.05),而在中重度OSAS患者中更为显著(均为P<0.01)。与对照组比较,中重度OSAS患者EC凋亡水平显著升高(P<0.01)。OSAS患者EC凋亡水平(CD146AnnV+)与血浆ET呈显著正相关(r=0.598,P<0.01),与血浆NO呈显著负相关(r=-0.612,P<0.01)。结论 OSAS患者存在明显的血管内皮功能障碍和血管EC凋亡,尤以中重度患者为甚,其血管内皮功能损伤与血管EC凋亡密切相关。

关键词：阻塞性睡眠呼吸暂停一氧化氮内皮素血管内皮凋亡

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当前反腐倡廉建设形势分析与对策研究

中国井冈山干部学院学报 2009年第4期2卷 66-72页

作者：江西省社科院江西省社科联课题组姜玮黎康江西省社科院江西省社会科学院江西南昌330077

本文从国际金融危机、网络舆论环境、民主政治和国际合作等四个视角分析了我国当前反腐倡廉建设的形势及面临的挑战。全面推进反腐倡廉建设,必须信心与决心并举,着力形成反腐倡廉建设顺利推进的合力;教育与文化并重,着力营造反腐与倡廉... 详细信息

本文从国际金融危机、网络舆论环境、民主政治和国际合作等四个视角分析了我国当前反腐倡廉建设的形势及面临的挑战。全面推进反腐倡廉建设,必须信心与决心并举,着力形成反腐倡廉建设顺利推进的合力;教育与文化并重,着力营造反腐与倡廉相得益彰的良好环境;制度与监督并行,着力构筑源头预防和惩治腐败的坚固防线;"抓大"与"惩小"并用,着力实现基层反腐倡廉建设的新突破。

关键词：反腐倡廉形势与挑战对策

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An integrative Study Ascertained S0D2 as a Susceptibility Gene for Osteoporosis in Chinese

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An Integrative Study Ascertained S0D2 as a Susceptibility Ge...

International guideline on natural orifice specimen extraction surgery(NOSES)for colorectal cancer(2023 version)

中华医学会第六次全国骨质疏松和骨矿盐疾病学术会议暨中华医学会骨质疏松和骨矿盐疾病分会成立十周年

作者： Shu-Feng Lei~(1,2),Fei-Yan Deng~(1,2),Xiang-Ding Chen~1,Li-Jun Tan~1,Xue-Zhen Zhu~3,Hong-Wen Deng~(1,2,3) 1 Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education,College of Life Sciences,Hunan Normal University,Changsha,Hunan 410081,P. R.China 2 Center of Bioinformatics and Genomics,School of Public Health and Tropical medicine,Tulane University,New Orleans,LA 70112,USA 3 Center of Systematic Biomedical Research,University of Shanghai for Science and Technology,Shanghai 200093,P.R.China.

Osteoporosis(OP)is characterized by low bone mineral density(BMD)and has strong genetic ***,specific genetic variants influencing BMD and contributing to pathogenesis of osteoporosis are largely *** genetic studies in bone filed, which aimed at identification of OP risk genes,are mostly focused on DNA,RNA,or protein level

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Holistic integrative Oncology 2023年第1期2卷 93-100页

作者： Zheng Liu Xu Guan Mingguang Zhang Xiyue Hu Ming Yang Junge Bai Jun Li Shaojun Yu Kefeng Ding Qingsi He Liang Kang Dan Ma Chuangang Fu Junhong Hu Ye Wei Donghui Sun Gang Yu Songbing He Changyou Wang Yanwei Gao Guiyu Wang Hongliang Yao Jian Peng Yangchun Zheng Bo Jiang Taiyuan Li Zhiguo Xiong Xuejun Sun Zhenning Wang William Meng William Tzu-Liang Chen Ming-Yin Shen John H.Marks Charles A.Ternent Darcy DShaw Jim SKhan Petr Tsarkov Inna Tulina Sergey Efetov Joaquim Manuel da Costa Pereira Fernanda Nogueira Ricardo Escalante Joel Leroy Avanish Saklani Audrius Dulskas Cuneyt Kayaalp Atsushi Nishimura Kay Uehara Woo-Yong Lee Sang-Hoo Kim Suk-Hwan Lee Xishan Wang Committee of Colorectal Cancer Society Chinese Anti-Cancer association International NOSES Alliance Department of Colorectal Surgery National Cancer CenterNational Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100021China Department of Colorectal Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of General Surgery Shandong University Qilu HospitalJinanShandongChina Department of Colorectal Surgery The Sixth Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina Department of General Surgery Xinqiao HospitalThird Military Medical UniversityChongqingChina Department of Gastrointestinal Surgery Shanghai East HospitalTongji University School of MedicineShanghaiChina Department of Anorectal Surgery First Affiliated HospitalZhengzhou UniversityZhengzhouHenanChina Department of General Surgery Zhongshan HospitalFudan UniversityShanghaiChina Department of Gastric and Colorectal Surgery Jilin University First HospitalChangchunChina Department of General Surgery Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityJinanChina Department of General Surgery the First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Affiliated Hospital of North China University of Science and Technology TangshanHebeiChina Inner Mongolia Autonomous Region People’s Hospital HuhhotInner Mongolia Autonomous RegionChina Department of Colorectal Cancer Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of General Surgery The Second Xiangya HospitalCentral South UniversityChangshaHunanChina Department of General Surgery Xiangya HospitalCentral South UniversityChangshaChina Department of Gastrointestinal Surgery Sichuan Cancer HospitalChengduChina Department of Colorectal and Anal Surgery Shanxi Cancer HospitalTaiyuanShanxiChina Department of General Surgery The First Affiliated Hospital of Nanchang UniversityNanchangChina Department of Gastrointestinal Surgery Hubei Provincial Cancer Hosp

Purpose In recent years,natural orifice specimen extraction surgery(NOSES)has gained widespread attention as an alternative *** the safety and feasibility of NOSES have been well documented,many questions remain open for *** aim of this guideline is to provide more evidence for the promotion of *** This guideline has been prepared by the CACA Committee of Colorectal Cancer Society and the International NOSES Alliance,based on the latest *** The guideline on NOSES for colorectal cancer include the definition,classification,technology requirement,indications,technical difficulties and clinical *** The guideline provides a full introduction of the theoretical and technical aspects of NOSES for colorectal cancer which will beneficial to development of NOSES.

关键词： Colorectal cancer Guideline Treatment Surgery Holistic integrative medicine Natural orifice specimen extraction surgery

CACA Guidelines for Holistic integrative Management of Breast Cancer

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Holistic integrative Oncology 2022年第1期1卷 76-126页

作者： Jiong Wu Daiming Fan Zhimin Shao Binghe Xu Guosheng Ren Zefei Jiang Yongsheng Wang Feng Jin Jin Zhang Qingyuan Zhang Fei Ma Jinli Ma Zhonghua Wang Shusen Wang Xiaojia Wang Shu Wang Haibo Wang Tao Wang Xiang Wang Jing Wang Jia Wang Biyun Wang Li Fu Hongyuan Li Yehui Shi Lu Gan Yunjiang Liu Jian Liu Zhenzhen Liu Qiang Liu Qiang Sun Wenwu Cheng Keda Yu Zhongsheng Tong Xinhong Wu Chuangui Song Jianguo Zhang Jian Zhang Junjie Li Bin Li Man Li Huiping Li Wentao Yang Hongjian Yang Benlong Yang Hong Bu Juping Shen Zhenzhou Shen Yiding Chen Ceshi Chen Da Pang Zhimin Fan Ying Zheng Xiaoli Yu Guangyu Liu Xichun Hu Yiqun Ling Jinhai Tang Yongmei Yin Cuizhi Geng Peng Yuan Yajia Gu Cai Chang Xuchen Cao Yuan Sheng Yuanxi Huang Jian Huang Weijun Peng Xiaohua Zeng Yuntao Xie Ning Liao Committee of Breast Cancer Society,Chinese Anti-Cancer association Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghai Medical College of Fudan UniversityShanghaiChina Department of Oncology Shanghai Medical College of Fudan UniversityShanghaiChina Department of Gastroenterology Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina State key Laboratory of Cancer Biology National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’anChina National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Endocrine and Breast Surgery The First Affliated Hospital of Chongqing Medical UniversityYuzhongChongqingChina medicine-Oncology The Affliated Hospital of Military Medical Sciences(The 307th Hospital of Chinese People’s Liberation Army)BeijingChina Breast Disease Center Shandong Cancer HospitalJinanChina Department of Breast Surgery The First Affliated Hospital of China Medical UniversityShenyangChina The 3rd Department of Breast Cancer China Tianjin Breast Cancer PreventionTreatment and Research CenterTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center of CancerTianjinChina Harbin Medical University Cancer Hospital HarbinChina Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghai Medical College of Fudan UniversityShanghaiChina Sun Yat-Sen University Cancer Center GuangzhouChina Zhejiang Cancer Hospital HangzhouChina Breast Center Peking University People’s HospitalBeijingChina Department of Breast Center The Affliated Hospital of Qingdao UniversityShandongChina Department of Oncology Fifth Medical Center of Chinese PLA General HospitalBeijingChina Department of Breast Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Departmen

Purpose:Breast cancer is now the most common malignant tumor *** one-fourth of female cancer patients all over the world sufer from breast *** about one in six female cancer deaths worldwide is caused by breast *** terms of absolute numbers of cases and deaths,China ranks frst in the *** CACA Guidelines for Holistic integrative Management of Breast Cancer were edited to help improve the diagnosis and comprehensive treatment in ***:The Grading of Recommendations Assessment,Development and Evaluation(GRADE)was used to classify evidence and ***:The CACA Guidelines for Holistic integrative Management of Breast Cancer include the epidemiology of breast cancer,breast cancer screening,breast cancer diagnosis,early breast cancer treatment,advanced breast cancer treatment,follow-up,rehabilitation,and traditional Chinese medicine treatment of breast cancer ***:We to standardize the diagnosis and treatment of breast cancer in China through the formulation of the CACA Guidelines.

关键词： Epidemiology of breast cancer Breast cancer screening Breast cancer diagnosis Early breast cancer treatment Advanced breast cancer treatment Traditional Chinese medicine treatment of breast cancer