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MMAE-loaded PLGA nanomedicine with improved biosafety to achieve efficient antitumor treatment

Journal of Innovative Optical Health Sciences 2024年第2期17卷 79-93页

作者： Changqiang Xie Yan Wang Zhenzhen Cai jianghai du Zhengyu Chen Junjie Wang Xingzhou Peng State Key Laboratory of Digital Medical Engineering School of Biomedical Engineering Hainan University Haikou 570228P.R.China Key Laboratory of Biomedical Engineering of Hainan Province One Health Institute Hainan University Haikou 570228P.R.China Key Laboratory of Hainan Trauma and Disaster Rescue The First Affiliated Hospital of Hainan Medical University Hainan Medical University Haikou 571199P.R.China Engineering Research Center for Hainan Bio.Smart Materials and Bio-Medical Devices Key Laboratory of Emergency and Trauma Ministry of EducationKey Laboratory of Hainan Functional Materials and Molecular ImagingCollege of Emergency and Trauma Hainan Medical UniversityHaikou 571199P.R.China

Monomethyl auristatin E(MMAE)is a derivative of the marine peptide Dolastatin 10,which has therapeutic effects against various cancers according to its antimitotic activity in multiple clinical *** antibody drug conjugate(ADC)of MMAE is currently used in clinical ***,the safety issues of MMAE-based ADC,such as high drug toxicity and poor bioavailability,still exist when using it for anticancer therapy.A sustained release of drug delivery approach should be used to reduce toxicity and achieve sufficient anticancer ***,PLGA-b-PEG 2000 with excellent biocompatibility and slow degradation ability was adopted to construct MMAE-loaded nanoparticles for safe and effective *** sustained release effect and the immunogenic cell death(ICD)effect of PLGA-MMAE nanoparticles were assessed by in vitro *** PLGA-MMAE nanoparticles effectively accumulated in the tumor through the enhanced permeability and retention(EPR)effect,inducing cell apoptosis and causing a certain degree of immune *** sustained drug release of PLGA-MMAE improved the bioavailability and effectively reduced the toxicity and development of the tumor compared to the effect of free MMAE or ***,this study provides a safe and effective chemotherapeutic approach,as well as a simple and effective synthetic process for MMAE-based nanoparticles,improving their therapeutic efficacy and safety.

关键词： Monomethyl auristatin E poly(lactic-co-glycolic acid)nanoparticles sustained release chemotherapy immunogenic cell death

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Provenance of the Lower Jurassic pyroclastic sediments in the Zigui Basin:Implication for crustal thickening in the eastern Qinling orogenic belt

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Science China Earth Sciences 2024年第1期67卷 196-207页

作者： Rong CHAI jianghai YANG Yuansheng du Chengshan WANG School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing 100023China School of Earth Sciences China University of Geosciences(Wuhan)Wuhan 430074China Chinese Academy of Geological Sciences Beijing 100037China

The Late Triassic witnessed significant collisional orogenic events in the Qinling orogenic belt,accompanied by magma underplating and tectonic *** processes potentially resulted in substantial crustal thickening and uplift of the Qinling ***,due to the absence of igneous rock records from this period in the eastern section of the Qinling orogen,the changes in crustal thickness during this orogenic process have not been thoroughly investigated.A series of foreland basins emerged during the Early Mesozoic to the south of the East Qinling orogenic *** basins have preserved clastic sedimentary rocks derived from the uplift and erosion of the orogenic *** sedimentary records serve as crucial records to reconstruct the evolutionary history of the Qinling *** further clarify the collisional orogenic process of the Qinling orogenic belt,this study conducted in situ volcanic lithic fragment geochemistry,detrital zircon U-Pb chronology and trace element composition analysis on the sandstones of the Lower Jurassic Tongzhuyuan Formation in the Zigui *** results suggest that the sandstones,which exhibit a significant abundance of volcanic lithic fragments,has a characteristic detrital zircon age group of 250–200 Ma,indicating a major provenance from the Triassic volcanic *** with regional correlation and paleocurrent analysis,the detrital zircon U-Pb age data show that the source area of volcanic rocks should be in the Qinling orogenic belt to the north of the *** interpretation is further supported by the Triassic granitic rocks exposed in the western part of the orogenic belt,representing the magmatism during the Triassic collisional orogenesis in the Qinling *** on the co-varying relationships between present-day crust thickness with the chemical compositions of granite rocks and zircons,the La/Yb ratio of volcanic lithic fragments in the Tongzhuyuan Formation and the Eu/Eu*ratio of detrital zircon

关键词： Qinling orogenic belt Zigui Basin Late Triassic Detrital zircons Crustal thickening

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A novel method for vibration signal transmission and attenuation analysis in complex planetary gearboxes

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Science China(Technological Sciences) 2024年第9期67卷 2939-2953页

作者： WEI ChaoHu CAO HongRui SHI jianghai YANG Yang du MingGang National and Local Joint Engineering Research Center of Equipment Operation Safety and Intelligent Monitoring Xi’an Jiaotong UniversityXi’an 710049China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China China North Vehicle Research Institute Beijing 100072China

Planetary gearboxes play a crucial role in altering rotary speed and transmitting power in large machines like wind turbines and sophisticated vehicles. There are many nonlinear interfaces, such as splines, bearings, and gear pairs, in planetary gearboxes, and the resulting vibration signal transmission and attenuation mechanisms are still unknown. In this study, a novel method for quantitatively analyzing the transmission and attenuation of vibration signals is proposed. A multibody dynamic model of the planetary gearbox considering nonlinear gear meshing is presented and experimentally validated. To avoid the interference of foundation vibration on the transmission of the fault signal, the fault impact factor(FIF) is used to describe the intensity of the failure, which aligns well with the experimental signals. Based on the FIF, the vibration signal attenuation of nonlinear interfaces such as splines, bearings, and gear meshing interfaces is quantitatively evaluated. To clarify the transfer paths of fault vibration signals inside the gearbox, the transfer path area method(TPAM) based on FIF is proposed. According to the simulated results,the primary transfer paths of fault vibration signals within the gearbox have been identified, which is of great help in understanding the transmission and attenuation of vibration signals in planetary gearboxes.

关键词： planetary gearbox nonlinear interface fault mechanism vibration transmission vibration attenuation

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Plastic deformation behavior of a Cu-10Ta alloy under strong impact loading

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Defence Technology（防务技术） 2024年第2期32卷 368-382页

作者： Ping Song jianghai Liu Wenbin Li Yiming Li Research Institute of Chemical Defense Academy of Military ScienceBeijing102205China Ministerial Key Laboratory of ZNDY Nanjing University of Science and TechnologyNanjing210094China

In this work,a Cu-10Ta alloy with a copper to tantalum mass ratio of 9:1 is prepared using powder metallurgy *** properties of the alloy,including density,microstructure,melting point,and constant-volume specific heat,are *** the split Hopkinson pressure bar(SHPB)and flyerplate impact experiments,the relationship between equivalent stress and equivalent plastic strain of the material is studied at temperatures of 298-823 K and under strain rates of 1×10^(-3)-5.2×10^(3)s^(-1),and the Hugoniot relationship at impact pressures of 1.46-17.25 GPa and impact velocities of 108-942 m/s is *** of the Cu-10Ta microstructure that occurs during high-strain-rate impact is *** indicate that the Cu-10Ta alloy possesses good thermal stability,and at ambient temperatures of up to 50%its melting point,stress softening of less than 15%of the initial strength is observed.A modified J-C constitutive model is employed to accurately predict the variation of yield strength with strain *** strong impact,the copper phase is identified as the primary source of plastic deformation in the Cu-10Ta alloy,while significant deformation of the high-strength tantalum particles is less ***,the longitudinal wave speed D is found to correlate linearly with the particle velocity u upon strong *** reveals that the sound speed and spallation strength of the alloy increase with increasing impact pressure.

关键词： Cu-10Ta SHPB Plastic deformation Flyer impact Hugoniot relationship

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Study on moisture absorption characteristics of glass fibrereinforced epoxy resin material for composite insulators based on the 3D-Fick model

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High Voltage 2024年第4期9卷 888-901页

作者： Yuming Zhang Yunpeng Liu Sizu Hou jianghai Geng Ping Wang Hebei Provincial Key Laboratory of Power Transmission Equipment Security Defense North China Electric Power UniversityBaodingChina Hebei Key Laboratory of Power Internet of Things Technology BaodingChina

Long-term exposure to moisture leads to a gradual deterioration of performance and reduced service life of glass fibre-reinforced epoxy resin(GFRP)material in composite ***,it is necessary to analyse the moisture absorption characteristics of GFRP material and the evolution of damage to their internal interface *** absorption tests on GFRP rod material used in composite insulators to obtain their three-dimensional diffusion coefficients are *** force microscopy was then employed to obtain the composite material system's fibre/matrix interfacial phase ***,a finite element model incorporating representative volume elements with interfacial phases and a mesoscale transient moisture absorption finite element model for the composite material was ***,the moisture absorption characteristics of GFRP material and the evolution of damage to the interfacial phase under thermal-humidity cycling conditions were *** results showed that the diffusion coefficient along the fibre direction in GFRP material was higher than that in the perpendicular *** moisture diffusion finite element model,incorporating an anisotropic interfacial phase,fitted the anisotropic diffusion coefficients of GFRP material more *** moisture invaded the GFRP material,the mismatch stresses continuously increased during the moisture ***,the non-uniform arrangement of fibres resulted in uneven distribution of moistureinduced stresses inside the material,leading to higher mismatch stresses in areas with dense fibre arrangements in the *** high and low humidity cycles led to the development of micro-cracks,micro-porosity,and interface debonding along the fibre direction at the GFRP material interfaces,thereby affecting the anisotropic moisture absorption characteristics of the *** findings of this study provide valuable insights into the mechanisms underlying the

关键词： composite fibre moisture

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Study on the dynamic mechanical properties of winding-block axial structure considering short circuit strain rate effect

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High Voltage 2024年第2期9卷 380-390页

作者： Xinyu Wang Ping Wang jianghai Geng Zikang Zhang Fangcheng Lü Shuguo Gao Hebei Provincial Key Laboratory of Power Transmission Equipment Security Defense North China Electric Power UniversityBaodingChina State Grid Hebei Electric Power Research Institute ShijiazhuangChina

Transformers may suffer multiple short-circuit impacts during long-term operation,and axial instability is one of the typical types of serious accidents caused by short-circuit *** axial instability form of the winding-block structure is analysed,and the dynamic solution of the winding short-circuit electromagnetic force is obtained by estab-lishing the three-dimensional magnetic-circuit-force multi-physical field coupling simulation *** influence of strain rate on the cushion block constitutive equation is corrected,and the modified model is verified by short-circuit impact test and quasi-static *** research results show that for 110 kV 31.5 MVA transformers,the maximum electromagnetic axial resultant force of winding is 363.16 kN,and the ultimate tilt force is 1214.2 *** pre-tightening force configuration is accordingly recom-mended to range from 363.16 to 608.28 kN,which is narrowed by 18.49%compared with the static calculation method;Meanwhile,adding a logarithmic strain rate correction term to the classical constitutive equation of the cushion block can achieve a good correction of the stress-strain relationship with the coefficient of determination above 0.99,and the cushion block has a larger elastic modulus under high strain rate *** research results provide an important theoretical reference for the axial stability structure of transformers.

关键词： axial correction structure

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Predicting Turbidite Channel in Deep-Water Canyon Based on Grey Relational Analysis-Support Vector Machine Model:A Case Study of the Lingshui Depression in Qiongdongnan Basin,South China Sea

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Energy Engineering 2024年第9期121卷 2435-2447页

作者： Haichen Li jianghai Li Li Li Zhandong Li School of Earth and Space Sciences Peking UniversityBeijing100871China Key Laboratory of Orogenic Belts and Crustal Evolution Peking UniversityBeijing100871China Geotechnical Physical and Mechanical Properties Laboratory Langfang Normal UniversityLangfang065000China Heilongjiang Northeast Petroleum University Science Park Development Co. Ltd.Daqing163318China College of Petroleum Engineering Northeast Petroleum UniversityDaqing163318China

The turbidite channel of South China Sea has been highly *** by the complex fault and the rapid phase change of lithofacies,predicting the channel through conventional seismic attributes is not accurate *** response to this disadvantage,this study used a method combining grey relational analysis(GRA)and support vectormachine(SVM)and established a set of prediction technical procedures suitable for reservoirs with complex geological *** the case study of the Huangliu Formation in Qiongdongnan Basin,South China Sea,this study first dimensionalized the conventional seismic attributes of Gas Layer Group I and then used the GRA method to obtain the main relational factors.A higher relational degree indicates a higher probability of responding to the attributes of the turbidite *** study then accumulated the optimized attributes with the highest relational factors to obtain a first-order accumulated sequence,which was used as the input training sample of the SVM model,thus successfully constructing the SVM turbidite channel *** results prove that the GRA-SVMmethod has a high drilling coincidence *** the core and logging data and taking full use of the advantages of seismic inversion in predicting the sand boundary of water channels,this study divides the sedimentary microfacies of the Huangliu Formation in the Lingshui 17-2 Gas *** comprehensive study has shown that the GRA-SVM method has high accuracy for predicting turbidite channels and can be used as a superior turbidite channel prediction method under complex geological conditions.

关键词： Support vector machine channel Huangliu Formation Qiongdongnan Basin

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Influence of mantle plume on continental rift evolution: A case study of the East African rift system

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PETROLEUM RESEARCH 2024年第3期9卷 409-417页

作者： Xu, Haixuan Li, jianghai Wang, Lijie Zhang, Xiaoyu Feng, Bo Peking Univ Sch Earth & Space Sci MOE Key Lab Orogen Belts & Crustal Evolut Beijing 100871 Peoples R China Peking Univ Inst Oil & Gas Sch Earth & Space Sci Beijing 100871 Peoples R China

Mantle plume is an essential component of the mantle convection system, and its influence on the geodynamics of continental rifts is of great significance for understanding the crust-mantle interaction. The East African Rift System, as the largest continental rift in the Cenozoic and in the initial stage, provides an excellent option for studying the interaction between the mantle plume and the continental crust. Based on the data such as GPS, seismic tomography, and global crustal model, a viscoelastic-plastic 2D thermodynamic numerical model is established to reconstruct the evolution of the Afar depression, Ethiopian Rift, and Kenyan Rift. By comparing the differences between the models of the Afar depression, Ethiopian Rift, and Kenyan Rift, the relationship between the mantle plume and pre-existing structures and their influence on the evolution of continental rifts are discussed. The results show that the mantle plume can increase the depth of the rift faults, concentrate the distribution of the faults, and strengthen the control of main faults on the rifts, allowing the possibility of narrow rifts. Pre-existing structures control the fault styles and symmetry of the rifts and also the morphology of the mantle plume. (c) 2024 The Authors. Publishing services provided by Elsevier B.V. on behalf of KeAi Communication Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://***/licenses/ by-nc-nd/4.0/).

关键词： Mantle plume Continental rift East Africa rift system Numerical simulation MAIN ETHIOPIAN RIFT PROPAGATION MODELS SINGLE

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滇东南八布早二叠世含火山岩屑砂岩指示古特提斯洋俯冲

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地球科学（中国地质大学学报） 2017年第1期42卷 24-34页

作者：杨江海杜远生于鑫黄虎柴嵘中国地质大学生物地质与环境地质国家重点实验室湖北武汉430074 中国地质大学地球科学学院湖北武汉430074 成都理工大学沉积地质研究院四川成都610059

滇东南八布基性/超基性岩体被认为代表洋壳残片,与越北Song Hien构造带内的蛇绿岩体共同构成八布-Song Hien古特提斯缝合带的重要岩石记录,是认识华南西南缘古特提斯构造演化的重要窗口.环绕八布基性/超基性岩体分布大面积碎屑岩系,内... 详细信息

滇东南八布基性/超基性岩体被认为代表洋壳残片,与越北Song Hien构造带内的蛇绿岩体共同构成八布-Song Hien古特提斯缝合带的重要岩石记录,是认识华南西南缘古特提斯构造演化的重要窗口.环绕八布基性/超基性岩体分布大面积碎屑岩系,内夹有硅质岩序列,长期以来被认为是三叠纪浊流沉积,但缺少确切的古生物化石和放射性年代学证据.为确定这套碎屑岩的沉积时代和物质来源,对紧邻八布岩体的龙林西含火山岩屑砂砾岩进行LA-ICPMS碎屑锆石U-Pb同位素和微量元素分析.结果显示,碎屑锆石年龄谱与华南西南缘的二叠系-三叠系年龄谱明显不同,但与Song Hien构造带晚二叠世砂岩和哀牢山带绿春二叠纪砂岩年龄谱相似.最年轻锆石年龄组约为285Ma,在微量元素组成上与弧/造山型岩浆结晶锆石一致,对应于安山质-流纹质火山岩屑,指示早二叠世火山岩浆活动.结合碎屑锆石年龄谱的对比分析和八布村东硅质岩序列的新发现,结果表明八布碎屑岩的沉积时代应为早二叠世,而非中三叠世,其早二叠世火山岩源区与八布-Song Hien古特提斯洋俯冲有关.

关键词：滇东南八布早二叠世古特提斯洋俯冲碎屑锆石火山岩岩屑岩石学

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断裂岩石排替压力预测方法的改进及其应用

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石油与天然气地质 2024年第3期45卷 866-872页

作者：徐海轩李江海北京大学地球与空间学学院北京100871 造山带与地壳演化教育部重点实验室北京100871

为了解决目前断裂岩石排替压力预测方法尚存在的问题,以便更准确、科学地反映地下实际情况,根据断裂岩石和围岩排替压力与压实成岩程度之间的正相关关系,利用断裂岩石与相同埋深围岩排替压力之比应等于断裂岩石与相同埋深围岩压实成岩... 详细信息

为了解决目前断裂岩石排替压力预测方法尚存在的问题,以便更准确、科学地反映地下实际情况,根据断裂岩石和围岩排替压力与压实成岩程度之间的正相关关系,利用断裂岩石与相同埋深围岩排替压力之比应等于断裂岩石与相同埋深围岩压实成岩程度之比的关系,推导出了断裂岩石与相同埋深围岩排替压力之间关系,进而改进了目前断裂岩石排替压力的预测方法。利用该方法预测海拉尔盆地贝尔凹陷呼和诺仁背斜带F1断裂在大磨拐河组一段下亚段区域性泥岩盖层内的断裂岩石排替压力,结果表明改进后方法的预测结果明显小于改进前方法的预测结果,更符合F1断裂处南屯组二段油气仅分布在构造高部位的实际情况。改进后的断裂岩石排替压力预测方法适用于碎屑岩含油气盆地张性断裂在脆性地层中的断裂岩石排替压力预测。

关键词：围岩盖层排替压力断裂岩石海拉尔盆地

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