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Adeno-associated virus as a delivery vector for gene therapy of human diseases

Signal Transduction and Targeted Therapy 2024年第5期9卷 1808-1840页

作者： jiang-hui wang Dominic J.Gessler Wei Zhan Thomas L.Gallagher Guangping Gao Horae Gene Therapy Center University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Department of Microbiology and Physiological Systems University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVIC3002Australia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVIC3002Australia Department of Neurological Surgery University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Department of Neurosurgery University of MinnesotaMinneapolisMN55455USA Department of Medicine University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Li Weibo Institute for Rare Diseases Research University of Massachusetts Chan Medical SchoolWorcesterMA01605USA

Adeno-associated virus(AAV)has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different *** AAV(rAAV)has been engineered for enhanced specificity and developed as a tool for treating various ***,as rAAV is being more widely used as a therapy,the increased demand has created challenges for the existing manufacturing *** rAAV-based gene therapy products have received regulatory approval,but there continue to be concerns about safely using high-dose viral therapies in humans,including immune responses and adverse effects such as genotoxicity,hepatotoxicity,thrombotic microangiopathy,and *** this review,we explore AAV biology with an emphasis on current vector engineering strategies and manufacturing *** discuss how rAAVs are being employed in ongoing clinical trials for ocular,neurological,metabolic,hematological,neuromuscular,and cardiovascular diseases as well as *** outline immune responses triggered by rAAV,address associated side effects,and discuss strategies to mitigate these *** hope that discussing recent advancements and current challenges in the field will be a helpful guide for researchers and clinicians navigating the ever-evolving landscape of rAAV-based gene therapy.

关键词： diseases specificity approval

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Preparation and Characteristic of Glass-Ceramics with Super Low Thermal Expansion Coefficient

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Journal of Rare Earths 2006年第z1期24卷 119-121页

作者： Zhao Chunxia Fan Shigang Chen Guangle jiang hui wang Shengjun wang Kun Research Institute of Synthetic Crystals Beijing 100018 China Research Institute of Synthetic Crystals Beijing 100018 China Research Institute of Synthetic Crystals Beijing 100018 China Research Institute of Synthetic Crystals Beijing 100018 China Research Institute of Synthetic Crystals Beijing 100018 China Research Institute of Synthetic Crystals Beijing 100018 China

The preparation technics of glass-ceramics with super low coefficient of thermal expansion containing β-quartz solid solution as a main crystal phase based on the glass in the system Li2O-Al2O3-SiO2 was introduced. The composition of base glass, technics of melting and heat treatment effecting on characteristic of glass-ceramics was described. Specimens were prepared by melting, anneal and controlled two steps heat treatment. Crystal phase, microstructure and elementary distributing were studied by using XRD, SEM and EDS respectively. Prepared specimens show excellent transparency and super low thermal expansion coefficient of 2×10-8 ·K-1, which reaches international advanced level.

关键词： low thermal expansion Li2O-Al2O3-SiO2 transparent glass-ceramics

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A case of aggravation of hemolytic anemia, elevated liver enzymes and low platelet count syndrome after delivery

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Chinese Medical Journal 2011年第8期124卷 1261-1263页

作者： jiang Yuan-hui wang Yong-qing wang Jing YE Rong-hua Department of Obstetrics and Gynecology Peking UniversityThird Hospital Beijing 100191 China

Background Hemolytic anemia, elevated liver enzymes and low platelet count （HELLP） syndrome is a severe obstetric complication which usually resolves in most patients after *** We report a rare case of aggravation of HELLP syndrome after *** The patient underwent the treatment for HELLP syndrome,.including glucocorticoid therapy. The symptoms of HELLP syndrome reappeared and became more severe than before the termination of pregnancy. The patient also had severe and persistent hypoproteinemia, hyponatremia and *** HELLP syndrome is an acute and critical obstetric syndrome which can have heterogeneous presentations and variable prognosis. We should be fully aware of the diverse clinical characteristics of this condition.

关键词： HELLP syndrome hypocalcemia hyponatremia hypoproteinemia

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Clinical and microbiological features of community-acquired and nosocomial bloodstream infections in the surgical department of a tertiary-care hospital in Beijing

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Chinese Medical Journal 2013年第22期126卷 4242-4246页

作者： LU You GUO Peng YE Ying-jiang wang hui SHEN Zhan-long wang Qi ZHAO Chun-jiang GAO Zhi-dong ZHANG Xin CAO Jian jiang Ke-wei wang Shan Peking Univ Peking Univ Peoples Hosp Dept Surg Gastroenterol Beijing 100044 Peoples R China Peking Univ Peking Univ Peoples Hosp Dept Clin Lab Beijing 100044 Peoples R China Shihezi Univ Affiliated Hosp 1 Dept Hepatobiliary Surg Shihezi 832008 Xinjiang Peoples R China

Background Bloodstream infections （BSls） remain a major cause of morbidity and mortality in patients undergoing surgery. This study aimed at elucidating the clinical characteristics of community-acquired BSIs （CABs） and nosocomial BSIs （nBSIs） in patients admitted to the surgical wards of a teaching hospital in Beijing, China. Methods This cross-sectional study compared 191 episodes of BSIs in 4074 patients admitted to the surgical wards between January 2008 and December 2011. Cases of BSIs were classified as CABs or nBSIs, and the characteristics, relevant treatments, and outcomes of CABs and nBSIs were compared. Results Of the 191 BSIs, 52 （27.2%） and 139 （72.8%）were CABs and nBSIs, respectively. Escherichia coli, coagulasenegative staphylococci, and Klebsiella spp, were the most frequently isolated microorganisms. There were significant differences between CABs and nBSIs with respect to the use of hormonal drugs, ventilation, acute physiology and chronic health evaluation （APACHE） Ⅱand American Society of Anesthesiologists scores, and prevalence of cancer （P 〈0.05）. Empirical antibacterial therapy did not decrease the crude mortality, but multivariate analysis showed that high APACHE Ⅱwas independently associated with a risk of mortality （odds ratio =0.97, 95% confidence interval： 0.93-1.02 for APACHE Ⅱ）. Conclusions We found significant differences in the clinical characteristics of surgical patients with CABs and nBSIs. The outcome of patients seems to be related to hiah APACHE Ⅱ scores.

关键词： bacteremia bloodstream infection, surgery, nosocomial infection, community-acquired injection

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Cleaner production for continuous digester processes based on hybrid Pareto genetic algorithm

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Journal of Environmental Sciences 2003年第1期15卷 129-135页

作者： JIN Fu\|jiang, wang hui, LI Ping (Institute of Industrial Process Control, Zhejiang University, Hangzhou 310027, China. Institute of Industrial Process Conlnil Zhejiang University Hangzhnu 310027

Pulping production process produces a large amount of wastewater and pollutant emitted, which has become one of the main pollution sources in pulp and paper industry. To solve this problem, it is necessary to implement cleaner production by using modeling and optimization technology. This paper studies the modeling and multi\|objective genetic algorithms for continuous digester process. First, model is established, in which environmental pollution and saving energy factors are considered. Then hybrid genetic algorithm based on Pareto stratum\|niche count is designed for finding near\|Pareto or Pareto optimal solutions in the problem and a new genetic evaluation and selection mechanism is proposed. Finally using the real data from a pulp mill shows the results of computer simulation. Through comparing with the practical curve of digester,this method can reduce the pollutant effectively and increase the profit while keeping the pulp quality unchanged.

关键词： cleaner production multi\|objective optimization genetic algorithm Pareto stratum concentration of residual alkali Kamyr continuous digester

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Moderate Deviations for Parameter Estimation in the Fractional Ornstein–Uhlenbeck Processes with Periodic Mean

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1308-1324页

作者： hui jiang Shi Min LI Wei Gang wang School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China The People's Bank of China Operations Ofice of Nanjing Branch Nanjing 210016P.R.China School of Statistics and Mathematics Zhejiang Gongshang UniversityHangzhou 310018P.R.China

In this paper,we study the asymptotic properties for the drift parameter estimators in the fractional Ornstein-Uhlenbeck process with periodic mean function and long range *** Cremér-type moderate deviations,as well ... 详细信息

关键词： Cramér-type moderate deviation fractional Ornstein-Uhlenbeck process parameter estimation multiple Wiener-Ito integrals

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Do nocturnal birds use acoustic and visual cues to avoid predation by bats?

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Integrative Zoology 2024年第3期19卷 524-537页

作者： Lixin GONG Huan WU Zhiqiang wang hui WU jiang FENG Tinglei jiang Jilin Provincial Key Laboratory of Animal Resource Conservation and Utilization Northeast Normal UniversityChangchunChina Key Laboratory of Vegetation Ecology of Education Ministry Institute of Grassland ScienceNortheast Normal UniversityChangchunChina College of Life Science Jilin Agricultural UniversityChangchunChina

Anti-predation strategies are critical to animal survival and are fundamental to deciphering predator–prey *** an important defense strategy,sensory predator detection(such as through acoustic and visual cues)enables animals to assess predation risk and execute predator-avoidance behavior;however,there are limited studies on the anti-predation behavior of nocturnal *** prey of bats provides an excellent representative system for examining the anti-predation behavior of nocturnal ***,we broadcasted different types of echolocation calls of the bird-eating bat Ia io to two wild passerine birds,namely,Zosterops japonicus and Sinosuthora webbiana,that are preyed upon by ***,and presented the birds with individual bats under different light *** results showed that both bird species were able to perceive the low-frequency audible portion of the bats’echolocation calls;however,they did not exhibit escape responses to the acoustic *** the dark and under moonlit conditions,both bird species were unable to respond to active bats at close range and the birds only exhibited evasive flight behavior when bats approached or touched *** results suggest that nocturnal passerine birds may not be able to use acoustic or visual cues to detect bats and adopt evasive maneuvers to avoid *** work suggests that bat predation pressure may not elicit primary predator-avoidance responses in nocturnal passerine *** results provide new insights into the anti-predation behavior of nocturnal animals.

关键词： anti-predation behavior nocturnal animals sensory cues sensory defenses

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A Reverse Path Planning Approach for Enhanced Performance of Multi-Degree-of-Freedom Industrial Manipulators

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1357-1379页

作者： Zhiwei Lin hui wang Tianding Chen Yingtao jiang Jianmei jiang Yingpin Chen Key Laboratory of Light Field Manipulation and System Integration Applications in Fujian Province School of Physics and Information EngineeringMinnan Normal UniversityZhangzhou363000China Department of Electrical and Computer Engineering University of NevadaLas Vegas89154USA College of Material Engineering Fujian Agriculture and Forestry UniversityFuzhou350000China

In the domain of autonomous industrial manipulators,precise positioning and appropriate posture selection in path planning are pivotal for tasks involving obstacle avoidance,such as handling,heat sealing,and *** Multi-Degree-of-Freedom(MDOF)manipulators offer kinematic redundancy,aiding in the derivation of optimal inverse kinematic solutions to meet position and posture requisites,their path planning entails intricate multiobjective optimization,encompassing path,posture,and joint motion *** satisfactory results in practical scenarios remains *** response,this study introduces a novel Reverse Path Planning(RPP)methodology tailored for industrial *** approach commences by conceptualizing the manipulator’s end-effector as an agent within a reinforcement learning(RL)framework,wherein the state space,action set,and reward function are precisely defined to expedite the search for an initial collision-free *** enhance convergence speed,the Q-learning algorithm in RL is augmented with ***,we formulate the cylindrical bounding box of the manipulator based on its Denavit-Hartenberg(DH)parameters and propose a swift collision detection ***,the motion performance of the end-effector is refined through a bidirectional search,and joint weighting coefficients are introduced to mitigate motion in high-power *** efficacy of the proposed RPP methodology is rigorously examined through extensive simulations conducted on a six-degree-of-freedom(6-DOF)manipulator encountering two distinct obstacle configurations and target *** results substantiate that the RPP method adeptly orchestrates the computation of the shortest collision-free path while adhering to specific posture constraints at the target ***,itminimizes both posture angle deviations and joint motion,showcasing its prowess in enhancing the operational performance of MDOF industrial manipulators.

关键词： Reverse path planning Dyna-Q bidirectional search posture angle joint motion

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Progressive fragmentation of granular assemblies within rockslides: Insights from discrete-continuous numerical modeling

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Journal of Mountain Science 2024年第4期21卷 1174-1189页

作者： jiang hui ZHOU Yuande wang Jinting DU Xiuli HUANG Hailong Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China. Key Laboratory of the Hydrosphere Sciences of the Ministry of Water Resources Tsinghua UniversityBeijing 100084China China Three Gorges Construction Management Co. Ltd.Chengdu 610000China

Rock fragmentation plays a critical role in rock avalanches,yet conventional approaches such as classical granular flow models or the bonded particle model have limitations in accurately characterizing the progressive disintegration and kinematics of multi-deformable rock blocks during *** present study proposes a discrete-continuous numerical model,based on a cohesive zone model,to explicitly incorporate the progressive fragmentation and intricate interparticle interactions inherent in *** rock granular assemblies are released along an inclined plane and flow onto a horizontal *** numerical scenarios are established to incorporate variations in slope angle,initial height,friction coefficient,and particle *** evolutions of fragmentation,kinematic,runout and depositional characteristics are quantitatively analyzed and compared with experimental and field data.A positive linear relationship between the equivalent friction coefficient and the apparent friction coefficient is *** general,the granular mass predominantly exhibits characteristics of a dense granular flow,with the Savage number exhibiting a decreasing trend as the volume of mass *** process of particle breakage gradually occurs in a bottom-up manner,leading to a significant increase in the angular velocities of the rock blocks with increasing *** simulation results reproduce the field observations of inverse grading and source stratigraphy preservation in the *** propose a disintegration index that incorporates factors such as drop height,rock mass volume,and rock *** findings demonstrate a consistent linear relationship between this index and the fragmentation degree in all tested scenarios.

关键词： Rock fragmentation Rockslide Numerical modelling Discrete-continuous modelling Runout Cohesive zone model

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Insight into the Role of Isolated Gold Atoms-Ceria Conjunction in Catalyzing the Water-Gas Shift Reaction

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Chinese Journal of Chemistry 2024年第6期42卷 636-644页

作者： Xin-Pu Fu hui-Zhao Wei-Wei wang Chun-jiang Jia Key Laboratory for Colloid and Interface Chemistry Key Laboratory of Special Aggregated MaterialsSchool of Chemistry and Chemical EngineeringShandong UniversityJinanShandong250100 China

As the promising catalysts for the water-gas shift(WGS)reaction,the activity of Au-CeO_(2) composites is susceptible to the aggregation size and electronic state of Au *** reports were extensively focused on the discrepancy between nonmetallic Au and metallic Au nanoparticles,whereas the understanding of the authentic role of the isolated Au atoms was ***,we investigated the catalytic behavior and structural information over two types of Au/CeO_(2) catalysts,in which the predominant conjunctions were isolated Au1-CeO_(2) and Aun-CeO_(2),*** on comprehensive characterizations,particularly by in-situ Raman and in-situ DRIFTS,we found that the isolated Au atoms were responsible for enhancing the reducibility of the CeO_(2) *** CO adsorption ability on the isolated Au sites was significantly inferior to clustered Au atoms,especially at relatively high temperatures(>200°C).As a result,the boosted O vacancy on the isolated Au1-CeO_(2) conjunctions could improve the H2O activation ability for the Au-CeO_(2) catalysts and demonstrate a comparable activity to the clustered Aun-CeO_(2) *** work might deepen understanding of the catalytic function for the isolated Au1 site within Au/CeO_(2) systems while catalyzing the WGS reaction.

关键词： Isolated Au atoms Ceria-based catalysts Water-gas shift reaction Defect Adsorption

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