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Expression and clinical significance of S100A2 and p63 in esophageal carcinoma

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World Journal of Gastroenterology 2009年第33期15卷 4183-4188页

作者： Li-Yu cao Yu Yin Hao Li Yan jiang hong-Fu zhang Department of Pathology Anhui Medical University Hefei 230032 Anhui Province China

AIM： TO investigate the expression and clinical significance of S100A2 mRNA and protein, p63 protein in esophageal squamous cell carcinoma （ESCC） and their roles in carcinogenesis and progression of esophageal carcinoma （EC）. METHODS： Immunohistochemical staining （S-P method） for S100A2 and p63 protein were performed in 40 samples of ESCC and 40 samples of normal esophageal mucosa. In situ hybridization （ISH） was used to detect the expression of S100A2 mRNA. RESULTS： Expression of S100A2 mRNA in ESCC was positive in 77.5% of samples, which was lower than that in normal mucosa （100%） by ISH （P = 0.002）. The expression level of S100A2 mRNA was closely related to differentiation and and node-metastasis （P = 0.012, P = 0.008）. Expression of $100A2 protein was positive in 72.5% of ESCC samples and expression of p63 protein was positive in 37.5% of ESCC samples, and was lower than that in normal mucosa （100%）（P = 0.000）. The expression of S100A2 protein was correlated with the differentiation and node-metastasis （P = 0.007, P = 0.001）, but no relationship was observed between the expression of p63 protein and clinical pathological manifestations. S100A2 protein was positively correlated with the expression of S100A2 mRNA, and negatively associated with the expression of p63 protein （P = 0.000, P = 0.002）. CONCLUSION： S100A2 and p63 protein both play important roles in the carcinogenesis of ESCC. An investigation into the combined expression of S100A2 and p63 may be helpful in early diagnosis and in evaluating the prognosis of ESCC.

关键词： Immunohistochemistry In situ hybridization Esophageal carcinoma p63 S100A2

Bioassay and Identification of Root Exudates of Three Fruit Tree Species

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Journal of Integrative Plant Biology 2007年第3期49卷 257-261页

作者： jiang-hong zhang Zhi-Quan Mao Li-Qin Wang Huai-Rui Shu College of Horticultural Science and Engineering Shandong Agricultural University Taian 271018 Shandong China College of Horticulture Agricultural University of Hebei Baoding 071001 China

A laboratory bioassay was designed to determine the aileiopathic potential of root exudates of three fruit tree species on apple germination. The results showed that root exudates of apple （Malus pumila L.） and peach （Prunus persica L.）, each at concentrations of 0.02 and 0.2 mg/L, inhibited germination and radicle growth of apple seeds by 56.7%, 60.7%, 51.5%, and 59.3%, respectively. The corresponding shoot growth inhibition rate was 49.5%, 46.7%, 36. 4%, and 44%, respectively. Root exudates of jujube （Ziziphus jujuba Mill.） had no significant effect on apple seeds. Qualitative determination of root exudates of apple, peach, and jujube tree was developed with gas chromatography-mass spectrometry. The root exudates of apple seedlings mainly contain organic acids, glycol, esters, and benzenphenol derivatives. Peach root exudates contained phenolic acids and benzenphenoi derivatives in addition to two unidentified compounds. The root exudates of jujube did not contain any phenolic acids.

关键词： bioassay fruit tree root exudates

High-Temperature Oxidation Behavior of Vanadium,Titanium-Bearing Magnetite Pellet

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Journal of Iron and Steel Research International 2011年第8期18卷 14-19页

作者： HAN Gui-hong jiang Tao zhang Yuan-bo HUANG Yan-fang LI Guang-hui School of Minerals Processing and Bioengineering Central South University Changsha 410083 Hunan China

By means of isothermal oxidation and chemical analysis, great importance was attached to the parameters that made effects on the oxidation degree of vanadium, titanium-bearing magnetite pellet in high-temperature processing （1 073- 1 323 K）. Based on the experimental data, oxidation kinetics of pellet was analyzed according to shrinking unreacted-core model subsequently. Experiment results display that the oxidation degree of pellet increases with increasing of oxidation time, oxidation temperature and oxygen content, as well as shrinking of pellet diameter. Under the condition of oxidation time 20 min, oxidation temperature 1223 K, oxygen content 15%, and pellet diameter 12 mm, oxidation degree of pellet reaches 92.92%. The analysis of oxidation kinetics indicates that oxidation process of pellet is controlled by chemical reaction with activation energy 68.64 kJ/mol at a relatively lower temperature （1073-1 173 K）. Oxidation process of pellet is mixed-controlled by chemistry reaction and diffusion with activation energy 39.66 kJ/mol in the temperature range of 1 173-1 273 K. When oxidation temperature is higher than 1 273 K, the limited link of oxidation reaction is the diffusion control with the activation energy 20.85 kJ/mol. These results can serve as a reference to the production of vanadium, titanium-hearing magnetite pellet.

关键词： vanadium titanium-bearing magnetite oxidation degree pellet shrinking unreaeted-core model oxidation kinetics

The Genetic Diversity and Phylogenetic Status of Luxi Cattle

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Agricultural Sciences in China 2006年第8期5卷 629-634页

作者： MAO Yong-jiang CHANG hong YANG zhang-ping XU Ming zhang Liu CHANG Guo-bin SONG Wei- tao WANG Dong-lei Animal Science and Technology College Yangzhou University Yangzhou 225009 P.R.China

A total of 87 individuals of Luxi cattle from Juanchen and Liangshan counties, Shangdong Province, China, were sampled by simple random sampling in typical colony. Twenty-one blood proteins and enzymes loci were detected by polyacrylamide gel electrophoresis （PAGE） and starch gel electrophoresis （SGE）. In the meantime, the data of 7 loci of 13 cattle populations in China and other countries were collected and phylogeny relationships were studied. The results indicated that 9 out of 21 loci showed polymorphism （42.86%）; the level of genetic variation in Luxi cattle population was relatively high, the mean heterozygosity was 0.1416. The Luxi cattle have a close phylogenetic relationship with the cattle populations of east and south of Asia, and this further confirmed the fact that Luxi cattle were the cross-breed between the Bos taurus and Bos indicus in China, but it is impossible that yellow cattle contained the blood of of Bali.

关键词： Luxi cattle genetic diversity cluster analysis

Production,Duplication and Characteristics Extinction:An Analysis on Crisis of City Characteristics with Theory of “Production of Space”

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China City Planning Review 2010年第3期19卷 40-49页

作者： jiang hong, zhang Siwei,QIAN Fang

With the theory of "production of space", the paper interprets the phenomenon of characteristics crisis that occurs in Chinese cities nowadays. Through analyzing the relationship between the characteristics crisis and the production of capitalized space, the paper tries to prove that the crisis of city characteristics is inevitable amid the rapid urbanization of China. The paper also suggests that in order to resist the trend, urban planning should adopt certain methods in the practice.

关键词： production of space characteristics crisis Neo-Mar

Risk factors for gastroesophageal reflux disease,reflux esophagitis and non-erosive reflux disease among Chinese patients undergoing upper gastrointestinal endoscopic examination

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World Journal of Gastroenterology 2007年第45期13卷 6009-6015页

作者： Juan Du jiang Liu hong zhang Chao-Hui Yu You-Ming Li Department of Gastroenterology First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 Zhejiang Province China

AIM: To analyze the spectrum and risk factors of gastroesophageal reflux disease (GERD) based on presenting symptoms and endoscopic f indings. METHODS: A cross-sectional survey in a cluster random sample was conducted from November 2004 to June 2005 using a validated Chinese version Reflux Disease Questionnaire (RDQ) and other items recording the demographic characteristics and potential risk factors for GERD. Subjects were def ined as having GERD symptoms according to the RDQ score (> 12). All subjects were endoscopied and the def inition and severity of erosive esophagitis were evaluated by Los Angeles classif ication. The statistical analysis was performed with SPSS13.0 programs. RESULTS: Of 2231 recruited participants, 701 (31.40%) patients were diagnosed as having GERD while 464 (20.80%) patients had objective findings of reflux esophagitis (RE). Of those 464 patients, only 291 (13.00%) were reported as subjects with GERD symptoms. A total of 528 (23.70%) patients were found to have GERD symptoms, including 19.50% patients with grade A or B reflux esophagitis, 0.90% with grade C and 0.40% with grade D. On multivariate analysis, old age, male, moderate working burden, divorced/widowed and strong tea drinking remained as signif icant independent risk factors for erosive esophagitis. Meanwhile, routine usage of greasy food and constipation were considered as significant independent risk factors for non-erosive reflux disease (NERD). CONCLUSION: GERD is one of the common GI diseaseswith a high occurrence rate in China and its main associated factors include sex, anthropometrical variables and sociopsychological characteristics.

关键词： Gastroesophageal reflux disease Refluxesophagitis Non-erosive reflux disease Prevalence Riskfactors Endoscopy

Identification for Heat Tolerance in Backcross Recombinant Lines and Screening of Backcross Introgression Lines with Heat Tolerance at Milky Stage in Rice

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Rice science 2011年第4期18卷 279-286页

作者： jiang-lin LIAO hong-yu zhang Xue-lian SHAO Ping-an Zhong Ying-jin HUANG Key Laboratory of Crop Physiological Ecology and Genetic Breeding Ministry of Education Jiangxi Agricultural University Nanchang 330045 China

The present study aimed at breeding new rice germplasms with similar genome but significantly differed in heat tolerance during the grain filling stage.A total of 791 BC1F8 backcross recombinant lines,derived from the cross of Xieqingzao B /N22 //Xieqingzao B,were used as *** rice line was separated evenly into two groups,and the heat tolerance of all rice lines were evaluated at natural high temperature in *** rice lines with heat tolerant index higher than 90% or lower than 40% were selected to compare the phenotypic characters and further identify heat tolerance at the early milky stage in a *** lines with similar phenotypic characters but significantly differed in heat tolerance at the milky stage were analyzed by 887 simple sequence repeat markers that were evenly distributed on the 12 rice *** the result,12(6 pairs) rice lines with similar phenotypic characters but significantly differed in heat tolerance at the milky stage were *** marker analysis indicated that the genomic polymorphism between 703T and 704S was the smallest in the 6 pairs of rice lines,with only 16 polymorphic sites,including 22 different *** application of these two backcross introgression rice lines for future study on the mechanisms of heat tolerance in rice at the milky stage will be theoretically beneficial in reducing the interference caused by genetic differences from experimental materials.

关键词： rice heat tolerance milky stage backcross recombinant line backcross introgression line

Auto-Bcklund Transformation and Exact Solutions to the Generalized Kadomtsev-Petviashvili Equation with Variable Coefficients

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Communications in Theoretical Physics 2004年第9期42卷 325-328页

作者： HUANG Ding-jiang zhang hong-Qing Department of Applied Mathematics,Dalian University of Technology,Dalian 116024,China

By using the extended homogeneous balance method,a new auto-B cklund transformation(BT)to thegeneralized Kadomtsev-Petviashvili equation with variable coefficients(VCGKP)are *** making use of theauto-BT and choosing a special seed solution,we get many families of new exact solutions of the VCGKP equations,which include single soliton-like solutions,multi-soliton-like solutions,and special-soliton-like *** the KPequation and cylindrical KP equation are all special cases of the VCGKP equation,and the corresponding results ofthese equations are also given respectively.

关键词： generalized Kadomtsev-Petviashvili equation auto-B(?)cklund transformation exact solutions soliton-like solutions homogeneous balance method

Expressions of inducible nitric oxide synthase and matrix metalloproteinase-9 and their effects on angiogenesis and progression of hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第38期11卷 5931-5937页

作者： Min-Hua Sun Xi-Chun Han Ming-Ku Jia Wei-Dong jiang Min Wang hong zhang Gang Han Yi jiang Department of General Surgery Second Hospital Jilin University Changchun 130041 Jilin Province China

AIM： To determine the expressions of inducible nitric oxide synthase （iNOS） and matrix metalloproteinase-9 （MMP-9） in hepatocellular carcinoma （HCC） and to investigate the relationship between iNOS and MMP-9 expression and their effects on angiogenesis and progression of HCC.METHODS： In this study, we examined iNOS, MMP-9, and CD34 expression in specimens surgically removed from 32 HCC patients and 7 normal liver tissues by immunohistochemical staining. Meanwhile, microvessel density （MVD） was determined as a marker of angiogenesis by counting CD34-positive cells. RESULTS： The positive rates of iNOS and MMP-9 expression were 71.88% （23/32） and 78.13% （25/32） in HCC. MMP-9 expression was significantly correlated with tumor size, capsule status, TNM stage, and risk of HCC recurrence （P = 0.032, P= 0.033, P= 0.007, and P= 0.001, respectively）. There was also a significant relationship between iNOS expression and capsule status and risk of HCC recurrence （P = 0.049 and P = 0.004, respectively）, but no correlation between iNOS expression and tumor size and TNM stage. There was a positive association between MVD and TNM stage and risk of HCC recurrence （P = 0.037 and P = 0.000, respectively）. The count of MVD was significantly different in different iNOS and MMP-9 immunoreactivity groups （F= 17.713 and 17.097, P= 0.000 and P = 0.000, respectively）. The examination of Spearman＇s rank correlation coefficient showed that there was a significant positive correlation between MVD and iNOS, MMP-9 immunoreactivity （r = 0.754 and 0.751, P= 0.000 and P=-0.000, respectively）. There was also a significant association between MMP-9 and iNOS expression in HCC （P = 0.010）. CONCLUSION： Nitric oxide （NO） produced by iNOS could modulate MMP-9 production and therefore contribute totumor cell angiogenesis and invasion and metastasis in HCC. The strong expression of iNOS and MMP-9 in HCC may be helpful in evaluating the recurrence of HCC, predicting poor prognosis. For patients with str

关键词： Inducible nitric oxide synthase Matrixmetalloproteinase-9 Angiogenesis Hepatocellular carcinoma