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地卷柏的化学成分及其α-葡萄糖苷酶抑制活性研究

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天然产物研究与开发 2024年第1期36卷 37-43页

作者：姜红宇吕敬崑邵金华陈小明湖南科技学院化学与生物工程学院湖南省银杏工程技术研究中心湖南恒伟药业股份有限公司永州425100

研究地卷柏(Selaginella prostrata ***)的化学成分及其α-葡萄糖苷酶抑制活性,综合运用硅胶、Sephadex LH-20和半制备HPLC等多种色谱分离技术,从地卷柏全草的95%乙醇提取物中分离得到10个化合物,通过现代波谱学方法鉴定其结构为seprost... 详细信息

研究地卷柏(Selaginella prostrata ***)的化学成分及其α-葡萄糖苷酶抑制活性,综合运用硅胶、Sephadex LH-20和半制备HPLC等多种色谱分离技术,从地卷柏全草的95%乙醇提取物中分离得到10个化合物,通过现代波谱学方法鉴定其结构为seprostrataoid A(1)、(3 S,5 R,8 S)-5,8-epoxy-6-megastigmadien-3,9-diol(2)、(-)-黑麦草内酯(3)、(3 S,5 R,6 R,7 E)-3,5,6-三羟基-7-巨豆烯-9-酮(4)、(7 R,8 S)-ceplignan(5)、(2 R,3 S)-二氢-2-(3′,5′-二甲氧基-4′-羟基苯基)-3-羟甲基-7-甲氧基-5-乙酰基苯骈呋喃(6)、5,5′-二甲氧基木香酚A(7)、穗花衫双黄酮(8)、异柳杉双黄酮(9)、扁柏双黄酮(10)。其中,化合物1为新的倍半萜类化合物,化合物2~10为首次从地卷柏中分离得到。α-葡萄糖苷酶抑制活性测试结果显示,化合物7~10具有较好的α-葡萄糖苷酶抑制活性,IC 50值分别为72.14±2.67、42.68±1.54、61.26±4.32、55.43±2.17μmol/L。

关键词：地卷柏化学成分倍半萜双黄酮 α-葡萄糖苷酶

“新木桶理论”视域下县域公共体育服务发展的现实瓶颈与突破路径

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福建体育科技 2024年第2期43卷 1-7页

作者：李理熊薇蒋宏宇湖南科技大学体育学院湖南湘潭411201

县域作为承上启下、贯通城乡的重要枢纽,是推进全面建设社会主义现代化国家的基础与核心。本文基于“新木桶理论”视角,运用文献资料等研究方法,对县域公共体育服务发展现状展开分析与思考。县域公共体育服务发展的现实瓶颈主要包括底... 详细信息

县域作为承上启下、贯通城乡的重要枢纽,是推进全面建设社会主义现代化国家的基础与核心。本文基于“新木桶理论”视角,运用文献资料等研究方法,对县域公共体育服务发展现状展开分析与思考。县域公共体育服务发展的现实瓶颈主要包括底板薄弱、围板间隙以及桶箍限制3个方面,具体表现为服务经费投入不足、多元协同结构失衡、内外主体监督疲软。据此,提出促进服务经费稳步增长以夯实拓宽桶底;引领多元主体融合共治以密合围板间隙;推进数字监督平台以发挥桶箍效用。

关键词：新木桶理论县域公共体育服务

19种中药提取物对海洋致病溶藻弧菌生长和生物被膜的影响

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天然产物研究与开发 2024年第6期36卷 1013-1021页

作者：李百元张叶敏夏晶晶姜红宇曹林艳陈丹湖南科技学院化学与生物工程学院、湖南南岭地区植物资源研究开发湖南省工程研究中心、湘南优势植物资源综合利用湖南省重点实验室永州425199

溶藻弧菌爆发和流行给海水养殖造成巨大经济损失,生物被膜的形成导致溶藻弧菌的致病性和耐药性进一步加强。目前,中草药已经在防治病原性细菌感染疾病中展现出积极的潜力。本研究选取19种中药(枸杞、重楼、紫菀、何首乌、鸡血藤、厚朴... 详细信息

溶藻弧菌爆发和流行给海水养殖造成巨大经济损失,生物被膜的形成导致溶藻弧菌的致病性和耐药性进一步加强。目前,中草药已经在防治病原性细菌感染疾病中展现出积极的潜力。本研究选取19种中药(枸杞、重楼、紫菀、何首乌、鸡血藤、厚朴、墨旱莲、广金钱草、栀子、桃金娘、连翘、公丁香、白英、黄柏、艾叶、知母、盐知母、酒知母、炒知母),采用不同溶剂进行提取,旨在深入探究这些中药提取物对溶藻弧菌的生长和生物被膜形成的影响。通过采用牛津杯法和96孔培养法,系统性地分析了其提取物对溶藻弧菌生长的影响;利用结晶紫染色法,探究了这些中药提取物在其亚抑制浓度下对溶藻弧菌生物被膜形成的潜在影响。结果发现其中12种中药的水提物有抑菌活性,17种中药的乙醇提取物和15种中药的乙酸乙酯提取物有抑菌活性;此外,公丁香水提取物、重楼和知母乙醇提取物、桃金娘和连翘乙酸乙酯提取物对溶藻弧菌生物被膜的形成产生了明显的抑制效果;同时,我们还发现知母及其炮制品在抑菌活性方面存在一定差异,但在对生物被膜形成的作用表现出一定的相似性。本研究的发现为细菌的防治和抗生物被膜制剂的研发具有重要的指导意义。这些发现有望为应对溶藻弧菌暴发提供新的、可持续的策略,有助于保护海洋养殖业的可持续性,维护食品安全,以及维护人类健康。

关键词：溶藻弧菌中药提取物生物被膜抑菌

Protease-activated receptor 2 modulating cancer cell signal transduction and functions

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中国药理学与毒理学杂志 2019年第10期 766-767页

作者： jiang yu-hong Institute for Molecular Bioscience The University of Queensland School of Life Science and Engineering Southwest Jiaotong University

Protease-activated receptor 2 is a subfamily of G protein-coupled receptor activated by proteases（like trypsin, tryptase）, which is highly expressed on tumor cells and actively participates in tumour progressions. This receptor can regulate ERK, Ca;, PI3 K/AKT and other signal transduction as well as a variety of cellular functions such as apoptosis, migration, autophagy. We have designed and constructed biased agonists, which could selectively activate a signalling pathway without affecting others in cancer cells, through a structure-function selective relationship. AY254 as an ERK-biased agonist selectively activates ERK signalling and related functions, while the other two calcium-biased agonists DF253 and AY77 fail to regulate ERK-related functions. Moreover, from the perspective of receptor pharmacology, it was found that a novel allosteric antagonist, I-191, showed effective inhibitions for multiple signalling pathways and cell functions induced by different PAR2 agonists in cancer cells, such as cytokine secretion, migration, and apoptosis, in a noncompetitive and insurmountable manner. The new roles of these PAR2 ligands as well underlying mechanisms are further investigated in different types of tumor cells,in order to provide a platform for basic research and application of PAR2 in cancer therapy.

关键词： protease-activated receptor 2 agonists antagonists signalling pathways metastasis

A Regional-Scale Method of Forecasting Debris Flow Events Based on Water-Soil Coupling Mechanism

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Journal of Mountain Science 2014年第6期11卷 1531-1542页

作者： ZHANG Shao-jie WEI Fang-qiang LIU Dun-long YANG hong-juan jiang yu-hong Key Laboratory of Mountain Hazards and Earth Surface Process Chinese Academy of Sciences Institute of Mountain Hazards and Environment Chinese Academy of Sciences

A debris flow forecast model based on a water-soil coupling mechanism that takes the debrisflow watershed as a basic forecast unit was established here for the prediction of disasters at the watershed *** was achieved through advances in our understanding of the formation mechanism of debris *** expand the applicable spatial scale of this forecasting model,a method of identifying potential debris flow watersheds was used to locate areas vulnerable to debris flow within a forecast *** these watersheds as forecasting units and a prediction method based on the water-soil coupling mechanism,a new forecasting method of debris flow at the regional scale was *** order to test the prediction ability of this new forecasting method,the Sichuan province,China was selected as a study zone and the large-scale debris flow disasters attributable to heavy rainfall in this region on July 9,2013 were taken as the study *** to debris flow disaster data on July 9,2013 which were provided by the geo-environmental monitoring station of Sichuan province,there were 252 watersheds in which debris flow events actually *** current model predicted that 265 watersheds were likely to experience a debris flow *** these,43 towns including 204 debrisflow watersheds were successfully forecasted and 24 towns including 48 watersheds *** false prediction rate and failure prediction rate of thisforecast model were 23% and 19%,*** results show that this method is more accurate and more applicable than traditional methods.

关键词： Debris flow Forecasting Water-soil coupling mechanism Watershed

Identification of Quantitative Trait Loci for Grain Appearance and Milling Quality Using a Doubled-Haploid Rice Population

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Journal of Integrative Plant Biology 2005年第11期47卷 1391-1403页

作者： Gong-Hao jiang Xue-yu hong Cai-Guo XU Xiang-Hua LI yu-Qing HE State Key Laboratory of Crop Genetic Improvement and National Center of Crop Molecular Breeding Huazhong Agricultural University Wuhan 430070 China

Improving grain quality, which is composed primarily of the appearance of the grain and its cooking and milling attributes, is a major objective of many rice-producing areas in China. In the present study, we conducted a marker-based genetic analysis of the appearance and milling quality of rice （Oryza sativa L.） grains using a doubled-haploid population derived from a cross between the indica inbred Zhenshan 97 strain and the japonica inbred Wuyujing 2 strain. Quantitative trait locus （QTL） analysis using a mixed linear model approach revealed that the traits investigated were affected by one to seven QTLs that individually explained 4.0%-30.7% of the phenotypic variation. Cumulatively, the QTL for each trait explained from 12.9% to 61.4% of the phenotypic variation. Some QTLs tended to have a pleiotropic or location-linked association as a cause of the observed phenotypic correlations between different traits. Improvement of the characteristics of grain appearance and grain weight, as well as an improvement in the milling quality of rice grains, would be expected by a recombination of different QTLs using marker-assisted selection.

关键词： doubled-haploid population grain appearance quality grain milling quality Oryza sativa quantitative trait locus.

Synergistic Effects of Activin A and Fibroblast Growth Factor 2 in the Modulation of Insulin Expression

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Chemical Research in Chinese Universities 2006年第2期22卷 229-232页

作者： BAO Yong-li jiang hong-yu Ji Shou-xian WU Yin MENG Xiang-ying LI yu-xin Institute of Genetics and Cytology Northeast Normal University Changchun 130024 P. R. China The First Affiliated Hospital Jilin University Changchun 130021 P. R. China The Second Affiliated Hospital Jilin University Changchun 130041 P. R. China

Diabetes is the most prevalent and serious metabolic disease, and the number of diabetic patients worldwide is increasing. The reduction of insulin biosynthes is in pancreatic E-cells is closely associated with the onset and progression of diabetes, therefore, it is important to search for ways to induce insulin-producing cells in non-E-cells. In the present study, it has been reported that activin A and a basic fibroblast growth factor 2 （ FGF2）, can synergistically increase the insulin mRNA level, in both mouse El4 striatal primary cell cultures and the hippocampal neuronal cell line HT22. Activin A and FGF2 can jointly stimulate the nuclear translocation of Smad3 and specifically activate ERK1/2. It is interesting to note that a specific inhibitor for MEK, U0126, can efficiently block the induction of an insulin promoter activity by activin A and FGF2. This indicates that activin A collaborates with FGF2, giving a signal to induce the insulin gene through selective activation of the ERK-type MAP kinase and Smad3 in mouse striatal and HT22 cells. These data suggest that activin A may act in concert with FGF2 for the development of insulin -positive neurons

关键词： Activin A Fibroblast growth factor 2 (FGF2) Insulin

A critique of the Guilt versus Shame Dichotomy in the Comparison of Chinese and Western Culture Based on an Analysis of Moral Self-discipline

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学术界 2010年第7期 272-275页

作者： jiang hong yu Ning Nanjing Normal University hong Kong Polytechnic University

*** Origin of the IssueRuth Benedict analyzes the behavior,psychology and values of Japanese people in the Chrysanthemum and the Sword,and points out that a sense of shame dominates the motive power of Japanese psychology; a sense of guilt dominates the motive power of Western *** scholars think the entire East,including Japan,is in the shame culture system,and they hold that the characteristic differences between Eastern and Western culture are the sense of shame versus the sense of guilt,and heteronomy versus autonomy.

关键词： A critique of the Guilt versus Shame Dichotomy in the Comparison of Chinese and Western Culture Based on an Analysis of Moral Self-discipline

Reliability analysis of carbon fiber rod-reinforced umbilical cable under tension using an improved sampling method

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Petroleum Science 2024年第4期21卷 2769-2778页

作者： yu Zhang hong-yu Zhang Ran Xia Si-Ao jiang Fang Wang College of Safety and Ocean Engineering China University of Petroleum China Academy of Aerospace Aerodynamics China Aerospace Science and Technology Group College of Engineering Science and Technology Shanghai Ocean University

The umbilical cable is a vital component of subsea production systems that provide power, chemical agents, control signals et al., and its requirement for reliability is exceedingly high. However, as the umbilical cable is a composite structure comprising multiple functional units, the reliability analysis of such cables involves numerous parameters that can impact calculation efficiency. In this paper, the reliability analysis of a new kind of umbilical cable with carbon fiber rod under tension is analyzed. The global dynamic analytical model is first established to determine the maximum tension load, then the local analytical model of umbilical cable including each unit are constructed by finite element method(FEM). Based on the mechanical analytical model, the reliability of umbilical cable under tension load is studied using response surface method(RSM) and Monte Carlo method. During the calculation process, a new tangent plane sampling method to calculate the response surface function(RSF) is proposed in this paper, which could make sampling points faster come close to the RSF curve, and it is proved that the calculation efficiency increases about 33% comparing with traditional method.

关键词： Umbilical cable Carbon fiber rod Failure analysis Response surface method Reliability