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Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models

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World Journal of Gastroenterology 2024年第9期30卷 1164-1176页

作者： Yan-Li jiang Juan Li Peng-Fei Zhang Feng-Xian Fan Jie zou Pin Yang Peng-Fei Wang Shao-Yu Wang Jing Zhang Department of Magnetic Resonance Imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Second Clinical School Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Gansu Province Clinical Research Center for Functional and Molecular Imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Hepatology The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina MR Scientific Marketing Siemens HealthineersXi’an 710065Shaanxi ProvinceChina

BACKGROUND Diffusion-weighted imaging(DWI)has been developed to stage liver ***,its diagnostic performance is inconsistent among ***,it is worth studying the diagnostic value of various diffusion models for liver fibrosis in one *** To evaluate the clinical potential of six diffusion-weighted models in liver fibrosis staging and compare their diagnostic *** This prospective study enrolled 59 patients suspected of liver disease and scheduled for liver biopsy and 17 healthy *** participants underwent multi-b value *** main DWI-derived parameters included Mono-apparent diffusion coefficient(ADC)from mono-exponential DWI,intravoxel incoherent motion model-derived true diffusion coefficient(IVIM-D),diffusion kurtosis imaging-derived apparent diffusivity(DKI-MD),stretched exponential model-derived distributed diffusion coefficient(SEM-DDC),fractional order calculus(FROC)model-derived diffusion coefficient(FROC-D)and FROC model-derived microstructural quantity(FROC-μ),and continuous-time random-walk(CTRW)model-derived anomalous diffusion coefficient(CTRW-D)and CTRW model-derived temporal diffusion heterogeneity index(CTRW-α).The correlations between DWI-derived parameters and fibrosis stages and the parameters’diagnostic efficacy in detecting significant fibrosis(SF)were assessed and *** CTRW-D(r=-0.356),CTRW-α(r=-0.297),DKI-MD(r=-0.297),FROC-D(r=-0.350),FROC-μ(r=-0.321),IVIM-D(r=-0.251),Mono-ADC(r=-0.362),and SEM-DDC(r=-0.263)were significantly correlated with fibrosis *** areas under the ROC curves(AUCs)of the combined index of the six models for distinguishing SF(0.697-0.747)were higher than each of the parameters alone(0.524-0.719).The DWI models’ability to detect SF was *** combined index of CTRW model parameters had the highest AUC(0.747).CONCLUSION The DWI models were similarly valuable in distinguishing SF in patients with liver *** combined index of CTRW paramet

关键词： Liver fibrosis Magnetic resonance imaging Diffusion-weighted magnetic resonance Liver biopsy Significant fibrosis

Icaritin inhibits the progression of urothelial cancer by suppressing PADI2-mediated neutrophil infiltration and neutrophil extracellular trap formation

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3916-3930页

作者： Zezhong Mou Yiling Chen Jinzhong Hu Yun Hu Lujia zou Xinan Chen Shenghua Liu Qiuping Yin Jian Gong Shuchen Li Shanhua Mao Chenyang Xu Haowen jiang Department of Urology Huashan HospitalFudan UniversityShanghai 200040China Fudan Institute of Urology Fudan UniversityShanghai 200040China National Clinical Research Center for Aging and Medicine Fudan UniversityShanghai 200040China

Tumor relapse and metastasis are the major causes of mortality associated with urothelial *** the tumor microenvironment,negative regulatory molecules and various immune cell subtypes suppress antitumor *** inflammatory microenvironment,associated with neutrophils and neutrophil extracellular traps(NETs),promotes tumor ***,no drugs are currently available to specifically inhibit neutrophils and *** this study,we first demonstrated that icaritin(ICT),a Chinese herbal remedy that is a first-line treatment for advanced and incurable hepatocellular carcinoma,reduces NETs caused by suicidal NETosis and prevents neutrophil infiltration in the tumor ***,ICT binds to and inhibits the expression of PADI2 in neutrophils,thereby suppressing PADI2-mediated histone ***,ICT inhibits ROS generation,suppresses the MAPK signaling pathway,and inhibits NET-induced tumor ***,ICT inhibits tumoral PADI2-mediated histone citrullination,which consequently suppresses the transcription of neutrophil-recruiting genes such as GM-CSF and *** downregulation of IL-6 expression,in turn,forms a regulatory feedback loop through the JAK2/STAT3/IL-6 *** a retrospective study of clinical samples,we found a correlation between neutrophils,NETs,UCa prognosis,and immune *** ICT with immune checkpoint inhibitors may have synergistic *** summary,our study demonstrated that ICT could be a novel inhibitor of NETs and a novel UCa treatment.

关键词： Icaritin Neutrophil Neutrophil extracellular trap PADI2 Urothelial cancer

Elevated nitrogen and co-evolution history with competitors shape the invasion process of Galinsoga quadriradiata

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Journal of Plant Ecology 2024年第4期17卷 9-22页

作者： Wen-Gang Zhang Xing-jiang Song Laís Petri Gang Liu Xiao-Yan Chen Rui-Ling Liu Fang-Fang Huang Jia-Bin zou Zhi-Hong Zhu College of Life Sciences Shaanxi Normal UniversityXi’an 710119China School for Environment and Sustainability University of MichiganAnn ArborMI 48109USA Research Center for UAV Remote Sensing Shaanxi Normal UniversityXi’an 710119China Changqing Teaching&Research Base of Ecology Shaanxi Normal UniversityXi’an 710119China Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhou 510520China

Invasive plants usually experience population differentiation as they expand from their initial invasive range to the ***,invasive plants usually encounter competitors which shared different co-evolutionary histories with *** factors may lead to varying responses of invasive plant populations to elevated nitrogen deposition during ***,this issue has received limited attention in prior *** address these challenges,we conducted a greenhouse experiment to investigate how population differentiation of Galinsoga quadriradiata interacts with the presence of various competitors in response to increased nitrogen *** types(new or old that shared short or long co-evolutionary history with the invader,respectively)were set to compete with the invasive central and edge populations under different nitrogen addition *** from the central population of ***,originating from the initial invasion range,showed greater total mass,reproduction and interspecific competitiveness compared with the edge *** addition improved growth and reproductive performance in both populations,and the central population had a stronger response compared with the edge *** performance of *** was inhibited more effectively by old competitors than new *** results indicate that population differentiation occurs in terms of growth and competitiveness during the range expansion of ***,with the central population exhibiting superior ***-evolutionary history with competitors is considered unfavorable for invasive plants in this *** results highlight the combined effects of population differentiation in invasive species and their co-evolution history with competitors in the context of global change factors.

关键词： Galinsoga quadriradiata central population edge population interspecific competition population differentiation elevated nitrogen

Trimethyltriazine-derived olefin-linked covalent organic framework with ultralong nanofibers

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Science Bulletin 2020年第19期65卷 1659-1666,M0004页

作者： Fan Zhang Shice Wei Weiwei Wei jiang zou Guoying Gu Dongqing Wu Shuai Bi Fan Zhang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Robotics Institute School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240China

Two-dimensional(2D)olefin-linked covalent organic frameworks(COFs)with excellentπ-electron communication and high stability are emerging as promising crystalline polymeric ***,because of the limited species of COFs,their characteristics,processability and potential applications have not been completely understood and *** this work,we prepared two novel olefin-linked 2D COFs through Knoevenagel condensation of 2,4,6-trimethyl-1,3,5-triazine with tritopic triazine-cored *** resulting COFs exhibit highly crystalline honeycomb-like structures stacked from hexagonallatticed polymeric layers and display well-defined nanofibrillar morphologies with the uniform diameters of ca.80 nm and ultra-lengths up to several *** COF nanofibers can be readily composited with carbon nanotubes into high-quality continuous thin films,which are further compacted by a typical hot-pressing process to enhance their densities and mechanical strength without changing their fibrous *** film-fabricated interdigital microelectrodes and the ionogel electrolyte are assembled into planar micro-supercapacitors(MSCs),which exhibit an outstanding areal capacitance of 44.3 mF cm^-2,large operating voltage window of 2.5 V,high volumetric energy density of 38.5 mWh cm^-3 as well as excellent cycling stability.

关键词： Covalent organic framework Olefin linkage Nanofiber Micro-supercapacitor Energy storage

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电子陶瓷材料钛酸钡的制备与性能研究

铸造技术 2017年第3期38卷 566-568页

作者：江伟邹静六盘水师范学院矿业工程系贵州六盘水553004 六盘水师范学院材料工程系贵州六盘水553004

采用固相反应法制备电子工业用BaZr_xTi_(1-x)O_3材料,研究不同烧结温度和时间的物相组成、显微组织形貌和介电性能。结果表明,随着烧结温度的升高,BaZr_xTi_(1-x)O_3中的物相组成没有明显变化,但结构由四方体变为立方体;当烧结温度从1 ... 详细信息

采用固相反应法制备电子工业用BaZr_xTi_(1-x)O_3材料,研究不同烧结温度和时间的物相组成、显微组织形貌和介电性能。结果表明,随着烧结温度的升高,BaZr_xTi_(1-x)O_3中的物相组成没有明显变化,但结构由四方体变为立方体;当烧结温度从1 250℃升高至1 350℃时,材料的平均晶粒尺寸从29μm增加至39μm;当晶粒尺寸较小时,材料主要形成90°畴和180°畴,增加晶粒尺寸,材料主要形成180°畴。

关键词：钛酸钡烧结温度保温时间介电常数温度

Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019

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Biomedical and Environmental Sciences 2024年第3期37卷 278-293页

作者： jiang Jie Ying LIANG Dan WANG Li XIAO Yun LIANG Yu Feng KE Bi Xia SU Juan XIAO Hong WANG Tao zou Min LI Hong Jian KE Chang Wen School of Public Health Shantou UniversityShantou 515063GuangdongChina Guangdong Provincial Center for Disease Control and Prevention Guangdong Workstation for Emerging Infectious Disease Control and PreventionGuangzhou 511430GuangdongChina Guangdong Provincial Key Laboratory of Virology Institute of Medical MicrobiologyJinan UniversityGuangzhou 510632GuangdongChina School of Public Health Sun Yat-sen UniversityGuangzhou 510275GuangdongChina School of Public Health Southern Medical UniversityGuangzhou 510515GuangdongChina Shantou University Medical College Shantou 515041GuangdongChina

Objective This study aimed to understand the epidemic status and phylogenetic relationships of rotavirus group A(RVA)in the Pearl River Delta region of Guangdong Province,*** This study included individuals aged 28 days–85 years.A total of 706 stool samples from patients with acute gastroenteritis collected between January 2019 and January 2020 were analyzed for 17 causative pathogens,including RVA,using a Gastrointestinal Pathogen Panel,followed by genotyping,virus isolation,and complete sequencing to assess the genetic diversity of *** The overall RVA infection rate was 14.59%(103/706),with an irregular epidemiological *** proportion of co-infection with RVA and other pathogens was 39.81%(41/103).Acute gastroenteritis is highly prevalent in young children aged 0–1 year,and RVA is the key pathogen circulating in patients 6–10 months of age with diarrhea.G9P[8](58.25%,60/103)was found to be the predominant genotype in the RVA strains,and the 41 RVA-positive strains that were successfully sequenced belonged to three different RVA genotypes in the phylogenetic *** analysis showed that gene reassortment events,selection pressure,codon usage bias,gene polymorphism,and post-translational modifications(PTMs)occurred in the G9P[8]and G3P[8]*** This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China,further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic *** the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.

关键词： Infectious diarrheal disease Rotavirus Phylogenetic analysis Gene rearrangement Codon usage bias Genetic diversity

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微小交错流道散热块传热性能

航空动力学报 2008年第5期23卷 845-850页

作者：邹江彭晓峰颜维谋清华大学相变与界面传递现象实验室北京100084 台湾华梵大学机电工程系中国台湾台北223

实验研究微小交错流道散热块的传热性能以及热阻系数.随着Re数增加,交错流道与直通流道内流动换热性能均会升高,前者的变化更加显著,对流热阻系数与Re数接近指数关系;相同Re数条件下,交错流道对流热阻系数约比直通流道下降18%.散热块底... 详细信息

实验研究微小交错流道散热块的传热性能以及热阻系数.随着Re数增加,交错流道与直通流道内流动换热性能均会升高,前者的变化更加显著,对流热阻系数与Re数接近指数关系;相同Re数条件下,交错流道对流热阻系数约比直通流道下降18%.散热块底面温度分布明显不一致,流体轴向温升对温度分布影响显著,温度在空间与时间上均有波动;预测交错流道在Re数为700左右开始发生流动转捩.

关键词：航空、航天推进系统交错流道传热强化热阻系数散热块

Electronic Structure Investigation of 12442 Iron-Based Superconductors Based on Block-Layer Model

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材料科学与工程（中英文B版） 2024年第1期14卷 21-26页

作者： Jianan Bian Xinyuan jiang Yuchen zou Yiming Yu School of Science Jiliang UniversityHangzhou 310018China

Superconducting transition temperature(Tc),as a crucial parameter,exploring its relationship with various macroscopic and microscopic factors helps to understand the mechanism of high-temperature superconductivity from multiple perspectives,aiding in a multidimensional comprehension of high-temperature superconductivity *** inspiration from the block-layer structure models of cuprate superconductors,we computationally investigated the interlayer interaction energies in the 12442-type iron-based superconducting materials AkCa_(2)Fe_(4)As_(4)F_(2)(Ak=K,Rb,Cs)systems based on the block-layer model and explored their relationship with *** observed that an increase in interlayer combinative energy leads to a decrease in Tc,while conversely,a decrease in interlayer combination energy results in an increase in ***,we found that the contribution of the Fe 3d band structure,especially the 3dz2 orbital,to charge transfer is significant.

关键词： Block-layer structural mode iron-based superconductor combinative energy superconducting transition temperature

The burgeoning importance of PIWI-interacting RNAs in cancer progression

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Science China(Life Sciences) 2024年第4期67卷 653-662页

作者： Xinpei Deng Tianle Liao Jindong Xie Da Kang Yiwei He Yuying Sun Zhangling Wang Yongluo jiang Xuan Miao Yixuan Yan Hailin Tang Lewei Zhu Yutian zou Peng Liu State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Medicine Sun Yat-sen UniversityShenzhen 518107China Key Laboratory of Cardiovascular and Cerebrovascular Medicine Nanjing Medical UniversityNanjing 211166China Guanghua School of Stomatology Sun Yat-sen UniversityGuangzhou 510062China The First People’s Hospital of Foshan Foshan 528000China

PIWI-interacting RNAs(pi RNAs)are a class of small noncoding RNA molecules that specifically bind to piwi protein family members to exert regulatory functions in germ *** studies have found that pi RNAs,as tissue-specific molecules,both play oncogenic and tumor suppressive roles in cancer progression,including cancer cell proliferation,metastasis,chemoresistance and ***,the atypical manifestation of pi RNAs and PIWI proteins in various malignancies presents a promising strategy for the identification of novel biomarkers and therapeutic targets in the diagnosis and management of ***,the precise functions of pi RNAs in cancer progression and their underlying mechanisms have yet to be fully *** review aims to examine current research on the biogenesis and functions of pi RNA and its burgeoning importance in cancer progression,thereby offering novel perspectives on the potential utilization of pi RNAs and piwi proteins in the management and treatment of advanced cancer.

关键词： PIWI-interacting RNAs/piRNAs cancer progression metastasis chemoresistance stemness