检索结果-南通市图书馆

Particuology 2024年第7期90卷 470-477页

作者： Wenwen Li Yanni Wang Zhenzhen Zhao Meiqi Liu Qing Liang Yuhua Liu Fuxi Liu Zhou jiang Xu zou Bingsen Zhang Wei Zhang Key Laboratory of Automobile Materials MOE School of Materials Science&EngineeringJilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsElectron Microscopy CenterInternational Center of Future ScienceJilin UniversityChangchun 130012China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences110016ShenyangChina

Hydrogen production from proton exchange membrane water electrolysis is constrained by the sluggish kinetics of the anodic oxygen evolution ***_(2)has attracted considerable attention due to its low reaction overpotential,but its inferior stability remains a major ***,a strategy is proposed to enhance the catalytic activity and stability of CoRuOx nanoparticles by doping Co and regulating the ordering degree of carbon nanotubes(CNTs)by air *** was found that the CoRuOx@CNTs-300 catalyst exhibited the best catalytic activity and stability when the annealing temperature was 300°*** the current density of 10 mA cm−2,the overpotential of this catalyst was only 201 mV,which was nearly 100 mV lower than that of commercial RuO_(2)(300 mV).Surprisingly,there was no significant increase in the overpotential when tested at a current density of 10 mA cm−2 for 50 *** density functional theory calculations indicate that the high activity of the catalyst is due to the electronic coupling of CoRuOx nanoparticles and CNTs,and that the introduction of Co and CNTs improves the electronic structure and solvation energies of the Ru in the active site,dramatically increasing the structural stability.

关键词： Electrocatalysis RuO_(2) CNTs Oxygen evolution reaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

纳米控释紫杉醇对小鼠乳癌的凋亡诱导研究

中国肿瘤临床 2007年第7期34卷 407-410页

作者：邹江孙慧天津市第一中心医院乳腺癌防治教育部重点实验室天津市肿瘤防治重点实验室天津医科大学附属肿瘤医院天津市300060

目的:研究纳米紫杉醇体内对BCML-TA299乳癌的抑制作用和凋亡的诱导。方法:建立小鼠体内荷BCML-TA299乳癌模型,用纳米紫杉醇载体注入小鼠皮下,观察肿瘤生长情况并计算肿瘤体内抑瘤率,应用HE染色形态学观察、BaxmRNA原位杂交以及流式细胞... 详细信息

目的:研究纳米紫杉醇体内对BCML-TA299乳癌的抑制作用和凋亡的诱导。方法:建立小鼠体内荷BCML-TA299乳癌模型,用纳米紫杉醇载体注入小鼠皮下,观察肿瘤生长情况并计算肿瘤体内抑瘤率,应用HE染色形态学观察、BaxmRNA原位杂交以及流式细胞仪检测等方法,了解纳米控释紫杉醇诱导小鼠乳癌细胞凋亡的作用。结果:纳米紫杉醇10mg/kg、15mg/kg给小鼠乳癌原位注射,对BCML-TA299乳癌有明显抑制作用和诱导凋亡作用,且有剂量依赖关系。结论:纳米紫杉醇体内对BCML-TA299乳癌模型细胞增殖均有抑制作用,诱导肿瘤细胞死亡的主要途径可能是凋亡。

关键词：紫杉醇 PCL纳米粒子凋亡乳腺癌 Bax

Heparin is an effective treatment for preventing liver failure after hepatectomy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第22期30卷 2881-2892页

作者： Zhi-Ying Xu Min Peng Ming-Ming Fan Qi-Fei zou Yi-Ran Li Dong jiang Hepatic Surgery IV Shanghai Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China Ultrasound Diagnosis PLA Naval Medical CenterShanghai 200437China Department of Ultrasound Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND Posthepatectomy liver failure(PHLF)is one of the most important causes of death following liver ***,an established anticoagulant,can protect liver function through a number of mechanisms,and thus,prevent liver *** To look at the safety and efficacy of heparin in preventing hepatic dysfunction after *** The data was extracted from Multiparameter Intelligent Monitoring in Intensive Care III(MIMIC-III)v1.4 pinpointed patients who had undergone hepatectomy for liver cancer,subdividing them into two cohorts:Those who were injected with heparin and those who were *** statistical evaluations used were unpaired ttests,Mann-Whitney U tests,chi-square tests,and Fisher’s exact tests to assess the effect of heparin administration on PHLF,duration of intensive care unit(ICU)stay,need for mechanical ventilation,use of continuous renal replacement therapy(CRRT),incidence of hypoxemia,development of acute kidney injury,and ICU *** regression was utilized to analyze the factors related to PHLF,with propensity score matching(PSM)aiming to balance the preoperative disparities between the two *** In this study,1388 patients who underwent liver cancer hepatectomy were *** yielded 213 matched pairs from the heparin-treated and control *** univariate analyses indicated that heparin potentially reduces the risk of PHLF in both matched and unmatched *** analysis in the matched cohorts confirmed a significant association,with heparin reducing the risk of PHLF(odds ratio:0.518;95%confidence interval:0.295-0.910;P=0.022).Additionally,heparin treatment correlated with improved short-term postoperative outcomes such as reduced ICU stay durations,diminished requirements for respiratory support and CRRT,and lower incidences of hypoxemia and ICU *** Liver failure is an important hazard following hepatic *** ICU care heparin administration has been proved to decr

关键词： Liver resection Posthepatectomy liver failure Prophylactic treatment Heparin Prognosis of hepatectomy

丙泊酚改善缺氧诱导的宫颈癌细胞增殖、G2/M期阻滞和辐射抗性

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肿瘤预防与治疗 2024年第2期37卷 101-109页

作者：毛远舟郭巧姗黄建鸣邹江陈一丁张可贤舒进军四川省肿瘤临床医学研究中心四川省肿瘤医院·研究所四川省癌症防治中心电子科技大学附属肿瘤医院麻醉科成都610041 四川省肿瘤临床医学研究中心四川省肿瘤医院·研究所四川省癌症防治中心电子科技大学附属肿瘤医院实验研究部成都610041 四川省骨科医院麻醉科成都610041

目的:探讨丙泊酚对氯化钴环境下宫颈癌Hela细胞的增殖、G2/M期阻滞和抗辐射抵抗作用及其与HIF-1α和VEGF的关系。方法:CoCl_(2)诱导Hela细胞构建缺氧化学模型;结晶紫染色检测细胞增殖活性;流式细胞术检测细胞周期;克隆形成实验检测细胞... 详细信息

目的:探讨丙泊酚对氯化钴环境下宫颈癌Hela细胞的增殖、G2/M期阻滞和抗辐射抵抗作用及其与HIF-1α和VEGF的关系。方法:CoCl_(2)诱导Hela细胞构建缺氧化学模型;结晶紫染色检测细胞增殖活性;流式细胞术检测细胞周期;克隆形成实验检测细胞辐射敏感性;荧光定量PCR检测HIF-1α和VEGF转录水平表达;免疫印迹和酶联免疫吸附实验检测HIF-1α和VEGF蛋白水平表达。结果:CoCl_(2)处理条件下丙泊酚抑制Hela细胞增殖,且呈剂量依赖性;与对照组相比,CoCl_(2)处理诱导了G0/G1/S期细胞比例显著增加和G2/M期细胞比例显著减少(P<0.001),而丙泊酚处理后显著反转了此结果(P<0.001);在CoCl_(2)处理后的Hela细胞中,丙泊酚降低0、1、2、4 Gy剂量辐射后Dq、SF2和D0值;机制上,丙泊酚处理恢复了CoCl_(2)处理诱导的HIF-1α和VEGF转录和翻译表达水平的下调(P<0.001)。结论:丙泊酚可通过下调宫颈癌Hela细胞HIF-1α和VEGF的表达来逆转缺氧诱导的增殖、G2/M期阻滞和辐射抵抗。

关键词：宫颈癌丙泊酚氯化钴辐射抗性 HIF-1α VEGF

High-Performance and Large-Area Inverted Perovskite Solar Cells Based on NiO_(x) Films Enabled with A Novel Microstructure-Control Technology

在线全文

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第1期7卷 153-159页

作者： Guibin Shen Xin Li Yuqin zou Hongye Dong Dongping Zhu Yanglin jiang Xin Ren Ng Fen Lin Peter Müller-Buschbaum Cheng Mu Key Laboratory of Advanced Light Conversion Materials and Biophotonics Department of ChemistryRenmin University of ChinaBeijing 100872China Solar Energy Research Institute of Singapore(SERIS) National University of SingaporeSingapore 117574Singapore Physik-Department Lehrstuhl für Funktionelle MaterialienTechnische Universität MünchenJames-Franck-Straße 185748Garching Germany Heinz Maier-Leibnitz Zentrum(MLZ) Technische Universität MünchenLichtenbergstr.185748Garching Germany

The improvement in the efficiency of inverted perovskite solar cells(PSCs)is significantly limited by undesirable contact at the NiO_(x)/perovskite *** this study,a novel microstructure-control technology is proposed for fabrication of porous NiO_(x)films using Pluronic P123 as the structure-directing agent and acetylacetone(AcAc)as the coordination *** synthesized porous NiO_(x)films enhanced the hole extraction efficiency and reduced recombination defects at the NiO_(x)/perovskite ***,without any modification,the power conversion efficiency(PCE)of the PSC with MAPbl_(3)as the absorber layer improved from 16.50%to 19.08%.Moreover,the PCE of the device composed of perovskite Cs0.05(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))_(3)improved from 17.49%to 21.42%.Furthermore,the application of the fabricated porous NiO_(x)on fluorine-doped tin oxide(FTO)substrates enabled the fabrication of large-area PSCs(1.2 cm^(2))with a PCE of 19.63%.This study provides a novel strategy for improving the contact at the NiO_(x)/perovskite interface for the fabrication of high-performance large-area perovskite solar cells.

关键词： interfacial contact inverted and large-area perovskite solar cells photovoltaic materials porous NiO_(x)films renewable energy

ZIF-8 coated gold nanospheres: A multi-responsive drug delivery system promoting the killing effect of photothermal therapy against osteosarcoma cells

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第3期17卷 1772-1784页

作者： Miao Lei Weiye Cai Luetao zou Bin Yu Lin Chen Yang Cao Shanlin Xiang Chao Song Jiandu Lei Wei jiang Zhenming Hu Department of Orthopedics Orthopedic Laboratory of Chongqing Medical UniversityThe First Affiliated Hospital of Chongqing Medical UniversityNo.1 Youyi RoadChongqing 400010China The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou 646699China Department of Orthopedics The Third Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Radiology The First Affiliated Hospital of Chongqing Medical UniversityNo.1 Youyi RoadChongqing 400010China Department of Orthopedics Chongqing University Three Gorges HospitalChongqing 404000China Department of Geriatrics The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550025China Beijing Key Laboratory of Lignocellulosic Chemistry College of Material Science and TechnologyBeijing Forestry UniversityBeijing 100083China

Photothermal therapy(PTT)has been widely used in the treatment of tumors,but its efficacy is greatly limited by the inability of precise drug delivery and the increase of heat shock proteins(HSPs)caused by high *** article describes a therapeutic strategy to enhance PTT with starvation therapy in conjunction with ferroptosis mechanism.A nanoparticle platform ZIF-8@GA was constructed by wrapping together glucose oxidase(GOX)and gold nanospheres(AuNPs)loaded with dihydroartemisinin(DHA)with zeolitic imidazolate framework-8(ZIF-8).This platform can take advantage of the micro-environment of osteosarcoma(OS)cells,featuring low pH and high reactive oxygen species(ROS),for precision drug *** can effectively catalyze glucose to produce gluconic acid and H_(2)O_(2),and DHA can also induce ROS production in OS *** produced by GOX and DHA can further generate lipid peroxidation(LPO)and lead to ferroptosis of OS *** the same time,ROS and LPO produced can inhibit the expression of HSPs,thereby increasing the therapeutic effect of *** vitro experiments show that the nanoparticles are pH and ROS responsive.1μg/mL GOX combined with 0.2μg/mL DHA promotes ferroptosis of OS cells,and increases the killing effect of near-infrared(NIR)on OS *** in vivo experiments showed that the nano drug-delivery platform combined with PTT can effectively inhibit the growth of OS ***,this study provides a new idea for the treatment of OS with biomaterials combined with various treatment methods.

关键词： zeolitic imidazolate framework-8(ZIF-8) gold nanospheres(AuNPs) photothermal therapy(PTT) starvation therapy ferroptosis

Protective and Adverse Roles of DDX3X in Different Cell Types in Nonalcoholic Steatohepatitis Progression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research 2024年第3期6卷 561-574页

作者： Suzhen Yang Lin Zhou Tianming Zhao Hanlong Zhu Tingting Luo Kang jiang Xiaoxiao Shi Chunyan Chen Han Zhang Si Zhao Xiaoping zou Yuzheng Zhuge Fangyu Wang Lei Wang Mingzuo jiang Bing Xu Department of Gastroenterology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolJiangsuNanjing210002China. Department of Gastroenterology and Hepatology the Affiliated Jinling Hospital of Nanjing University Medical SchoolJiangsuNanjing210002China School of Medicine Northwest UniversityShaanxiXi’an710069China. Department of Gastroenterology Nanjing Drum Tower HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeJiangsuNanjing210008China.

Persistent hepatic cellular metabolic stress and liver inflammatory stimuli are key signatures of nonalcoholic steatohepatitis(NASH).DDX3X is a vital molecule involved in cell fate decisions in both pro-survival stress granule(SG)and pro-death NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome assembly in response to stress ***,the role of DDX3X in NASH remains *** characterized the cell type-specific roles of DDX3X in *** liver tissues from NASH patients and normal control subjects were collected to assess DDX3X expression and *** steatohepatitis models were constructed by feeding macrophage-specific DDX3X knockout(DDX3^(XΔMφ)),hepatocyte-specific DDX3X knockout(DDX3X^(Δhep)),and wild-type control(DDX3X^(fl/fl))mice a high-fat and high-cholesterol(HFHC)diet,a methionine-and choline-deficient(MCD)diet,and a high-fat/high-iron/high-fructose/high-cholesterol,low-methionine,and choline-deficient(HFHIHFHC-MCD)*** study demonstrated that DDX3X was predominantly expressed in macrophages and hepatocytes in control liver tissues,and its expression was down-regulated in patients or mice with *** to DDX3X^(fl/fl) littermates,DDX3^(XΔMφ)mice showed improved liver histology in nutritional steatohepatitis *** of macrophage DDX3X inhibited NLRP3 inflammasome-mediated pyroptosis,causing anti-inflammatory M2 polarization and alleviating hepatocyte steatohepatitic ***3X^(Δhep) mice developed marked steatohepatitis in multiple nutritional steatohepatitis models compared to DDX3X^(fl/fl) ***3X-deleted hepatocytes showed impaired SG assembly,leading to increased sensitivity and intolerance to metabolic stimulation and resultant *** conclusion,DDX3X plays opposite roles in different cell types during the progression of NASH.A better understanding of the cell-specific differences in the crosstalk between SG formation and NLRP3 activation is crucial for developing pr

关键词： NLRP3 impaired inhibited

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

论我国地方财政运行中的道德风险问题

中央财经大学学报 2006年第1期 8-13页

作者：邹江涛厦门大学经济学院厦门361005

在我国财政分权改革中,地方政府逐渐成为相对独立的公共实体。由于我国现行体制下,上级政府对下级政府、中央政府对地方政府的隐性财政担保关系缺乏有效的风险约束机制,引致了地方财政运行中道德风险蔓延,提高了我国的财政风险。防范地... 详细信息

在我国财政分权改革中,地方政府逐渐成为相对独立的公共实体。由于我国现行体制下,上级政府对下级政府、中央政府对地方政府的隐性财政担保关系缺乏有效的风险约束机制,引致了地方财政运行中道德风险蔓延,提高了我国的财政风险。防范地方政府道德风险需构建风险约束机制,并在改革进程中进一步完善财政管理体制。

关键词：道德风险财政机会主义风险约束机制

在线全文

学校读者我要写书评

暂无评论

基于层次分析法的高校教师素质评价体系

南昌大学学报（人文社会科学版） 2007年第6期38卷 178-180页

作者：邹江南昌大学科学技术学院江西南昌330029

合理客观的教师素质评价对高校教师队伍的建设具有重要的意义。引进层次分析法,建立高校教师素质综合评价指标体系,可以实现定性到定量的转化,使评价体系能全面客观地对教师素质进行评价。

关键词：层次分析法高校教师素质评价体系定量化

在线全文

学校读者我要写书评

暂无评论

基于USBD12和加速度计的空中键鼠

现代电子技术 2017年第18期40卷 101-103页

作者：邹江遵义师范学院物理与电子科学学院贵州遵义563006

设计基于USBD12和加速度计的空中键鼠,通过手势在空中的动作便可控制鼠标的移动。设计的研发调试过程中,采用了加速度传感器数据采集、USB设备gadget层HID设备、LCD-NOKIA5110显示、AVR单片机熔丝位的配置、蓝牙模块、手势动作识别算法... 详细信息

设计基于USBD12和加速度计的空中键鼠,通过手势在空中的动作便可控制鼠标的移动。设计的研发调试过程中,采用了加速度传感器数据采集、USB设备gadget层HID设备、LCD-NOKIA5110显示、AVR单片机熔丝位的配置、蓝牙模块、手势动作识别算法、菜单与UI界面等模块的软、硬件调试,接收端有一个USB口,插入PC后被识别为一个标准HID人体学输入设备,无须驱动,即插即用。用户的操作达到可动态交互的目的。采用动作手势识别算法,蓝牙模块等实现了通过手势在空中的动作便可控制鼠标的移动,通过按键进行对键盘的操作,并且不需要连接线,通过蓝牙与插在电脑上的接收端相连接通信,达到动态交互的目的。

关键词：蓝牙 USB 免驱动键鼠