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Giant nontraumatic myositis ossificans in a child:A case report

World Journal of Clinical Cases 2022年第9期10卷 2901-2907页

作者： An-Ning Xia jiang-sheng wang Department of Orthopedic Shenzhen Children’s HospitalShenzhen 518000Guangdong ProvinceChina

BACKGROUND Nontraumatic myositis ossificans is a rare disease whose specific pathogenesis is *** diagnosis of this disease is very difficult in children because of difficulties in determining medical history and nonspecific early clinical manifestations,which may lead to the failure of timely and effective diagnosis and treatment in some *** report the diagnosis and treatment of a child with nontraumatic myositis ossificans and summarize the clinical characteristics and diagnosis and treatment of the *** SUMMARY An 8-year-old girl first came to our hospital for more than a week with pain in the right lower *** was no history of trauma or strenuous *** physical examination,no mass on the right thigh was found,and the movement of the right lower extremity was *** showed synovitis of the hip,and bed rest was *** days later,the child’s pain persisted and worsened,accompanied by fever and other *** came to our hospital again and a mass was found on the right thigh with redness and swelling on the *** images showed a soft tissue tumor on the right thigh with *** blood tests revealed that the inflammation index was significantly *** case of infection,the patient was given antibiotics,and the pain was relieved soon after,without ***,the right thigh mass persisted and *** patient underwent incision biopsy more than 1 mo later,and the postoperative pathology showed nontraumatic myositis *** approximately 9 mo of observation,the tumor still persisted,which affected the life of the child,and then resection was *** follow-up,there has been no *** Due to the difficulty in discerning a child’s medical history and the diverse early manifestations,it is difficult to diagnose nonossifying muscle disease in children in its early *** such as timely follow-up and periodic image monitoring are

关键词： Myositis ossificans Nontraumatic myositis ossificans Child Case report

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Hydrological eco-service of rubber plantations in Hainan Island and its effect on local economic development

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Journal of Environmental Sciences 2003年第5期15卷 701-709页

作者： jiang Ju sheng , wang Ru song (Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China. jushen

The impacts of economic forest on global environmental change(GEC) are one of the hot issues in environmental study. Based on the 3 year observation data and 40 year climate data, GEC and analysis of the hydrological dynamic characteristics of rubber plantations and estimate of the water balance in the rubber plantations in Hainan Island were made. The results showed that the rainfall intercepted by the canopy of the plantations accounted for 11 45% of the annual rainfall, the total runoff for 23 71%, the total evaporation and transpiration for 63 24%, the soil moisture storage for 1 6%. Analysis of the 40 year rainfall data in the 19 counties of Hainan Island during 1951—1990 showed that the large scale substitution of the natural vegetation with the rubber plantations had no significant effect on the local rainfall in Hainan Island. The main reasons are (1) 80% of the rainfall in Hainan is brought by typhoons; (2) the proportion of 11 6% rubber plantations in total forest coverage in Hainan is not enough to influence the local rainfall in Hainan Island; and (3) although the rubber plantation is artificial vegetation, it has the similar function to the tropical rain forest. Analysis of the total water resource and total GDP of Hainan in 1997 showed that the economic benefit resulted from the water resource was 1 0 RMB Yuan/m 3 The value of hydrological of the rubber plantation in Hainan was 113 9 million RMB Yuan/a when compared with the tropical rain forest. The paper reaches conclusion that the hydrological eco service function of rubber plantation has been enhanced after transformed from natural vegetation, which includes the natural service and powerful social service.

关键词： eco service rubber plantation hydrological function Hainan Island

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Muscle hypertrophy in transgenic mice due to over-expression of porcine myostatin mutated at its cleavage site

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Journal of Integrative Agriculture 2016年第11期15卷 2571-2577页

作者： QIAN Li-li MA De-zun GAO Peng-fei jiang sheng-wang wang Qing-qing CAI Chun-bo XIAO Gao-jun AN Xiao-rong CUI Wen-tao State Key Laboratory of Agrobiotechnology China Agricultural University State Key Laboratory for Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural Sciences

Myostatin, a member of the transforming growth factor beta（TGF-β） superfamily, is a dominant inhibitor that acts to limit skeletal muscle growth and development. In this study, we generated transgenic mice that express porcine myostatin containg mutations at its cleavage site（RSRR） to evaluate its effect on muscle mass. Results showed that the weight of four skeletal muscles including gastrocnemius, rectus femoris, tibialis anterior, and pectoralis increased by 17.83 and 28.39%, 21.76 and 28.70%, 34.31 and 41.62%, 53.21 and 27.54% in transgenic male and female mice, respectively, compared to their corresponding non-transgenic control mice. Measurement of muscle fiber size and number indicated that the mean myofiber size increased by 50.73 and 61.30% in transgenic male and female mice respectively compared to the non-transgenic controls. However, there was no difference in the number of myofiber between transgenic and non-transgenic male mice. These results clearly demonstrated that the increase in skeletal muscle mass in transgenic mice is caused by hypertrophy instead of hyperplasia.

关键词： porcine myostatin muscle mass transgenic mice mutation hypertrophy hyperplasia

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Targeted myostatin loss-of-function mutation increases type Ⅱ muscle fibers in Meishan pigs

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Journal of Integrative Agriculture 2022年第1期21卷 188-198页

作者： QIAN Li-li XIE Jing-yi GAO Ting CAI Chun-bo jiang sheng-wang BI Han-fang XIE Shan-shan CUI Wen-tao Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao 266021P.R.China Institute of Animal Sciences Chinese Academy of Agricultural SciencesBeijing 100193P.R.China College of Animal Medicine China Agricultural UniversityBeijing 100193P.R.China

Myostatin(MSTN) is a negative regulator of skeletal muscle growth and development. The skeletal muscle in MSTN^(-/-)mice is significantly hypertrophied, with muscle fiber type II increasing significantly while muscle fiber type I ***, it is still not clear how the skeletal muscle types change in MSTN^(-/-)pigs, and how the mechanism for MSTN regulates fiber types, especially in large animals like pigs. This study conducted a comprehensive analysis of the composition of skeletal muscle fibers in MSTN^(-/-)pigs produced in our laboratory. It was observed that, compared with wild-type(WT) pigs, both the total mass of skeletal muscle and type IIb muscle fibers increased significantly(P<0.01),while the type I and type IIa muscle fibers decreased significantly(P<0.01), in MSTN^(-/-)Meishan pigs. In addition, to explore the influence of MSTN on muscle fiber type and its regulation mechanism in the embryonic stage, this study selected a few genes(Myf5, Mef2 d, MyoD and Six1) associated with muscle fiber type and validated their expression by quantitative RT-PCR. Herein, it was found that Myh7, Myh2, Myh4 and Myh1 can be detected in the skeletal muscle of pigs at 65 days of gestation(dg). Compared with WT pigs, in MSTN^(-/-)Meishan pigs, Myh7 decreased significantly(P<0.01), while Myh4(P<0.001) and Myh1(P<0.05) increased significantly. Meanwhile, the increased expression of Myf5(P<0.05), Mef2 d(P<0.01) and Six1(P<0.05) in MSTN^(-/-)Meishan pigs suggested that MSTN should regulate the directional development of muscle fiber types in the early stage of embryonic development. Thus, at the embryonic stage, the type II muscle fibers began to increase in MSTN^(-/-)pigs. These results can provide valuable information not only for pig meat quality improvement, but also for the study of human skeletal muscle development and disease treatment.

关键词： MSTN Meishan pigs muscle fiber type muscle fiber development

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Design and screening of antisense oligodeoxynucleotides against PAI-1 mRNA in endothelial cells in vitro

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Acta Pharmacologica Sinica 2006年第8期27卷 1018-1023页

作者： Qi-sheng jiang sheng-qi wang~2 Beijing Institute of Radiation Medicine,Beijing 100850,China Beijing Institute of Radiation Medicine Beijing 100850 China

Aim:To design and screen antisense oligodeoxynucleotides(ASODNs),whichinhibit type-1 plasminogen activator inhibitor(PAI-1)expression in human umbili-cal vein endothelial cells(HUVEC)in ***:Twenty seven ASODNsagainst different sites of PAI-1 mRNA were designed and transfected to HUVECby lipofectin in *** effects of ASODNs on PAI-1 antigen,PAI-1 activityand PAI-1 mRNA expression were detected by ELISA,amidolytical assay and RT-PCR,***:Transforming growth factor β1(TGF-β1)-treatedHUVEC increased the expression of PAI-1 compared with the normal *** among twenty seven designed ASODNs were effective in inhibiting the in-crease in PAI-1 antigen and PAI-1 activity in a dose-dependent manner after *** particular,ASODN 14(AO14)exhibited the best inhibitory *** control sequences of AO14,including sense,scramble,and mismatchsequences,did not significantly inhibit PAI-1 *** was revealed that theinhibitory efficacy of AO14 was in a sequence-specific ***-PCR showedthat ASODN 1,7,8,14,and 15 decreased PAI-1 mRNA expression induced byTGF-β1and AO14 showed the best inhibitory ***:ASODN 1,7,8,14,and 15,among twenty seven designed ASODNs against PAI-1 mRNA,signifi-cantly decreased PAI-1 antigen and PAI-1 activity induced by TGF-β1x in a dose-dependent manner in HUVEC in ***14 showed the best inhibitory effect onPAl-1 expression in a sequence-specific *** results of RT-PCR indicatedthat inhibitory effects of ASODNs on PAI-1 biosynthesis occurred at the *** among five effective target sites of ASODNs located at the translationinitiation Site or within the translation area of PAI-1 mRNA,suggesting that thesesites may be promising sites for the design of effective ASODNs.

关键词： plasminogen activator inhibitor 1 antisense oligodeoxynucleotide endothelial cells

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Exploration of Gas‑Dependent Self‑Adaptive Reconstruction Behavior of Cu_(2)O for Electrochemical CO_(2)Conversion to Multi‑Carbon Products

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Nano-Micro Letters 2025年第3期17卷 280-296页

作者： Chaoran Zhang Yichuan Gu Qu jiang Ziyang sheng Ruohan Feng Sihong wang Haoyue Zhang Qianqing Xu Zijian Yuan Fang Song State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Structural reconstruction of electrocatalysts plays a pivotal role in catalytic performances for CO_(2)reduction reaction(CO_(2)RR),whereas the behavior is by far superficially ***,we report that CO_(2)accessibility results in a universal self-adaptive structural reconstruction from Cu_(2)O to Cu@CuxO composites,ending with feeding gas-dependent microstructures and catalytic *** CO_(2)-rich atmosphere favors reconstruction for CO_(2)RR,whereas the CO_(2)-deficient one prefers that for hydrogen evolution *** the assistance of spectroscopic analysis and theoretical calculations,we uncover a CO_(2)-induced passivation behavior by identifying a reductionresistant but catalytic active Cu(I)-rich amorphous layer stabilized by*CO ***,we find extra CO production is indispensable for the robust production of *** inverse correlation between durability and FECO/FEC2H4 is disclosed,suggesting that the selfstabilization process involving the absorption of*CO intermediates on Cu(I)sites is essential for durable *** by this insight,we design hollow Cu_(2)O nanospheres for durable and selective CO_(2)RR electrolysis in producing *** work recognizes the previously overlooked passivation reconstruction and self-stabilizing behavior and highlights the critical role of the local atmosphere in modulating reconstruction and catalytic processes.

关键词： CO_(2)reduction reaction Electrocatalysts Cu_(2)O Reconstruction Self-adaptive electrocatalysis

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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li Sai wang Shao-jiang wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

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Wafer‑Scale Vertical 1D GaN Nanorods/2D MoS_(2)/PEDOT:PSS for Piezophototronic Effect‑Enhanced Self‑Powered Flexible Photodetectors

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Nano-Micro Letters 2025年第3期17卷 102-116页

作者： Xin Tang Hongsheng jiang Zhengliang Lin Xuan wang Wenliang wang Guoqiang Li State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Department of Electronic Materials School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640People’s Republic of China

van der Waals(vdW)heterostructures constructed by lowdimensional(0D,1D,and 2D)materials are emerging as one of the most appealing systems in next-generation flexible ***,hand-stacked vdW-type photodetectors are not compatible with large-areaarray fabrication and show unimpressive performance in self-powered ***,vertical 1D GaN nanorods arrays(NRAs)/2D MoS_(2)/PEDOT:PSS in wafer scale have been proposed for self-powered flexible photodetectors arrays *** as-integrated device without external bias under weak UV illumination exhibits a competitive responsivity of 1.47 A W^(−1)and a high detectivity of 1.2×10^(11)Jones,as well as a fast response speed of 54/71μs,thanks to the strong light absorption of GaN NRAs and the efficient photogenerated carrier separation in type-II ***,the strain-tunable photodetection performances of device have been ***,the device at−0.78%strain and zero bias reveals a significantly enhanced photoresponse with a responsivity of 2.47 A W^(−1),a detectivity of 2.6×10^(11)Jones,and response times of 40/45μs,which are superior to the state-of-the-art self-powered flexible *** work presents a valuable avenue to prepare tunable vdWs heterostructures for self-powered flexible photodetection,which performs well in flexible sensors.

关键词： Vertical nanorod arrays van der Waals heterostructure Piezophototronic effect Self-powered photodetection Flexible sensors

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Offload Strategy for Edge Computing in Satellite Networks Based on Software Defined Network

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Computers, Materials & Continua 2025年第1期82卷 863-879页

作者： Zhiguo Liu Yuqing Gui Lin wang Yingru jiang Communication and Network Laboratory Dalian UniversityDalian116622China College of Environment and Chemical Engineering Dalian UniversityDalian116622China

Satellite edge computing has garnered significant attention from researchers;however,processing a large volume of tasks within multi-node satellite networks still poses considerable *** sharp increase in user demand for latency-sensitive tasks has inevitably led to offloading bottlenecks and insufficient computational capacity on individual satellite edge servers,making it necessary to implement effective task offloading scheduling to enhance user *** this paper,we propose a priority-based task scheduling strategy based on a Software-Defined Network(SDN)framework for satellite-terrestrial integrated networks,which clarifies the execution order of tasks based on their ***,we apply a Dueling-Double Deep Q-Network(DDQN)algorithm enhanced with prioritized experience replay to derive a computation offloading strategy,improving the experience replay mechanism within the Dueling-DDQN ***,we utilize the Deep Deterministic Policy Gradient(DDPG)algorithm to determine the optimal resource allocation strategy to reduce the processing latency of *** results demonstrate that the proposed d3-DDPG algorithm outperforms other approaches,effectively reducing task processing latency and thus improving user experience and system efficiency.

关键词： Satellite network edge computing task scheduling computing offloading

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Anomaly Detection of Controllable Electric Vehicles through Node Equation against Aggregation Attack

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Computers, Materials & Continua 2025年第1期82卷 427-442页

作者： Jing Guo Ziying wang Yajuan Guo Haitao jiang State Grid jiangsu Electric Power Co. Ltd.Research InstituteState Grid Corporation of ChinaNanjing211100China

The rapid proliferation of electric vehicle(EV)charging infrastructure introduces critical cybersecurity vulnerabilities to power grids *** study presents an innovative anomaly detection framework for EV charging stations,addressing the unique challenges posed by third-party aggregation *** approach integrates node equations-based on the parameter identification with a novel deep learning model,xDeepCIN,to detect abnormal data reporting indicative of aggregation *** employ a graph-theoretic approach to model EV charging networks and utilize Markov Chain Monte Carlo techniques for accurate parameter *** xDeepCIN model,incorporating a Compressed Interaction Network,has the ability to capture complex feature interactions in sparse,high-dimensional charging *** results on both proprietary and public datasets demonstrate significant improvements in anomaly detection performance,with F1-scores increasing by up to 32.3%for specific anomaly types compared to traditional methods,such as wide&deep and DeepFM(Factorization-Machine).Our framework exhibits robust scalability,effectively handling networks ranging from 8 to 85 charging ***,we achieve real-time monitoring capabilities,with parameter identification completing within seconds for networks up to 1000 *** research contributes to enhancing the security and reliability of renewable energy systems against evolving cyber threats,offering a comprehensive solution for safeguarding the rapidly expanding EV charging infrastructure.

关键词： Anomaly detection electric vehicle aggregation attack deep cross-network

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