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Induction of acute hepatic inj.ry by endotox.n in mice

Hepatobiliary & Pancreatic Diseases International 2002年第4期1卷 558-564页

作者： x.e G.-Q. jiang j.-x. Chen Y.-H. Liu D.W. Zhu P.-F. Wang Z.-G. Emergency Department 152nd Hospital PLA Pingdingshan 467000 China Research Institute of Surgery Daping Hospital Third Military Medical University Chongqing 400042 China

Obj.ctive: To investigate the changes of scavenger re-ceptor （SR） and CD14 in Kupffer cells in endotox.emia in order to uncover the mechanism of the liverto turn a defense organ into effector one in ***: Mouse models of endotox.mia of differentseverity were reproduced by inj.ction of different do-ses of lipopolysaccharide （LPS） via the tail *** ex.ression of SR and CD14 in the liver was as-sayed by immunohistochemistry and was subsequent-ly analyzed with an image analysis system. The levelsof TNF-α and IL-6 in liver tissue were determinedwith ***: The ex.ression of SR in the liver in the high-dose group was markedly decreased one hour afterinj.ction of LPS, and also in the low-dose group at 3hours. The ex.ression of SR in the liver in the twogroups was shown to be progressively decreased withthe time prolonged. There was significant differencein average optical density （OD） values of SR be-tween the two groups. The ex.ression of CD14 in thetwo groups was shown to be significantly increasedone hour after inj.ction of LPS, and more signifi-cantly with the time prolonged. But there was no sig-nificant difference in OD values of CD14 between thetwo groups. The contents of intrahepatic proinflam-matory mediators TNF-α, IL-6, ALT and TBILwere significantly increased after inj.ction of *** analysis revealed that the changes ofTNF-α, IL-6, ALT, and TBIL were negatively cor-related with the ex.ression of SR, and positively withthe ex.ression of CD14.Conclusion: The up-regnlation of CD14 ex.ressionand down-regulation of SR ex.ression on Kupffercells might be one of the important mechanisms forthe conversion of Kupffer cells from immune defen-sive to inflammatory response cells in acute hepaticinj.ry.

关键词： hepatic inj.ry endotox.mia scavenger receptor CD14 tumor necrosis factor-α interleukin

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Revolutionizing plasmonic platform via magnetic field-assisted confined ultrafast laser deposition of high-density,uniform,and ultrafine nanoparticle arrays

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International j.urnal of Ex.reme Manufacturing 2024年第3期6卷 428-438页

作者： j.n x. Lingfeng Wang Peilin Yang Haoqing jiang Huai Zheng Licong An x.ngtao Liu Gary j.Cheng School of Industrial Engineering Purdue UniversityWest LafayetteIN 47906United States of America Institute of Technological Sciences Wuhan UniversityWuhanHubei 430072People’s Republic of China

The remarkable capabilities of 2D plasmonic surfaces in controlling optical waves havegarnered significant ***,the challenge of large-scale manufacturing of uniform,well-aligned,and tunable plasmonic surfaces has hindered their *** address this,we present a groundbreaking tunable plasmonic platform design achieved throughmagnetic field(MF)assisted ultrafast laser direct deposition in *** precise control of metal nanoparticles(NPs),with cobalt(Co)serving as the model material,employing an MF,and fine-tuning ultrafast laser parameters,we have effectively converted coarse and non-uniform NPs into densely packed,uniform,and ultrafine NPs(~3 nm).This revolutionary advancement results in the creation of customizable plasmonic‘hot spots,’which play a pivotal role insurface-enhanced Raman spectroscopy(SERS)*** profound impact of this designable plasmonic platform lies in its close association with plasmonic resonance and *** the plasmonic nanostructures resonate with incident light,they generate intense local electromagnetic fields,thus vastly increasing the Raman scattering *** enhancement leads to an outstanding 2–18 fold boost in SERS performance and unparalleled sensing sensitivity down to 10^(-10)***,the plasmonic platform also demonstratesrobustness,retaining its sensing capability even after undergoing 50 cycles of rinsing andre-loading of ***,this work adheres to green manufacturing standards,making it an efficient and environmentally friendly method for customizing plasmonic‘hot spots’inSERS *** study not only achieves the formation of high-density,uniform,and ultrafine NP arrays on a tunable plasmonic platform but also showcases the profound relation betweenplasmonic resonance and energy *** outstanding results observed in SERS sensors further emphasize the immense potential of this technology for energy-relatedapplications,including photocatalysis,ph

关键词： magnetic field manipulation laser deposition metasurface SERS

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Adeno-associated virus as a delivery vector for gene therapy of human diseases

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1808-1840页

作者： jiang-Hui Wang Dominic j.Gessler Wei Zhan Thomas L.Gallagher Guangping Gao Horae Gene Therapy Center University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Department of Microbiology and Physiological Systems University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVIC3002Australia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVIC3002Australia Department of Neurological Surgery University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Department of Neurosurgery University of MinnesotaMinneapolisMN55455USA Department of Medicine University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Li Weibo Institute for Rare Diseases Research University of Massachusetts Chan Medical SchoolWorcesterMA01605USA

Adeno-associated virus(AAV)has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene ex.ression in different *** AAV(rAAV)has been engineered for enhanced specificity and developed as a tool for treating various ***,as rAAV is being more widely used as a therapy,the increased demand has created challenges for the ex.sting manufacturing *** rAAV-based gene therapy products have received regulatory approval,but there continue to be concerns about safely using high-dose viral therapies in humans,including immune responses and adverse effects such as genotox.city,hepatotox.city,thrombotic microangiopathy,and *** this review,we ex.lore AAV biology with an emphasis on current vector engineering strategies and manufacturing *** discuss how rAAVs are being employed in ongoing clinical trials for ocular,neurological,metabolic,hematological,neuromuscular,and cardiovascular diseases as well as *** outline immune responses triggered by rAAV,address associated side effects,and discuss strategies to mitigate these *** hope that discussing recent advancements and current challenges in the field will be a helpful guide for researchers and clinicians navigating the ever-evolving landscape of rAAV-based gene therapy.

关键词： diseases specificity approval

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A Reverse Path Planning Approach for Enhanced Performance of Multi-Degree-of-Freedom Industrial Manipulators

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1357-1379页

作者： Zhiwei Lin Hui Wang Tianding Chen Yingtao jiang j.anmei jiang Yingpin Chen Key Laboratory of Light Field Manipulation and System Integration Applications in Fuj.an Province School of Physics and Information EngineeringMinnan Normal UniversityZhangzhou363000China Department of Electrical and Computer Engineering University of NevadaLas Vegas89154USA College of Material Engineering Fujian Agriculture and Forestry UniversityFuzhou350000China

In the domain of autonomous industrial manipulators,precise positioning and appropriate posture selection in path planning are pivotal for tasks involving obstacle avoidance,such as handling,heat sealing,and *** Multi-Degree-of-Freedom(MDOF)manipulators offer kinematic redundancy,aiding in the derivation of optimal inverse kinematic solutions to meet position and posture requisites,their path planning entails intricate multiobj.ctive optimization,encompassing path,posture,and j.int motion *** satisfactory results in practical scenarios remains *** response,this study introduces a novel Reverse Path Planning(RPP)methodology tailored for industrial *** approach commences by conceptualizing the manipulator’s end-effector as an agent within a reinforcement learning(RL)framework,wherein the state space,action set,and reward function are precisely defined to ex.edite the search for an initial collision-free *** enhance convergence speed,the Q-learning algorithm in RL is augmented with ***,we formulate the cylindrical bounding box.of the manipulator based on its Denavit-Hartenberg(DH)parameters and propose a swift collision detection ***,the motion performance of the end-effector is refined through a bidirectional search,and j.int weighting coefficients are introduced to mitigate motion in high-power *** efficacy of the proposed RPP methodology is rigorously ex.mined through ex.ensive simulations conducted on a six.degree-of-freedom(6-DOF)manipulator encountering two distinct obstacle configurations and target *** results substantiate that the RPP method adeptly orchestrates the computation of the shortest collision-free path while adhering to specific posture constraints at the target ***,itminimizes both posture angle deviations and j.int motion,showcasing its prowess in enhancing the operational performance of MDOF industrial manipulators.

关键词： Reverse path planning Dyna-Q bidirectional search posture angle j.int motion

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An Enhanced Conic Reformulation for Capacity-Constrained Assortment Optimization Under the Mix.ure of Multinomial Logit Model

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j.urnal of the Operations Research Society of China 2024年第3期12卷 757-771页

作者： Shan jiang Ka-Meng Nip School of Management Xiamen UniversityXiamen361005FujianChina School of Mathematical Sciences Xiamen UniversityXiamen361005FujianChina

In this work,we study the conic quadratic mix.d-integer formulation for assortment optimization problem under the mix.ure of multinomial logit(MMNL)*** MMNL model generalizes the widely studied multinomial logit choice model and can approx.mate any random utility model with an arbitrary additive *** important operational decision problem in revenue management is assortment optimization problem,which aims to find a subset of products to make available to customers that max.mizes the ex.ected revenue of the *** is known that assortment optimization problem under the MMNL model is NP-hard and inapprox.mable within any constant performance *** used methods for solving such problem are heuristical approaches or customized combinatorial optimization *** the meanwhile,studies related to global optimization approaches are relatively *** propose an enhanced conic quadratic mix.d-integer formulation for solving assortment optimization problem under the MMNL model with a higher computational ***,we conduct ex.ensive numerical ex.eriments to demonstrate that the proposed reformulation significantly outperforms the ex.sting conic reformulations for assortment optimization under the MMNL model.

关键词： Assortment optimization MMNL model Conic reformulation Capacitated constrained

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基于状态空间模型的激光再制造熔池温度控制系统

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表面工程与再制造 2024年第2期24卷 50-50页

作者： Yang G.-Z. Liu T.-M. Song B.-x. jiang x.-Y. Wang Z.-S. Chen K.-Q. Liu W.-j. School of Mechanical Engineering Shenyang University of Technology Shenyang China

激光再制造是用于再制造的一项重要技术,在航空航天、冶金、能源等领域应用广泛。然而,形状控制问题一直是制约其规模化和工业化应用的瓶颈。在激光再制造过程中,熔池温度是决定再制造件形状和性能稳定性的关键。基于此,本文提出了一种... 详细信息

激光再制造是用于再制造的一项重要技术,在航空航天、冶金、能源等领域应用广泛。然而,形状控制问题一直是制约其规模化和工业化应用的瓶颈。在激光再制造过程中,熔池温度是决定再制造件形状和性能稳定性的关键。基于此,本文提出了一种基于状态空间模型的激光再制造熔池温度实时在线控制方法,解决了控制机理模型难以建立和多变量约束的问题。

关键词：状态空间模型激光再制造熔池温度航空航天形状控制控制系统变量约束性能稳定性

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A Planning Method for Operational Test of UAV Swarm Based on Mission Reliability

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1889-1918页

作者： j.ngyu Wang Ping jiang j.anj.n Qi College of Systems Engineering National University of Defense TechnologyChangsha410073China Beij.ng Special Engineering Design Institution Beijing100028China

The unmanned aerial vehicle(UAV)swarm plays an increasingly important role in the modern battlefield,and the UAV swarm operational test is a vital means to validate the combat effectiveness of the UAV *** to the high cost and long duration of operational tests,it is essential to plan the test in *** solve the problem of planning UAV swarm operational test,this study considers the multi-stage feature of a UAV swarm mission,composed of launch,flight and combat stages,and proposes a method to find test plans that can max.mize mission ***,a multi-stage mission reliability model for a UAV swarm is proposed to ensure successful implementation of the mission.A multi-obj.ctive integer optimization method that considers both mission reliability and cost is then formulated to obtain the optimal test *** study first constructs a mission reliability model for the UAV swarm in the combat ***,the launch stage and flight stage are integrated to develop a complete PMS(Phased Mission Systems)reliability ***,the Binary Decision Diagrams(BDD)and Multi Obj.ctive Quantum Particle Swarm Optimization(MOQPSO)methods are proposed to solve the *** optimal plans considering both reliability and cost are *** proposed model supports the planning of UAV swarm operational tests and represents a meaningful ex.loration of UAV swarm test planning.

关键词： UAV swarm PMS MOQPSO BDD mission reliability operational test planning

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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov x.C.Ai L.P.An R.Aliberti Q.An x.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai j.j.Cao Q.H.Cao x.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.x.Chen j.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen x.Chen x.F.Chen x.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng j.Cheng S.Cheng T.G.Cheng j.P.Dai L.Y.Dai x.C.Dai D.Dedovich A.Denig I.Denisenko j.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.j.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.j.Fang G.Fedotovich C.Q.Feng x.Feng Y.T.Feng j.L.Fu j.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl j.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo j.C.Guo j.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han x.Q.Hao j.B.He S.Q.He x.G.He Y.L.He Z.B.He Z.x.Heng B.L.Hou T.j.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.j.Hu W.H.Hu x.H.Hu Y.C.Hu j.Hua G.S.Huang j.S.Huang M.Huang Q.Y.Huang W.Q.Huang x.T.Huang x.j.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.j. j.j.j.a S.j.a Z.K.j.a H.B.jiang j.jiang S.Z.jiang j.B.j.ao Z.j.ao H.j.j.ng x.L.Kang x.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.j.Li H.L.Li j.M.Li j.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.j.Li x.Li x.H.Li x.Q.Li x.H.Li Y.Li Y.Y.Li Z.j.Li H.Liang j.H.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.x.Lin D.x.Lin x.S.Lin B.j.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu j.Liu j.j.Liu j.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu x.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu j.x.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.j.Luo T.Luo x.F.Luo Y.H.Luo H.j.Lyu x.R.Lyu j.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.x.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova x.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng x.Y.Peng x.j.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao j.j.Qin j.j.Qin L.Q.Qin x.S.Qin T.L.Qiu j.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangx. Normal University Guilin 541004China Guangx. Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China j.lin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for ex.loring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for ex.tic hadrons and physics beyond the Standard *** STCF proj.ct in China is under development with an ex.ensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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Recent advancements in thermal conductivity of magnesium alloys

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j.urnal of Magnesium and Alloys 2024年第5期12卷 1687-1708页

作者： Hao Lv j.n Tan Qian Yuan Fanglei Wang Yunx.an Zhou Quan Dong Aitao Tang j.rgen Eckert Bin jiang Fusheng Pan National Engineering Research Center for Magnesium Alloys College of Materials Science and EngineeringChongqing UniversityChongqing 400044China National Key Laboratory of Advanced Casting Technologies Chongqing UniversityChongqing 400044China Department of Materials Science Chair of Materials PhysicsMontanuniversität LeobenJahnstraße 12Leoben A-8700Austria Erich Schmid Institute of Materials Science Austrian Academy of SciencesJahnstraße 12Leoben A-8700Austria

As highly integrated circuits continue to advance,accompanied by a growing demand for energy efficiency and weight reduction,materials are confronted with mounting challenges pertaining to thermal conductivity and lightweight *** virtue of numerous intrinsic mechanisms,as a result,the thermal conductivity and mechanical properties of the Mg alloys are often inversely related,which becomes a bottleneck limiting the application of Mg *** on several effective modification methods to improve the thermal conductivity of Mg alloys,this paper describes the law of how they affect the mechanical properties,and clearly indicates that peak aging treatment is one of the best ways to simultaneously enhance an alloy's thermal conductivity and mechanical *** the most frequently used Mg alloy,cast alloys ex.ibit substantial potential for achieving high thermal ***,recent reports indicate that hot deformation can significantly improve the mechanical properties while maintaining,and potentially slightly enhancing,the alloy's thermal *** presents a meaningful way to develop Mg alloys for applications in the field of small-volume heat dissipation components that require high *** comprehensive review begins by outlining standard testing and prediction methods,followed by the theoretical models used to predict thermal conductivity,and then ex.lores the primary influencing factors affecting thermal *** review summarizes the current development status of Mg alloys,focusing on the quest for alloys that offer both high thermal conductivity and high *** concludes by providing insights into forthcoming prospects and challenges within this field.

关键词： Mg alloy Thermal conductivity Mechanical properties Solute atom Second phase

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Ex.erimental and numerical simulation study on forced ventilation and dust removal of coal mine heading surface

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International j.urnal of Coal Science & Technology 2024年第1期11卷 204-220页

作者： Haotian Zheng Bingyou jiang Haoyu Wang Yuannan Zheng Key Laboratory of Industrial Dust Prevention and Control&Occupational Health and Safety Ministry of EducationAnhui University of Science and TechnologyHuainan232001China j.int National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan232001China School of Safety Science and Engineering Anhui University of Science and TechnologyHuainan232001China

In order to study the problems of unreasonable airflow distribution and serious dust pollution in a heading surface,an ex.erimental platform for forced ventilation and dust removal was built based on the similar *** the similar ex.eriment and numerical simulation,the distribution of airflow field in the roadway and the spatial and temporal evolution of dust pollution under the conditions of forced ventilation were *** airflow field in the roadway can be divided into three zones:j.t zone,vortex.zone and reflux.*** dust concentration gradually decreases from the head to the rear of the *** the forced ventilation conditions,there is a unilateral accumulation of dust,with higher dust concentrations away from the *** position of the equipment has an interception effect on the *** max.mum error between the test value and the simulation result is 12.9%,which verifies the accuracy of the ex.erimental *** research results can provide theoretical guidance for the application of dust removal technology in coal mine.

关键词： Heading surface Forced ventilation Airflow field Dust pollution

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