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Cu-doped SnO_(2)/rGO nanocomposites for ultrasensitive H2S detection at low temperature

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微系统与纳米工程(英文) 2023年第3期9卷 61-71页

作者： Tingting Chen Jianhai Sun Ning Xue Wen Wang Zongchang Luo Qinqin Liang Tianye Zhou Hao Quan haoyuan Cai Kangsong Tang Kaisheng jiang State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of Sciences100194 BeijingChina School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of Sciences100049 BeijingChina State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of Sciences100190 BeijingChina Guangxi Key Laboratory of Intelligent Control and Maintenance of Power Equipment School of Electronic EngineeringGuangxi UniversityNanning 530004 GuangxiChina Electric Power Research Institute of Guangxi Power Grid Co. Ltd.Nanning 530013 GuangxiChina

Hydrogen sulfide(H_(2)S)detection remains a significant concern and the sensitivity,selectivity,and detection limit must be balanced at low ***,we utilized a facile solvothermal method to prepare Cu-doped SnO_(2)/rGO nanocomposites that have emerged as promising candidate materials for H_(2)S *** of the Cu-SnO_(2)/rGO was carried out to determine its surface morphology,chemical composition,and crystal *** optimal sensor response for 10 ppm H_(2)S was~1415.7 at 120℃,which was over 320 times higher than that seen for pristine SnO_(2)CQDs(R_(a)/R_(g)=4.4)at 280℃.Moreover,the sensor material exhibited excellent selectivity,a superior linear working range(R^(2)=0.991,1-150 ppm),a fast response time(31 s to 2 ppm),and ppb-level H_(2)S detection(R_(a)/R_(g)=1.26 to 50 ppb)at 120℃.In addition,the sensor maintained a high performance even at extremely high humidity(90%)and showed outstanding long-term *** superb H_(2)S sensing properties were attributed to catalytic sensitization by the Cu dopant and a synergistic effect of the Cu-SnO_(2)and rGO,which offered abundant active sites for O_(2)and H_(2)S absorption and accelerated the transfer of electrons/holes.

关键词： stability. selectivity attributed

Advancing drug delivery to articular cartilage:From single to multiple strategies

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药学学报:英文版 2023年第10期13卷 4127-4148页

作者： Tianyuan Zhao Xu Li Hao Li haoyuan Deng Jianwei Li Zhen Yang Songlin He Shuangpeng jiang Xiang Sui Quanyi Guo Shuyun Liu Institute of Orthopedics The First Medical CenterChinese PLA General HospitalBeijing Key Lab of Regenerative Medicine in OrthopedicsKey Laboratory of Musculoskeletal Trauma&War Injuries PLABeijing 100853China School of Medicine Nankai UniversityTianjin 300071China Musculoskeletal Research Laboratory Department of Orthopedics&TraumatologyThe Chinese University of Hong Kong999077Hong KongChina Arthritis Clinic&Research Center Peking University People’s HospitalPeking UniversityBeijing 100044China Department of Joint Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Articular cartilage(AC) injuries often lead to cartilage degeneration and may ultimately result in osteoarthritis(OA) due to the limited self-repair ability. To date, numerous intra-articular delivery systems carrying various therapeutic agents have been developed to improve therapeutic localization and retention, optimize controlled drug release profiles and target different pathological processes. Due to the complex and multifactorial characteristics of cartilage injury pathology and heterogeneity of the cartilage structure deposited within a dense matrix, delivery systems loaded with a single therapeutic agent are hindered from reaching multiple targets in a spatiotemporal matched manner and thus fail to mimic the natural processes of biosynthesis, compromising the goal of full cartilage regeneration. Emerging evidence highlights the importance of sequential delivery strategies targeting multiple pathological processes. In this review, we first summarize the current status and progress achieved in single-drug delivery strategies for the treatment of AC diseases. Subsequently, we focus mainly on advances in multiple drug delivery applications, including sequential release formulations targeting various pathological processes, synergistic targeting of the same pathological process, the spatial distribution in multiple tissues, and heterogeneous regeneration. We hope that this review will inspire the rational design of intraarticular drug delivery systems(DDSs) in the future.

关键词： Drug delivery systems Articular cartilage Cartilage injury Osteoarthritis Cartilage regeneration Multiple drug delivery strategy Biomaterials Therapeutic factors

miR-3189-3p对结直肠癌患者预后的影响及作用机制探讨

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中国临床新医学 2024年第2期17卷 206-211页

作者：曹宇生梁浩源李林涛蒋开海黄天赋李广生黄许森右江民族医学院临床医学院百色533000 右江民族医学院附属医院胃肠外科百色533000

目的探讨miR-3189-3p对结直肠癌(CRC)患者预后的影响及作用机制。方法基于CancerMIRNome数据库和ENCORI数据库数据分析miR-3189-3p在CRC组织和正常组织中的表达差异,探讨miR-3189-3p表达水平对患者生存预后的影响。分别将hsa-miR-3189-3... 详细信息

目的探讨miR-3189-3p对结直肠癌(CRC)患者预后的影响及作用机制。方法基于CancerMIRNome数据库和ENCORI数据库数据分析miR-3189-3p在CRC组织和正常组织中的表达差异,探讨miR-3189-3p表达水平对患者生存预后的影响。分别将hsa-miR-3189-3p mimics、miR-3189-3p NC转染至LOVO细胞,通过Western blot实验探讨miR-3189-3p对LOVO细胞上皮细胞-间充质转化(EMT)关键蛋白[波形蛋白(vimentin)和N钙黏蛋白(N-cadherin)]表达水平的影响,通过划痕实验和Transwell实验探讨miR-3189-3p对LOVO细胞迁移和侵袭能力的影响。结果CRC组织的miR-3189-3p表达水平显著高于正常组织(P<0.05)。miR-3189-3p高表达CRC患者的生存预后较低表达者更好(P<0.05)。过表达miR-3189-3p后,LOVO细胞的迁移和侵袭能力显著减弱(P<0.05),vimentin和N-cadherin蛋白表达水平显著降低(P<0.05)。结论miR-3189-3p可能通过调控CRC细胞的迁移、侵袭以及EMT对患者的生存预后造成影响。

关键词： miR-3189-3p 结直肠癌上皮细胞-间充质转化迁移侵袭

RNA pull-down联合质谱分析lncRNA HSFAS在增生性瘢痕中的作用及机制

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中国组织工程研究 2025年第12期29卷 2492-2499页

作者：夏童童马芳孙浩原刘虹麟张正皓杨佳琪张慧萍吴凯沈江涌姜怡邓李桂忠国家卫生健康委员会代谢性心血管疾病研究重点实验室宁夏回族自治区银川市750004 宁夏医科大学基础医学院宁夏回族自治区银川市750004 宁夏医科大学临床医学院宁夏回族自治区银川市750004 宁夏医科大学检验学院宁夏回族自治区银川市750004 湖南省妇幼保健院医学遗传科湖南省长沙市410008 宁夏医科大学总医院烧伤科宁夏回族自治区银川市750004

背景:课题组前期研究发现,增生性瘢痕特异性长链非编码RNA HSFAS是一种可用于增生性瘢痕诊断的新型生物标志物,但其如何在增生性瘢痕中发挥作用尚不清楚。目的:探讨长链非编码RNA HSFAS在增生性瘢痕中的作用及机制。方法:临床收集3例行... 详细信息

背景:课题组前期研究发现,增生性瘢痕特异性长链非编码RNA HSFAS是一种可用于增生性瘢痕诊断的新型生物标志物,但其如何在增生性瘢痕中发挥作用尚不清楚。目的:探讨长链非编码RNA HSFAS在增生性瘢痕中的作用及机制。方法:临床收集3例行增生性瘢痕组织切除手术患者的新鲜增生性瘢痕皮肤组织和增生性瘢痕旁正常皮肤组织标本,应用免疫荧光技术检测两种皮肤组织冰冻切片中长链非编码RNA HSFAS的表达。应用酶消化法体外分离增生性瘢痕皮肤组织与正常皮肤组织原代成纤维细胞,采用qRT-PCR检测细胞中长链非编码RNA HSFAS mRNA表达,通过RNA pull-down联合质谱技术检测与长链非编码RNA HSFAS相互结合的蛋白,利用GO和KEGG分析长链非编码RNA HSFAS参与增生性瘢痕进展的主要功能和通路,通过catRAPID和RPISeq网站分析确定长链非编码RNA HSFAS与蛋白的靶向结合。结果与结论:①与正常皮肤组织相比,增生性瘢痕组织中的长链非编码RNA HSFAS表达升高(P<0.05);与正常皮肤组织来源成纤维细胞相比,增生性瘢痕组织来源成纤维细胞中长链非编码RNA HSFAS mRNA表达升高(P<0.05);②RNA pull-down联合质谱技术明确与长链非编码RNA HSFAS相互结合的蛋白有510个;GO和KEGG分析结果显示:这些蛋白主要涉及RNA剪接和加工、染色体合成和分离、细胞周期等过程,其中涉及RNA剪接和加工的蛋白有支架附着因子B2和DICER1,并且与长链非编码RNA HSFAS的结合分数较高;生物信息学技术分析验证结果显示,长链非编码RNA HSFAS与支架附着因子B2和DICER1蛋白存在相互结合;③结果显示,长链非编码RNA HSFAS可能通过与支架附着因子B2和DICER1蛋白相互结合调控RNA剪接和加工修饰影响基因表达,从而促进增生性瘢痕的发生发展。

关键词：增生性瘢痕 lncRNA HSFAS 成纤维细胞 RNA pull-down 质谱分析

Reversible hydrogenation restores defected graphene to graphene

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Science China Chemistry 2021年第6期64卷 1047-1056页

作者： Lin jiang Pauline MGvan Deursen Hadi Arjmandi-Tash Liubov ABelyaeva haoyuan Qi Jiao He Vincent Kofman Longfei Wu Valery Muravev Ute Kaiser Harold Linnartz Emiel JMHensen Jan PHofmann Grégory FSchneider Leiden Institute of Chemistry Leiden UniversityEinsteinweg 552333CC LeidenThe Netherlands Central Facility for Electron Microscopy Electron Microscopy Group of Materials ScienceUlm UniversityAlbert-Einstein-Allee 11Ulm 89081Germany Laboratory for Astrophysics Leiden ObservatoryLeiden UniversityNiels Bohrweg 22333 CA LeidenThe Netherlands Laboratory for Inorganic Materials and Catalysis Department of Chemical Engineering and ChemistryEindhoven University of TechnologyP.O.Box 5135600 MB EindhovenThe Netherlands Center for Advancing Electronics Dresden(cfaed)and Faculty of Chemistry and Food Chemistry Technical University of Dresden010069 DresdenGermany

Graphene as a two-dimensional material is prone to hydrocarbon contaminations,which can significantly alter its intrinsic electrical ***,we implement a facile hydrogenation-dehydrogenation strategy to remove hydrocarbon contaminations and preserve the excellent transport properties of monolayer *** electron microscopy we quantitatively characterized the improved cleanness of hydrogenated graphene compared to untreated *** situ spectroscopic investigations revealed that the hydrogenation treatment promoted the adsorption of water at the graphene surface,resulting in a protective layer against the re-deposition of hydrocarbon ***,the further dehydrogenation of hydrogenated graphene rendered a more pristine-like basal plane with improved carrier mobility compared to untreated pristine *** findings provide a practical post-growth cleaning protocol for graphene with maintained surface cleanness and lattice integrity to systematically carry a range of surface chemistry in the form of a well-performing and reproducible transistor.

关键词： graphene reversible hydrogenation surface cleanness in situ spectroscopy transistors

Detecting Abnormal Start-Ups, Unusual Resource Consumptions of the Smart Phone: A Deep Learning Approach

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ZTE Communications 2019年第2期17卷 38-43页

作者： ZHENG Xiaoqing LU Yaping PENG haoyuan FENG jiangtao ZHOU Yi jiang Min MA Li ZHANG Ji JI Jie School of Computer Science Fudan UniversityShanghai 201203China Software R&D Center/Terminal Business Division ZTE CorporationShanghai 201203China

The temporal distance between events conveys information essential for many time series tasks such as speech recognition and rhythm *** traditional models such as hidden Markov models(HMMs)and discrete symbolic grammars tend to discard such information,recurrent neural networks(RNNs)can in principle learn to make use of *** an advanced variant of *** short-term memory(LSTM)has an alternative(arguably better)mechanism for bridging long time *** propose a couple of deep neural network-based models to detect abnormal start-ups,unusual CPU and memory consumptions of the application processes running on smart *** results showed that the proposed neural networks achieve remarkable performance at some reasonable computational *** speed advantage of neural networks makes them even more competitive for the applications requiring real-time response,offering the proposed models the potential for practical systems.

关键词： deep learning time series analysis convolutional neural network RNN

考虑输出功率相关性的光伏电站典型场景生成方法研究

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电力工程技术 2021年第2期40卷 11-17,25页

作者：陈颢元蒋玮韩俊东南大学电气工程学院江苏南京210096 国网江苏省电力有限公司经济技术研究院江苏南京210008

含光伏的传统概率潮流计算常使用Beta、Weibull等分布模型,但这些模型难以精确体现不同场景下输出功率特性的变化。针对此问题,文中提出一种光伏输出功率多场景生成方法。该方法将多个光伏电站输出功率的相关性以及相关性跟随外界条件... 详细信息

含光伏的传统概率潮流计算常使用Beta、Weibull等分布模型,但这些模型难以精确体现不同场景下输出功率特性的变化。针对此问题,文中提出一种光伏输出功率多场景生成方法。该方法将多个光伏电站输出功率的相关性以及相关性跟随外界条件的变化纳入考量范围,可实现多个光伏电站输出功率的精确建模。首先,对光伏电站历史输出功率数据进行基于密度中心的聚类处理,产生的多个聚类中心作为输出功率场景;其次,对不同场景进行核密度估计,建立Copula函数以描述多个输出功率的概率分布;然后,对生成的多场景概率分布模型进行拉丁超立方采样,利用生成的样本进行概率潮流计算,评估含光伏的配电网运行状态;最后,分析算法的稳定性,讨论采样规模对计算结果的影响。结果表明,文中提出的多场景生成方法有助于提升光伏输出功率的建模精度和概率潮流计算精度。

关键词：概率潮流蒙特卡洛场景生成聚类分析光伏电站建模

Evaluation and Analysis of uplink signal interference in GEO satellite system

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Evaluation and Analysis of uplink signal interference in GEO...

第十四届中国卫星导航年会

作者： Xuyu Wang Dongfang jiang Bingjie Liu Li Wang haoyuan Yu Hai Sha Heng Wei Yingying Zhao 32021 Troops of the PLA

Aiming at the problem of uplink signal interference in the satelliteearth link of GEO satellite system,this paper analyzes the satellite communication link interference model and interference evaluation methods,and the link interference model is constructed by considering various factors ***,the interference evaluation method based on the spectral separation coefficient is used to quantitatively evaluate the attenuation of carrier-to-noise ratio of the useful signals received by the receiving station from multiple *** results show that the interference effect increases with the increase of uplink interference signal power,and presents an exponential increase after reaching a certain value;Under the same interference signal power,the increase of the number of interference stations will lead to the decrease of the attenuation rate of carrier-to-noise ratio of useful signals and gradually *** closer the interference station is deployed to the area near the transmitting station,the more obvious the interference effect will ***,due to the power characteristics of the satellite transparent transponder,its position change in the nearby region has little influence on the interference effect.

关键词：

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格构式钢管混凝土风力发电塔架设计

辽宁工程技术大学学报（自然科学版） 2012年第2期31卷 202-205页

作者：姜顺先王存堂于浩源江苏大学机械电子工程江苏镇江212013

针对格构式钢管混凝土组合结构塔架在风力发电中应用问题,结合钢管混凝土统一理论,采用有限元法,借助于ANSYS有限元软件,对钢管混凝土立柱的稳定性、格构式钢管混凝土塔架静强度进行了分析.结果表明:圆钢管混凝土立柱的稳定性优于薄壁... 详细信息

针对格构式钢管混凝土组合结构塔架在风力发电中应用问题,结合钢管混凝土统一理论,采用有限元法,借助于ANSYS有限元软件,对钢管混凝土立柱的稳定性、格构式钢管混凝土塔架静强度进行了分析.结果表明:圆钢管混凝土立柱的稳定性优于薄壁钢管立柱;格构式钢管混凝土形式塔架能够满足风机塔架强度要求,但格构式塔架最大应力处于塔架迎风或背风一侧的某一高度,因该高度的弯矩比较大,构件连接节点部位出现了较大应力集中,对此高度组合材料的含钢率应适当加大.该结果对格构式钢管混凝土组合结构塔架的总体设计有一定的参考价值.

关键词：格构式塔架钢管混凝土风力发电有限元稳定性静强度模态