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Translational medicine in China Ⅰ:Perspectives from Chinese physicians and scientists

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Science China(Life Sciences) 2011年第12期54卷 1071-1073页

作者： jiang chengyu Department of Biochemistry and Molecular Biology Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100005 China

Ever since Dr. Elias Zerhouni, then director of the National Institutes of Health, proposed ＂The NIH Roadmap＂ in 2003 [1], life sciences and medical fields worldwide have empha- sized translational medical research. In this special topic, we have invited distinguished physicians and scientists to offer their perspectives on translational medical research in China.

关键词：科学家美国国立卫生研究院中国医学转化医生生命科学路线图

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深部高应力巷道失稳特征与围岩控制技术研究

煤 2025年第2期34卷 16-20页

作者：张诺张毅江成玉大方县能源局能源发展技术服务中心贵州毕节551700 贵州大学勘察设计研究院有限责任公司贵州贵阳550025 贵州大学矿业学院贵州贵阳550025

鄂尔多斯市中部某煤矿围岩收敛变形现象严重,原始支护技术无法有效控制围岩失稳,基于现场实际情况及组合拱理论,提出“增加支护+补强锚杆”的支护方案,通过增加锚固长度和管缝式锚杆间排距,锚杆与围岩形成了良好的自稳结构。利用数值模... 详细信息

鄂尔多斯市中部某煤矿围岩收敛变形现象严重,原始支护技术无法有效控制围岩失稳,基于现场实际情况及组合拱理论,提出“增加支护+补强锚杆”的支护方案,通过增加锚固长度和管缝式锚杆间排距,锚杆与围岩形成了良好的自稳结构。利用数值模拟对比分析原始支护与优化支护后的应力场,位移场和塑性区,通过定性与定量相结合的分析方法,结果表明优化支护方案对围岩控制效果良好,应力释放范围小,最大位移量仅为原始支护位移量的0.57倍,塑性区破坏单元减少了85%以上。通过现场监测发现数值模拟结果准确,顶板下沉量减少了50%,帮部收敛量减少了41%,验证了该优化支护方案对深部高应力大断面巷道具有良好的控制作用。

关键词：深部高应力巷道定量分析塑性区补强支护

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Large-scale Patterning of Hydrophobic Silicon Nanostructure Arrays Fabricated by Dual Lithography and Deep Reactive Ion Etching

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Nano-Micro Letters 2013年第1期5卷 7-12页

作者： Zhibo Ma chengyu jiang Weizheng Yuan Yang He Key Laboratory of Micro/Nano Systems for Aerospace Ministry of EducationNorthwestern Polytechnical University

We describe a simple but efficient technique to fabricate large-scale arrays of highly ordered silicon nanostructures. By coupling dual lithography using light of 351.1 nm wavelength with deep reactive ion etching(DRIE), silicon nanostructures of excellent regularity and uniform coverage were achieved. The proposed nanofabrication method not only simplified the nanofabrication process but also produced highaspect-ratio(higher than 15) nanostructures. The scalloping problem was also controlled by regulating DRIE parameters. The process is rapid, cheap, examined to optimize the fabrication process, and has the potential to be scaled up to large areas. The contact angle of a water droplet atop the surface is larger than 150?.Moreover, by coupling black silicon process with DRIE-based microfabrication, three-dimensional nano/nano dual-scale structures which show robust and stable hydrophobicity have been achieved. This process opens new application possibilities in optical, photoelectric, microelectronic, catalytic and biomedical applications.

关键词： Hydrophobic Nanostructure arrays DRIE High-aspect-ratio

Potential oligonucleotide drugs in Bencao sRNA Atlas

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Science China(Life Sciences) 2023年第12期66卷 2943-2945页

作者： Fengming Huang Jiaqi Liu Sifen Du Yexuan Lin chengyu jiang State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of BiochemistrySchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China

Dear Editor,We read the Letter of Professor Shanfa Lu(Lu,2023)titled“Are herbal sRNAs really novel precision medicines?”In this Letter,Lu(2023)commented on our previously published manuscripts(Du et al.,2019;Huang et al.,2019)and concluded that“HJT-sRNA-m1–HJT-sRNA-m8,the eight sRNAs thought to be derived from ***,are actually derived from animal and/or human beings”.

关键词： really Letter Atlas

From herbal small RNAs to one medicine

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Science China(Life Sciences) 2019年第3期62卷 285-287页

作者： Chao Ji Skirmantas Kriaucionis Benedikt M.Kessler chengyu jiang Institute of Basic Medical Sciences Chinese Academy of Medical SciencesDepartment of PharmacologyPeking Union Medical College Ludwig Institute for Cancer Research University of Oxford Target Discovery Institute Nuffield Department of MedicineCAMS-Oxford InstituteUniversity of Oxford State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesCAMS-Oxford InstituteChinese Academy of Medical SciencesDepartment of BiochemistryPeking Union Medical College

In this special topic "Herbal small RNAs, novel precision medicine from Mother Nature", we present four original articles that study the entry of small RNAs derived from herbs used in traditional Chinese medicine into mammalian cells and their function within human and mouse cells, and one review paper focusing on current trends in herb genomics (Du et al., 2017;Huang et al., 2018;Zhang et al., 2018;Li et al., 2019;Xin et al., 2018).

关键词： From herbal small RNAs one medicine

Analysis of non-coding small RNA similarity/sharing between plant and animal genomes

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Science China(Life Sciences) 2023年第10期66卷 2437-2440页

作者： Fengming Huang Xiangyu Qiao Song Mei Cong Zhang chengyu jiang State Key Laboratory of Common Mechanism Research for Major Diseases Department of BiochemistryInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China

Dear Editor,During the construction and analysis of the Bencao(herbal)small RNA(s RNA)Atlas,the fact that many s RNAs from the human genome are present in the Bencao(herbal)database attracted our attention(Cao et al.,2023).The Bencao Atlas contains millions of s RNAs from hundreds of plants used in traditional Chinese Medicines(TCMs).

关键词： herbal Atlas

NUMERICAL CALCULATION FOR 2-DIMENSIONAL HEAT TRANSFER IN KEYHOLE LASER WELDING

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Chinese Journal of Mechanical Engineering 1998年第3期11卷 20-25页

作者： Xu Jiuhua Zhang Jingzhou jiang chengyu Luo Yumei Mechanical Engineering Institute, Nanjing University of Aeronautics and Astronautics Nanjing Univ of Aeronautics and Astronautics Nanjing China

A numerical method is presented for analysing 2 dimensional quasi steady state heat transfer in high power density laser keyhole welding processes. The mathematical model is established according to the conservation of mass, momentum and energy. Computation is performed by using the finite control volume method in the curvilinear coordinate system. A position prediction correction procedure is employed to identify the solid liquid interface location. This method is applied to the study of a typical keyhole welding process of an AISI 304 stainless steel plate and its feasibility is verified.

关键词： Laser welding Heat transfer Keyhole Temperature distribution

Endowing inorganic nanomaterials with circularly polarized luminescence

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Aggregate 2022年第1期3卷 108-121页

作者： Dongxue Han Chengxi Li chengyu jiang Xue Jin Xiongbin Wang Rui Chen Jiaji Cheng Pengfei Duan CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingP.R.China Key Laboratory for the Green Preparation and Application of Functional Materials Ministry of EducationSchool of Materials Science and EngineeringHubei UniversityWuhanP.R.China University of Chinese Academy of Sciences BeijingP.R.China Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhenP.R.China

Recently,materials with circularly polarized luminescence(CPL)properties have attracted substantial attention because they offer new perspectives in fundamental research and wide applications in photonics,bio-encoding,catalysis,and so *** importance has recently promoted the development of CPL-active materials from the traditional realm of organics to newly released areas in *** to the advantages of inorganic nanomaterials in stability,high luminescent quantum efficiency,material diversity,and the diversity of shapes and sizes,extensive research about CPL active inorganic nanomaterials has been done in the past decades leading to great signs of progress on synthesis,characterizations,and potential *** this review,therefore,we will thoroughly describe the general design principles of inorganic nanomaterials with CPL activity,basically according to the origins of chirality in inorganic nanomaterials:intrinsic chirality in inorganic nanomaterials,ligand-induced chirality,and structural chirality caused by the supramolecular assembly,*** representative applications of the CPL-active inorganic nanomaterials are presented with respect to challenges,prospective,and problems that unsolved to date.

关键词： circularly polarized luminescence inorganic nanomaterials perovskite nanocrystal quantum dot upcon-version nanoparticle

EXPERIMENTAL STUDY ON IN-PROCESS MONITORING OF CUTTING CHATTER

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Chinese Journal of Aeronautics 1990年第3期5卷 216-223页

作者： jiang chengyu, Xu Hongjun, Zhang Youzhen and Pu XuefengNanjing Aeronautical Institute

The most significant characteristic in frequency domain during cutting chatter occurring process is the steep rise of the vibration energy in certain narrow frequency band containing the chatter frequency. In accordance with the frequency band-energy principle, a reliable criterion for chatter judgement is proposed and the in-process detection of cutting chatter is realized by the use of microcomputer. This method has the advantages of rapidity, high sensitivity, accuracy and high resistance to interference. Some concrete measures taken in practical applications are also discussed.

关键词： ting EXPERIMENTAL STUDY ON IN-PROCESS MONITORING OF CUTTING CHATTER BPF mode FH