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YMDD variants of HBV DNA polymerase gene: Rapid detection and clinicopathoiogical analysis with long-term Iamivudine therapy after liver transplantation

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World Journal of Gastroenterology 2005年第18期11卷 2714-2719页

作者： FeiPei Jun-yuning jiang-FengYou Jing-PinYang JieZheng DepartmentofPathology HealthScienceCenterPekingUniversityBeijing100083China

AIM: To look for a rapid low-cost technique for the detection of HBV ***: Two patients who underwent orthotopic liver transplantation (OLT) for HBV infection were treated with lamivudine (100 mg daily) and HBV infection recurred in the grafted livers. The patients were monitored intensively for liver enzymes, hepatitis B surface antigen (HBsAg) and HBV DNA in serum. Liver biopsy was performed regularly. HBV DNA in a conserved polymerase domain (the YMDD locus) was amplified from serum of each patient by PCR and sequenced. HBV genotypes were analyzed by restriction fragment length polymorphism (RFLP) of the PCR products generated from a fragment of the polymerase ***: YMDD wild-type HBV was detected in one patient by PCR-RFLP and DNA sequencing 19 mo after OLT, and YIDD mutant-type HBV in the other patient, 16 mo after ***: PCR-RFLP assay is an accurate and simple method for genotyping lamivudine-resistant HBV variants.

关键词： Liver transplantation HBV DNA Polymerase gene YMDD variants PCR-RFLP

Construction of Au@Metal-organic framework for sensitive determination of creatinine in urine

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Journal of Innovative Optical Health Sciences 2021年第4期4卷 55-63页

作者： yuning jiang Yanzheng Cai Sen Hu Xiaoyu Guo Ye Ying Ying Wen Yiping Wu Haifeng Yang College of Chemistry and Materials Science Shanghai Normal University Shanghai 200234P.R.China

Creatinine level in urine is an important biomarker for renal function diseases,such as renal failure,glomerulonephritis,and chronic *** Au@MIL-101(Fe)was prepared by in situ growth of Au nanoparticles in MIL-101(Fe)as a selective SERS *** Au@MIL-101(Fe)offers the great local surface plasmon resonance(SPR)effect due to gold nanoparticles aggre-gation inside metal-organic *** framework structure could enrich trace target samples and drag them into SPR hot *** optimal Au@MIL-101(Fe)composite substrate is used for analyzing creatinine in urine and the limit of detection is down to 0.1μmol/L and a linear relationship is ranging from 1μmol/L to 100μmol/L.

关键词： surface enhanced Raman scattering Au@MIL-101(Fe) creatinine

Study on blood pressure rhythm in hypertensive patients with Yin deficiency syndrome and a random forest model for predicting hypertension with Yin deficiency syndrome

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Journal of Traditional Chinese Medicine 2024年第3期44卷 564-571页

作者： ZHOU Ying LI Ping LUAN Jianwei SHEN Rui WU Yinglan XU Qiwen WANG Xinyue ZHU Yao XU Xiangru LIU Zitian jiang yuning ZHONG Yong HE Yun jiang Weimin Department of Cardiology the Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Traditional Chinese MedicineNanjing 210029China Department of Health Management Centre Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Emergency Department Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of General Internal Medicine the Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Traditional Chinese MedicineNanjing 210029China

OBJECTIVE: To investigate blood pressure rhythm(BPR)in Yin deficiency syndrome of hypertension(YDSH)patients and develop a random forest model for predicting ***: Our study was consistent with technical processes and specification for developing guidelines of Evidence-based Chinese medicine clinical practice(T/CACM 1032-2017). We enrolled 234 patients who had been diagnosed with primary hypertension without antihypertensive medications prior to the enrollment. All participants were divided into Yin deficiency group(YX, n = 74) and non-Yin deficiency group(NYX, n = 160).Participants were professionally grouped by three experienced chief Traditional Chinese Medicine(TCM)physicians according to four examinations(i.e.,inspection, listening and smelling, inquiry and palpation).We collected data on 24 h ambulatory blood pressure monitoring(ABPM) and YDSH rating scale. We divided 24 h of a day into 12 two-hour periods [Chen-Shi(7:00-9:00), Si-Shi(9:00-11:00), Wu-Shi(11:00-13:00), Wei-Shi(13:00-15:00), Shen-Shi(15:00-17:00), You-Shi(17:00-19:00), Xu-Shi(19:00-21:00), Hai-Shi(21:00-23:00), ZiShi(23:00-1:00), Chou-Shi(1:00-3:00), Yin-Shi(3:00-5:00), Mao-Shi(5:00-7:00)] according to the theory of “midnight-midday ebb flow”. We used random forest to build the diagnostic model of YDSH, with whether it was Yin deficiency syndrome as the outcome. RESULTS: Compared with NYX group, YX group had more female participants with older age, lower waist circumference, body mass index(BMI), diastolic blood pressure(DBP), and smoking and drinking rate(all P < 0.05). The YDSH rating scores of YX group [28.5(21.0-36.0)] were significantly higher than NYX group [13.0(8.0-22.0)](P < 0.001), and the typical symptoms of YX group included vexing heat in the chest, palms and soles, dizziness, dry eyes, string-like and fine pulse, soreness and weakness of lumbus and knees, palpitations, reddened cheeks, and tinnitus(all P < 0.05). The ratio of non-dipper hypertension in YX group was higher t

关键词： hypertension Yin deficiency syndrome random forest blood pressure rhythm blood pressure variability

Bazi Bushen alleviates reproductive aging in aged male mice

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Chinese Journal of Natural Medicines 2024年第5期22卷 416-425页

作者： MA Kun LI Mengnan SONG Yahui MAO Xinjing ZHANG Shaolan ZHANG Yaping jiang yuning JI Chuanyuan NIU Kunxu LI Hongrong HOU Yunlong WEI Cong Graduate School Hebei University of Chinese MedicineShijiazhuang 050091China State Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang 050035China Key Laboratory of State Administration of TCM(Cardio-Cerebral Vessel Collateral Disease) Shijiazhuang 050035China College of Traditional Chinese Medicine·College of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China Hebei Provincial Key Laboratory of Luobing Shijiazhuang 050035China Key Disciplines of State Administration of TCM for Luobing Shijiazhuang 050035China

Bazi Bushen(BZBS),a traditional Chinese medicine(TCM),has demonstrated therapeutic efficacy in testicular dysfunction within D-galactose and NaNO_(2)mouse *** study aimed to ascertain if BZBS could also mitigate the decline in testicular function associated with natural ***,male aged mice were employed to evaluate the preventive effects of BZBS on male reproductive *** was achieved by assessing sex hormone production,testicular histomorphology,and *** to the untreated aged control group,BZBS administration elevated the levels of sex hormones and spermatocyte populations and preserved normal testicular structure in aged ***,spermatogenesis was *** analyses,including malondialdehyde(MDA)assays and real-time PCR,indicated that BZBS diminished testicular oxidative stress and the inflammatory *** these findings,mice treated with BZBS exhibited reductions in the populations of senescent and apoptotic cells within the seminiferous tubules,suggesting alleviated cellular *** contrast,we observed that rapamycin,a drug known for its longevity benefits,induced excessive testicular apoptosis and did not decrease lipid ***,our results highlight BZBS’s promising clinical potential in counteracting male reproductive aging,underlining its mechanisms of action.

关键词： Traditional Chinese medicine Male reproductive aging Spermatogenic cells Cell senescence Apoptosis

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我国农村地区城镇化建设与土地流转

知与行 2016年第1期 150-154页

作者：蒋宇宁东北财经大学公共管理学院辽宁大连116025

党的十八大后,为了在全国范围内推进经济体制改革,农村被赋予了前所未有的重要历史使命,由于我国是传统的农业大国,无论是从农村地区占我国总面积的比例还是农民人口占人口总数的比例来看,农村与农民问题都是我国本轮经济体制改革的关... 详细信息

党的十八大后,为了在全国范围内推进经济体制改革,农村被赋予了前所未有的重要历史使命,由于我国是传统的农业大国,无论是从农村地区占我国总面积的比例还是农民人口占人口总数的比例来看,农村与农民问题都是我国本轮经济体制改革的关键所在。新农村建设成为未来一个时期国家对于农村的基本政策导向,而城镇化建设又是当前我国新农村建设的必由之路,在农村推行城镇化势在必行,在农村城镇化进程的诸多决定因素中,农村人口与农村土地是农业生产的两大重要物质基础,而农民又是基于土地而存在的,因此,农村的土地资源就成为所有与农村有关问题的重中之重。而农村土地的使用方式一直以来都是关乎农村地区城镇化建设的重要因素,这其中,农村地区土地经营使用权能否合理有效地流转,因其牵涉到土地的使用效率进而直接影响我国城镇化的整体进程,而成为农村城镇化建设成败的关键因素。

关键词：农村城镇化土地流转

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生物阻抗身份识别研究

生物医学工程学杂志 2016年第4期33卷 609-615页

作者：何想覃元元苏明亮江宇宁王新安北京大学深圳研究生院信息工程学院深圳518055

本研究旨在根据生物电阻抗理论和模式识别算法,对不同的人进行生物电阻抗的测量并进行身份识别。本文利用AD5933芯片设计阻抗采集电路来采集不同人手掌处的生物电阻抗,获得1-100kHz频率激励下的阻抗谱信息,计算阻抗曲线的分段频率值作... 详细信息

本研究旨在根据生物电阻抗理论和模式识别算法,对不同的人进行生物电阻抗的测量并进行身份识别。本文利用AD5933芯片设计阻抗采集电路来采集不同人手掌处的生物电阻抗,获得1-100kHz频率激励下的阻抗谱信息,计算阻抗曲线的分段频率值作为特征参数。为了提高识别率和防止过度拟合,将被测人员分成训练集和测试集,设计了一个3层的向后传播（BP）神经网络模型,对样本进行训练和预测。研究结果表明,BP神经网络对测试样本能进行有效识别,训练集的准确率达到97.62%,验证集的准确率达到88.79%,测试集的准确率达到86.34%,综合的识别准确率为94.22%。该网络可以很好地识别出已存在于训练网络中的人和不属于训练网络的陌生人,验证了基于生物电阻抗的模式识别方法对身份进行辨识的可行性与可靠性,为身份识别提供了一个简单有效的补充性技术。

关键词：模式识别身份识别生物电阻抗向后传播神经网络

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基于生成式对抗网络的图像超分辨率重建算法

计算机工程 2021年第3期47卷 249-255页

作者：姜玉宁李劲华赵俊莉青岛大学数据科学与软件工程学院山东青岛266071 青岛市船舶建造智能精度测量工程研究中心山东青岛266071

针对传统图像超分辨率重建算法存在网络训练困难与生成图像存在伪影的问题,提出一种利用生成式对抗网络的超分辨率重建算法。去除生成式对抗网络的批量归一化层降低计算复杂度,将其中的残差块替换为密集残差块构成生成网络,使用VGG19网... 详细信息

针对传统图像超分辨率重建算法存在网络训练困难与生成图像存在伪影的问题,提出一种利用生成式对抗网络的超分辨率重建算法。去除生成式对抗网络的批量归一化层降低计算复杂度,将其中的残差块替换为密集残差块构成生成网络,使用VGG19网络作为判别网络的基础框架,以全局平均池化代替全连接层防止过拟合,引入纹理损失函数、感知损失函数、对抗损失函数和内容损失函数构成生成器的总目标函数,利用纹理损失增强局部信息匹配度,采用激活层前的特征信息计算感知损失获取更多细节特征,使用WGAN-GP理论优化网络模型的对抗损失加速收敛,运用内容损失提升图像低频信息的准确性。实验结果表明,该算法重建图像的平均峰值信噪比为27.97 dB,平均结构相似性为0.777,与SRGAN和EDSR等算法相比,其在未延长较多运行时间的情况下,重建结果的纹理细节更清晰且亮度信息更准确,更符合视觉感官评价要求。

关键词：超分辨率重建生成式对抗网络密集卷积网络纹理损失梯度惩罚Wasserstein生成式对抗网络

基于构件S-N曲线的波纹管速度外压耦合加载下疲劳寿命研究

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机械工程学报 2022年第20期58卷 269-282页

作者：皇涛赵家鑫宋克兴张学宾蒋宇宁郝留成河南科技大学材料科学与工程学院洛阳471023 河南省有色金属材料科学与加工重点实验室洛阳471023 平高集团有限公司平顶山467000

真空灭弧室用波纹管服役工况复杂,采用传统的理论计算方法和试验手段难以准确预测其疲劳寿命,一定程度上制约波纹管的设计与选用。本文利用数字图像相关技术,基于拉伸试验、疲劳试验,精细化获得了波纹管构件的S-N曲线,基于ANSYS有限元... 详细信息

真空灭弧室用波纹管服役工况复杂,采用传统的理论计算方法和试验手段难以准确预测其疲劳寿命,一定程度上制约波纹管的设计与选用。本文利用数字图像相关技术,基于拉伸试验、疲劳试验,精细化获得了波纹管构件的S-N曲线,基于ANSYS有限元分析软件,建立波纹管弹塑性变形有限元模型,通过XTDIC验证了模型的准确性,结合nCode DesignLife对波纹管疲劳寿命进行了预测,并验证其准确性。研究了关键工艺参数(压力、位移、速度)对波纹管波峰、波谷等关键特征区域应力、应变和疲劳寿命的分布演变规律。研究表明:波纹管在只施加外压的工况下,波峰内壁处更容易产生疲劳损伤,位移载荷对波纹管应力应变分布影响更为显著,位移越大,波纹管更容易产生应力集中。在加载位移不变时,速度越大,波纹管等效应力越大,此时耦合0.2 MPa外压,抵消部分应力集中。在0.2 MPa外压下,当压缩速度由0.5 m/s增加到4 m/s,最大等效应力由378.89 MPa增加到424.27 MPa,疲劳寿命由49540次减小到3064次。

关键词：波纹管有限元 S-N曲线疲劳寿命

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一种八卦小花纹织物的设计与应用

艺术研究快报 2018年第4期7卷 82-89页

作者：蒋愈宁钱飞盐城工业职业技术学院江苏盐城

为了传承中国传统文化,并将中国传统文化融入进日常生活中,设计了一种八卦小花纹织物。该织物运用了两套纹板方案,采用了双面异色的表里换层织物结构,同时对传统的八卦小花纹图案进行了重新组合设计,从而完成了较为复杂的八卦小花纹织... 详细信息

为了传承中国传统文化,并将中国传统文化融入进日常生活中,设计了一种八卦小花纹织物。该织物运用了两套纹板方案,采用了双面异色的表里换层织物结构,同时对传统的八卦小花纹图案进行了重新组合设计,从而完成了较为复杂的八卦小花纹织物的设计。市场分析证明,该产品应用领域广泛,实用性强,并传承了中国古典文化,具有较高的国内外市场的销售应用前景。

关键词：八卦表里换层小花纹织物设计