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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang jin-Jie Yu Feng Su Tian jiang Shao-Yuan Zhang Lu Lv tao Long Hui-Wen Pan Jun-Qing Qi Qiang Zhou Wei-Feng Tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

Achieving full mutualism with massive passive devices for multiuser MIMO symbiotic radio

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Science China(Information Sciences) 2024年第9期67卷 196-212页

作者： jingran XU Zhuoyin DAI yong ZENG Shi jin tao jiang National Mobile Communications Research Laboratory Southeast University Purple Mountain Laboratories Research Center of 6G Mobile Communications School of Cyber Science and Engineering and Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology

Symbiotic radio(SR) is one of the attractive communication technologies to facilitate largescale Internet of Things(IoT) connections with enhanced energy and spectrum efficiency, where passive backscatter devices(BDs) modulate their information over the radio frequency(RF) signals emitted by the active primary transmitters(PTs). Meanwhile, the primary transmission can be strengthened with the additional multipaths created by BDs. To capitalize to a greater extent on the mutualism relationship between the two types of communication, this paper studies multiple-input multiple-output(MIMO) SR communication systems including multiple PTs and massive BDs. We derive the achievable rate expressions of each PT and BD, as well as the sum rate expressions of primary and secondary communication, *** asymptotic analysis is given to derive the active and passive communication rates with a large number of BDs. Furthermore, for the general case with a finite number of BDs, we study the precoding optimization problem to maximize the sum rate of primary communication, while ensuring that the sum rate of secondary communication and the individual rate for each PT and BD in the prescribed active and passive user sets satisfy the specified thresholds. Simulation results are presented to verify the analytical studies.

关键词： multiuser MIMO SR backscattering massive backscatter devices asymptotic analysis active and passive communication

Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 58-64页

作者： Ji-Kui Wang Di Zhang jin-Feng Wang Wan-Lin Lu jing-Yuan Wang Shi-Feng Liang Ran Liu jing-Xin jiang Hong-tao Li Xuan Yang Department of General Thoracic Surgery Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina Department of Health Management Center Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina

BACKGROUND At present,the existing internal medicine drug treatment can alleviate the high glucose toxicity of patients to a certain extent,to explore the efficacy of laparoscopic jejunoileal side to side anastomosis in the treatment of type 2 diabetes,the report is as *** To investigate the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes mellitus(T2DM).METHODS We retrospectively analyzed the clinical data of 78 patients with T2DM who were treated via jejunoileal lateral *** indicators were collected preoperatively,as well as at 3 and 6 months *** metabolic indicators analyzed included body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FBG),2-hour blood glucose(PBG),glycated hemoglobin(HbA1c),fasting C-peptide,2-hour C-peptide(PCP),fasting insulin(Fins),2-hour insulin(Pins),insulin resistance index(HOMA-IR),βCellular function index(HOMA-β),alanine aminotransferase,aspartate aminotransferase,serum total cholesterol(TC),low-density lipoprotein cholesterol(L DL-C),triglycerides(TG),high-density lipoprotein,and uric acid(UA)*** SBP,DBP,PBG,HbA1c,LDL-C,and TG were all significantly lower 3 months postoperative vs preoperative values;body weight,BMI,SBP,DBP,FBG,PBG,HbA1c,TC,TG,UA,and HOMA-IR values were all significantly lower 6 months postoperative vs at 3 months;and PCP,Fins,Pins,and HOMA-βwere all significantly higher 6 months postoperative vs at 3 months(all P<0.05).CONCLUSION Side-to-side anastomosis of the jejunum and ileum can effectively treat T2DM and improve the metabolic index levels associated with it.

关键词： Metabolic diseases Type 2 diabetes Jejunoileal side-to-side anastomosis Glycolipid metabolism Islet function

Reaction characteristics of carbon-bearing pellets of Bayan Obo lean iron ores in a static magnetic field

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Journal of Iron and Steel Research International 2023年第9期30卷 1687-1700页

作者： yong-li jin jin-tao jiang Hong-xing Dai Xu-dong Zhang Zeng-wu Zhao School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou 014010Inner MongoliaChina HBIS GROUP Handan Iron&Steel Company Hanbao Steelmaking Plant Handan 056000HebeiChina WISDRI Engineering and Research Incorporation Limited Xiangtan 411101HunanChina

The use of low-grade,refractory and composite paragenetic mineral resources is necessary for overcoming the shortage of iron ore resources in *** a solution to the treatment of such iron ores,the direct reduction of carbon-bearing pellets can ensure complete iron removal and the effective enrichment of other high-value ***,this technology enjoys a broad application ***,there are several problems with low-temperature reduction,such as low iron ore reaction efficiency,long reaction time,and high energy *** improve the low-temperature carbothermic reduction efficiency of iron ores,a static magnetic field with magnetic induction intensity of 1.0 T was *** isothermal reduction experiment was conducted at 1223 K to study the low-temperature self-reduction characteristics of carbon-bearing pellets of Bayan Obo lean iron ores in the static magnetic ***,the acting mechanism of the magnetic field was explored from the perspective of the reduction process,reaction efficiency,phase composition,microstructure changes,and dynamic behavior of iron *** results showed that the magnetic field can increase the low-temperature reduction rate of carbon-bearing pellets of Bayan Obo lean iron *** the conditions of reduction temperature of 1223 K,magnetic induction intensity of 1.0 T,and reduction time of 60 min,the reduction degree was 92.42%,1.65 times that without a magnetic *** magnetic field promoted the replacement of Ca^(2+)and Fe^(2+),so that the hard-to-reduce iron-bearing silicates were reduced in the order of Fe2SiO_(4)→(Ca,Na)FeSiO_(4)→FeO→*** magnetic field enabled loose minerals,more pores and cracks,and changes in the growth morphology and distribution position of metallic *** with the case under the non-magnetic condition,the metallic iron precipitated from the slag phase in a foliated shape,separated from the matrix iron oxides,and grew up at the junction of the slag phase and *** m

关键词： Static magnetic field Bayan obo lean iron ore Carbon-bearing pellet Reduction rate Phase evolution Dynamic behavior

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-tao jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

BOP shear force evaluation under complex scenarios

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Petroleum Science 2023年第4期20卷 2442-2451页

作者： Feng-Li Zhang jin-tao Ni Lai-Bin Zhang yong-Sheng Chen jin-jiang Wang School of Mechanical and Transportation Engineering China University of PetroleumBeijing102249China School of Safety and Ocean Engineering China University of PetroleumBeijing102249China Key Laboratory of Oil and Gas Production Safety and Emergency Technology Ministry of Emergency ManagementBeijing102249China

As the“throat”of the drilling well control system,ram blowout preventers(BOPs)can effectively prevent blowout ***,the ram shear mechanism under complex working conditions is unclear,and it is difficult to evaluate the ram BOP shear force,leading to frequent shear failure accidents in *** at the above problems,this paper takes the double-V ram BOP as the research object,and integrates the methods of theoretical analysis,simulation modeling,and test verification to analyze the shear force in the pipe shear process under both static and moving conditions.A ram BOP shear force evaluation method is proposed based on equivalent ***,by comparing with calculation data and experimental data,the error between them is less than 5%,demonstrating the applicability and effectiveness of the proposed *** research results can provide a theoretical basis for oilfield operations of ram BOPs.

关键词： Double-V ram Blowout preventer Shear force assessment Moving state shearing Finite element analysis Shear test under pressure

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Block Copolymer Colloidal Particles with Unique Structures through Three-dimensional Confined Assembly and Disassembly

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Chinese Journal of Polymer Science 2019年第8期37卷 744-759页

作者： jiang-Ping Xu jin-tao Zhu Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of Education Hubei Key Laboratory of Materials Chemistry and Service Failure School of Chemistry and Chemical Engineering Huazhong University of Science and Technology (HUST) Wuhan 430074 China State Key Laboratory of Materials Processing and Mold Technology HUST Wuhan 430074 China

Structured block copolymer(BCP) particles have gained increasing attention due to their potential applications in separation,catalysis, controlled release, and other fields. Three-dimensional(3D) confined assembly has been proved as a facile yet robust approach for generating BCP particles with controllable shapes and internal structures. In this feature article, we summarized the preparation of structured polymeric particles through 3D confined self-assembly of BCPs. The effects of interfacial interactions, degree of confinement,and additives on the shape and internal structure of BCP microparticles were comprehensively discussed. In addition, we highlighted the recent progress in using disassembly as a route to synthesize colloidal particles with unique structures. Two strategies were introduced in this part:(a) disassembling the discrete domains resulted in mesoporous microparticles;(b) disassembling the continuous domains led to the dissociation of microparticles into micelle-like nano-objects. The applications of the structured colloidal particles in photonic crystals,controlled release, and directed growth of inorganic materials were also presented. Finally, we discussed the current challenges and future opportunities in this promising area.

关键词： Block copolymers Self-assembly Confinement Polymer particles Nano-objects

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第01期 369-376页

作者： Song-Meng Wang Hao Nian Yan-Fang Wang Li-Shuo Zheng Yu-tao Zheng Yi-Wei Dong Liping Huang Xiaoping Wang Wei jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Progress on molecular biomarkers and classification of malignant gliomas

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Frontiers of Medicine 2013年第2期7卷 150-156页

作者： Chuanbao Zhang Zhaoshi bao Wei Zhang tao jiang Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China Beijing Neurosurgical Institute Beijing 100050China

Gliomas are the most common primary intracranial tumors in *** gliomas(WHO gradeⅢ)and glioblastomas(WHO gradeⅣ)represent the major groups of malignant gliomas in the *** diagnostic,predictive,and prognostic biomarkers for malignant gliomas have been reported over the last few decades,and these markers have made great contributions to the accuracy of diagnosis,therapeutic decision making,and prognosis of ***,heterogeneity in patient outcomes may still be observed,which highlights the insufficiency of a classification system based purely on *** efforts have been made to incorporate new information about the molecular landscape of gliomas into novel classifications that may potentially guide *** this review,we summarize three distinctive biomarkers,three most commonly altered pathways,and three classifications based on microarray data in malignant gliomas.

关键词： malignant glioma molecular biomarker IDH1 MGMT molecular classification