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Protein hydrogels for biomedical applications

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Biosurface and Biotribology 2024年第3期10卷 106-131页

作者： Xinyi Wang Yue Hou Xiong Lu Chaoming Xie yanan jiang Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduSichuanChina Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuanChina Obesity and Metabolism Medicine-Engineering Integration Laboratory Department of General SurgeryThe Third People's Hospital of ChengduThe Affiliated Hospital of Southwest Jiaotong UniversityChengduSichuanChina

Hydrogels,characterised as highly hydrophilic three-dimensional polymer networks,have gained increasing attention due to their unique physicochemical properties,finding applications in various *** polymer hydrogels exhibit higher biocompatibility and biodegradability compared to traditional synthetic polymer ***,being the principal materials of natural polymer hydrogels,bear numerous modifiable functional *** resultant hydrogel possesses responsiveness,adjustable degradability,and underway as an excellent *** common raw materials used to construct protein hydrogels are *** terms of comparing natural polymer hydrogels with traditional synthetic polymer hydrogels,the authors conduct a detailed analysis and comparison,highlighting the advantages of natural polymer hydrogels in terms of biocompatibility and biodegradability,and summarising their *** authors also address the limitations of various protein hydrogels and list existing strengthening cross-linking strategies,proposing new insights to overcome the application limits of protein ***,the applications of protein hydrogels in drug delivery,biosensing,bio-inks and tissue engineering are *** authors conclude by summarising the current challenges faced by protein hydrogels and prospecting its future development.

关键词： biomaterials biomedical application

Analysis of the Clinical Effect of Chinese Medicine Combined with Acupuncture and Moxibustion on Insomnia

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Research and Inheritance of Traditional Chinese Medicine

Research and Inheritance of Traditional Chinese Medicine 2024年第1期2卷 1-6页

作者： Lizhou He yanan jiang Ziqi Lian College of Pharmacy Shandong University of Traditional Chinese Medicine

Objective:To explore and analyze the clinical efficacy of Chinese medicine combined with acupuncture and moxibustion in the treatment of ***:80 patients with primary insomnia were selected as the study sample,with 20 cases randomly selected as the control group and the rest as the observation *** control group was treated with ordinary western medicine,while the observation group patients were treated with traditional Chinese medicine combined with acupuncture and moxibustion based on this syndrome *** comparison items were treatment effect,sleep quality,mental health,quality of life,specific sleep indicators,cerebral blood flow and ***:The treatment effectiveness showed that the observation group had a higher treatment effectiveness rate than the control group(P<0.05);The results of sleep quality showed that after treatment,the scores of the observation group were lower than those of the control group in seven dimensions:sleep quality,sleep time,sleep onset time,sleep efficiency,sleep disorders,hypnotic drugs,and daytime dysfunc‐tion score(P<0.05);The quality of life results showed that after treatment,the observa‐tion group had higher scores than the control group in eight dimensions:physiological function,physiological function,physical pain,health status,energy,social function,emotional function,and mental health(P<0.05);The results of slow wave sleep time and fast eye movement sleep time showed that after treatment,the HAMA and HAMD scores of the physiological mechanism in the observation group were lower than those in the control group(P<0.05);The results of cerebral blood flow and neurotransmitter indica‐tors show that after treatment,glutamateγ-The peak systolic blood flow velocity of ami‐nobutyric acid,vertebral artery,and basilar artery in the observation group was higher than that in the control group(P<0.05).Conclusion:The clinical treatment of Chinese medicine combined with acupuncture and moxibusti

关键词： primary insomnia acupuncture and moxibustion traditional Chinese medicine sleep quality quality of life

Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD

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Protein & Cell 2024年第2期15卷 121-134页

作者： Hui Sun Tingting Deng Yali Zhang Yanling Lin yanan jiang Yichao jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China National Institute of Diagnostics and Vaccine Development in Infectious Diseases School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China State Key Laboratory of Vaccines for Infectious Diseases School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China Xiang An Biomedicine Laboratory Xiamen 361102China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalSchool of MedicineSouthem University of Science and TechnologyShenzhen 518112China The Second Affliated Hospital School of MedicineSouthern University of Science and TechnologyShenzhen 518112China Research Unit of Frontier Technology of Structural Vaccinology Chinese Academy of Medical SciencesXiamen 361102China

Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or *** rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus ***,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron ***-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric *** antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant ***,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines.

关键词： SARS-CoV-2 broad neutralizing antibody rearrangement synergistic neutralization

机理引导下的阶跃型滑坡位移预测深度学习模型

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测绘学报 2024年第6期53卷 1128-1139页

作者：蒋亚楠郑林枫许强汤明高朱星成都理工大学地球与行星科学学院四川成都610059 成都理工大学地质灾害防治与地质环境保护国家重点实验室四川成都610059 四川省工业互联网智能监测及应用工程技术研究中心四川成都610059

阶跃型滑坡变形时间曲线呈阶梯状,阶跃变形量大,准确预警预报困难。针对现有模型在阶跃型滑坡快速变形阶段预测误差大的问题,提出一种机理引导下的阶跃型滑坡变形预测模型,该模型在深入分析滑坡变形机理上,结合变分模态分解开展滑坡位... 详细信息

阶跃型滑坡变形时间曲线呈阶梯状,阶跃变形量大,准确预警预报困难。针对现有模型在阶跃型滑坡快速变形阶段预测误差大的问题,提出一种机理引导下的阶跃型滑坡变形预测模型,该模型在深入分析滑坡变形机理上,结合变分模态分解开展滑坡位移和影响因子的动态响应分析,为Informer模型提供合理有效的外部影响因子输入,结合多头注意力机制和池化层,实现阶跃期时序数据关键周期信息的有效提取。本研究以三峡库区白水河滑坡为例,收集水库蓄水以来连续15年的逐月位移监测数据及同期逐天的降雨和库水位数据。试验结果表明,本文模型在阶跃型滑坡位移预测中整体预测精度较高,与主流预测模型相比,该模型对快速变形期的阶跃变形预测较为准确,预测误差较小。

关键词：阶跃型滑坡变形机理位移预测 Informer 自注意力机制影响因子

La修饰提高CO_(2)制甲醇催化剂Cu/ZnO/Al_(2)O_(3)的稳定性

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燃料化学学报（中英文） 2024年第8期52卷 1095-1102页

作者：牛萌萌姜雅楠张弦张翠娟刘源天津大学化工学院天津市应用催化科学与工程重点实验室天津300350 鄂尔多斯市碳中和研究应用有限公司内蒙古鄂尔多斯017000

CO_(2)加氢制甲醇反应中Cu/ZnO/Al_(2)O_(3)催化剂的失活是限制其应用的主要原因之一,实验通过向Cu/ZnO/Al_(2)O_(3)催化剂中添加不同含量的La,合成了一系列La改性的Cu/ZnO/Al_(2)O_(3)催化剂,以提高其对CO_(2)加氢制甲醇反应的催化稳... 详细信息

CO_(2)加氢制甲醇反应中Cu/ZnO/Al_(2)O_(3)催化剂的失活是限制其应用的主要原因之一,实验通过向Cu/ZnO/Al_(2)O_(3)催化剂中添加不同含量的La,合成了一系列La改性的Cu/ZnO/Al_(2)O_(3)催化剂,以提高其对CO_(2)加氢制甲醇反应的催化稳定性。在温度200℃,压力3 MPa,空速12000 mL/(g·h)条件下进行的100 h短期稳定性测试,未改性的Cu/ZnO/Al_(2)O_(3)催化剂在100 h内活性衰减明显,添加La后催化剂稳定性逐渐得到提高,当La添加量为5%时活性最佳(CO_(2)转化率4%,甲醇选择性85%),并且该催化剂在1000 h长期稳定性测试中表现出较高的稳定性(在190−220 h失活17%后保持稳定)。通过X射线衍射(XRD)、X射线光电子能谱(XPS)表征发现,加入5%La提高了Cu/ZnO/Al_(2)O_(3)催化剂中Cu、ZnO的分散度,抑制了催化剂中Cu的烧结;同时稳定了Cu^(0/+),延缓了催化剂中Cu的氧化,从而提高了催化剂的稳定性。

关键词： Cu/ZnO/Al_(2)O_(3) La助剂稳定性

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基于时序InSAR与机器学习的大范围地面沉降预测方法

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地球科学 2024年第5期49卷 1736-1745页

作者：罗袆沅许强蒋亚楠孟冉蒲川豪成都理工大学地质灾害防治与地质环境保护国家重点实验室四川成都610059 成都理工大学地球科学学院四川成都610059

地面沉降是由自然因素和人为因素综合作用下形成的地面标高损失,为预防这种累进性的缓变地质灾害,高效的大范围地面沉降预测显得尤为重要.现有的预测方法忽略了地面沉降的空间特征,且基于单点循环预测存在高耗时现象.针对上述问题,提出... 详细信息

地面沉降是由自然因素和人为因素综合作用下形成的地面标高损失,为预防这种累进性的缓变地质灾害,高效的大范围地面沉降预测显得尤为重要.现有的预测方法忽略了地面沉降的空间特征,且基于单点循环预测存在高耗时现象.针对上述问题,提出了一种基于时序InSAR与机器学习的大范围地面沉降预测方法.首先,利用SBAS-InSAR技术获取大范围的地面沉降时序信息;其次,采用经验正交函数(empirical orthogonal function,EOF)提取时序信息的空间模态及对应的主成分(principal components,PCs);最后,采用基于误差反馈的岭多项式神经网络(ridge polynomial neural network with error-output feedbacks,RPNN-EOF)模型训练与预测PCs,将预测结果重构回地面沉降时序.以延安新区2018年8月至2021年5月的84景Sentinel-1A数据为例,获取了新区的地面沉降时序.同时,EOF所提取的空间模态能清晰地表达整个新区的空间变化特征.预测结果显示,相较于传统点循环模式以及主流的时间序列预测方法,本文方法的均方根误差至少降低了22.7%,建模耗时至少降低了27.5%,因此该方法具有良好的实用性.

关键词：机器学习时间序列预测经验正交函数空间模态神经网络时序InSAR 地面沉降灾害

联合Sentinel-1A升降轨数据的滑坡多维形变反演

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地球物理学进展 2024年第4期39卷 1427-1439页

作者：周全蒋亚楠吕鹏王栋曾锐成都理工大学地球科学学院成都610059 成都理工大学地质灾害防治与地质环境保护国家重点实验室成都610059

金沙江位于长江上游一带,因其特殊的地形地貌及脆弱的地质条件影响,两岸地质灾害频发.文章首先采用SBAS-InSAR技术获取了西藏自治区金沙江流域贡觉县沙东乡至雄松乡2014年10月至2018年10月期间的滑坡地表形变特征,再结合升、降轨DInSAR... 详细信息

金沙江位于长江上游一带,因其特殊的地形地貌及脆弱的地质条件影响,两岸地质灾害频发.文章首先采用SBAS-InSAR技术获取了西藏自治区金沙江流域贡觉县沙东乡至雄松乡2014年10月至2018年10月期间的滑坡地表形变特征,再结合升、降轨DInSAR数据集获取了此区域的二维形变信息.在此基础上,选取沙东滑坡为研究对象,通过引入地表平行流约束模型,开展三维形变反演研究.结果表明:(1)研究区地表破碎,地质灾害发育,升、降轨Sentinel-1A数据可分别探测出9处和13处形变区域,其中变形区最大形变速率达到150 mm/a;(2)二维形变结果显示东西向和垂直向形变速率最大分别为147 mm/a和-70 mm/a,不同位置滑坡的形变空间分布特征并不相同;(3)三维形变结果展示了沙东滑坡不同部位的运动方向,其坡体水平滑动方向主要为东北向,同时伴有下沉的状态;(4)结合该区域降雨数据,分析了典型滑坡形变与降雨的相关性,结果表明,强降雨是导致滑坡加速形变的重要驱动因素.

关键词：金沙江滑坡形变 SBAS-InSAR 地表平行流多维形变反演

Research on Trajectory Tracking Method of Redundant Manipulator Based on PSO Algorithm Optimization

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Computer Modeling in Engineering & Sciences 2020年第10期125卷 401-415页

作者： Shifu Xu yanan jiang Faculty of Mechanical Engineering and Automation College of Science and Technology of Ningbo UniversityCixi315300China

Aiming at the problem that the trajectory tracking performance of redundant manipulator corresponding to the target position is difficult to optimize,the trajectory tracking method of redundant manipulator based on PSO algorithm optimization is *** kinematic diagram of redundant manipulator is created,to derive the equation of motion trajectory of redundant manipulator *** inverse Jacobi matrix is used to solve the problem of manipulator *** on the tracking ellipse of redundant manipulator,the tracking shape of redundant manipulator is determined with the overall tracking index as the second index,and the optimization method of tracking index is *** redundant manipulator contour is located by active contour model,on this basis,combined with particle swarm optimization algorithm,the point coordinates on the circumference with the relevant joint point as the center and joint length as the radius are selected as the algorithm particles for iteration,and the optimal tracking results of the overall redundant manipulator trajectory are *** experimental results show that under the proposed method,the tracking error of the redundant manipulator is low,and the error jump range is *** shows that this method has high tracking accuracy and reliability.

关键词： PSO algorithm optimization redundant manipulator trajectory tracking overall tracking index

融合双极化Sentinel-1数据监测大型桥梁形变

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测绘科学 2024年第5期49卷 64-74页

作者：陆展雄蒋亚楠廖露罗沅成都理工大学地球科学学院成都610059 成都理工大学地质灾害防治与地质环境保护国家重点实验室成都610059 四川测绘地理信息局测绘技术服务中心成都610081

针对合成孔径雷达在面对结构较为复杂的桥梁时,会出现部分区域点状目标密度低、精度低的问题,提出了一种融合双极化Sentinel-1数据监测大型桥梁的方法:(1)采用PS-InSAR和SBAS-InSAR技术获取桥梁VV和VH极化的时序形变结果;(2)根据不同极... 详细信息

针对合成孔径雷达在面对结构较为复杂的桥梁时,会出现部分区域点状目标密度低、精度低的问题,提出了一种融合双极化Sentinel-1数据监测大型桥梁的方法:(1)采用PS-InSAR和SBAS-InSAR技术获取桥梁VV和VH极化的时序形变结果;(2)根据不同极化数据对相同区域响应能力的差异,利用双策略对双极化结果进行优化与融合,以提升桥面点目标密度和精度;(3)对比分析双极化与单一极化结果的差异性。结果显示,桥面上的低相干性区域,VV和VH极化数据能够互补,融合结果较单一极化结果的点目标数提升了15%~20%。结果表明:本文提出的双极化融合方法,提高了对雷达影像信息的利用与挖掘,对悬索桥与斜拉桥的形变监测结果有较大提升。

关键词： InSAR 桥梁形变分析双极化Sentinel-1数据干涉图极化优化信息分析