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CircPMS1 promotes proliferation of pulmonary artery smooth muscle cells,pulmonary microvascular endothelial cells,and pericytes under hypoxia

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Animal Models and Experimental Medicine 2024年第3期7卷 310-323页

作者： Xiaoyi Hu shang Wang Hui Zhao Yaqin Wei Ruowang Duan Rong jiang Wenhui Wu Qinhua Zhao Sugang Gong Lan Wang Jinming Liu Ping Yuan Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Institute of Bismuth Science University of Shanghai for Science and TechnologyShanghaiChina Department of Geriatrics Shanghai Institute of GeriatricsHuadong HospitalFudan UniversityShanghaiChina Department of Anesthesiology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina

Background:Circular RNAs(circRNAs)have been recognized as significant regulators of pulmonary hypertension(PH);however,the differential expression and function of circRNAs in different vascular cells under hypoxia remain ***,we identified co-differentially expressed circRNAs and determined their putative roles in the proliferation of pulmonary artery smooth muscle cells(PASMCs),pulmonary microvascular endothelial cells(PMECs),and pericytes(PCs)under ***:Whole transcriptome sequencing was performed to analyze the differential expression of circRNAs in three different vascular cell *** analysis was used to predict their putative biological *** real-time polymerase chain reaction,Cell Counting Kit-8,and EdU Cell Proliferation assays were carried out to determine the role of circular postmeiotic segregation 1(circPMS1)as well as its potential sponge mechanism in PASMCs,PMECs,and ***:PASMCs,PMECs,and PCs exhibited 16,99,and 31 differentially expressed circRNAs under hypoxia,***1 was upregulated in PASMCs,PMECs,and PCs under hypoxia and enhanced the proliferation of vascular ***1may upregulate DEP domain containing 1(DEPDC1)and RNA polymerase II subunit D expression by targeting microRNA-432-5p(miR-432-5p)in PASMCs,upregulate MAX interactor 1(MXI1)expression by targeting miR-433-3p in PMECs,and upregulate zinc finger AN1-type containing 5(ZFAND5)expression by targeting miR-3613-5p in ***:Our results suggest that circPMS1 promotes cell proliferation through the miR-432-5p/DEPDC1 or miR-432-5p/POL2D axis in PASMCs,through the miR-433-3p/MXI1 axis in PMECs,and through the miR-3613-5p/ZFAND5 axis in PCs,which provides putative targets for the early diagnosis and treatment of PH.

关键词： circular postmeiotic segregation 1 circular RNAs hypoxia pulmonary hypertension vascular cells

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箔式镱应力传感器及试验研究

兵工学报 2006年第4期27卷 757-761页

作者：余尚江杨吉祥李科杰北京理工大学机电工程学院北京100081 总参工程兵科研三所河南洛阳471023

为测量弹药爆炸及武器侵彻等强冲击荷载下岩体及混凝土结构中应力,研制了箔式镱应力传感器。对传感器工作原理进行了分析,研究出了镱敏感元件的加工工艺,合理设计了传感器结构。对传感器进行了试验研究,试验表明传感器具有横向效应小、... 详细信息

为测量弹药爆炸及武器侵彻等强冲击荷载下岩体及混凝土结构中应力,研制了箔式镱应力传感器。对传感器工作原理进行了分析,研究出了镱敏感元件的加工工艺,合理设计了传感器结构。对传感器进行了试验研究,试验表明传感器具有横向效应小、量程范围宽、过载能力强、频响高、结构简单、使用方便等优点,可广泛应用于强冲击荷载下混凝土或岩石等介质中的应力测试。

关键词：爆炸力学镱敏感栅应力传感器性能试验

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浅议当前我国电机产业的发展战略及对策

特区经济 2009年第6期 212-213页

作者：江茜汤尚颖中国地质大学经济管理学院湖北武汉430074

本文运用SWOT分析方法,从我国现实出发,对我国电机产业的优势、劣势、机会、威胁进行分析,从而认清我国电机产业的现状,寻求我国电机产业发展的机遇,提出我国电机产业的发展战略对策,来应对日益激烈的国际竞争。

关键词：电机产业 SWOT分析战略对策

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基于多种连通域特征的结构表面裂缝提取方法

华中科技大学学报（自然科学版） 2019年第10期47卷 52-55,68页

作者：徐港赵恬悦蒋赏高德军三峡大学土木与建筑学院湖北宜昌443002 三峡大学防灾减灾湖北省重点实验室湖北宜昌443002

针对传统裂缝图像信息提取方法的局限性,提出了一种基于多种连通域特征的工程结构表面裂缝提取方法.在采用最大类间方差(Otsu)法对原始图像进行初始分割的基础上,对裂缝图像的连通域面积、最小外接矩形长宽比和连通域内最远距离等连通... 详细信息

针对传统裂缝图像信息提取方法的局限性,提出了一种基于多种连通域特征的工程结构表面裂缝提取方法.在采用最大类间方差(Otsu)法对原始图像进行初始分割的基础上,对裂缝图像的连通域面积、最小外接矩形长宽比和连通域内最远距离等连通域特征参数分别进行K-means聚类分析,得到了裂缝目标和噪声背景区域的连通域特征参数分布范围;进而建立了一种新的裂缝信息提取方法,并给出了具体算法流程.该方法与其他方法对比验证表明:该算法计算得到有效性评价系数平均值为0.039 3,比其他方法具有更强的抗噪性和适用性.

关键词：混凝土裂缝结构检测聚类分析图像处理

Comparing the efficacy and safety of low,medium,and high dosages of selexipag for treating pulmonary hypertension:A systematic review and meta-analysis

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Animal Models and Experimental Medicine 2024年第1期7卷 56-70页

作者： shang Wang Yi Yan Jian Zhang Ping Yuan Ci-Jun Luo Hong-Ling Qiu Hui-Ting Li Jian Xu Lan Wang Tian-Lan Li Rong jiang Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Heart Center and shanghai Institute of Pediatric Congenital Heart Disease Shanghai Children's Medical CenterNational Children's Medical CenterShanghai Jiaotong University School of MedicineShanghaiChina Department of Respiratory and Critical Care Medicine The 416 Hospital of Nuclear IndustryThe Second Affiliated Hospital of Chengdu Medical CollegeChengduChina Department of Hematology The Affiliated Hospital of Qingdao UniversityQingdaoChina

Background:The maintenance dosage of selexipag is categorized as low,medium or *** order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypertension(PAH),we performed a sys-tematic review and ***:Studies assessing PAH risk stratification indices,such as the World Health Organization functional class(WHO-FC),six-minute walk distance(6MWD),N-terminal pro-B-type natriuretic peptide(NT-proBNP)level,right atrial pressure(RAP),cardiac index(CI)and mixed venous oxygen saturation(SvO2),were ***:Thirteen studies were *** led to improvements in the 6MWD(MD:24.20 m,95%CI:10.74-37.67),NT-proBNP(SMD:-0.41,95%CI:-0.79-0.04),CI(MD:0.47 L/min/m^(2),95%CI:0.17-0.77)and WHO-FC(OR:0.564,95%CI:0.457-0.697).Subgroup analysis demonstrated that all three dosages improved the 6MWD.A moderate dosage led to improvements in the CI(MD:0.30 L/min/m^(2),95%CI:0.15-0.46)and WHO-FC(OR:0.589,95%CI:0.376-0.922).Within 6 months of treatment,only the WHO-FC and CI were significantly improved(OR:0.614,95%CI:0.380-0.993;MD:0.30 L/min/m^(2),95%CI:0.16-0.45,respectively).More than 6 months of treatment significantly improved the 6MWD,WHO-FC and NT-proBNP(MD:40.87 m,95%CI:10.97-70.77;OR:0.557,95%CI:0.440-0.705;SMD:-0.61,95%CI:-1.17-0.05,respectively).Conclusions:Low,medium,and high dosages of selexipag all exhibited good *** treatment lasted for more than 6 months,selexipag exerted obvious effects,even in the low-dosage *** finding is important for guiding individualized treatments.

关键词： individualized treatments meta-analysis prostacyclin receptor agonist risk stratification systematic review

考虑自动驾驶仪动态特性与攻击角约束的模糊自适应动态面末制导律

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系统工程与电子技术 2019年第2期41卷 389-401页

作者：姜尚田福庆孙世岩梁伟阁尤栋海军工程大学兵器工程学院湖北武汉430033 西北机电工程研究所陕西咸阳712099

在大口径舰炮制导炮弹打击近岸机动目标的末制导段,考虑自动驾驶仪二阶动态特性与攻击角约束,基于模糊自适应逼近与动态面控制提出一种末制导律。构建二维弹目相对运动模型,运用扩张状态观测器估计目标加速度。为零化视线角的跟踪误差... 详细信息

在大口径舰炮制导炮弹打击近岸机动目标的末制导段,考虑自动驾驶仪二阶动态特性与攻击角约束,基于模糊自适应逼近与动态面控制提出一种末制导律。构建二维弹目相对运动模型,运用扩张状态观测器估计目标加速度。为零化视线角的跟踪误差与视线角速率,采用自适应指数趋近律设计非奇异终端动态面滑模,设计模糊自适应系统逼近变结构项,削弱自动驾驶仪的控制指令抖振。通过Lyapunov第二法证明了闭环系统中视线角的跟踪误差与视线角速率均一致最终有界。仿真实验表明:该制导律使制导炮弹在打击具有不同加速度形式的目标时,均具备较好的末制导性能。

关键词：末制导律攻击角约束模糊自适应动态面扩张状态观测器

THE INVESTIGATION ON CALCULATING THE EFFECT OF NOISES FROM UNDERWATER VORTEX GENERATOR ON SAIL HULL

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THE INVESTIGATION ON CALCULATING THE EFFECT OF NOISES FROM U...

2016年全国压电和声波理论及器件应用研讨会

作者： Yong-wei LIU De-jiang shang Qi LI Sheng-feng FU Hong-yang CHEN Acoustic Science and Technology Laboratory Harbin Engineering University College of Underwater Acoustic Engineering Harbin Engineering University National Key Laboratory on Ship Vibration & Noise China Ship Development and Design Center

Background, Motivation and Objective In the airplane, vortex generator is used to suppress flow separation. There are several kinds of vortex generators, such as conventional, boundary layer, sub-boundary layer, mininature, and jet-flow. When ships run at high speed, cavitation is formed in the bulge area. Because cavitation can make big noises, it will be a threat to the sonar. Cavitation can also destroy the blades of propellers. In the paper, a method has been proposed that underwater cavitation is suppressed through the utilization of vortex generation. However, two noises have been produced by vortex generator. One is flow noise from vortex generator;the other is radiated noise from the vibration of vortex generator by the flow. Unfortunately, there are only a little research has been done on the noises from underwater vortex generator. Statement of Contribution/Methods In the paper, the numerical model of underwater sail hull is built up. The flow field of sail hull model is calculated by the software, FLUENT. After the data is dealt with fast fourier transform, FFT, the sound field of sail hull model has been calculated by the software, ACTRAN. Then, the trapezoidal vortex generator is placed on the model of sail hull. The sound field of sail hull model with trapezoidal vortex generator has been calculated through the listed process. After that, the effect of flow noise and radiated noise from vortex generator on sail hull model has been investigated. Results Through the comparison of flow field, we find that vortex generator has changed the transition area of sail hull model. The results indicate that flow noise and radiated noise from underwater vortex generator is very little, compared to that of sail hull model. The total level of sound radiation power from the model of sail hull and with vortex generator is less than that of sail hull model. Because vortex generator changes the direction of water flow, the excitation of sail hull model by the flow has be

关键词： Vortex generator Flow noise Radiated noise Transition area

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姜良铎“从态论治”思想临床解析

中国中医基础医学杂志 2016年第11期22卷 1552-1554,1568页

作者：王春勇康雷姜尚上北京大学第三医院北京100191

总结姜良铎教授从态论治经验,从案例解析其从态论治"疑难病症的具体操作思路,即运用当代的生物-心理-社会医学模式为研究背景,结合现代科学对疑难病的最新认识,辨证时着眼于病灶的微观状态,又关注患者的脏腑、三焦、气血宏观状态,总的... 详细信息

总结姜良铎教授从态论治经验,从案例解析其从态论治"疑难病症的具体操作思路,即运用当代的生物-心理-社会医学模式为研究背景,结合现代科学对疑难病的最新认识,辨证时着眼于病灶的微观状态,又关注患者的脏腑、三焦、气血宏观状态,总的立法以通调三焦为大法,治疗时整体把握,结合心理、行为等方法多因素干预,使复杂病症得以合理有效的治疗。

关键词：从态论治临床解析姜良铎

THE INVESTIGATION ON ACCELERATING THE AGING OF WINE BY ULTRASONIC WAVE

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THE INVESTIGATION ON ACCELERATING THE AGING OF WINE BY ULTRA...