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Onset and Recurrence Characteristics of Chinese Patients with Noncardiogenic Ischemic Stroke in Chinese Medicine Hospitals

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Chinese Journal of Integrative Medicine 2022年第6期28卷 492-500页

作者： GAO Yang XIE Yan-ming WANG Gui-qian CAI Ye-feng SHEN Xiao-ming ZHAO De-xi XIE Ying-zhen ZHANG Yin meng Fan-xing YU Hai-qing jiang Jun-jie WEI Rui-Li Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China Department of Rehabilitation Dongfang HospitalBeijing University of Chinese MedicineBeijing100078China Department of Emergency Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Neurology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China Department of Neurology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Neurology the Affiliated Hospital of Changchun University of Chinese MedicineChangchun130017China Department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Department of Neurology Taiyuan Hospital of Traditional Chinese MedicineTaiyuan140107China

Objective:To delineate the onset and recurrence characteristics of noncardiogenic ischemic stroke patients in ***:A prospective,multicenter and registry study was carried out in 2,558 patients at 7 representative clinical sub-centers during November 3,2016 to February 17,2019.A questionnaire was used to collect information of patients regarding CM syndromes and constitutions and associated risk ***,stroke recurrence was defined as a primary outcome ***:A total of 327(12.78%)patients endured recurrence events,1,681(65.72%)patients were men,and the average age was 63.33±9.45 *** 1,741(68.06%)patients suffered first-ever ischemic stroke,1,772(69.27%)patients reported to have hypertension,and1,640(64.11%)of them reported dyslipidemia,1,595(62.35%)patients exhibited small-artery occlusion by The Trial of Org 10172 in Acute Stroke Treatment(TOAST)***,1,271(49.69%)patients were considered as qi-deficient constitution,and 1,227(47.97%)patients were determined as stagnant blood *** were 1,303(50.94%)patients diagnosed as blood stasis syndrome,1,280(50.04%)patients exhibited phlegm and dampness syndrome and 1,012(39.56%)patients demonstrated qi deficiency *** 1,033(40.38%)patients declared intracranial artery stenosis,and 478(18.69%)patients reported carotid artery *** plaque in 1,508(41.36%)patients were of ***,41.09%of them demonstrated abnormal levels of glycated hemoglobin(HbA1 c)***:Recurrence in minor and small-artery stroke cannot be ***,dyslipidemia,abnormal HbA1 c,intracranial artery stenosis and carotid plaque were more common in stroke ***,phlegm-dampness and blood stasis syndromes,as well as qi deficiency and blood stasis constitutions,were still the main manifestations of stroke.(Trial registration at ***,***03174535)

关键词： noncardiogenic ischemic stroke Chinese medicine hospital onset characteristics recurrence

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Periodontal-orthodontic interdisciplinary management of a“periodontally hopeless”maxillary central incisor with severe mobility:A case report and review of literature

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World Journal of Clinical Cases 2022年第14期10卷 4550-4562页

作者： Ke jiang Li-Shan jiang Hou-Xuan Li Lang Lei Department of Orthodontics Nanjing Stomatological HospitalMedical School of Nanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Periodontics Nanjing Stomatological HospitalMedical School of Nanjing UniversityNanjing 210008Jiangsu ProvinceChina

BACKGROUND Treating periodontally hopeless teeth with advanced bone resorption and severe tooth mobility is a great challenge for both orthodontists and ***-induced periodontal inflammation and occlusal trauma-related inflammation may synergistically aggravate tooth *** case report illustrates that even periodontally hopeless teeth can be saved and have long-term stability with comprehensive periodontal treatment to control periodontal inflammation and promote periodontal bone regeneration and intricate orthodontic mechanical control to correct cross bite and occlusal *** SUMMARY A 27-year-old female patient whose chief complaint was severe tooth mobility and discomfort of the maxillary incisor was diagnosed with severe aggressive periodontitis by clinical and radiographic *** reduce tooth mobility and establish stable occlusion,we combined orthodontic treatment with periodontal therapy to preserve the *** treatment was performed after basic periodontal therapy and periodontal *** loosened upper right central incisor was successfully retained,and the periodontal tissue remained stable during *** Teeth with severe mobility and bone loss can be saved through interdisciplinary treatment when periodontal inflammation is strictly controlled.

关键词： Occlusal trauma Periodontally hopeless teeth Periodontitis Orthodontics Guided tissue regeneration Interdisciplinary management Case report

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Ethical, Legal, and Social Implications of Genomics in China: A Scoping Review and Implications for Precision Public Health

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China CDC weekly 2022年第32期4卷 706-710,I0002-I0004页

作者： Zhuo Chen Wei jiang Jianhong Xu Lan jiang Guoyu Wang Department of Health Policy and Management College of Public HealthUniversity of GeorgiaAthensGAUSA School of Economics Faculty of Humanities and Social SciencesUniversity of Nottingham Ningbo ChinaNingbo CityZhejiang ProvinceChina School of Philosophy Fudan UniversityShanghai MunicipalityChina Center for Biomedical Ethics Fudan UniversityShanghai MunicipalityChina

We conducted a scoping review of Chinese language studies on the ethical,legal,and social implications of genomics and identified four broad themes:ethical considerations,regulatory framework,perceptions of genomics and precision medicine,and future directions of ***,legal,and social implications of genomics are growing in importance and are highly relevant to public health in China.

关键词： legal directions Ethical

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Fast local wavenumber （FLW） method for the inversion of magnetic source parameters

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Applied Geophysics 2018年第2期15卷 353-360,365页

作者： Ma Guo-Qing Ming Yan-Bo Han jiang-Tao Li Li-Li meng Qing-Fa College of Geoexploration Science and Technology Jilin University Changchun China

The current local wavenumber methods for the interpretation of magnetic anomalies compute the locations of geological bodies by solving complex matrices. Presently, such methods require to know the structural index, which is a parameter that represents the source type. The structural index is hard to know in real data; consequently, the precision of current methods is low. We present the fast local wavenumber （FLW） method, and define the squared sum of the horizontal and vertical local wavenumbers as the cumulative local wavenumber. The FLW method is the linear combination of the umulative local wavenumberand other wavenumbers, and is used to compute the locations and structural index of the source without a priori information and matrix solution. We apply the FLW method to synthetic magnetic anomalies, and the results suggest that the FLW method is insensitive to background and oblique magnetization. Next, we apply the FLW method to real magnetic data to obtain the location and structural index of the source.

关键词： Local wavenumber magnetic anomaly structural index

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Advances in treatment of neurodegenerative diseases: Perspectives for combination of stem cells with neurotrophic factors

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World Journal of Stem Cells 2020年第5期12卷 323-338页

作者： Jie Wang Wei-Wei Hu Zhi jiang Mei-jiang Feng Department of Geriatrics the Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Department of Neurology the Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjing 211100Jiangsu ProvinceChina Department of Geriatrics Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Key Laboratory for Aging&Disease Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina

Neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease and amyotrophic lateral sclerosis,are a group of incurable neurological disorders,characterized by the chronic progressive loss of different neuronal ***,despite its increasing prevalence among the everincreasing aging population,little progress has been made in the coincident immense efforts towards development of therapeutic *** interest has recently turned towards stem cells including stem cells-derived exosomes,neurotrophic factors,and their combination as potential therapeutic agents in neurodegenerative *** this review,we summarize the progress in therapeutic strategies based on stem cells combined with neurotrophic factors and mesenchymal stem cells-derived exosomes for neurodegenerative diseases,with an emphasis on the combination therapy.

关键词： Neurodegenerative diseases Stem cells Brain-derived neurotrophic factor Glial cell line-derived neurotrophic factor Nerve growth factor Combination therapy

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Alleviation of Cadmium Toxicity to Medicago Truncatula by AMF Involves the Changes of Cd Speciation in Rhizosphere Soil and Subcellular Distribution

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 403-415页

作者： Yuying jiang Renhua Huang Lei jiang Ke Chen Wenkun Zhu School of Life Science and Engineering Southwest University of Science and TechnologyMianyang621010China State Key Laboratory of Environmentally Friendly Energy Materials National Collaborative Innovation Center for Nuclear Waste and Environmental SafetySchool of National DefenceSichuan Civil-Military Integration InstituteSouthwest University of Science and TechnologyMianyang621010China

Arbuscular mycorrhizal fungi(AMF)can improve plant tolerance to several abiotic stresses,including heavy metals,drought or salinity ***,the role of AMF in alleviation of soil cadmium(Cd)-induced toxicity to plants is still largely *** this study,Cd speciation in soil and subcellular distribution of Cd were used to characterize the roles of application AM fungi in the alleviation of Cd toxicity in alfalfa *** results showed that the addition of Glomus mosseae in Cd contaminated soil(10 mg/Kg)significantly increased soil pH,cation exchange capacity(CEC)and organic matter in rhizosphere soil with Medicago truncatula L.,and then account for significantly decreased contents of exchangeable and carbonate-bounded Cd speciation in rhizosphere soil,indicating alleviation of plant toxicity by reduction of bioavailable fractions of *** there is no significant difference found in Cd accumulation by roots and shoots respectively between Cd and AM-Cd treatments,more portion of Cd was recorded compartmentalization in cell wall fraction of both root and shoot in treatment of Cd with AM application,indicating alleviation of Cd toxicity to plant ***,application of AM fungi in Cd treatments performed to inhibit the appearance of Cd toxicity symptoms,including the improvement of leaf electrolyte leakage,root elongation,seedling growth and *** information provides a clearer understanding of detoxification strategy of AM fungi on Cd behavior with development and stabilization of soil structure and subcellular distribution of plant.

关键词： AM fungi cadmium toxicity Cd form subcellular compartmentalization phytoremediation

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面向产品族设计的模块规划

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上海交通大学学报 2006年第11期40卷 1869-1872,1876页

作者：孟祥慧蒋祖华上海交通大学机械与动力工程学院上海200240

基于零部件分析法,提出了面向产品族设计的模块规划准则:①将个性化部件分离出来,使产品差异点后移;②将未来易于变化的零部件与其他零部件相分离,从而改善模块整体的通用性和稳定性;③力争模块的功能独立性,并使模块之间的物理关联和... 详细信息

基于零部件分析法,提出了面向产品族设计的模块规划准则:①将个性化部件分离出来,使产品差异点后移;②将未来易于变化的零部件与其他零部件相分离,从而改善模块整体的通用性和稳定性;③力争模块的功能独立性,并使模块之间的物理关联和几何关联最小.给出了各规划准则的量化计算方法和模块规划的目标函数,并以基于整数编码的遗传算法对模块规划问题进行求解.实例研究表明,所提出的模块规划方法能够高效地给出合理的结果.

关键词：模块规划产品族大批量定制遗传算法

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Sedimentation rates and provenance analysis in the Southwestern Okinawa Trough since the mid-Holocene

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Chinese Science Bulletin 2009年第7期54卷 1234-1242页

作者： LI ChuanShun jiang Bo LI AnChun LI TieGang jiang FuQing Key Laboratory of Marine Geology and Environment Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Graduate University Chinese Academy of Sciences Beijing 100049 China China Ocean Press Beijing 100081 China

As a high-sedimentation rate depocenter along the path of the Kuroshio Current, the southwesternmost part of the Okinawa Trough is a key area to understand the Kuroshio history and sediments transpor-tation. A 34.17-m-long sediment core was obtained by the advanced piston corer of Marco Polo/IMAGES XII MARION DUFRESNE during the May 2005 from the Southern Okinawa Trough at site MD05-2908. The recovered sediments were analyzed by AMS 14C dating, coarse size fraction (>63 μm) extraction and moisture content determination in order to study its sedimentation flux and provenance. The depth-age relationship of core MD05-2908 was well constrained by 17 14C dating points. The sediments span across the mid-Holocene (6.8 ka B.P.) and have remarkablely high sedimentation rates between 1.8 and 21.2 m ka?1, which is well consistent with the modern observations from sediment traps. We identified five 70―200 a periods of abnormally rapid sedimentation events at 6790―6600 a B.P., 5690―5600 a B.P., 4820―4720 a B.P., 1090―880 a B.P., and 260―190 a B.P., during which the highest sedimentation rate is up to 21.2 m/ka. In general, the lithology of the sediments were dominated by silt and clay, associated with less than 5% coarse size fraction (>63 μm). As the most significant sediment source, the Lanyang River in northeastern Taiwan annually deliver about 10Mt materials to the coastal and offshore region of northeast Taiwan, a portion of which could be carried northward by currents toward the study area. Therefore, we concluded that the 5 abnormally rapid sedimentation events may be related to intensified rainfall in Taiwan and thus increased materials to our study area at that time. However, a few extreme-rapid sedimentation events cannot be explained by normal river runoff alone. The large earth-quakes or typhoons induced hyperpycnal discharge of fluvial sediment to the ocean may also act as a potential source supply to the Okinawa Trough.

关键词：南冲绳海槽沉积速率河流沉积物异常事件中期西南泥沙来源马可波罗

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Amplitude and phase controlled absorption and dispersion of coherently driven five-level atom in double-band photonic crystal

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Chinese Physics B 2019年第2期28卷 241-246页

作者： Li jiang Ren-Gang Wan Department of Physics Changchun University of Science and Technology School of Physics and Information Technology Shaanxi Normal University

The absorption–dispersion properties of a microwave-driven five-level atom embedded in an isotropic photonic bandgap(PBG) have been studied. Due to the singular density of modes(DOM) in the isotropic PBG and the dynamically coherence induced by the coupling fields, modified reservoir-induced transparency and quantum interference-induced transparency emerge simultaneously. Their interaction leads to ultra-narrow spectral structure. As a result of closed-loop configuration, these features can be manipulated by the amplitudes and relative phase of the coherently driven fields. The position and width of PBG also have an influence on the spectra. The theoretical studies can provide us with more efficient methods to control the atomic absorption–dispersion properties, which have applications in optical switching and slow light.

关键词： isotropic photonic bandgap absorption–dispersion spectra phase and amplitude control ultranarrow spectral structure

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Identification of eight novel mutations in 11 Chinese patients with maple syrup urine disease

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World Journal of Pediatrics 2020年第4期16卷 401-410页

作者： Wei-Hua Sun Bing-Bing Wu Ya-Qiong Wang meng-Yuan Wu Xin-Ran Dong Yue-Ping Zhang Wei Lu Ping Zhang Bin Yang Min Zhang Hong-jiang Wu Wen-Hao Zhou Institute of Pediatrics Shanghai Key Laboratory of Birth DefectsChildren’s Hospital of Fudan UniversityWanyuan Road 399Shanghai201102China Key Laboratory of Neonatal Diseases Ministry of HealthChildren’s Hospital of Fudan UniversityShanghai201102China Department of Endocrinology Children’s Hospital of Fudan UniversityShanghai201102China Shanghai Ji-ai Genetics and IVF Institute Obstetrics and Gynecology HospitalFudan UniversityShanghai200011China Shanghai Key Laboratory of Birth Defects The Translational Medicine Center of Children Development and Disease of Fudan UniversityChildren’s Hospital of Fudan UniversityShanghai201102China Department of Radiology Children’s Hospital of ShanghaiShanghai201102China Department of Neurology Children’s Hospital of Fudan UniversityShanghai201102China

Background Maple syrup urine disease(MSUD)is an autosomal recessive inherited disorder that affects the degradation of branched-chain amino acids and is associated with acute and chronic brain *** study presents 11 new patients with MSUD and describes the clinical characteristics and gene mutations reported in Chinese *** During 2011–2018,11 pedaitric patients with MSUD from 11 Chinese families were analyzed based on clinical characteristics and mass spectrometry,with confirmation via gene *** mutations affecting protein function were predicted with Mutation-Taster,PolyPhen-2,CADD and SIFT software.3D models of the mutated proteins were generated by using the SWISS-MODEL online server,and the models were visualized in *** characteristics and gene mutations in patients with MSUD were analyzed *** Seventeen mutations in the BCKDHA,BCKDHB and DBT genes were found,8 of which are novel:c.55C>/T,c.349C>T,c.565C>T,c.808G>A,c.859C>G,and c.1270dupC in BCKDHA;c.275-2A>G in BCKDHB;and c.1291C>T in *** patients *** patients had severe mental retardation and were physically *** patient with the intermediate type had relatively good prognosis,with mild psychomotor retardation and *** mothers underwent amniocentesis for prenatal diagnosis during their second pregnancy;two fetuses were wild type,and two were carriers of one heterozygous *** Eight novel mutations were associated with MSUD in Chinese *** diagnosis was successfully performed by genetic *** in the BCKDHB gene were found in the majority of Chinese patients with MSUD.

关键词： Branched-chain amino acids Maple syrup urine disease Mutation Prenatal diagnosis

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