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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua li Xiao-jiang li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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Feasible synthesis of porous h-BN by Mg^(2+)induced lattice dislocations for hydrogen and ammonia storage

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Nano Research 2025年第1期18卷 94-99页

作者： Xiaojia Huang Zihao Wang Yihan Kong li jiang Baolin Wang jiangtao Jia Heping Ma Guangshan Zhu Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Northeast Normal UniversityChangchun 130024China School of Chemical Engineering and Technology Xi’an Jiaotong University Xi’an 710049China

Hexagonal boron nitride(h-BN)is a two-dimensional(2D)layered material with a structure similar to graphite and it has potential as a hydrogen and ammonia storage ***,dense packing in the standard h-BN structure limits its surface area and prevents the B and N from being adsorption *** this study,the addition of Mg^(2+)during h-BN synthesis facilitated the growth of lattice dislocations and led to a crosslinked three-dimensional(3D)porous structure.A proposed formation mechanism for porous h-BN was confirmed by several characterization routes,most clearly by high-resolution transmission electron microscopy(HRTEM).Porous Mg/BNs exhibited high H_(2)and NH_(3)uptakes and showed potential for H_(2)and NH_(3)storage.

关键词： hexagonal boron nitride porous material dislocation gas storage

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基于近代史料的黄梅戏源流问题重考

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黄冈师范学院学报 2025年第1期45卷 26-34,75页

作者：江离深圳信息职业技术学院广东深圳518172

现有近代史料仍支持黄梅戏的起源是湖北黄梅。基于“黄梅戏”“采茶调”“采茶戏”“黄梅腔”“黄梅调”等关键词,考查近代史料发现:“黄梅戏”一词最早见于1921年《宿松县志》;“采茶调”一词最早见于明代王云凤的诗,描绘的是陕西西安... 详细信息

现有近代史料仍支持黄梅戏的起源是湖北黄梅。基于“黄梅戏”“采茶调”“采茶戏”“黄梅腔”“黄梅调”等关键词,考查近代史料发现:“黄梅戏”一词最早见于1921年《宿松县志》;“采茶调”一词最早见于明代王云凤的诗,描绘的是陕西西安的民风,近代则最早见于1918年天津《益世报》;“采茶戏”最早出现在1818年嘉庆版《石门县志》;“黄梅腔”最早在1935年天津《北洋画报》中出现;“黄梅调”的新闻最早见于1879年《申报》。从相关史料可推断出,黄梅戏大约在1875-1879年传入安徽,名为“采茶小戏”或“黄梅戏”。“黄梅调”最早于1879年开始在安庆城外表演,1918年安庆城外始有戏园表演,1922年安庆城内始有戏班上演;“採茶戏”最早于1887年在江西九江城外上演。史料中关于黄梅戏的称呼多为“淫戏”,屡遭禁演但屡禁不绝。相比安徽其他城市,安庆城是最早接纳黄梅戏之地。黄梅戏从安庆开始快速发展,逐渐摆脱过去乡村酬神模式,成为新的戏曲形式。

关键词：黄梅戏源流近代史料

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Unraveling the mechanism of action of Shangxia liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao liang Yong-Hong Tang li jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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1-萘酚的太赫兹光谱实验及理论研究

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原子与分子物理学报 2025年第4期42卷 33-39页

作者：王利民朱立江孙延华国家能源集团煤焦化有限责任公司乌海016000

1-萘酚是煤化工产物萘的合成产物,对环境和人体健康有危害.采用太赫兹时域光谱(THz-TDS)技术,获得了1-萘酚在0.5~4.0 THz范围内的实测太赫兹吸收谱,同时运用密度泛函理论(DFT)平面波赝势模型对1-萘酚晶胞模型进行理论光谱计算,探讨了平... 详细信息

1-萘酚是煤化工产物萘的合成产物,对环境和人体健康有危害.采用太赫兹时域光谱(THz-TDS)技术,获得了1-萘酚在0.5~4.0 THz范围内的实测太赫兹吸收谱,同时运用密度泛函理论(DFT)平面波赝势模型对1-萘酚晶胞模型进行理论光谱计算,探讨了平面波截断能在800~1600 eV范围内对理论光谱的影响,并对吸收峰的振动模式进行了理论归属.实验结果表明,1-萘酚在0.5~4.0 THz范围内有1.14 THz、1.60 THz、2.16 THz、2.81 THz、3.56 THz共5个吸收峰,平面波截断能1400 eV下得到的理论吸收谱与实测吸收谱在吸收峰个数、峰位、归一化峰强度上均有较好的一致性,5个吸收峰的振动模式均是以两元环为平面的受氢键束缚的面外摇摆振动或者面内扭转振动引起的.这为太赫兹技术对1-萘酚的识别提供了实验和理论基础,具有一定的理论意义和实际应用价值.

关键词：太赫兹密度泛函理论(DFT) 理论光谱 1-萘酚

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THE IMPACTS OF PRICING SCHEMES ON DECENTRAliZED ASSEMBLY SYSTEMS

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Journal of Systems Science and Systems Engineering 2008年第1期17卷 36-49页

作者： li jiang Department of Logistics The Hong Kong Polytechnic University Hong Kong China

We study an assembly system where one assembler produces a final product to satisfy the price sensitive and uncertain demands. One unit of final product needs inputs from n complementary components each provided from a distinct supplier. The assembler orders from the suppliers and their relationships are governed by price-only contracts. The assembler practices two alternative pricing schemes： a fixed pricing scheme by which she fixes a retail price in all market situations, and a responsive pricing scheme by which she adjusts retail prices after observing actual demand curves. We find that, when the assembler practices the two pricing schemes, the suppliers charge the same wholesale prices, channel profit is allocated among the firms according to the same proportions, and the relative performances of the system under decentralized decision makings with respect to those under centralized decision makings are the same. Furthermore, responsive pricing improves the assembler＇s absolute performance, and the gains pass over to the suppliers in terms of higher profits and to the customers in terms of enhanced product availability and lowered market price.

关键词： Pricing assembly system decentralization

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Consumer Entry: Impact on Expert's Pricing and Overcharging Behavior

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Journal of Systems Science and Systems Engineering 2021年第2期30卷 236-250页

作者： Qijun Qiu li jiang School of Management Science and Engineering Nanjing University of Information Science&TechnologyNcinjing 210044China Faculty of Business The Hong Kong Polytechnic UniversityHong Kong SARChina

In a credence goods market,a consumer(he)is unaware of his true need,w hich can be either intense or minor.A n expert(she)designs a menu that either charges a u n iform price to both services,termed pooling pricing,or varies charges according to service types,termed differential *** the menu offered by the expert and anticipating her behavior in serving consumers,a consumer weighs the expected u tility of service provision against the cost incurred in transportation to decide w hether to visit the expert,termed entry *** arrival of a consumer,the expert discerns his true need and recommends a service along w ith the associated *** the lia b ility assumption,the expert provides a service to satisfy the consumer's ***,the consumer is unable to discern the nature of the service actually *** can induce the expert w ho adopts differential pricing to recommend intense service to a consumer w ith m inor need,termed *** investigate the effects of consumers'entry decision on the expert's optim al pricing strategy and the occurrence of overcharging,and study the robustness of the main results to practical features.

关键词： Credence goods consumer entry overcharging pricing competition

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Hybrid Static-dynamic Sensation Electrotactile Feedback for Hand Prosthesis Tactile and Proprioception Feedback

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Journal of Bionic Engineering 2023年第1期20卷 267-277页

作者： Bin Yang li jiang State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin150001China

Tactile and proprioception feedback are essential to myoelectric hand prostheses control for regaining functionality of lost hands of *** studies focus on tactile feedback,while the lack of appropriate multisensory feedback,especially proprioception feedback,limits the grasping ***,a typical non-invasive stimulation scheme for sensation feedback uses stimulation on the stationary site of the skin continuously,which can lead to fatigue and adaptation of sensation,further reduces the feedback consistency,and increases the cognitive burden for the *** the sensitivity and modality matching of sensation,this study presented a multimodal sensations feedback scheme based on hybrid static-dynamic sensation elicited by multisite Transcutaneous Electrical Nerve Stimulation(TENS)to deliver grasping force and joint position *** the proposed scheme,stimulation of single electrode produced only in-loco tactile sensation under the electrode,and the sensation intensity was adjusted according to grasping force;sequential activation of multi-electrodes produced an illusion dynamic sensation of a stimulus moving,and the velocity and direction of movement were adjusted according to finger joint *** test results demonstrated the identifiability of stimulus in the proposed ***,prosthetic hand closed-loop grasping tasks evaluate the effectiveness of the proposed feedback *** results showed that the proposed feedback scheme could substantially improve the grasping accuracy and *** addition,the study outcomes also demonstrated the benefit of artificial proprioception feedback in grasping rapidity and security.

关键词： TENS-Prosthetic hand control-Bioinspired sensation-Multimodal sensations Proprioception feedback Tactilefeedback Myoelectric control

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A New Biphenyl Glycoside from the Leaves of Eriobotrya japonica

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Chinese Chemical Letters 2006年第1期17卷 35-37页

作者： li li jiang li jiang XUAN Shanghai Institute of Matefia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203

A new biphenyl glycoside along with six known compounds were isolated from the water soluble fraction of the fresh leaves of Eriobotrya japonica. Its structure was elucidated as 5,5＇-dihydroxy-3＇-methoxybiphenyl-2-O... 详细信息

关键词： Eriobotryajaponica biphenyl glycoside antifungal activity.

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Grain growth of Al-4Cu-Mg alloy during isothermal heat treatment

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Journal of University of Science and Technology Beijing 2006年第1期13卷 67-72页

作者： Haitao jiang Miaoquan li Materials Science and Engineering School Northwestern Polytechnical University Xi＇an 710072 China

The microstructure of an Al-4Cu-Mg alloy during isothermal heat treatment in the Strain Induced Melt Activation （SIMA） process was investigated and the kinetics of grain growth was analyzed, The grain growth during isothermal heat treatment of the Al-4Cu-Mg alloy coincided with the Ostwald ripening theory. During isothermal heat treatment, both grain shape and the high volume fraction of solid phase have significant effects on grain growth. Therefore, a new grain growth model based on the Ostwald ripening theory was proposed taking into consideration the grain shape and the volume fraction of solid phase. By comparing the calculated results with the experimental results, it was confirmed that the present model could be applied to grain growth during isothermal heat treatment of the Al-4Cu-Mg alloy in the SIMA process.

关键词： grain growth semi-solid isothermal heat treatment Al-4Cu-Mg alloy

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