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World Journal of Gastroenterology 2000年第1期6卷 147-149页

作者： Yang YH Fu XB Sun TZ jiang lx Gu XM The 304th Hospital of PLA Beijing 100037China

INTRODUCTION Intestinal isehemia/rePerfusion(I/R)oeeureommonly in eritieally 111 *** 15 wellreeognized that gutl/R may eause tissue damageand dysfunetion of intestine,and induee

关键词： Subject headings ischemia-reperfusion injury intestinal basic fibroblast growth factor transforming growth factor β gene expression

Endoscopic full-thickness resection of gastric stromal tumor arising from the muscularis propria

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Chinese Medical Journal 2013年第13期126卷 2435-2439页

作者： Zhang B Huang LY Wu CR Cui J jiang lx Zheng HT Department of GastroenterologyYantai Yuhuangding Hospital affiliated to Medical College of Qingdao University Yantai Shandong 264000 China Department of Abdominal SurgeryYantai Yuhuangding Hospital affiliated to Medical College of Qingdao University Yantai Shandong 264000 China

Background Gastric stromal tumors are the most common type of tumor originating from mesenchymal tissue. The traditional method for the treatment of gastric stromal tumor is surgical operation or therapeutic laparoscopy. More recently, endoscopic micro-traumatic surgery has become possible for gastric stromal tumors, with any perforation caused by endoscopic therapy mended endoscopically. We assessed the effectiveness of endoscopic full-thickness resection （EFR） in the treatment of gastric stromal tumors arising from the muscularis propria. Methods Of the 42 gastric stromal tumors, each 〉2.0 cm in diameter, arising from the muscularis propria, 22 were removed by EFR and 20 by laparoscopic surgery. Tumor expression of CD34, CDl17, Dog-l, S-100, and smooth muscle actin （SMA） was assessed immunohistochemically. Operating time, complete resection rate, length of hospital stay, incidence of complications, and recurrence rates were compared between the two groups. Continuous data were compared by using independent samples t-tests and categorical data by using Xz tests. Results Comparisons of the 22 gastric stromal tumors treated with EFR and the 20 treated with laparoscopic surgery showed similar operation times （60-155 minutes （mean, （90±17） minutes） vs. 50-210 minutes （mean, （95±21） minutes）, P 〉0.05）, complete resection rates （100% vs. 95%, P 〉0.05）, and length of hospital stay （4-10 days （mean, （6.0±1.8） days） vs. 4-12 days （mean, （7.3±1.7） days）, P 〉0.05）. None of the patients treated with EFR experienced complications, whereas one patient treated with laparoscopy required a conversion to laparotomy and one experienced postoperative gastroparesis. No recurrences were observed in either group. stromal tumors diagnosed by gastroscopy and endoscopic remaining 36 were stromal tumors. mmunohistochemical staining showed that of the 42 gastric ultrasound, six were leiomyomas （SMA-positive） and the Conclusions Gastric stromal tumors arising from the muscularis propria can be

关键词： gastrointestinal stromal tumor " treatment " endoscopy " muscularis propria " resection

Association of N-terminal pro-brain natriuretic peptide with the severity of coronary artery disease in patients with normal left ventricular ejection fraction

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Chinese Medical Journal 2014年第4期127卷 627-632页

作者： Wu NQ Guo YL Li XL Liu J Qing P Xu RX Zhu CG Jia Y J Liu G Dong Q jiang lx Li J J Ma FL Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Cardiology First Hospital of Hohhot Hohhot Inner Mongolia 010030 China

Backround N-terminal pro-brain natriuretic peptide （NT-proBNP） is a reliable predictor in acute coronary artery disease （CAD）. Little is known about patients with stable CAD, especially Chinese patients with CAD. The aim of the present study was to investigate the association of NT-proBNP levels with the severity of CAD in patients with normal left ventricular ejection fraction. Methods A total of 658 consecutive patients were divided into two groups based on angiograms： CAD group （n=484） and angiographic normal control group （n=174）. The severity of CAD was evaluated by modified Gensini score, and its relationship with NT-proBNP was analyzed. Results The prevalence of risk factors such as age, male gender, diabetes mellitus （DM）, dyslipidemia, smoking, and family history of CAD in the CAD group were higher than that in the control group. In multivariate regression model analysis, age, gender, and DM were determinants of the presence of CAD. NT-pro BNP was found to be an independent predictor for CAD （OR：1.66 （95% CI： 1.06-2.61）, P 〈0.05）. In a receiver operating characteristic （ROC）curve analysis, an NT-proBNP value of 641.15 pmol/L was identified as a cut-off value in the diagnosis or exclusion of CAD （area under curve （AUC）=0.56, 95% CI： 0.51-0.61）. Furthermore, NT-proBNP was positively correlated with Gensini score （r=0.14, P 〈0.001） in patients with CAD. Conclusion NT-proBNP was an independent predictor for Chinese patients with CAD, suggesting that the NT-proBNP level might be associated with the presence and the severity of CAD.

关键词： N-terminal pro-brain natriuretic peptide coronary artery disease risk factors modified Gensini score

A PAT STUDY OF INFLUENCES OF PRECIPITATION ON DEFECTS AND ELECTRONIC DENSITY IN Al-Li-Cu-Mg-Zr ALLOYS

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中国有色金属学会会刊：英文版 1997年第1期7卷 43-46页

作者： Wu, WM Gao, YJ Luo, lx Deng, W Xu, SJ Zhong, XP jiang, XJ GUANGXI UNIV DEPT PHYSNANNING 530004PEOPLES R CHINA ACAD SINICA INST MET RESSHENYANG 110015PEOPLES R CHINA

ＡＰＡＴＳＴＵＤＹＯＦＩＮＦＬＵＥＮＣＥＳＯＦＰＲＥＣＩＰＩＴＡＴＩＯＮＯＮＤＥＦＥＣＴＳＡＮＤＥＬＥＣＴＲＯＮＩＣＤＥＮＳＩＴＹＩＮＡｌＬｉＣｕＭｇＺｒＡＬＬＯＹＳ①ＷｕＷｅｉｍｉｎｇ，ＧａｏＹｉｎｇｊｕｎ... 详细信息

ＡＰＡＴＳＴＵＤＹＯＦＩＮＦＬＵＥＮＣＥＳＯＦＰＲＥＣＩＰＩＴＡＴＩＯＮＯＮＤＥＦＥＣＴＳＡＮＤＥＬＥＣＴＲＯＮＩＣＤＥＮＳＩＴＹＩＮＡｌＬｉＣｕＭｇＺｒＡＬＬＯＹＳ①ＷｕＷｅｉｍｉｎｇ，ＧａｏＹｉｎｇｊｕｎ，ＬｕｏＬｉｘｉｏｎｇ，ＤｅｎｇＷ...

关键词： positron lifetime spectra Al Li Cu Mg Zr alloy ageing precipitation defects bulk electronic density

Protective mechanism of Paeoniae Radix Alba against chemical liver injury based on network pharmacology,molecular docking,and in vitro experiments

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 55-66页

作者： Shuangqiao Liu Xin Liu Sijia jiang Min Fu Jinxi Hu Jiaqi Liu Xiaoxu Fan Yingtong Feng Shujing Zhang Jingxia Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China School of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqi 830017China The Centre for Translational Biology Research Institute of McGill University Health CentreMontr eal H4A 3J1Canada

Objective:To explore and validate the potential targets of Paeoniae Radix Alba(***,Bai Shao)in protecting against chemical liver injury through network pharmacology,molecular docking technology,and in vitro cell ***:Network pharmacology was used to identify the common potential targets of *** and chemical liver *** docking was used to fit the components,which were subsequently verified in vitro.A cell model of hepatic fibrosis was established by activating hepatic stellate cell(HSC)-lx2 cells with 10 ng/mL transforming growth factor-β*** cells were exposed to different concentrations of total glucosides of paeony(TGP),the active substance of ***,and then evaluated using the cell counting kit-8 assay,enzyme-linked immunosorbent assay,and western ***:Analysis through network pharmacology revealed 13 key compounds of ***,and the potential targets for preventing chemical liver injury were IL-6,AKT serine/threonine kinase 1,jun protooncogene,heat shock protein 90 alpha family class A member 1(HSP90AA1),peroxisome proliferator activated receptor gamma(PPARG),PTGS2,and *** Ontology(GO)enrichment analysis indicated the involvement of response to drugs,membrane rafts,and peptide *** Encyclopedia of Genes and Genomes(KEGG)enrichment analysis revealed that the main pathways involved lipid and atherosclerosis and chemical carcinogenesis-receptor *** and albiflorin exhibited strong affinity for HSP90AA1,PTGS2,PPARG,and *** concentrations of TGP can inhibit the expression of COL-I,COL-III,IL-6,TNF-a,IL-1β,HSP-90a,and PTGS2 while increasing the expression of PPAR-γand CASP3 in activated HSC-lx2 ***:*** primarily can regulate targets such as HSP90AA1,PTGS2,PPARG,***,the main active compound of ***,protects against chemical liver injury by reducing the inflammatory response,activating apoptotic proteins,and promoting the apoptosis of activated HSCs.

关键词： Paeoniae Radix Alba Total glycosides of paeony Chemical liver injury Liver fibrosis Network pharmacology Hepatic stellate cells

Isolation and Structure Elucidation of Autolytimycin, A New Compound Produced by Streptomyces Autolyticus JX-47

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Chinese Chemical Letters 2001年第10期12卷 903-906页

作者： Li, MG Wu, SH Zhao, lx Zhang, Q Li, WJ Cui, XL Xu, LH Wu, DG jiang, CL Yunnan Univ Yunnan Inst Microbiol Minist Educ PR China Key Lab Microbial Resources Kunming 650091 Peoples R China

Autolytimycin 1 was isolated from the culture filtrate of Streptomyces autolyticus JX-47, together with two known compounds, lebstatin 2 and 17-O-demethyl-geldanamycin 3. These compounds showed the activities of anti-... 详细信息

关键词： Streptomyces autolyticus autolytimycin lebstatin 17-O-demethyl-geldanamycin

“岗课赛证”融通视域下物联网系统设计课程教学改革探索

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天津职业大学学报 2024年第2期33卷 57-62页

作者：江帆江苏联合职业技术学院苏州工业园区分院江苏苏州215123

针对现阶段高职院校物联网专业实施“岗课赛证”融通教学过程中存在职业岗位普适性较低、课程项目化程度不高、技能大赛融合不紧密、职业证书缺乏选择性等问题,分析岗课赛证四要素融通的基本逻辑,提出以课程为核心,以岗位为依据,以竞赛... 详细信息

针对现阶段高职院校物联网专业实施“岗课赛证”融通教学过程中存在职业岗位普适性较低、课程项目化程度不高、技能大赛融合不紧密、职业证书缺乏选择性等问题,分析岗课赛证四要素融通的基本逻辑,提出以课程为核心,以岗位为依据,以竞赛为载体,以证书为评价标准的教学改革思路。以物联网系统设计课程中的模块1为例,在教学设计、教学实施、教学效果三个方面,开展“岗课赛证”融通的教学改革实践。

关键词： “岗课赛证”融通高职院校物联网系统设计教学改革

数字化转型升级的内在影响机理实证研究——基于回归分析模型

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工业技术经济 2024年第10期43卷 83-88页

作者：李华京蒋薇薇南京大学商学院南京210093 苏州大学应用技术学院苏州215325

为深入探究数字化转型、技术创新投入和技术创新产出对数字化转型升级的影响,本文收集2014~2023年477家上市公司作为样本数据,分析数字化转型升级的内在驱动机制。其中,选取数字化转型升级水平为被解释变量,选取数字化转型、技术创新产... 详细信息

为深入探究数字化转型、技术创新投入和技术创新产出对数字化转型升级的影响,本文收集2014~2023年477家上市公司作为样本数据,分析数字化转型升级的内在驱动机制。其中,选取数字化转型升级水平为被解释变量,选取数字化转型、技术创新产出、技术创新投入为解释变量,选取企业规模、营运能力、成长能力、企业年龄为控制变量,通过回归分析验证数字化转型升级的内在影响机理,并开展稳健性检验。结果表明,数字化转型、技术创新投入和技术创新产出促进数字化转型升级的提升。根据实证结果得出:要实现数字化转型升级,应进一步加快对数字化资源的投入,同时加强技术创新,加快企业研发产出,从而才能更好地促进产业发展。

关键词：数字化转型升级技术创新投入技术创新产出企业规模运营能力成长能力数字化资源研发产品转化

离子土壤固化剂和水泥处理淤泥的固化效果及机理

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铁道建筑技术 2024年第2期 50-53页

作者：蒋水兵中铁建设集团有限公司华中分公司河南郑州450000

以离子土壤固化剂(ISS)和水泥固化处理淤泥为研究对象,通过Atterberg极限、含水率、pH值、无侧限压缩试验(UCT)与直剪试验(DST)等方法,研究离子土壤固化剂与硅酸盐水泥复合条件下对海洋淤泥的稳定效果。结果表明,最佳配比ISS∶水为1∶50... 详细信息

以离子土壤固化剂(ISS)和水泥固化处理淤泥为研究对象,通过Atterberg极限、含水率、pH值、无侧限压缩试验(UCT)与直剪试验(DST)等方法,研究离子土壤固化剂与硅酸盐水泥复合条件下对海洋淤泥的稳定效果。结果表明,最佳配比ISS∶水为1∶50,NaOH的加入进一步显著降低了固化土的含水量致使强度大幅提高;ISS-NaOH-水泥固化土样加固效果最佳,该稳定剂组合使用不仅可以节省水泥用量,还可加快固化速度,缩短水泥7 d内的凝结时间,达到固化要求,并提高了固化土的强度。

关键词：离子土壤固化剂水泥淤泥质土无侧限抗压强度

哺乳动物减数分裂联会复合体的结构、功能与人类不孕不育

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中国科学：生命科学 2024年第1期54卷 4-15页

作者：蒋涵玮樊岁兴史庆华合肥综合性国家科学中心大健康研究院合肥230027 中国科学技术大学附属第一医院生殖与遗传分院合肥230027 合肥微尺度物质科学国家研究中心合肥230027 中国科学技术大学基础医学院合肥230027 安徽省生物医学与健康实验室合肥230027

同源染色体联会,即联会复合体的形成,是减数第一次分裂的关键事件之一.联会复合体作为减数分裂前期染色体行为的结构基础,对减数分裂程序性DSB的产生、修复及重组交换的形成都有必不可少的支持和调控作用.当因为联会复合体相关蛋白突变... 详细信息

同源染色体联会,即联会复合体的形成,是减数第一次分裂的关键事件之一.联会复合体作为减数分裂前期染色体行为的结构基础,对减数分裂程序性DSB的产生、修复及重组交换的形成都有必不可少的支持和调控作用.当因为联会复合体相关蛋白突变导致联会复合体不能正常形成时,将导致多种减数分裂异常,从而激活不同的减数分裂前期检验点,诱发减数分裂停滞、配子不能产生和不孕不育.本综述将重点针对小鼠减数分裂联会复合体相关的重要发现进行回顾,总结联会复合体的组成、结构、组装过程以及在减数分裂中的作用,分析迄今发现的联会复合体相关蛋白突变与人类不孕不育的关系,并展望联会复合体相关的研究方向和重点.

关键词：减数分裂联会复合体哺乳动物人类不孕不育