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MicroRNAs in colorectal cancer as markers and targets:Recent advances

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World Journal of Gastroenterology 2014年第15期20卷 4288-4299页

作者： Jing-Jia Ye jiang cao Clinical Research Center The Second Affiliated HospitalZhejiang University School of Medicine

MicroRNAs are evolutionarily conserved small noncoding RNA molecules encoded by eukaryotic genomic DNA,and function in post-transcriptional regulation of gene expression via base-pairing with complementary sequences in target mRNAs,resulting in translational repression or degradation of target *** represent one of the major types of epigenetic modification and play important roles in all aspects of cellular *** expression of microRNAs has been found in various human diseases including *** efforts have been made to discover the characteristic microRNA expression profiles,to understand the roles of aberrantly expressed microRNAs and underlying mechanisms in different *** the application of DNA microarray,real-time quantitative polymerase chain reaction and other molecular biology techniques,increasing evidence has been accumulated which reveal that aberrant microRNAs can be detected not only intracellularly within the cancer cells,but also extracellularly in plasma of patients,postulating the potential of aberrant microRNAs as promising diagnostic/prognostic markers and attracting therapeutic *** review is intended to provide the most recent advances in microRNA studies in one of the most common cancers,colorectal cancer,especially the identification of those specifically altered microRNAs in colorectal cancer,validation for their relevance to clinical pathological parameters of patients,functional analyses and potential applications of these microRNAs.

关键词： MicroRNA Epigenetic modification Colorectal cancer Marker Therapy

Reduction of SO2 to elemental sulfur over rare earth-iron catalysts

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Journal of Rare Earths 2009年第5期27卷 744-748页

作者： DENG Gengfeng jiang Kun cao Xia LIAO Chunfa School of Materials and Chemical Engineering Jiangxi University of Science and Technology Ganzhou 341000 China School of Materials and Chemical Engineering Jiangxi University of Science and Technology Ganzhou 341000 China Nanchang Engineering and Research Institute of Nonferrous Metals Nanchang 330000 China School of Materials and Chemical Engineering Jiangxi University of Science and Technology Ganzhou 341000 China

With coal gas as a reducing agent, the catalytic reduction of SO2 to sulfur in the flue gas produced in metallurgical processes was studied over catalysts of rare earth-Fe/Al2O3 (REFe/Al2O3). The catalytic activity of the REFe/Al2O3 catalyst on the reduction of SO2 to sul-fur was investigated based on kinds and the contents of rare earths and different preparation method of the catalyst. Additionally, the mecha-nism of this catalytic reduction reaction was also explored. Results showed that different rare earth imposed different effect on the activity of the Fe/Al2O3 catalyst. Especially, the addition of Sm and Dy greatly improved the catalytic activity of Fe/Al2O3. The yield of sulfur over SmFe/Al2O3was increased to 86.62% at 360 ℃, which was 40.5% higher than that over Fe/Al2O3at the same temperature; and the sulfur yield over DyFe/Al2O3was increased to 91.62% at 400 ℃, 26.4% higher than that over Fe/Al2O3. The catalytic activity of REFe/Al2O3 was somehow dependent on the content of rare earth. For SmFe/Al2O3, the content of Sm was optimized to be about 1.0 wt.%. The rare earth catalyst prepared with different methods also showed varied activity. The sulfur yield over rare-earth transition metal catalysts follows the order: Sm and iron solution mixing impregnationSm first, then iron solution impregnationiron first, then Sm solution impregnation. The reaction mechanism of SO2 reduction to sulfur with coal gas was proposed to be an intermediate mechanism.

关键词： sulfur dioxide catalytic reduction sulfur flue gas rare earths

Estrogen receptors in gastric cancer:Advances and perspectives

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World Journal of Gastroenterology 2016年第8期22卷 2475-2482页

作者： Muhammad Saif Ur Rahman jiang cao Clinical Research Center The Second Affiliated Hospital Zhejiang University School of Medicine

Worldwide, gastric cancer is one of the most common malignancies with high mortality. Various aspects of thedevelopment and progression of gastric cancer continue to be extensively investigated in order to further our understanding and provide more effective means for the prevention, diagnosis, and treatment of the disease. Estrogen receptors(ERs) are steroid hormone receptors that regulate cellular activities in many physiological and pathological processes in different tissues. There are two distinct forms of ERs, namely ERα and ERβ, with several alternative-splicing isoforms for each. They show distinct tissue distribution patterns and exert different biological functions. Dysregulation of ERs has been found to be associated closely with many diseases, including cancer. A number of studies have been conducted to investigate the role of ERs in gastric cancer, the possible mechanisms underlying these roles, and the clinical relevance of deregulated ERs in gastric cancer patients. To date, inconsistent associations of different ERs with gastric cancer have been reported. These inconsistencies may be caused by variations in in vitro cell models and clinical samples, including assay conditions and protocols with regard to different forms of ERs. Given the potential of the deregulated ERs as diagnostic/prognostic markers or therapeutic targets for gastric cancer, it will be important to identify/confirm the association of each ER isoform with gastric cancer, to determine the specific roles and interactions that these individual ER isoforms play under specific conditions in the development and/or progression of gastric cancer, and to elucidate precisely these mechanisms. In this review, we summarize the achievements from early ER studies in gastric cancer to the most up-to-date discoveries, with an effort to provide a comprehensive understanding of the role of ERs roles in gastric cancer and its possible mechanisms. Furthermore, we propose directions for future investig

关键词： Gastric cancer Estrogen receptor Isoform Carcinogenesis Mechanism Genomic pathway Nongenomic pathway

Effect of superheat on quality of central equiaxed grain zone of continuously cast bearing steel billet based on two-dimensional segregation ratio

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Journal of Iron and Steel Research International 2018年第1期25卷 9-18页

作者： Wei Wang Zi-bing Hou Yi Chang jiang-hai cao College of Materials Science and Engineering ChongqingUniversity Chongqing 400044 China

The quality of central equiaxed grain zone （CEGZ） of GCr15 bearing steel billets was investigated at different superheats （20, 25 and 35 ℃ by experimental observations and a finite element model in order to optimize superheat in continuous casting process. Several GCrl5 billets were collected from the continuous casting shop, and the same CEGZ was chosen for comparison of internal quality of GCrl5 billets. Considering the limitation of segregation index at some points, two- dimensional segregation ratio in CEGZ was introduced. Firstly, the segregation ratio and the area of center large dark points in CEGZ obtain the minimum at 25 ℃ superheat, which indicates that the quality of CEGZ at 25 ~C superheat is improved compared with those at 20 and 35 ℃ superheats for corresponding continuously cast billets. The highest superheat and the lowest superheat are not beneficial for improving the central zone quality in the billets. Secondly, the quality of CEGZ of GCr15 billets increases with a decrease in the secondary dendrite arm spacing of CEGZ. Finally, according to the established finite element model, it is deduced that the secondary dendrite arm spacing of CEGZ is closely related to its later solidifica- tion time at solid fraction of 0.5-1.0, and the former will be decreased when decreasing the latter.

关键词： Superheat Continuously cast billet Equiaxed grain zone Segregation Solidification time

Fire Detection Method Based on Depthwise Separable Convolution and YOLOv3

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International Journal of Automation and computing 2021年第2期18卷 300-310页

作者： Yue-Yan Qin jiang-Tao cao Xiao-Fei Ji School of Information and Control Engineering Liaoning Shihua UniversityFushun 113001China School of Automation Shenyang Aerospace UniversityShenyang 110136China

Recently,video-based fire detection technology has become an important research topic in the field of machine *** paper proposes a method of combining the classification model and target detection model in deep learning for fire ***,the depthwise separable convolution is used to classify fire images,which saves a lot of detection time under the premise of ensuring detection ***,You Only Look Once version 3(YOLOv3)target regression function is used to output the fire position information for the images whose classification result is fire,which avoids the problem that the accuracy of detection cannot be guaranteed by using YOLOv3 for target classification and position *** the same time,the detection time of target regression for images without fire is greatly reduced *** experiments were tested using a network public *** detection accuracy reached 98%and the detection rate reached *** method not only saves the workload of manually extracting flame characteristics,reduces the calculation cost,and reduces the amount of parameters,but also improves the detection accuracy and detection rate.

关键词： Fire detection depthwise separable convolution fire classification You Only Look Once version 3(YOLOv3) target regression

Fabrication of high nitrogen austenitic stainless steels with excellent mechanical and pitting corrosion properties

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International Journal of Minerals,Metallurgy and Materials 2009年第4期16卷 387-392页

作者： Hua-bing Li Zhou-hua jiang Yang cao Zu-rui Zhang School of Materials and Metallurgy Northeastern University Shenyang 110004 China

A series of high nitrogen austenitic stainless steels were successfully developed with a pressurized electroslag remelting furnace. Nitride additives and deoxidizer were packed into the stainless steel pipes, and then the stainless steel pipes were welded on the surface of an electrode with low nitrogen content to prepare a compound electrode. Using Si3N4 as a nitrogen alloying source, the silicon contents in the ingots were prone to be out of the specification range, the electric current fluctuated greatly and the surface qualities of the ingots were poor. The surface qualities of the ingots were improved with FeCrN as a nitrogen alloying source. The sound and compact macrostructure ingot with the maximum nitrogen content of 1.21wt% can be obtained. The 18Cr18Mn2Mo0.9N high nitrogen austenitic stainless steel exhibits high strength and good ductility at room temperature. The steel shows typical ductile-brittle transition behavior and excellent pitting corrosion resistance properties.

关键词： high nitrogen austenitic stainless steels electroslag remelting nitrogen alloying ductile-brittle transition pitting corrosion resistance

COMPLEX SYMMETRIC TOEPLITZ OPERATORS ON THE UNIT POLYDISK AND THE UNIT BALL

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Acta Mathematica Scientia 2020年第1期40卷 35-44页

作者： cao jiang Xingtang DONG Zehua ZHOU School of Mathematics and Information Sciences Nanchang Hangkong UniversityNanchang 330063China School of Mathematics Tianjin UniversityTianjin 300350China

In this article,we study complex symmetric Toeplitz operators on the Bergman space and the pluriharmonic Bergman space in several ***,the necessary and sufficient conditions for Toeplitz operators to be complex symmetric on these two spaces with certain conjugations are just the ***,some interesting symmetry properties of complex symmetric Toeplitz operators are obtained.

关键词： complex symmetric operator Toeplitz operator Bergman space pluriharmonic Bergman space

Comparison of the modified Wiltse’s approach with spinal minimally invasive system and traditional approach for the therapy of thoracolumbar fracture

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The Journal of Biomedical Research 2020年第5期34卷 379-386页

作者： Jie Chang jiang cao Ziyan Huang Boyao Wang Tao Sui Xiaojian cao Department of Orthopedics the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Thoracolumbar fractures are usually treated by open posterior pedicle screw ***,this procedure involves massive paraspinal muscle stripping,inflicting surgical trauma,and prolonged X-ray *** this study,we observed 127 patients with single-segment injury thoracolumbar ***-six patients were treated by the modified Wiltse’s paraspinal approach with minimally invasive channel system,while 91 patients were treated via traditional posterior *** time,intraoperative blood loss,intraoperative fluoroscopy frequency,screw placement accuracy,visual analogue scale score,and Cobb’s angle of two groups were *** X-ray exposure times were notably reduced(4.2±1.6) in the new approach group(P<0.05).The pedicle screw placement accuracy and Cobb’s angle after surgery were similar in the two *** conclude that modified Wiltse’s paraspinal approach w ith spinal minimally invasive channel system surgery can significantly reduce the X-ray exposure times and is an alternative therapy for the thoracolumbar fracture.

关键词： thoracolumbar fracture Wiltse’s paraspinal approach spinal minimally invasive channel system

A Self-supporting,Surface Carbonized Filter Paper Membrane for Efficient Water-in-Oil Emulsion Separation

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Chinese Journal of Polymer Science 2021年第2期39卷 181-188,I0006页

作者： jiang-Yong-Quan cao Si-Chong Chen Jie Zhang Yang-Yang Xie Yu-Zhong Wang The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials National Engineering Laboratory of Eco-Friendly Polymeric Materials(Sichuan)Sichuan UniversityCollege of ChemistrySichuan UniversityChengdu 610064China

Due to the important role of oil source in our life,the separation of water-in-oil emulsion is urgent and *** seperation technology has been an efficient and widely used method in separating oil-water ***,we report a versatile approach to fabricate surface carbonized membranes with self-standing property from biomass-derived precursor by synergistic charring of phytic acid,arginine and filter *** obtained membrane exhibited superhydrophobicity in oil,excellent fouling resistance,and self-supporting *** membrane can be cycle-used at least 12 times with high permeation flux(up to 1380 L·m^(-2)·h^(-1))and separation efficiency(up to 99.4%).

关键词： Water-in-oil emulsion separation Filter paper membrane Surface carbonized Self-supporting