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Antiglycating effects of citrus flavonoids and associated mechanisms

Food Science and Human Wellness 2024年第5期13卷 2363-2372页

作者： Yunli Xiao Junfeng Shen jianfeng zhan Limin Guo Chi-Tang Ho Shiming Li College of Biology and Agricultural Resources Huanggang Normal UniversityHuanggang 438000China Institute of Agro-Products Storage and Processing Xinjiang Academy of Agricultural SciencesUrumqi 830091China Department of Food Science Rutgers UniversityNew Brunswick 08901USA

Glycation of proteins and DNA forms advanced glycation end products(AGEs)causing cell and tissue dysfunction and subsequent various chronic diseases,in particular,metabolic and age-related *** AGE inhibition includes scavengers of reactive carbonyl species(RCS)such as methylglyoxal(MG),glyoxalase-1 enhancers,Nrf2/ARE pathway activators,AGE/RAGE formation inhibitors and other antiglycatng *** flavonoids have demonstrated antioxidant and anti-inflammatory effects and are also found to be effective antiglycating ***,we reviewed the up to date progress of the antiglycation effects of citrus flavonoids and associated *** citrus flavonoids,hesperedin and its aglycone,hesperetin,inhibited glycation by scavenging MG forming mono-or di-flavonoid adducts with MG,enhanced the activity of glyoxase-1,activated Akt/Nrf2 signal pathway while inhibiting AGE/RAGE/NF-κB pathway,reduced the formation of Nε-(carboxylmethyl)lysine(CML)and pentosidine,inhibited aldol reductase activity and decreased the levels of *** antiglycating activity and mechanisms of other flavonoids was also summarized in this *** conclusion,citrus flavonoids possess effective antiglycating activity via different mechanisms,yet there are many challenging questions remaining to be studied in the near future such as in vivo testing and human study of citrus flavonoids for efficacy,effectiveness and adverse effects of citrus flavonoids as a functional food in managing high levels of AGEs and controlling AGE-induced chronic diseases,diabetic complications in particular.

关键词： Citrus flavonoids Hesperedin Advanced glycation end products Antiglycation Diabetic complication

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Changes in Polyphenols and Antioxidant Activities of Yingshan Yunwu Tea during Digestion in Vitro

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Medicinal Plant 2024年第2期15卷 21-25页

作者： Ruyi ZHENG Jinjie ZHOU Wenzhuo WU jianfeng zhan Peng WU Ting DING Weixin WANG College of Biology and Agricultural Resources Huanggang Normal UniversityHubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie MountainsHubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive UtilizationHuanggang 438000China Hubei Hongan County Public Inspection and Testing Center Huanggang 438000China

[Objectives]To explore the change rule of polyphenol content and antioxidant activity of coarse old leaves of Yingshan Yunwu Tea in the process of human digestion.[Methods]The coarse and old leaves of Yunwu tea in Yingshan,Huanggang,Hubei Province were selected as the research object,and their digestion in vitro was *** total polyphenol content was determined by Folin-phenol reagent colorimetric method,and the DPPH radical scavenging activity and total antioxidant activity were determined.[Results]After simulated gastrointestinal digestion in vitro,the polyphenol content and antioxidant activity of coarse old leaf tea soup showed a downward *** gastrointestinal digestion,the polyphenol content in tea infusion separately decreased by 31.8%and 8.5%;the scavenging rate of DPPH free radical was 97%before digestion,decreased to 92%after gastric digestion and 65%after intestinal digestion,which decreased by 5%and 27%,respectively;after gastrointestinal digestion,the total antioxidant capacity of tea soup decreased by 4.7%and 3.1%,respectively.[Conclusions]This study provided a reference for the development and application of coarse old leaves of Yingshan Yunwu tea,and provided a reference for the nutritional value evaluation and comprehensive utilization of coarse old leaves,so as to make the best use of coarse tea leaves and reduce the waste of resources.

关键词： Coarse old leaves of Yunwu tea Polyphenol Digestion in vitro Antioxidant activity

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油蜡热处理对木材物理性能及尺寸稳定性的影响

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森林工程 2024年第1期40卷 106-113页

作者：蒋金成李璟张镜元王秉泉战剑锋东北林业大学材料科学与工程学院哈尔滨150040

为探究植物油蜡热处理对不同树种木材的物理性能及尺寸稳定性的影响,以臭冷杉、落叶松和条纹乌木为研究对象,自主配置的植物油蜡溶液为加热介质,分别在不同温度(140、170、200℃)下对木材进行4 h的高温热处理,再通过充分的冷却确保植物... 详细信息

为探究植物油蜡热处理对不同树种木材的物理性能及尺寸稳定性的影响,以臭冷杉、落叶松和条纹乌木为研究对象,自主配置的植物油蜡溶液为加热介质,分别在不同温度(140、170、200℃)下对木材进行4 h的高温热处理,再通过充分的冷却确保植物油蜡完全进入木材内部,并利用扫描电镜观察其内部结构。研究结果表明,室温冷却阶段是木材油蜡热处理的关键,该阶段植物油蜡大量进入木材内部,这主要表现为木材试件增重百分比(Weight Percentage Gain,WPG)的变化。经植物油蜡联合热处理后,3种木材最大颜色变化(ΔE^(*))分别为48.24、40.67、5.95;表面疏水性均有稳定提高,接触角(Water Contact Angle,WCA)稳定提升至70°左右;不同树种的弦向、径向线湿胀率及体积膨胀率均有不同程度的降低,抗膨胀效率(Anti Swelling Efficiency,ASE)有效提高,3种木材最大提高49.64%、48.24%、38.86%,说明植物油蜡热处理可以提升木材尺寸稳定性。

关键词：植物油蜡热处理木材物理性能尺寸稳定性

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Multi-layer dynamic and asymmetric convolutions

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High Technology Letters 2022年第3期28卷 227-236页

作者： LUO Chunjie zhan jianfeng Institute of Computing Technology Chinese Academy of SciencesBeijing 100190P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China

Dynamic networks have become popular to enhance the model capacity while maintaining efficient inference by dynamically generating the weight based on *** bring much more parameters and increase the difficulty of the *** this paper,a multi-layer dynamic convolution(MDConv) is proposed,which scatters the over-parameters over multi-layers with fewer parameters but stronger model capacity compared with scattering horizontally;it uses the expanding form where the attention is applied to the features to facilitate the training;it uses the compact form where the attention is applied to the weights to maintain efficient ***,a multi-layer asymmetric convolution(MAConv) is proposed,which has no extra parameters and computation cost at inference time compared with static *** results show that MDConv achieves better accuracy with fewer parameters and significantly facilitates the training;MAConv enhances the accuracy without any extra cost of storage or computation at inference time compared with static convolution.

关键词： neural network dynamic network attention image classification

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PhiBench 2.0: characterizing data analytics workloads on Intel Knights Landing

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High Technology Letters 2019年第2期25卷 121-128页

作者： Xie Biwei zhan jianfeng Wang Lei zhang Lixin Institute of Computing Technology Chinese Academy of SciencesBeijing 100190P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China

With high computational capacity, e.g. many-core and wide floating point SIMD units, Intel Xeon Phi shows promising prospect to accelerate high-performance computing(HPC) applications. But the application of Intel Xeon Phi on data analytics workloads in data center is still an open question. Phibench 2.0 is built for the latest generation of Intel Xeon Phi(KNL, Knights Landing), based on the prior work PhiBench(also named BigDataBench-Phi), which is designed for the former generation of Intel Xeon Phi(KNC, Knights Corner). Workloads of PhiBench 2.0 are delicately chosen based on BigdataBench 4.0 and PhiBench 1.0. Other than that, these workloads are well optimized on KNL, and run on real-world datasets to evaluate their performance and scalability. Further, the microarchitecture-level characteristics including CPI, cache behavior, vectorization intensity, and branch prediction efficiency are analyzed and the impact of affinity and scheduling policy on performance are investigated. It is believed that the observations would help other researchers working on Intel Xeon Phi and data analytics workloads.

关键词： Intel Xeon Phi data analytics workloads characterization Knights Landing(KNL) many core x86 processors

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Characterizing big data analytics workloads on POWER8 SMT processors

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High Technology Letters 2017年第3期23卷 245-251页

作者：贾禛 zhan jianfeng Wang Lei zhang Lixin State Key Laboratory of Computer Architecture Institute of Computing Technology Chinese Academy of Sciences Beijing 100080 P. R. China University of Chinese Academy of Sciences Beijing 100049 P. R. China

Big data analytics is emerging as one kind of the most important workloads in modern data centers. Hence,it is of great interest to identify the method of achieving the best performance for big data analytics workloads running on state-of-the-art SMT( simultaneous multithreading) processors,which needs comprehensive understanding to workload characteristics. This paper chooses the Spark workloads as the representative big data analytics workloads and performs comprehensive measurements on the POWER8 platform,which supports a wide range of multithreading. The research finds that the thread assignment policy and cache contention have significant impacts on application performance. In order to identify the potential optimization method from the experiment results,this study performs micro-architecture level characterizations by means of hardware performance counters and gives implications accordingly.

关键词： simultaneous multithreading(SMT) workloads characterization POWER8 big data analytics

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豌豆全粉对鱼糜凝胶品质的影响

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食品科技 2024年第6期49卷 142-146页

作者：陈训俭陈泽宇丁婷胡婷王蔚新占剑峰黄冈师范学院生物与农业资源学院大别山特色资源开发协同创新中心湖北省经济林种质资源改良与资源综合利用重点实验室湖北黄冈438000 湖北省红安县公共检验检测中心湖北黄冈438000

为提高鱼糜制品的品质,将豌豆全粉添加到冷冻白鲢鱼鱼糜中,分析不同添加量对鱼糜凝胶白度、持水性、蒸煮损失率、质构特性和感官品质等的影响。结果表明,随豌豆全粉添加量增加,持水性、感官评分、质构指标中的硬度、弹性以及咀嚼性先增... 详细信息

为提高鱼糜制品的品质,将豌豆全粉添加到冷冻白鲢鱼鱼糜中,分析不同添加量对鱼糜凝胶白度、持水性、蒸煮损失率、质构特性和感官品质等的影响。结果表明,随豌豆全粉添加量增加,持水性、感官评分、质构指标中的硬度、弹性以及咀嚼性先增加后减少,添加量为5%时,均达最大值。鱼糜凝胶的蒸煮损失率则呈下降趋势,白度变化不显著。反映质构特性的内聚性指标与对照组相比差异显著(P≤0.05),但添加量在1%~6%范围内时变化不显著。该研究结果可为改善淡水鱼鱼糜凝胶特性提供理论参考。

关键词：豌豆全粉品质鱼糜制品凝胶特性

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Scalable group management in large-scale virtualized clusters

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High Technology Letters 2011年第3期17卷 263-271页

作者： Zhou Wei Wang Lei Meng Dan Yuan Lin zhan jianfeng Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 P. R. China Bureaus of High-Tech Research and Development Chinese Academy of Sciences Beijing 100864 P. R. China

To save cost, more and more users choose provision resources at the granularity of virtual machines in cluster systems, especially data centres. Maintaining a consistent member view is the foundation of reliable cluster managements, and it also raises several challenge issues for large scale cluster systems deployed with virtual machines （which we call virtualized clusters）. In this paper, we introduce our experience in design and implementation of scalable member view management on large-scale virtual clusters. Our research contributions include three-aspects ： 1 ） we propose a scalable and reliable management infrastructure that combines a peer-to-peer structure and a hierarchy structure to maintain a consistent member view in virtual clusters; 2 ） we present a light-weighted group membership algorithm that can reach the consistent member view within a single round of message exchange; 3 ） we design and implement a scalable membership service that can provide virtual machines and maintain a consistent member view in virtual clusters. Our work is verified on Dawning 5000A, which ranked No. 10 of Top 500 super computers in November, 2008.

关键词： virtualized clusters consistent member view scalable group membership SGMS

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Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action

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Food Science and Human Wellness 2022年第5期11卷 1177-1182页

作者： Wenping Tang jianfeng zhan Shiming Li Yue Liu Chi-Tang Ho Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization Huanggang Normal UniversityHuanggang 438000China Department of Food Science Rutgers UniversityNew Brunswick 08901USA Department of Chemical Biology Rutgers UniversityPiscataway 08901USA

In 2021,there are approximately 537 million adults ageing 20-79 years affected by diabetes worldwide and the number is rising rapidly,hence it is important to manage and control diabetes mellitus and its associated *** is one of the key factors in preventing and combating diseases such as *** as a food and an herbal medicine,Polygonum multiflorum(PM)has been used as an anti-aging tonic,for hair darkening in traditional Chinese medicine for several *** recent research effort of PM has been focused on antioxidant,anti-ageing and anti-tumor *** the present study,we utilized the traditional processing of harvested raw PM,and identified several stilbene components and then evaluated the potential anti-diabetic effects of the processed PM extract(PME).PME(0.075%)was given to diabetic mice(KK CgAy/J)in drinking water and after 7 weeks,PME-treated mice had significantly lower glucose levels than mice in the diabetic control group(P<0.01).The mechanism was explored with ELISA and Western blotting and results suggested that the effect was through maintainingβ-cell function.

关键词： Diabetes Stilbene glycoside Polygonum multiflorum Hypoglycemic activity Homeostatic model assessment

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Focusing on the recent progress of tea polyphenol chemistry and perspectives

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Food Science and Human Wellness 2022年第3期11卷 437-444页

作者： Shiming Li Liang zhang Xiaochun Wan jianfeng zhan Chi-Tang Ho Hubei Key Laboratory of EFGIR Huanggang Normal UniversityHuanggang 438000China State Key Laboratory of Tea Plant Biology and Utilization School of Tea&Food ScienceAnhui Agricultural UniversityHefei 230036China Department of Food Science Rutgers UniversityNJ 08901USA

Myriad evidence attests to the health-promoting benefits of tea *** there are multiple factors of tea influencing the effective biological properties,tea polyphenols are the most significant and valuable *** chemical characterization and physical characteristics of tea polyphenols have been comprehensively studied over the previous *** the emergence of new chemistry in tea,particularly the property of scavenging reactive carbonyl species(RCS)and the newly discovered flavoalkaloid compounds,has drawn increasing *** this review,we summarize recent findings of a new class of compounds in tea-flavonoid alkaloids(flavoalkaloids),which exist in fresh tea leaves and can be generated during the process of post-harvesting,and also postulate the formation mechanism of flavoalkaloids between catechins and theanine-derived Strecker ***,we detail the up-to-date research results of tea polyphenols regarding their ability to trap RCS and their in vivo aminated metabolites to suppress advanced glycation ends products(AGEs).We further raise questions to be addressed in the near future,including the synthetic pathways for the generation of flavoalkaloids and AGEs in fresh tea leaves before processing and the concentrations of tea polyphenols that affect their RCS scavenging capability due to their pro-oxidant *** intensive research is warranted to elucidate the mechanisms of action underlying the biological activity of flavoalkaloids and the pharmacological application of tea polyphenols in scavenging RCS and impeding detrimental AGEs.

关键词： Tea chemistry Flavonoalkaloids RCS adducts Aminated tea polyphenols AGEs

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