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The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1292-1301页

作者： Leiqiong Gao Jing Zhou Sen Yang Lisha Wang Xiangyu Chen Yang Yang Ren Li Zhiwei Pan Jing Zhao Zhirong Li Qizhao Huang jianfang tang Li Hu Pinghuang Liu Guozhong Zhang Yaokai Chen Lilin Ye Institute of Immunology Third Military Medical UniversityChongqingChina Chongqing Public Health Medical Center ChongqingChina State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbinHeilongjiangChina College of Veterinary Medicine Northeast Agricultural UniversityHarbinHeilongjiangChina Key Laboratory of Animal Epidemiology of the Ministry of Agriculture College of Veterinary MedicineChina Agricultural UniversityBeijingChina Cancer Center The General Hospital of Western Theater CommandChengduSichuanChina Comparative Immunology Research Center College of Veterinary MedicineChina Agricultural UniversityBeijingChina

The adaptive immunity that protects patients from coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is not well *** particular,the asymptomatic patients have been found to induce weak and transient SARS-CoV-2 antibody responses,but the underlying mechanisms remain unknown;meanwhile,the protective immunity that guide the recovery of these asymptomatic patients is ***,we characterized SARS-CoV-2-specific B-cell and T-cell responses in 10 asymptomatic patients and 64 patients with other disease severity(mild,n=10,moderate,n=32,severe,n=12)and found that asymptomatic or mild symptomatic patients failed to mount virus-specific germinal center(GC)B cell responses that result in robust and prolonged humoral immunity,assessed by GC response indicators including follicular helper T(TFH)cell and memory B cell responses as well as serum CXCL13 ***,these patients mounted potent virus-specific TH1 and CD8+T cell *** sharp contrast,patients of moderate or severe disease induced vigorous virus-specific GC B cell responses and associated TFH responses;however,the virus-specific TH1 and CD8+T cells were minimally induced in these *** results,therefore,uncovered the protective immunity in asymptomatic patients and also revealed the strikingly dichotomous and incomplete humoral and cellular immune responses in COVID-19 patients with different disease severity,providing important insights into rational design of effective COVID-19 vaccines.

关键词： immunity patients severity

有限容量多服务员排队系统全忙期分布函数的一种直观计算途径

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工程数学学报 2023年第6期40卷 991-1000页

作者：余玅妙唐建芳四川师范大学数学科学学院成都610066 四川轻化工大学数学与统计学院自贡643000

排队系统忙期长度是衡量系统运行效率的重要性能指标,它在与排队系统相关的优化问题建模中有着广泛而重要的应用。受数学方法的制约,一段时间以来多服务员有限缓冲空间排队系统的忙期概率分布函数未得到充分的重视与研究。依托马氏多服... 详细信息

排队系统忙期长度是衡量系统运行效率的重要性能指标,它在与排队系统相关的优化问题建模中有着广泛而重要的应用。受数学方法的制约,一段时间以来多服务员有限缓冲空间排队系统的忙期概率分布函数未得到充分的重视与研究。依托马氏多服务员有限缓冲空间排队系统的子全忙期分布及与其相关联的有限缓冲空间排队系统全忙期分布之间的重要关系,给出了寻求马氏多服务员有限容量排队系统服务员全忙期分布函数Laplace-Stieltjes变换的一个迭代计算公式。同时,为了计算该全忙期分布函数在任意给定时刻处的函数值,利用有理函数部分分式分解方法和极点处的留数计算规则对上述Laplace-Stieltjes变换进行了从s域到时间域的反演,并给出了基于变换特征根的半解析化全忙期分布函数反演公式。使用Mathematica软件编程,在数值算例中通过与现有文献结果的对比,证实了所提出分析方法的可行性与简洁性。这为实际工程应用提供了一种较为直观且操作性较强的多服务台有限缓冲空间排队系统全忙期分布函数的计算方法。

关键词：忙期多服务员排队拉普拉斯–斯蒂尔切斯变换特征根留数

The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection

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Cellular & Molecular Immunology 2020年第3期17卷 247-260页

作者： Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei tang Zhenyu Liu Li Hu jianfang tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye Institute of Immunology PLAThird Military Medical University400038 ChongqingChina Institute for Molecular Engineering University of ChicagoChicagoIL 60637USA Institute of Cancer Xinqiao HospitalThird Military Medical University400038 ChongqingChina Cancer Center The General Hospital of Western Theater CommandChengduChina Section of Genetic Medicine Department of MedicineUniversity of ChicagoChicagoIL 60637USA Department of Hepatobiliary Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210009 JiangsuChina

Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)*** histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)***,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain *** a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 *** of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH ***,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell ***,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection.

关键词： EZH2 infection acute

Tumor-specific memory CD8^(+)T cells are strictly resident in draining lymph nodes during tumorigenesis

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Cellular & Molecular Immunology 2023年第4期20卷 423-426页

作者： Qiao Liu Ling Ran Zhengliang Yue Xingxing Su Lisha Wang Shuqiong Wen Shun Lei Xiaofan Yang Yan Zhang Jianjun Hu jianfang tang Zhirong Li Li Hu Bo Zhu Lifan Xu Lilin Ye Qizhao Huang Shanghai Public Health Clinical Center Fudan UniversityShanghaiChina Institute of Cancer Xinqiao HospitalThird Military Medical UniversityChongqingChina Institute of Immunology Third Military Medical UniversityChongqingChina Stomatological Hospital of Chongqing Medical University ChongqingChina Provincial Key Laboratory of Immune Regulation and Immunotherapy School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhouChina College of Veterinary Medicine Qingdao Agricultural UniversityShandongChina Institute of Immunological Innovation and Translation Chongqing Medical UniversityChongqingChina.8 These authors

The functional exhaustion of CD8^(+)T cells represents a fundamental hallmark of chronic viral infection and cancer and,in both scenarios,is driven by prolonged exposure to persistent cognate antigens in the context of an immunoinhibitory *** CD8^(+)T cells upregulate the expression of a wide diversity of coinhibitory immunoreceptors(also referred to as immune checkpoint receptors),such as PD-1,Tim-3,LAG-3,and ***,exhausted CD8^(+)T cells lose their potential to differentiate into functional memory cells and are characterized by hierarchical loss of effector function,leading to compromised tumor control and viral eradication[1,2].

关键词： drain strictly specific

Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19

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Signal Transduction and Targeted Therapy 2020年第1期5卷 921-926页

作者： Xiangyu Chen Zhiwei Pan Shuai Yue Fei Yu Junsong Zhang Yang Yang Ren Li Bingfeng Liu Xiaofan Yang Leiqiong Gao Zhirong Li Yao Lin Qizhao Huang Lifan Xu jianfang tang Li Hu Jing Zhao Pinghuang Liu Guozhong Zhang Yaokai Chen Kai Deng Lilin Ye Institute of Immunology PLAThird Military Medical University400038 ChongqingChina Institute of Human Virology Key Laboratory of Tropical Disease Control of Ministry of EducationZhongshan School of MedicineSun Yat-sen University510080 GuangzhouChina Guangdong Provincial People’s Hospital Guangdong Academy of Medical Sciences510080 GuangzhouChina State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural Sciences150001 HarbinHeilongjiangChina College of Veterinary Medicine Northeast Agricultural University150030 HarbinHeilongjiangChina Cancer Center The General Hospital of Western Theater Command610083 ChengduSichuanChina Biomedical Analysis Center Third Military Medical University400038 ChongqingChina Comparative Immunology Research Center College of Veterinary MedicineChina Agricultural University100193 BeijingChina Key Laboratory of Animal Epidemiology of the Ministry of Agriculture College of Veterinary MedicineChina Agricultural University100193 BeijingChina Chongqing Public Health Medical Center 400038 ChongqingChina Guangzhou Eighth People’s Hospital Guangzhou Medical University510050 GuangzhouChina

COVID-19 patients exhibit differential disease severity after SARS-CoV-2 *** is currently unknown as to the correlation between the magnitude of neutralizing antibody(NAb)responses and the disease severity in COVID-19 *** a cohort of 59 recovered patients with disease severity including severe,moderate,mild,and asymptomatic,we observed the positive correlation between serum neutralizing capacity and disease severity,in particular,the highest NAb capacity in sera from the patients with severe disease,while a lack of ability of asymptomatic patients to mount competent ***,the compositions of NAb subtypes were also different between recovered patients with severe symptoms and with mild-tomoderate *** results reveal the tremendous heterogeneity of SARS-CoV-2-specific NAb responses and their correlations to disease severity,highlighting the needs of future vaccination in COVID-19 patients recovered from asymptomatic or mild illness.

关键词： severity neutral mount

CBCT在正畸治疗中牙根吸收的诊断应用研究现状

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口腔医学 2015年第8期35卷 702-704页

作者：唐建方浙江省桐乡市第一人民医院口腔科浙江桐乡314500

牙根吸收作为正畸治疗中一个常见的并发症越来越受到医生的关注。早期诊断根吸收具有十分积极的意义。然而,常规二维X线检查由于其敏感性较低,不适于早期诊断。随着影像学技术的发展,特别是CBCT的出现,根吸收的精确诊断成为可能。该文... 详细信息

牙根吸收作为正畸治疗中一个常见的并发症越来越受到医生的关注。早期诊断根吸收具有十分积极的意义。然而,常规二维X线检查由于其敏感性较低,不适于早期诊断。随着影像学技术的发展,特别是CBCT的出现,根吸收的精确诊断成为可能。该文从近几年的研究情况着手对正畸治疗中根吸收的影响因素及CBCT的诊断应用作一综述。

关键词：牙根吸收正畸治疗 CBCT

Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor

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Cellular & Molecular Immunology 2020年第6期17卷 647-649页

作者： Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu jianfang tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye Institute of Immunology PLAThird Military Medical UniversityChongqing 400038China State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbinHeilongjiang 150001China College of Veterinary Medicine Northeast Agricultural UniversityHarbin Heilongjiang 150030China Chongqing Public Health Medical Center Chongqing 400038China Comparative Immunology Research Center College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Biomedical Analysis Center Third Military Medical UniversityChongqing 400038China Cancer Center The General Hospital of Western Theater CommandChengduSichuan 610083China Institute of Human Virology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalShenzhenGuangdong 518112China NHC Key laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical College100176 BeijingChina

According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020.

关键词： respiratory monoclonal mortality

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槽式太阳能集热管弯曲测量及溢出损失分析

太阳能学报 2023年第9期44卷 273-279页

作者：魏秀东付饶汤建方车晟许英朝长春理工大学光电工程学院长春130022 中广核太阳能开发有限公司北京100070 厦门理工学院光电与通信工程学院厦门361024

槽式太阳能集热管的弯曲变形会造成聚光能量的溢出损失,需要进行测量和分析。提出基于无人机摄影的槽式太阳能集热管弯曲测量方法:采用无人机搭载高分辨可见光相机,实现对槽式太阳能集热管的图像采集;基于边缘检测算法对集热管图像进行... 详细信息

槽式太阳能集热管的弯曲变形会造成聚光能量的溢出损失,需要进行测量和分析。提出基于无人机摄影的槽式太阳能集热管弯曲测量方法:采用无人机搭载高分辨可见光相机,实现对槽式太阳能集热管的图像采集;基于边缘检测算法对集热管图像进行处理,最终获得集热管的弯曲变形量。基于光线追迹理论建立槽式聚光器聚光过程数学模型,推导弯曲集热管的溢出损失计算公式。选取3种不同弯曲量的集热管进行测量实验,测得的最大弯曲量分别为1.23、7.75、18.79 mm,平均测量误差为±0.75 mm,计算对应的溢出损失分别为0.02%、0.57%、3.72%,结果表明:集热管弯曲量较大时,会造成较大的溢出损失。

关键词：太阳能热发电槽式太阳能集热管光学效率光线追迹

基于TMS320F2812的机床数控系统设计

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制造技术与机床 2007年第11期 50-52页

作者：安连祥屈学琴唐建芳杨毅河北工业大学天津300130

介绍了TMS320F2812的主要特点,研究了基于DSP的开放式机床数控系统,上位机(PC)与下位机(DSP)通过USB2.0接口进行高速数据传递,满足了系统的实时性要求。

关键词： DSP 数控机床控制系统 USB2.0