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SR-BI expression regulates the gastric cancer tumor immune microenvironment and is associated with poor prognosis

BIOCELL 2023年第5期47卷 991-1002页

作者： YI WANG SHANGQI CHEN PENGCHENG YU ZHEHAN BAO CAN HU YUHANG XIA RUOLAN zhang LI YUAN HUA RUAN jiancheng sun The First Clinical Medical College of Zhejiang Chinese Medical University Hangzhou310006China Department of General Surgery HwaMei HospitalUniversity of Chinese Academy of SciencesNingbo315010China The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Institutes of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou310022China Zhejiang Key Lab of Prevention Diagnosis and Therapy of Upper Gastrointestinal CancerZhejiang Cancer HospitalHangzhou310022China Department of Chinese Surgery Linping District Hospital of Traditional Chinese MedicineHangzhou311100China Department of Gastrointestinal Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325099China

Aim:Scavenger receptor class B,type I(SR-BI)is an integral plasma membrane protein that has been reported to be overexpressed in various malignancies,such as renal cancer,breast cancer,and prostate cancer,and is an independent prognostic ***,the clinical value and expression of SR-BI in GC are *** research aimed to explore the role of SR-BI in combination with immune markers as a diagnostic and prognostic marker for gastric cancer(GC).Methods:GC tissues,paracancerous tissues,and clinicopathological data of 149 patients were *** expression level of SR-BI,Tumor-infiltrating lymphocytes(TILs),and PD-L1 were evaluated by immunohistochemistry(IHC).The associations of the SR-BI staining intensity with clinicopathological features and immune markers were determined by the chi-square *** and multivariate COX regression analyses were used to evaluate independent prognostic ***–Meier analyses were performed to plot the survival ***:Our results indicated that SR-BI was expressed at higher levels in tumor tissues than in adjacent paracancerous tissues(p<0.001),and patients with high levels of SR-BI expression had a worse *** and multivariate analyses revealed that high SR-BI expression was an independent factor for poor *** chi-square test determined that the expression of SR-BI was negatively correlated with CD4+T cells and CD8+T cells(CD4+T cells,p=0.013;CD8+T cells,p=0.021),and positively correlated with PD-L1(p=0.022).Finally,survival analysis revealed that CD4+T cells were associated with the prognosis of GC patients(p=0.019),and the combined survival analysis of SR-BI and CD4+T cells was also statistically significant(p=0.030).Conclusion:SR-BI is highly expressed in GC tissue and associated with poor ***,SR-BI can also regulate the GC tumor immune microenvironment.

关键词： SR-BI Gastric cancer Tumor immune microenvironment(TIME) Immunohistochemistry Prognosis

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Intravenous route to choroidal neovascularization by macrophage-disguised nanocarriers for mTOR modulation

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2506-2521页

作者： Weiyi Xia Chao Li Qinjun Chen jiancheng Huang Zhenhao Zhao Peixin Liu Kai Xu Lei Li Fangyuan Hu Shujie zhang Tao sun Chen Jiang Chen Zhao Department of Ophthalmology and Vision Science Eye&ENT HospitalShanghai Medical SchoolFudan UniversityShanghai 200031China Key Laboratory of Smart Drug Delivery Ministry of EducationDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 201203China

Retinal pigment epithelial(RPE) is primarily impaired in age-related macular degeneration(AMD), leading to progressive loss of photoreceptors and sometimes choroidal neovascularization(CNV). mTOR has been proposed as a promising therapeutic target, while the usage of its specific inhibitor,rapamycin, was greatly limited. To mediate the mTOR pathway in the retina by a noninvasive approach, we developed novel biomimetic nanocomplexes where rapamycin-loaded nanoparticles were coated with cell membrane derived from macrophages(termed as MRaNPs). Taking advantage of the macrophage-inherited property, intravenous injection of MRaNPs exhibited significantly enhanced accumulation in the CNV lesions, thereby increasing the local concentration of rapamycin. Consequently, MRaNPs effectively downregulated the mTOR pathway and attenuate angiogenesis in the eye. Particularly, MRaNPs also efficiently activated autophagy in the RPE, which was acknowledged to rescue RPE in response to deleterious stimuli. Overall, we design and prepare macrophage-disguised rapamycin nanocarriers and demonstrate the therapeutic advantages of employing biomimetic cell membrane materials for treatment of AMD.

关键词： Choroidal neovascularization Age-related macular degeneration Biomimetic nanoparticles Targeted drug delivery mTOR signaling Rapamycin Macrophage membrane Inflammation

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Persistence in A Three Species Predator-Prey System

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Systems Science and Systems Engineering 1999年第2期9卷 203-208页

作者： sun jitao zhang Yinping(Iust. of Appl. Math., Shanghai Tiedao University, Shanghai 200331, China)

In this paper we consider the persistence of the following three species Lotka-Volterrapredator-prey modelIt’s proved that the Lotka-Volterra model is persistent under appropriate conditions.

关键词： persistence predator-prey system

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NOISE REDUCTION FOR FAST FADING CHANNEL BY RECURRENT LEAST SQUARES SUPPORT VECTOR MACHINES IN EMBEDDING PHASE SPACES

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Journal of Electronics(China) 2006年第6期23卷 926-928页

作者： Xiang Zheng zhang Taiyi sun jiancheng Dept of lnformation and Communication Engineering Xi ＇an Jiaotong University Xi ＇an 710049 China

A new strategy for noise reduction of fast fading channel is presented. Firstly, more information is acquired utilizing the reconstructed embedding phase space. Then, based on the Recurrent Least Squares Sup-port Vector Machines (RLS-SVM), noise reduction of the fast fading channel is realized. This filtering tech-nique does not make use of the spectral contents of the signal. Based on the stability and the fractal of the cha-otic attractor, the RLS-SVM algorithm is a better candidate for the nonlinear time series noise-reduction. The simulation results shows that better noise-reduction performance is acquired when the signal to noise ratio is 12dB.

关键词： Fading channel Noise reduction Support Vector Machines (SVM) Chaotic attractor

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One-year status of hepatic venous pressure gradient measurement from 85 hospitals in China

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Portal Hypertension & Cirrhosis 2024年第2期3卷 116-123页

作者： jitao Wang Ting Cui Linpeng zhang Zhiping Yan Lei Li Jinjun Chen Junhui sun Hua Xiang He Zhu Hao Wu Jiancuo Gengzang Feng zhang Wei Wu Guohong Cao Wuhua Guo Haibin Shi Hui Xue Guangjun Huang Qiang Yu Meng Niu Huiling Xiang Derun Kong Wei Gou Xuefeng Luo Fuliang He Min Yuan Wei Liu Yong Wang Hongjie Hu Xiaoli Zhu Tao Yu Qinxue sun Wei Qu Ting Lu Deqiang Ma Li zhang Jun Ma Jun Yang Ketao Mu Xiaoliang Zhu Kai Xiong Huiguo Ding Shengjuan Yao Mingsheng Huang Fang Wang Zexin Wang Yong Huang Jianan Li Hongfeng Yi Birun Huang Zhongwei Zhao Duiping Feng Yanming Lei Changlong Hou Wenbo Guo Shirong Liu Gaojun Teng Kangshun Zhu Fan Wu Xiaogang Hu Wenfeng zhang Shaoqi Yang Zhouchao Hu Pengfei Pang Shaowu Zhuang Weidong Wang Qingliang Zhu Kunpeng zhang Chengyu Liu Dongliang Li Chao Ma Hong Jiang Xingong Zhao Weixin Ren Zhiwei Wang Lei Yu Fuhuang Lin Chaoguang Yan Feng Wang Lei Yu Hui Huan Wenyong Shen Shaofei He Chengda zhang Jinlun Bao Jiangtao Liu Jun Wu Jianbo Zhao Jian zhang Xiaolong Qi Hebei Provincial Key Laboratory of Cirrhosis&Portal Hypertension Xingtai People's HospitalXingtaiHebeiChina Center of Portal Hypertension Department of RadiologyZhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsuChina Department of Interventional Therapy Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijingChina Department of Intervention Taiyuan Third People's HospitalTaiyuanShanxiChina Department of Intervention Zhongshan Hospital Affiliated to Fudan UniversityShanghaiChina Department of Interventional Medicine The First Hospital of Lanzhou UniversityLanzhouGansuChina Department of Infectious Diseases Nanfang Hospital of Southern Medical UniversityGuangzhouGuangdongChina Hepatobiliary and Pancreatic Intervention Center The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangChina Interventional Vascular Surgery Hunan Provincial People's HospitalChangshaHunanChina Department of Intervention Sixth People's Hospital of ShenyangShenyangLiaoningChina Department of Gastroenterology West China Hospital of Sichuan UniversityChengduSichuanChina Department of Intervention The Fourth People's Hospital of Qinghai ProvinceXiningQinghaiChina Department of Gastroenterology Nanjing Drum Tower HospitalNanjingJiangsuChina Department of Gastroenterology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Radiology Shulan(Hangzhou)HospitalHangzhouZhejiangChina Department of Intervention Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouFujianChina Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxiChina Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Department of Interventional Radiology Fifth Medical Center

Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in *** article aimed to investigate the status of hepatic venous pressure gradient measurement in China in ***:We investigated the overall status of HVPG technology in China-including hospital distribution,hospital level,annual number of cases,catheters used,average cost,indications,and current challenges by using online *** counting the number and percentages of cases of these results,we hope to clarify the current status of HVPG measurements in ***:According to the survey,85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces.A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022,of which 2813 cases(56.4%)were measured *** average cost of HVPG measurement was 5646.8±2327.9 *** the clinical teams who performed the measurements(sometimes multiple per hospital),94.3%(82/87)used the balloon method,and the majority of the teams(72.4%,63/87)used embolectomy ***:This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this *** is still necessary to continue promoting and popularizing this technology in the future.

关键词： application status hepatic vein pressure gradient questionnaire survey

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Stability of Time-varying Linear Systems with Time Delays

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Systems Science and Systems Engineering 1996年第2期6卷 175-178页

作者： sun jitao zhang Yingping(Dapt.of Math.,East China Institute of Metallurgy,Maanshan,Anhui,243002,China)

Easy ways to test the stability of systems involving time delays have been *** this paper,some unconditional stability and asymptotically stable with decay rate α criteria for time-varying linear systems with time de... 详细信息

关键词： Stability of Time-varying Linear Systems with Time Delays

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肝静脉压力梯度微创时代:基于前臂静脉入路的探索

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中华肝脏病杂志 2024年第1期32卷 35-39页

作者：王继涛李雷牛猛朱清亮赵中伟 Kohei Kotani Akira Yamamoto 张海军李双喜徐丹康宁李小果张昆鹏孙骏吴发宗张海龙刘登湘吕沐瀚纪建松 Norifumi Kawada 徐克祁小龙河北省肝硬化门静脉高压重点实验室河北医科大学附属邢台市人民医院邢台054000 兰州大学第一医院介入科兰州730000 中国医科大学附属第一医院介入科沈阳110000 西南医科大学附属医院消化内科泸州646000 丽水市中心医院介入诊疗中心丽水323000 日本大阪市立大学医院肝病科日本大阪日本大阪市立大学医学院放射介入科日本大阪东南大学附属中大医院门静脉高压中心南京210009

目的经颈静脉或经股动脉途径被用作当前实践中肝静脉压力梯度(HVPG)测量的常用方法。该研究旨在证实经前臂静脉途径测量HVPG的安全性和有效性。方法针对2020年9月至2020年12月前瞻性地从中国和日本的6所医院招募了经前臂静脉进行HVPG检... 详细信息

目的经颈静脉或经股动脉途径被用作当前实践中肝静脉压力梯度(HVPG)测量的常用方法。该研究旨在证实经前臂静脉途径测量HVPG的安全性和有效性。方法针对2020年9月至2020年12月前瞻性地从中国和日本的6所医院招募了经前臂静脉进行HVPG检测肝硬化患者,并收集患者的临床基线资料以及HVPG检测数据。入组患者均选择经右侧肘正中静脉或贵要静脉入路,采用HVPG标准化流程进行测压。研究数据采用SPSS 22.0统计学软件进行分析。定量资料采用中位数(四分位数间距)表示,定性资料采用频数和率表示。两组数据之间的相关性分析采用Pearson相关性分析。结果研究共入组43例患者,其中41例(95.3%)患者成功接受了经前臂静脉途径HVPG检测。无患者出现任何严重并发症。经前臂静脉途径HVPG检测中位操作时间为18.0min(12.3~38.8min)。研究证实HVPG与Child-Pugh评分(r=0.47,P=0.002)、白蛋白-胆红素评分(r=0.37,P=0.001)、Lok指数(r=0.36,P=0.02)、肝脏硬度(r=0.58,P=0.01)、脾硬度(r=0.77,P=0.01)呈正相关,且与白蛋白呈负相关(r=-0.42,P=0.006)。结论多中心回顾性研究结果提示经前臂静脉途径HVPG测量是安全可行的。

关键词：肝硬化肝静脉压力梯度前臂静脉

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绞股蓝总皂苷通过PPAR-γ与Wnt途径影响大鼠动脉粥样硬化及部分有效成分预测

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贵州医科大学学报 2024年第7期49卷 957-965页

作者：首朝曦张吉涛吴宁谢振欣刘宇航马粉花冯静李豪孙见飞廖健贵州医科大学口腔医学院贵州贵阳550004 綦江区疾病预防控制中心重庆綦江401420 贵州医科大学基础医学院贵州贵阳550004 昭通市第一人民医院云南昭通657000 贵州医科大学临床医学院贵州贵阳550004

目的探讨绞股蓝总皂苷对动脉粥样硬化大鼠主动脉炎症反应的影响及预测部分绞股蓝有效成分。方法将60只SD大鼠分为空白对照组(Nor组,)、模型组(Mod组)、辛伐他汀组(Sim组,5 mg/kg灌胃,13周)、绞股蓝总皂苷组(GPs组,160 mg/kg灌胃,13周)、... 详细信息

目的探讨绞股蓝总皂苷对动脉粥样硬化大鼠主动脉炎症反应的影响及预测部分绞股蓝有效成分。方法将60只SD大鼠分为空白对照组(Nor组,)、模型组(Mod组)、辛伐他汀组(Sim组,5 mg/kg灌胃,13周)、绞股蓝总皂苷组(GPs组,160 mg/kg灌胃,13周)、GW9662组(PPAR-γ抑制剂,10 mg/kg灌胃,13周)及GPs+GW9662组[GPs 160 mg/kg及GW966210 mg/(kg·d),灌胃,13周],其中Nor组普通饮食,其他组予以高脂饲料联合腹腔注射维生素D 3以构建动脉粥样硬化大鼠模型;建模13周后取大鼠血液、胸主动脉和腹主动脉,HE切片染色观察胸主动脉组织学变化,ELISA测定血清中IL-6含量,Western blot检测腹主动脉过氧化酶体增殖物激活受体-γ(PPAR-γ),Wnt3a及β-catenin蛋白表达、qRT-PCR检测腹主动脉PPAR-γ及Wnt3a及β-catenin mRNA表达;利用分子对接初步筛选绞股蓝总皂苷与PPAR-γ亲和力较高的有效成分。结果与Nor组比较,Mod组及其他干预组大鼠主动脉切片可见AS特征性病变,其中GW9662组病变明显,辛伐他汀和绞股蓝总皂苷各干预组病变较轻;与Mor组相比,GPs组大鼠血清白细胞介素-6(IL-6)含量显著减少;与Mor组大鼠腹主动脉比较,GPs组PPAR-γ蛋白和mRNA的表达显著减少(P<0.05)、其他非阳性对照干预组均不同程度增高,而Mor组Wnt3a、β-catenin和mRNA表达与Nor组相比明显升高(P<0.05)、其他非阳性对照干预组均不同程度减少,其中GPs组显著降低;分子对接结果显示野黄芩苷、胆固醇、菜油甾醇、谷甾醇、3′-甲基鼠李素对PPAR-γ具有较强的亲和力。结论绞股蓝总皂苷可能是通过调节PPAR-γ与Wnt经典途径改善大鼠动脉粥样硬化,野黄芩苷、胆固醇、菜油甾醇、谷甾醇、3′-甲基鼠李素成分是绞股蓝部分有效成分。

关键词：绞股蓝总皂苷动脉粥样硬化过氧化酶体增值物激活受体-γ Wnt/β-catenin经典途径炎症反应分子对接

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Robust Stabilization for Uncertain Control Systems Using Piecewise Quadratic Lyapunov Functions

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Journal of Systems Engineering and Electronics 2002年第4期13卷 56-60页

作者： zhang Yinping & sun jitao Dept. of Appl. Math., Tongji University, Shanghai 200092, P. R. China Dept. of Appl. Math. Tongji University Shanghai 200092 P. R. China

The sufficient condition based on piecewise quadratic simultaneous Lyapunov functions for robust stabilization of uncertain control systems via a constant linear state feedback control law is obtained. The objective is to use a robust stability criterion that is less conservative than the usual quadratic stability criterion. Numerical example is given, showing the advanteges of the proposed method.

关键词： Robust State feedback control, Stabilizing uncertain system.

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Exponential Stability of Interval Time-Varying Dynamical System with Multidelay

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Journal of Systems Engineering and Electronics 2002年第1期13卷 8-12页

作者： sun jitao & zhang Yinping Dept. of Application Mathematics, Tongji University, Shanghai 200092, P.R.China Liu Yongqing & Deng Feiqi Dept. of Automation, South China University of Technology, Guangzhou 510640, P.R.China Dept. of Application Mathematics Tongji University Shanghai 200092 P. R. China Dept. of Automation South China University of Technology Guangzhou 510640 P. R. China

This paper studies the exponential stability of interval time-varying dynamical system with multidelay. By the matrix measure and delay differential inequality, some sufficient conditions for exponential stability of interval time-varying dynamical system with multidelay are established. These conditions are an improvement and extension of the results achieved in earlier papers. Finally, a numerical example is given to demonstrate our result.

关键词： Dynamics Matrix algebra System stability Uncertain systems

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