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Wrecking neutrophil extracellular traps and antagonizing cancer-associated neurotransmitters by interpenetrating network hydrogels prevent postsurgical cancer relapse and metastases

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Bioactive Materials 2024年第9期39卷 14-24页

作者： Hang Zhou Chunyan Zhu Qing Zhao Jinliang Ni Haipeng Zhang Guangcan Yang jianchao ge Chao Fang Hong Wei Xianli Zhou Kun Zhang In-Patient Ultrasound Department Second Affiliated Hospital of Harbin Medical UniversitySurgeons’HallNo.246.XuefuRoadNangang DistrictHarbin CityHeilongjiang ProvPR China Department of Laboratory Medicine and Central Laboratory Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of Chin1No.32West Second SectionFirst Ring RoadChengdu610072SichuanPR China Ultrasound Research and Education Institute Shanghai Tenth People’s HospitalTongji University School of MedicineNo.301 Yan-chang-zhong RoadShanghai

Tumor-promoting niche after incomplete surgery resection(SR)can lead to more aggressive local progression and distant metastasis with augmented angiogenesis-immunosuppressive tumor microenvironment(TME).Herein,elevated neutrophil extracellular traps(NETs)and cancer-associated neurotransmitters(CANTs,e.g.,catecholamines)are firstly identified as two of the dominant ***,an injectable fibrin-alginate hydrogel with high tissue adhesion has been constructed to specifically co-deliver NETs inhibitor(DNase I)-encapsulated PLGA nanoparticles and an unselectiveβ-adrenergic receptor blocker(propranolol).The two components(i.e.,fibrin and alginate)can respond to two triggers(thrombin and Ca2+,respectively)in postoperative bleeding to gelate,shaping into an interpenetrating network(IPN)featuring high *** continuous release of DNase I and PR can wreck NETs and antagonize catecholamines to decrease microvessel density,blockade myeloid-derived suppressor cells,secrete various proinflammatory cytokines,potentiate natural killer cell function and hamper cytotoxic T cell *** reprogrammed TME significantly suppress locally residual and distant tumors,induce strong immune memory effects and thus inhibit lung ***,targetedly degrading NETs and blocking CANTs enabled by this in-situ IPN-based hydrogel drug depot provides a simple and efficient approach against SR-induced cancer recurrence and metastasis.

关键词： Neutrophil extracellular traps Cancer-associated neurotransmitters Interpenetrating network hydrogels Postsurgical cancer relapse and metastases Immunosuppressive tumor microenvironment

一种Gaussian-Hermite矩分块重构的抗几何攻击水印算法

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西安交通大学学报 2014年第4期48卷 20-25页

作者：贾晓琳葛建超綦艳丽邵利平西安交通大学电子与信息工程学院西安710049 陕西师范大学计算机科学学院西安710062

针对目前抗几何攻击水印算法易在大尺度几何攻击下失效的问题,提出了一种基于几何校正和分块重构的局部区域水印算法,从而提高水印的鲁棒性和提取精度。该算法利用图像不变质心进行几何形变参数的估计,对图像进行几何校正以实现载体的同... 详细信息

针对目前抗几何攻击水印算法易在大尺度几何攻击下失效的问题,提出了一种基于几何校正和分块重构的局部区域水印算法,从而提高水印的鲁棒性和提取精度。该算法利用图像不变质心进行几何形变参数的估计,对图像进行几何校正以实现载体的同步;根据几何攻击对图像视觉质量影响的分析,筛选可嵌入分块;利用高斯-埃尔米特矩良好的图像重构能力,修改特定矩集,实现水印嵌入,获得含水印图像。为验证算法的抗几何攻击能力,对含水印载体图像遭受旋转、缩放、平移和其他常规性攻击后的性能进行了实验测试。实验结果表明,所提算法可抵抗多种几何攻击及常规图像攻击,能提取出较高精度的水印信息,相对于其他算法,水印的鲁棒性虽然相差无几但在保持较高视觉不可见性的前提下,嵌入容量有了一定程度的提高。

关键词：数字水印几何攻击不变质心高斯-埃尔米特矩

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内镜技术在治疗胃食管反流病中的研究进展

胃肠病学 2014年第12期19卷 753-756页

作者：葛建超王云谭佳成王颖林琳南京医科大学第一附属医院消化科 210029

胃食管反流病(geRD)是由下食管括约肌(LES)功能不全导致胃、十二指肠内容物反流入食管引起不适症状和(或)并发症的一种疾病。目前geRD的主要治疗方法是药物和外科手术,但geRD患者多数需长期服药、且外科术后并发症较多。内镜技术是治疗G... 详细信息

胃食管反流病(geRD)是由下食管括约肌(LES)功能不全导致胃、十二指肠内容物反流入食管引起不适症状和(或)并发症的一种疾病。目前geRD的主要治疗方法是药物和外科手术,但geRD患者多数需长期服药、且外科术后并发症较多。内镜技术是治疗geRD的微创方法,可安全、有效改善geRD症状,特别是Stretta射频治疗、内镜下经口无创胃底折叠术(TIF)以及Lin X抗反流系统等。本文就内镜技术在治疗geRD中的研究进展作一综述。

关键词：胃食管反流食管内镜治疗经口无创胃底折叠术 LinX抗反流系统

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联合作战指挥信息系统软件可靠性设计

指挥信息系统与技术 2021年第6期12卷 85-93页

作者：刘猛潘仁前葛建超中国电子科技集团公司第二十八研究所南京210023

针对联合作战指挥信息系统网络化和服务化的特点,基于典型软件可靠性模型分析,研究了可提升系统可靠性的理论方法。根据各类软件的不同技术特点,将软件分为数据、传输、无状态应用和有状态应用等服务模式,给出了可靠性设计流程及设计要... 详细信息

针对联合作战指挥信息系统网络化和服务化的特点,基于典型软件可靠性模型分析,研究了可提升系统可靠性的理论方法。根据各类软件的不同技术特点,将软件分为数据、传输、无状态应用和有状态应用等服务模式,给出了可靠性设计流程及设计要点,分析了可靠性关键技术,从而为联合作战指挥信息系统软件可靠性设计提供参考。

关键词：集群无状态应用有状态应用

无创机械通气在卒中相关性肺炎患者中的临床应用

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当代医学 2022年第34期28卷 17-20页

作者：徐薛芬葛建超刘洪泱李婷南京医科大学附属脑科医院老年医学科江苏南京210029

目的探讨无创机械通气在卒中相关肺炎(SAP)患者中的临床应用。方法回顾性分析2017年1月至2020年12月本院收治的89例SAP患者的临床资料,根据有无使用无创机械通气分为观察组(n=43)和对照组(n=46)。观察组给予无创机械通气治疗,对照组给... 详细信息

目的探讨无创机械通气在卒中相关肺炎(SAP)患者中的临床应用。方法回顾性分析2017年1月至2020年12月本院收治的89例SAP患者的临床资料,根据有无使用无创机械通气分为观察组(n=43)和对照组(n=46)。观察组给予无创机械通气治疗,对照组给予常规吸氧治疗。比较两组临床疗效、治疗前后血气分析指标[血氧饱和度(SaO_(2))、氧分压(PO_(2))、二氧化碳分压(PCO_(2))、乳酸(Lac)]及炎症因子指标[C-反应蛋白(CRP),白细胞介素-6(IL-6)、降钙素原(PCT)]。结果观察组治疗总有效率为88.37%,高于对照组的71.73%,差异有统计学意义(P<0.05)。治疗后,两组SaO_(2)、PO2水平高于治疗前,PCO_(2)、Lac水平低于治疗前,且观察组SaO_(2)、PO_(2)水平高于对照组,PCO_(2)、Lac水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组CRP、IL-6、PCT水平均低于治疗前,且观察组CRP、PCT均低于对照组,差异有统计学意义(P<0.05),两组IL-6水平比较差异无统计学意义。结论无创机械通气治疗SAP疗效显著,其操作简单,安全性高,患者及家属接受度高,可明显降低气管插管率,有效缓解病情,缩短住院时间,减少费用,值得临床推广应用。

关键词：无创机械通气卒中相关性肺炎炎症因子

Multi-layer collaborative optimization fusion for semi-supervised learning

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Chinese Journal of Aeronautics 2023年第11期36卷 342-353页

作者： Quanbo ge Muhua LIU jianchao ZHANG Jianqiang SONG Junlong ZHU Mingchuan ZHANG School of Automation Nanjing University of Information Science and TechnologyNanjing 210044China School of Information Engineering Henan University of Science and TechnologyLuoyang 471023China Qiandao Lake Institute of Science Hangzhou 311799China

Recently,the Cooperative Training Algorithm(CTA),a well-known Semi-Supervised Learning(SSL)technique,has garnered significant attention in the field of image ***,traditional CTA approaches face challenges such as high computational complexity and low classification *** overcome these limitations,we present a novel approach called Weighted fusion based Cooperative Training Algorithm(W-CTA),which leverages the cooperative training technique and unlabeled data to enhance classification ***,we introduce the K-means Cooperative Training Algorithm(km-CTA)to prevent the occurrence of local optima during the training ***,we conduct various experiments to verify the performance of the proposed *** results show that W-CTA and km-CTA are effective and efficient on CIFAR-10 dataset.

关键词： Collaborative training Fusion Image classification K-means algorithm Semi-supervised learning

Control on Gradient Adhesive Loading of Porous Laminate:Effects on Multiple Performance of Composites with Bamboo Bundle and Sliver

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Journal of Renewable Materials 2021年第9期9卷 1555-1570页

作者： jianchao Deng Haiying Zhou Fuming Chen Shuangbao Zhang ge Wang Beijing Key Laboratory of Wood Science&Engineering College of Material Science&TechnologyBeijing Forestry UniversityBeijing100083China Key Laboratory of National Forestry and Grassland Administration/Beijing for Bamboo&Rattan Science and Technology International Center for Bamboo and RattanBeijing100102China

Elementary units“bamboo bundle”and“bamboo sliver”were processed and cross-linked as“bamboo-bundle veneer(BBV)”and“bamboo-sliver veneer(BSV)”for preparation of laminated *** concept of“high-content-adhesive surface treatment”was raised to improve boards’performance,rather than increasing adhesive absorption of every layer’s porous *** is,some BBVs experienced an extra“dipping&drying”to absorb more resin(named“HBBV”).The effect of the amount of knitting threads was also discussed for influencing BBV’s *** indicated that light transmittance of BBVs decreased as the amount of threads added from 3 to 8,while mechanical stiffness *** two skin layers of HBBVs symmetrically was helpful to enhance 24-hour underwater and 28-hour“boil-dry-boil”dimensional stability for boards with BSVs as core,while more than two pairs of HBBVs were needed to improve 28-hour“boil-dry-boil”dimensional stability of boards with BBVs as *** symmetrical surface layers of BBVs/HBBVs provided BSV-boards/BBV-boards with greater bending resistance,while such“surface treatment”would not raise shearing strength of BSV-boards upon 28-hour“boil-dry-boil”***,the data obtained from drop-hammer impact test indicated that more than two pair of surface BBVs or HBBVs were required for significant improvement in anti-impact property.

关键词： Bamboo bundle bamboo sliver laminated composites adhesive loading surface treatment

A Novel Ultra Short-Term Load Forecasting Method for Regional Electric Vehicle Charging Load Using Charging Pile Usage Degree

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Energy Engineering 2023年第5期120卷 1107-1132页

作者： Jinrui Tang Ganheng ge jianchao Liu Honghui Yang School of Automation Wuhan University of TechnologyWuhan430070China

Electric vehicle(EV)charging load is greatly affected by many traffic factors,such as road *** ultra short-term load forecasting(STLF)results for regional EV charging load are important to the scheduling plan of regional charging load,which can be derived to realize the optimal vehicle to grid *** this paper,a regional-level EV ultra STLF method is proposed and *** usage degree of all charging piles is firstly defined by us based on the usage frequency of charging piles,and then constructed by our collected EV charging transactiondata in ***,these usagedegrees are combinedwithhistorical charging loadvalues toform the inputmatrix for the deep learning based load ***,long short-termmemory(LSTM)neural network is used to construct EV charging load forecastingmodel,which is trained by the formed *** comparison experiment proves that the proposed method in this paper has higher prediction accuracy compared with *** addition,load characteristic index for the fluctuation of adjacent day load and adjacent week load are proposed by us,and these fluctuation factors are used to assess the prediction accuracy of the EV charging load,together with the mean absolute percentage error(MAPE).

关键词： Electric vehicle charging load density-based spatial clustering of application with noise long-short termmemory load forecasting

Testing final closure time of the Paleo-Asian Ocean along the Solonker suture by a transition of compressional and extensional setting

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geoscience Frontiers 2020年第6期11卷 1935-1951页

作者： Haidong Zhang jianchao Liu Jinkun Yang Jiakun ge Jinya Wang Zhen Li The School of Earth Science and Resources Chang’an UniversityXi’an 710054China Department of geology Northwest UniversityXi’an 710069China Laboratory of Mineralization and Dynamics Chang’an UniversityXi’an 710054China Anhui Branch of China National geological Exploration Center of Building Material Industry Hefei 230022China

The giant Central Asian Orogenic Belt is an extensive accretionary orogen,of which the Solonker suture,as a major regional suture,coincides closely with an early Permian paleobiogeographical *** suture is considered to mark the location of the final closure of the Paleo-Asian Ocean between the North China Craton and the Mongolian *** the closure time of the Paleo-Asian Ocean along the Solonker suture has generally been regarded as Late Permian-Early Triassic,uncertainty remains because of a lack of typical collisionrelated features(e.g.,high-grade regional metamorphism and well-developed fold-thrust structures)and a scarcity of *** present study reports Early Permian foliated gabbros and dikes(288-275 Ma)and Middle-Late Permian undeformed layered gabbros,strongly peraluminous granites,and I-type granites(265-254 Ma)in the Xinhure area along the northern margin of the North China *** Early Permian foliated intrusions have a subduction-related geochemical signature and were derived from partial melting of lithospheric mantle modified by subduction-related melts or fluids at the active margin of the North China *** contrast,the Late Permian undeformed layered gabbros and strongly peraluminous granites were derived from partial melting of lithospheric mantle and middle-upper crust,respectively,triggered by asthenospheric ***,a transition from an end-compressional to an extensional environment according to a transition from collision termination to postcollision of the North China Craton and Mongolian Terrane may have occurred between 275 Ma and 262 *** time span can be considered as the final closure time of the Paleo-Asian Ocean along the Solonker suture.

关键词： Central Asian orogenic belt Solonker suture Layered gabbro Strongly peraluminous granite Paleo-Asian ocean closure time