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柱花草SgMPK6互作蛋白的筛选与验证

草业学报 2024年第7期33卷 84-93页

作者：王芳张世子戴镕徽杨丽云罗丽娟蒋凌雁海南大学热带农林学院海南海口570228 海南大学三亚南繁研究院海南三亚572025

丝裂原活化蛋白激酶(MAPK)级联反应在调节植物免疫中起关键作用。柱花草炭疽病是危害柱花草生产的严重病害,柱花草SgMPK6基因具有抗炭疽菌的功能。为探究响应胶孢炭疽菌侵染的柱花草SgMPK6下游互作蛋白,本研究采用酵母双杂交技术,以SgM... 详细信息

丝裂原活化蛋白激酶(MAPK)级联反应在调节植物免疫中起关键作用。柱花草炭疽病是危害柱花草生产的严重病害,柱花草SgMPK6基因具有抗炭疽菌的功能。为探究响应胶孢炭疽菌侵染的柱花草SgMPK6下游互作蛋白,本研究采用酵母双杂交技术,以SgMPK6激酶结构域作为诱饵蛋白,筛选柱花草cDNA文库,共获得74个与SgMPK6激酶结构域潜在的互作蛋白,并通过酵母双杂交点对点试验,验证了候选互作蛋白SgbHLH32、SgbHLH33、SgbHLH44与SgMPK6激酶结构域间的互作关系。磷酸化位点预测显示,3个bHLH转录因子均具有MAPKs潜在的磷酸化位点。柱花草响应炭疽菌侵染的qRT-PCR分析表明,SgbHLH32、SgbHLH33、SgbHLH44转录因子均显著上调,预示互作蛋白可能作为SgMPK6的底物调控柱花草对炭疽病的抗性。本研究为进一步解析SgMPK6响应炭疽菌侵染的分子机制提供了试验依据。

关键词：柱花草酵母双杂交 MPK6 炭疽病 bHLH转录因子

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An overview and perspective of identifying lunar craters

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Science China Earth Sciences 2024年第5期67卷 1395-1416页

作者： yan jiang Changyi Xu ling CHEN State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100029China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100049China

The spatiotemporal evolution of lunar impact craters is crucial for investigating lunar interior structure,internal and external dynamic processes,and interplanetary impact *** in lunar crater identification are reviewed based on topography and gravity data,and the features and mechanisms of topographic or buried craters are analyzed regarding morphology,gravity anomalies,gravity gradients,and the underlying crust-mantle interface *** on the compiled crater catalog,the early lunar impact flux and thermal evolution are further discussed according to the basin ages and their interior *** some ancient impact basins,the crater size-frequency distribution measurements revealed age discrepancies from previous studies,suggesting that the lunar late heavy bombardment event started at~3.95 *** degraded bulge structures of the crust-mantle interface beneath mare basins reveal that these basins formed on the lunar crust surface under high-temperature conditions and underwent prolonged relaxation compared to highland ***,we reveal that the up-to-date identification of lunar buried craters remains inaccurate and incomplete,preventing us from accurately reconstructing lunar and interplanetary impact ***,we propose that a gravity model constructed using localized orthogonal basis functions can be useful for identifying lunar craters.

关键词： Moon Gravity field Craters Impact flux Early evolution

Mechanism study of Cu(Ⅱ) adsorption from acidic wastewater by ultrasonic-modified municipal solid waste incineration fly ash

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Chinese Journal of Chemical Engineering 2024年第3期67卷 157-165页

作者： Shunda lin yang Lu Lin Zheng ling Long Xuguang jiang Jianhua yan State Key Laboratory of Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou 310027China Zhejiang University Qingshanhu Energy Research Center Hangzhou 310027China Hangzhou Xiaoshan Jinjiang Green Energy Co. Ltd.XiaoshanHangzhou 310000China

High concentrations of copper ions(Cu(Ⅱ)) in water will pose health risks to humans and the ecological environment. Therefore, this study aims to utilize ultrasonic-cured modified municipal solid waste incineration(MSWI) fly ash for Cu(Ⅱ) adsorption to achieve the purpose of “treating waste by waste.” The effects of p H, adsorption time, initial concentration, and temperature on the modified MSWI fly ash’s adsorption efficiency were systematically studied in this article. The adsorption performance of the modified MSWI fly ash can be enhanced by the ultrasonic modification. At pH = 2, 3 and 4, the adsorption capacity of the modified MSWI fly ash for Cu(Ⅱ) increased by 2.7, 1.9 and 1.2 times, respectively. Furthermore, it was suggested that the adsorption process of the modified MSWI fly ash can be better simulated by the pseudo-second-order kinetic model, with a maximum adsorption capacity calculated by the Langmuir model of 24.196 mg.g-1. Additionally, the adsorption process is spontaneous,endothermic, and chemisorption-dominated from the thermodynamic studies(ΔH and ΔS > 0, ΔG < 0).Finally, the enhanced adsorption performance of the modified MSWI fly ash for Cu(Ⅱ) may be attributed to electrostatic interaction and chelation effects.

关键词： Ultrasound MSWI fly ash Cu(Ⅱ) Wastewater Adsorption

口服固体制剂颗粒的离散元建模与破碎行为分析

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药学学报 2024年第4期59卷 1057-1066页

作者：罗林秀管天冰罗安琪刘曾王宇婷姜彦伶路政唐劲草陈双扣孙会敏戴传云重庆科技大学化学化工学院制药过程数字化重庆市重点实验室重庆401331 中国食品药品检定研究院北京100050

单元颗粒在口服固体制剂(oral solid dosage forms,OSD)生产过程中的破碎规律与中间产品或终产品的质量息息相关。为精准表征颗粒和探索颗粒破碎演变规律,本论文采用离散元Bonding模型研究模型参数、颗粒形状和工艺条件(加载模式和加载... 详细信息

单元颗粒在口服固体制剂(oral solid dosage forms,OSD)生产过程中的破碎规律与中间产品或终产品的质量息息相关。为精准表征颗粒和探索颗粒破碎演变规律,本论文采用离散元Bonding模型研究模型参数、颗粒形状和工艺条件(加载模式和加载速率)对颗粒破碎的影响,以动态形变、力-时间曲线、破碎率、最大碎片尺寸比和断裂强度等表征颗粒破碎规律。结果表明,颗粒破碎受力分别与法向强度、黏结半径呈正相关,与单位面积法向刚度、单位面积切向刚度呈负相关,与切向强度呈弱相关;颗粒的破碎率与颗粒的长径比呈负相关,最大碎片尺寸比与颗粒的长径比呈正相关;三种加载模式中,压缩加载破碎率最大,剪切加载破碎率次之,磨损加载破碎率最小,且最大碎片尺寸比与加载速率呈正相关,加载模式和加载速率对颗粒破碎率无相互影响,但对最大碎片尺寸比有相互影响。研究结果将为我国OSD由批制造向先进制造转变提供理论基础。

关键词：原辅料颗粒离散元建模 Bonding模型破碎规律

Ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/GSK-3βSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第7期30卷 588-599页

作者： jiang Yu-xia ZHAO yan-na YU Xiao-ling YIN Li-ming Department of Hematology Tongde Hospital of Zhejiang ProvinceHangzhou310012China Institute of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China

Objective To investigate the role of ginsenoside Rd(GRd)in acute myeloid leukemia(AML)cell *** AML cells were treated with GRd(25,50,100 and 200µg/mL),retinoic acid(RA,0.1g/L)and PD98059(20 mg/mL)for 72 h,cell survival was detected by methylthiazolyldiphenyl-tetrazolium bromide and colony formation assays,and cell cycle was detected by flow *** morphology and differentiation were observed by Wright-Giemsa staining,peroxidase chemical staining and cellular immunochemistry assay,*** protein expression levels of GATA binding protein 1(GATA-1),purine rich Box-1(PU.1),phosphorylated-extracellular signal-related kinase(p-ERK),ERK,phosphorylated-glycogen synthase kinase-3β(p-GSK3β),GSK3βand signal transducer and activator of transcription 1(STAT1)were detected by Western ***-six mice were randomly divided into 3 groups using a random number table:model control group(non-treated),GRd group[treated with 200 mg/(kg·d)GRd]and homoharringtonine(HTT)group[treated with 1 mg/(kg·d)HTT].A tumor-bearing nude mouse model was established,and tumor weight and volume were *** of subcutaneous tumor tissue were observed after hematoxylin and eosin ***1 and GATA-1 expressions were detected by immunohistochemical *** The cell survival was inhibited by GRd in a dose-dependent manner and GRd caused G0/G1 cell arrest(p<0.05).GRd treatment induced leukemia cell differentiation,showing increased expressions of peroxidase and specific proteins concerning erythrogenic or granulocytic differentiation(p<0.05).GRd treatment elicited upregulation of p-ERK,p-GSK-3βand STAT1 expressions in cells,and reversed the effects of PD98059 on inhibiting the expressions of peroxidase,GATA-1 and PU.1(P<0.05).After GRd treatment,tumor weight and volume of mice were decreased,and tumor cells underwent massive apoptosis and necrosis(P<0.05).WT1 level was decreased,and GATA-1 level was significantly increased in subcutaneous tumor ti

关键词： ginsenoside Rd myeloid leukemia survival differentiation extracellular signal-related kinase signaling pathway

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鸡新城疫抗体消长规律及血清抗体稳定性

湖北农业科学 2024年第6期63卷 137-140页

作者：蒋玲艳王林果张在于乐秦张善广西农业职业技术大学动物科技学院南宁530007 普莱柯生物工程股份有限公司河南洛阳471000

为研究鸡新城疫灭活疫苗免疫后抗体消长规律及血清抗体稳定性,采用血凝抑制试验方法测定新城疫病毒-禽流感病毒(H9亚型)二联灭活疫苗免疫鸡血清新城疫抗体效价及经室温、4℃、-20℃、-80℃反复冻融和加热等不同方式处理的血清中新城疫... 详细信息

为研究鸡新城疫灭活疫苗免疫后抗体消长规律及血清抗体稳定性,采用血凝抑制试验方法测定新城疫病毒-禽流感病毒(H9亚型)二联灭活疫苗免疫鸡血清新城疫抗体效价及经室温、4℃、-20℃、-80℃反复冻融和加热等不同方式处理的血清中新城疫抗体效价。结果表明,试验鸡于1日龄和21日龄用灭活疫苗免疫两次后,在第二次免疫后14 d新城疫抗体平均效价达到8.1 log_(2),35 d达到最高值为8.9 log_(2);免疫后70 d抗体效价保持在7.8 log_(2),且自二免后14~70 d,新城疫抗体效价维持在7.8 log_(2)~8.9 log_(2)。血清新城疫抗体在室温和4℃相对稳定,室温下放置13 d对新城疫抗体效价几乎无影响;但4℃保存9 d,对新城疫抗体效价有一定影响,且差异显著(P<0.05);56℃下30 min对新城疫抗体效价无影响;反复冻融3次对新城疫抗体效价影响极显著(P<0.01)。肉鸡于1日龄和21日龄用灭活疫苗免疫两次后,新城疫抗体水平高,且高水平抗体维持时间长。鸡血清新城疫抗体可耐56℃加热,室温保存活性稳定,反复冻融则影响其效价。

关键词：鸡新城疫 HI试验抗体效价灭活疫苗抗体稳定性血清保存

Optimal AP Deployment in Cell-Free Massive MIMO Systems with LoS/NLoS Transmissions:A Stochastic Geometry Approach

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China Communications 2024年第9期21卷 146-158页

作者： jiang ling Zhang Qi Zhu Hongbo jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and TelecommunicationsNanjing 210003China

Cell-free massive multiple-input multipleoutput(MIMO)is a promising technology for future wireless communications,where a large number of distributed access points(APs)simultaneously serve all users over the same time-frequency *** users and APs may locate close to each other,the line-of-sight(Lo S)transmission occurs more frequently in cell-free massive MIMO ***,in this paper,we investigate the cell-free massive MIMO system with Lo S and non-line-of-sight(NLo S)transmissions,where APs and users are both distributed according to Poisson point *** tools from stochastic geometry,we derive a tight lower bound for the user downlink achievable rate and we further obtain the energy efficiency(EE)by considering the power consumption on downlink payload transmissions and circuitry *** on the analysis,the optimal AP density and AP antenna number that maximize the EE are *** is found that compared with the previous work that only considers NLo S transmissions,the actual optimal AP density should be much smaller,and the maximized EE is actually much higher.

关键词： cell-free massive MIMO energy efficiency LoS/NLoS transmissions stochastic geometry

Research progress and strategies for multifunctional rapeseed： A case study of China

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Journal of Integrative Agriculture 2016年第8期15卷 1673-1684页

作者： FU Dong-hui jiang ling-yan Annaliese S Mason XIAO Mei-li ZHU Long-rong LI Li-zhi ZHOU Qing-hong SHEN Chang-jian HUANG Chun-hui Key Laboratory of Crop Physiology Ecology and Genetic Breeding Ministry of Education/Agronomy College Jiangxi Agricultural University Nanchang 330045 P.R.China Department of Biochemistry University of Missouri Columbia 65211 USA Department of Plant Breeding IFZ Research Centre for Biosystems Land Use and Nutrition Justus Liebig University Heinrich- Buff-Ring 26-32 Giessen 35392 Germany jiangxi Province Key Laboratory of Animal Nutrition/Engineering Research Center of Feed Development Jiangxi Agricultural University Nanchang 330045 P.R. China Linli County Rural Practical Technology Research Institute Changde 415000 P.R. China

financially supported by the Key R＆D Program of jiangxi Province of China （20152ACF60010）;the Key Projects of Hunan Science and Technology Support Program of China （Application research of Guiye A male sterile line）;the Research Project of Humanities and Social Sciences in Universities of jiangxi Province, China（JC1315）;supported by Emmy Noether DFG grant MA 6473/1-1

关键词： multifunctional rapeseed sightseeing rapeseed remediation of cadmium pollution rapeseed oil fodder vegetables

Online Pareto optimal control of mean-field stochastic multi-player systems using policy iteration

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Science China(Information Sciences) 2024年第4期67卷 21-37页

作者： Xiushan jiang yanshuang WANG Dongya ZHAO ling SHI College of New Energy China University of Petroleum(East China) Department of Electronic and Computer Engineering Hong Kong University of Science and Technology

In this study, the Pareto optimal strategy problem was investigated for multi-player mean-field stochastic systems governed by It? differential equations using the reinforcement learning(RL) method.A partially model-free solution for Pareto-optimal control was derived. First, by applying the convexity of cost functions, the Pareto optimal control problem was solved using a weighted-sum optimal control problem. Subsequently, using on-policy RL, we present a novel policy iteration(PI) algorithm based on the Hrepresentation technique. In particular, by alternating between the policy evaluation and policy update steps,the Pareto optimal control policy is obtained when no further improvement occurs in system performance,which eliminates directly solving complicated cross-coupled generalized algebraic Riccati equations(GAREs).Practical numerical examples are presented to demonstrate the effectiveness of the proposed algorithm.

关键词： mean-field stochastic systems Pareto optimal control policy iteration scheme $\mathcal{H}$-representation