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“一贯煎”中外医学史课程教学模式的探索

中国中医药现代远程教育 2024年第14期22卷 30-33页

作者：宋一男徐梅汪剑谢洲杨艳林雅范文王维云南中医药大学基础医学院云南昆明650500 福建中医药大学药学院福建福州351022 昆明医科大学第二附属医院生殖医学科云南昆明650106

中外医学史是一门以多学科知识交叉融合为支撑的课程。在“新医科”建设要求指导下,帮助学生构建贯穿中西医的知识结构、形成贯通中西医的思维模式并贯注守正创新的精神,是培养优秀中西医临床医学人才的重要环节。团队以教学目标知识、... 详细信息

中外医学史是一门以多学科知识交叉融合为支撑的课程。在“新医科”建设要求指导下,帮助学生构建贯穿中西医的知识结构、形成贯通中西医的思维模式并贯注守正创新的精神,是培养优秀中西医临床医学人才的重要环节。团队以教学目标知识、能力、情感不同层级需求为基础,提出“贯穿-贯通-贯注”的“一贯煎”式教学模式,为开展构建多学科知识网络、提升中西医临床医学专业学生综合能力、熏陶学生完成课程思政情感素养内化的教学探索与实践提供了有效支撑;通过优化教学团队学科结构,重新搭建中外医学史知识结构体系,设置多个探讨式教学主题,灵活运用翻转课堂、情景演绎及辩论赛等多种形式,让中外医学史的课堂教学“活”了起来;为培养有思想、有技术、有深度、有灵魂的新时代中西医临床人才夯实了基础。

关键词：一贯煎贯穿-贯通-贯注中外医学史教学模式

A DFT study on the interaction of Co with an anatase TiO_2 (001)-(1×4) surface

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Journal of Natural Gas Chemistry 2009年第1期18卷 78-82页

作者： Zhijun Zuo wei Huang Peide Han Zhihong Li jian Huang Key Laboratory of Coal Science and Technology of Ministry of Education and Shanxi Province Taiyuan University of Technology Taiyuan 030024 Shanxi China College of Materials Science and Engineering Taiyuan University of Technology Taiyuan 030024 Shanxi China

The substitution/adsorption structures of Co on an anatase TiO2 （001）-（1 × 4） surface are investigated using the DFT/local density approximation （LDA） method. Theoretical calculation shows that the Co ion prefers to be adsorbed on the surface of anatase TiO2. The density of states （DOS） analysis finds that the Co 3d is located mainly in the energy gap region. The Co 3d partial density of states （PDOS） indicates that there is a substantial degree of hybridization between O 2s and Co 3d in valence band （VB） regions in the substitution models. The conclusion is that the mode of substitution is more active when the catalyst is a higher-energy surface.

关键词： DFT anatase (001)-(1 ×4) Co

Effect of rare earths on selective hydrogenation of p-chloronitrobenzene over PtMOx/CNTs catalysts

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Chinese Chemical Letters 2009年第1期20卷 96-98页

作者： Xiao Xiang Han jian Rong Li Ren Xian zhou Department of Applied Chemistry College of Food Science & Biotechnology Engineering Zhejiang Gongshang University Hangzhou 310035 China Institute of Catalysis Zhejiang University Hangzhou 310028 China

The effect of rare earths （Sm, Pr, Ce, Nd and La） on the hydrogenation properties ofp-chloronitrobenzene （CNB） over Pt/CNTs catalyst was studied in ethanol at 303 K and normal pressure. The results exhibited that the hydrogenation of p-CNB could be carried out over PtMOx/CNTs catalysts. Both catalytic activities and yields ofp-chloroaniline （CAN） were all improved. PtCeOx/ CNTs catalyst exhibited the best catalytic activity （TOF was 0.47 s^-1） and the highest yield of p-CAN （97.5 mol%）. PtCeOx/CNTs （1.0 wt%） catalyst exhibited good stability on the hydrogenation of p-CNB.

关键词： Rare earths Chloronitrobenzene Chloroaniline Carbon nanotubes (CNTs) Hydrogenation

Explicit solvent molecular dynamics simulations of chaperonin-assisted rhodanese folding

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Particuology 2009年第3期7卷 220-224页

作者： Ying Ren jian Gao Ji XU wei Ge Jinghai Li State Key Laboratory of Multiphase Complex System Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China Graduate University of the Chinese Academy of Sciences Beijing 100039 China

Chaperonins are known to facilitate the productive folding of numerous misfolded proteins. Despite their established importance, the mechanism of chaperonin-assisted protein folding remains unknown. In the present article, all-atom explicit solvent molecular dynamics （MD） simulations have been performed for the first time on rhodanese folding in a series of cavity-size and cavity-charge chaperonin mutants. A compromise between stability and flexibility of chaperonin structure during the substrate folding has been observed and the key factors affecting this dynamic process are discussed.

关键词： Molecular dynamics simulation Explicit solvent Chaperonin-assisted Protein folding Molecular chaperonin Rhodanese

Single-phase high-entropy intermetallic compounds(HEICs): bridging high-entropy alloys and ceramics

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Science Bulletin 2019年第12期64卷 856-864页

作者： Naixie zhou Sicong jiang Timothy Huang Mingde Qin Tao Hu jian Luo Department of Nanoengineering Program of Materials Science and EngineeringUniversity of CaliforniaSan DiegoCA 92093-0448USA Oerlikon Metco Inc. San DiegoCA 92121USA State Key Laboratory of High Performance and Complex Manufacturing School of Materials Science and EngineeringCentral South UniversityChangsha 410083China

High-entropy intermetallic compounds(HEICs)were fabricated by mechanical alloying and spark plasma sintering to fill a knowledge gap between the traditional high-entropy alloys(HEAs)and emerging highentropy ceramics(HECs).Notably,several four-or five-component equimolar aluminides,such as the B2-phase(Fe1/5 Co1/5 Ni1/5 Mn1/5 Cu1/5)Al,have been made into single-phase HEICs for the first *** modeling and a reversible,temperature-dependent,phase-stability experiment suggest that such B2-phase HEICs are entropy-stabilized *** structure of these HEICs resembles that of HECs with high-entropy mixing of fo ur or five elements of nearly equal fractions in one and only one sublattice,but with significant(10%)anti-site defects(differing from typical HECs).A new phase stability rule for forming single B2-phase HEICs is *** additional HEICs of predominantly D022 phases have also been *** study broadens the families of equimola r,single-phase,high-entropy materials that have been successfully fabricated.

关键词： High-entropy intermetallic compound Aluminide Phase stability High-entropy alloy High-entropy ceramic

不同激振力下碳纤维复合材料叶片振动特性的研究

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塑料科技 2024年第5期52卷 76-80页

作者：党鹏飞常健于华涛郑伟杨铮鑫沈阳化工大学机械与动力工程学院辽宁沈阳110142

为减小叶片在服役过程中振动导致损伤的问题,以高强度的碳纤维复合材料作为叶片基体,展开叶片的振动特性研究。基于振动分析理论,采用ANSYS Workbench软件对碳纤维复合材料叶片的振动特性进行研究。首先运用Solidworks软件建立叶片高保... 详细信息

为减小叶片在服役过程中振动导致损伤的问题,以高强度的碳纤维复合材料作为叶片基体,展开叶片的振动特性研究。基于振动分析理论,采用ANSYS Workbench软件对碳纤维复合材料叶片的振动特性进行研究。首先运用Solidworks软件建立叶片高保真模型;其次基于模态分析法得到碳纤维复合材料叶片自由振动的固有频率和各阶振型图,研究叶片的振动响应特性;其次分别在叶片叶尖处施加不同激振力,得到叶片叶尖在各个方向上的振动位移响应;再次根据得到的固有频率,绘制坎贝尔图,分析碳纤维复合材料叶片的振动特性规律。结果表明:叶片的主要振动形式为弯曲振动,随着激振力的增大,各个方向的振幅峰值对应的频率均向左发生偏移。从坎贝尔图中得出叶片在工作转速范围内有3个共振点。

关键词：叶片碳纤维复合材料振动特性激振力

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中国药品监管的科学化进程与监管科学发展

中国科学：生命科学 2024年第3期54卷 507-524页

作者：赵军宁王军志李波王辰杨悦周思源秦晓岺周乃元蒋露张伟华桦国家药品监督管理局药品监管科学全国重点实验室北京100038 中国食品药品检定研究院北京102629 中国医学科学院北京100730 清华大学药学院北京100083 国家药品监督管理局药品审评中心北京100022 中国药品监督管理研究会北京100050 四川省中医药科学院四川省中医药转化医学中心成都610041

国家药品监督管理局(National Medical Products Administration,NMPA)监管职责涉及所有中国人的生命、健康和福祉,是国际上监管事务和规模最为庞大的监管机构之一,在保证创新药品、人用疫苗、医疗器械、化妆品等医疗产品的安全性和有... 详细信息

国家药品监督管理局(National Medical Products Administration,NMPA)监管职责涉及所有中国人的生命、健康和福祉,是国际上监管事务和规模最为庞大的监管机构之一,在保证创新药品、人用疫苗、医疗器械、化妆品等医疗产品的安全性和有效性方面发挥至关重要的作用.伴随着药品监管科学化进程和药品监管科学行动计划的实施,我国对全球医药研发的贡献实现了历史性跨越,正朝向建立科学、高效、权威的药品监管体系战略目标迈进.本文基于科学轨迹和里程碑事件,将中国药品监管的科学化进程分为四个阶段:起步阶段——药物分析技术应用(1949~1984),发展阶段——药品注册标准建立(1985~2014),加速阶段——监管科学理念导入(2015~2018),跨越阶段——监管科学行动计划(2019~2023).“十四五”期间,中国药品监管的科学化进程进入新的发展时期——全面强化药品监管科学体系建设的新阶段,要进一步明确监管科学发展战略目标、重点任务、优先事项及各方责任,以全国重点实验、局重点实验室、监管科学基地三大平台建设为重点,完善药品监管科学的科技创新、技术评价、成果转化、学科培育、国际协调五大体系,以化学药、中药、生物制剂、医疗器械、化妆品、新兴交叉学科产品六大监管领域“卡脖子”问题为突破口,实施一批有助于加速新兴技术产品上市和可靠地生产药品的重点项目,持续创新药品监管新工具、新方法、新标准,解决药品监管基础性、关键性、前沿性和战略性技术问题,以期获得中国式现代化药监科技领域重大突破,更好地应对科技迅猛发展、公众健康需求、监管全球化带来的危机与挑战.

关键词：药品监督管理科学化进程监管科学医药产业技术创新

Compressed sensing based deconvolution algorithm for time-domain UWB channel modeling

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The Journal of China Universities of Posts and Telecommunications 2012年第1期19卷 62-68页

作者： LI De-jian LI Bin zhou Zheng ZHAI Shi-jun Key Laboratory of Universal Wireless Communications Ministry of EducationBeijing University of Posts and TelecommunicationsBeijing 100876China

Extracting the parameters of the multipath with high accuracy can be achieved by using high-resolution algorithm for time-domain ultra wideband （UWB） channel modeling. The CLEAN algorithm has been used as such a high-resolution algorithm for UWB time-domain characterization. This paper presents a compressed sensing （CS） based high-resolution deconvolution algorithm for time-domain UWB channel modeling. UWB wireless channels are a prime example of long and sparse channel impulse response （CIR）. Furthermore, the dictionary of parameterized waveforms that closely matches the waveform of multipath leads to that the UWB channel measurement signal is more compactly represented. By adjusting the parameter of dictionary, CIRs of different resolutions can be obtained. The matching pursuit （MP） algorithm is used as the signal reconstruction method for CS and outputs the CIR directly. We also demonstrated that if the dictionary of CS is designed specifically, MP is an equivalent of single template CLEAN. Finally, the computation complexity of CS-MP is analyzed and comparison of MP and CLEAN is performed. Simulation results show that compared to CLEAN, the proposed CS-MP deconvolution algorithm can achieve a comparable performance with much fewer samplings.

关键词： compressed sensing deconvolution channel modeling matching pursuit UWB

3D Human Pose Estimation Using Two-Stream Architecture with Joint Training

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Computer Modeling in Engineering & Sciences 2023年第10期137卷 607-629页

作者： jian Kang Wanshu Fan Yijing Li Rui Liu Dongsheng zhou National and Local Joint Engineering Laboratory of Computer Aided Design School of Software EngineeringDalian UniversityDalian116622China Dalian Maritime University Dalian116023China

With the advancement of image sensing technology, estimating 3Dhuman pose frommonocular video has becomea hot research topic in computer vision. 3D human pose estimation is an essential prerequisite for subsequentaction analysis and understanding. It empowers a wide spectrum of potential applications in various areas, suchas intelligent transportation, human-computer interaction, and medical rehabilitation. Currently, some methodsfor 3D human pose estimation in monocular video employ temporal convolutional network (TCN) to extractinter-frame feature relationships, but the majority of them suffer from insufficient inter-frame feature relationshipextractions. In this paper, we decompose the 3D joint location regression into the bone direction and length, wepropose the TCG, a temporal convolutional network incorporating Gaussian error linear units (GELU), to solvebone direction. It enablesmore inter-frame features to be captured andmakes the utmost of the feature relationshipsbetween data. Furthermore, we adopt kinematic structural information to solve bone length enhancing the use ofintra-frame joint features. Finally, we design a loss function for joint training of the bone direction estimationnetwork with the bone length estimation network. The proposed method has extensively experimented on thepublic benchmark dataset Human3.6M. Both quantitative and qualitative experimental results showed that theproposed method can achieve more accurate 3D human pose estimations.

关键词： 3D human pose improved TCN GELU kinematic structure